Select a medication above to begin.
Olinvyk
oliceridine
Black Box Warnings .
Appropriate Use
should only be prescribed by healthcare professionals knowledgeable about opioid use and how to mitigate assoc. risks; reserve opioid analgesics for pts w/ inadequate tx alternatives; proper dosing and titration essential to decr. resp. depression risk
Addiction, Abuse, and Misuse
opioid agonist Schedule II controlled substance w/ risk of addiction, abuse, and misuse, which can lead to overdose and death; assess opioid abuse or addiction risk prior to prescribing; regularly reassess all pts for misuse, abuse, and addiction
Respiratory Depression
serious, life-threatening, or fatal cases may occur even w/ recommended use, esp. during tx start or after dose incr; to decr. risk, initiate and titrate dose appropriately
Risks from Concomitant Use w/ Benzodiazepines, CNS Depressants
concomitant opioid use w/ benzodiazepines or other CNS depressants, incl. alcohol, may result in profound sedation, resp. depression, coma, and death; reserve concomitant use for pts w/ inadequate alternative tx options
Neonatal Opioid Withdrawal Syndrome
extended use in pregnant pts can lead to potentially life-threatening neonatal opioid withdrawal syndrome; advise pregnant pts of risks and ensure tx by neonatology experts avail. at delivery if extended opioid use required
Adult Dosing .
Dosage forms: INJ
pain, mod-severe acute
- [PCA route]
- Dose: 0.35-0.5 mg IV q6min prn; Start: 1.5 mg IV x1; Max: 3 mg/dose; 27 mg/day; Info: healthcare provider may give supplemental dose 0.75 mg IV q1h prn; refer to institution protocol; use lowest effective dose, shortest effective tx duration; consider low start dose, titrate slowly in pts 65 yo and older; consider decr. frequency in CYP2D6 poor metabolizers; taper to D/C if prolonged or long-term opioid use
- [IV route]
- Dose: individualize dose, frequency; Start: 1.5 mg IV x1; Max: 3 mg/dose; 27 mg/day; Info: use lowest effective dose, shortest effective tx duration; consider low start dose, titrate slowly in pts 65 yo and older; consider decr. frequency in CYP2D6 poor metabolizers; taper dose gradually to D/C if prolonged or long-term opioid use
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [see below]
- mild-moderate impairment: consider decr. usual frequency; severe impairment: consider decr. usual start dose, titrate slowly
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.