Gavreto

Adult Dosing .

Dosage forms:  CAP: 100 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments; D/C >5 days before elective surgery, restart >14 days after major surgery when wound fully healed

RET fusion-positive non-small cell lung CA, metastatic

[400 mg PO qd]

Info: give at least 1h before or 2h after food

RET fusion-positive thyroid CA, advanced or metastatic

[400 mg PO qd]

Info: for pts w/ radioactive iodine-refractory dz requiring systemic tx; give at least 1h before or 2h after food

RET-mutant medullary thyroid CA, advanced or metastatic

[indication withdrawn in US]

Info: postmarketing requirement not fulfilled

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  CAP: 100 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments; D/C >5 days before elective surgery, restart >14 days after major surgery when wound fully healed

RET fusion-positive thyroid CA, advanced or metastatic

[12 yo and older]

Dose: 400 mg PO qd; Info: for pts w/ radioactive iodine-refractory dz requiring systemic tx; give at least 1h before or 2h after food

RET-mutant medullary thyroid CA, advanced or metastatic

[indication withdrawn in US]

Info: postmarketing requirement not fulfilled

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[no adjustment]