Select a medication above to begin.
Retevmo
selpercatinib
Adult Dosing .
Dosage forms: CAP: 40 mg, 80 mg; TAB: 40 mg, 80 mg, 120 mg, 160 mg
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments; D/C >7 days before elective surgery, restart >14 days after major surgery when wound fully healed
RET fusion-positive non-small cell lung CA, locally advanced or metastatic
- [<50 kg]
- Dose: 120 mg PO bid; Info: do not crush/chew cap or tab
- [>50 kg]
- Dose: 160 mg PO bid; Info: do not crush/chew cap or tab
RET fusion-positive thyroid CA, advanced or metastatic
- [<50 kg]
- Dose: 120 mg PO bid; Info: for pts refractory to radioactive iodine; do not crush/chew cap or tab
- [>50 kg]
- Dose: 160 mg PO bid; Info: for pts refractory to radioactive iodine; do not crush/chew cap or tab
RET-mutant medullary thyroid CA, advanced or metastatic
- [<50 kg]
- Dose: 120 mg PO bid; Info: do not crush/chew cap or tab
- [>50 kg]
- Dose: 160 mg PO bid; Info: do not crush/chew cap or tab
RET fusion-positive solid tumors, locally advanced or metastatic
- [<50 kg]
- Dose: 120 mg PO bid; Info: for pts w/ progressive dz; do not crush/chew cap or tab
- [>50 kg]
- Dose: 160 mg PO bid; Info: for pts w/ progressive dz; do not crush/chew cap or tab
renal dosing
- [see below]
- eGFR >15: no adjustment; eGFR <15 or ESRD: not defined
- HD/PD: not defined
hepatic dosing
- [adjust dose amount]
- bilirubin 3.1-10x ULN: start 80 mg bid
Peds Dosing .
- Dosage forms: CAP: 40 mg, 80 mg; TAB: 40 mg, 80 mg, 120 mg, 160 mg
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments; D/C >7 days before elective surgery, restart >14 days after major surgery when wound fully healed
RET fusion-positive thyroid CA, advanced or metastatic
- [2-11 yo, BSA 0.33-0.65 m^2]
- Dose: 40 mg PO tid; Info: for pts refractory to radioactive iodine; do not crush/chew cap or tab
- [2-11 yo, BSA 0.66-1.08 m^2]
- Dose: 80 mg PO bid; Info: for pts refractory to radioactive iodine; do not crush/chew cap or tab
- [2-11 yo, BSA 1.09-1.52 m^2]
- Dose: 120 mg PO bid; Info: for pts refractory to radioactive iodine; do not crush/chew cap or tab
- [2-11 yo, BSA >1.53 m^2]
- Dose: 160 mg PO bid; Info: for pts refractory to radioactive iodine; do not crush/chew cap or tab
- [12 yo and older, <50 kg]
- Dose: 120 mg PO bid; Info: for pts refractory to radioactive iodine; do not crush/chew cap or tab
- [12 yo and older, >50 kg]
- Dose: 160 mg PO bid; Info: for pts refractory to radioactive iodine; do not crush/chew cap or tab
RET-mutant medullary thyroid CA, advanced or metastatic
- [2-11 yo, BSA 0.33-0.65 m^2]
- Dose: 40 mg PO tid; Info: do not crush/chew cap or tab
- [2-11 yo, BSA 0.66-1.08 m^2]
- Dose: 80 mg PO bid; Info: do not crush/chew cap or tab
- [2-11 yo, BSA 1.09-1.52 m^2]
- Dose: 120 mg PO bid; Info: do not crush/chew cap or tab
- [2-11 yo, BSA >1.53 m^2]
- Dose: 160 mg PO bid; Info: do not crush/chew cap or tab
- [12 yo and older, <50 kg]
- Dose: 120 mg PO bid; Info: do not crush/chew cap or tab
- [12 yo and older, >50 kg]
- Dose: 160 mg PO bid; Info: do not crush/chew cap or tab
RET fusion-positive solid tumors, locally advanced or metastatic
- [2-11 yo, BSA 0.33-0.65 m^2]
- Dose: 40 mg PO tid; Info: for pts w/ progressive dz; do not crush/chew cap or tab
- [2-11 yo, BSA 0.66-1.08 m^2]
- Dose: 80 mg PO bid; Info: for pts w/ progressive dz; do not crush/chew cap or tab
- [2-11 yo, BSA 1.09-1.52 m^2]
- Dose: 120 mg PO bid; Info: for pts w/ progressive dz; do not crush/chew cap or tab
- [2-11 yo, BSA >1.53 m^2]
- Dose: 160 mg PO bid; Info: for pts w/ progressive dz; do not crush/chew cap or tab
- [12 yo and older, <50 kg]
- Dose: 120 mg PO bid; Info: for pts w/ progressive dz; do not crush/chew cap or tab
- [12 yo and older, >50 kg]
- Dose: 160 mg PO bid; Info: for pts w/ progressive dz; do not crush/chew cap or tab
renal dosing
- [see below]
- eGFR >15: no adjustment; eGFR <15 or ESRD: not defined
- HD/PD: not defined
hepatic dosing
- [if usual dose 40 mg tid or 80 mg bid]
- bilirubin 3.1-10x ULN: start 40 mg bid
- [if usual dose 120 mg bid or 160 mg bid]
- bilirubin 3.1-10x ULN: start 80 mg bid