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Sevenfact (coagulation factor VIIa (recombinant)-jncw)
coagulation factor VIIa (recombinant)
Black Box Warnings .
Thrombosis
serious arterial and venous thrombotic/thromboembolic events, incl. fatal, have been reported; counsel pts on thrombosis risk and s/sx; monitor pts for coagulation system activation and thrombosis s/sx
Adult Dosing .
Dosage forms: INJ
Special Note
- [formulation clarification]
- Info: nonproprietary name = coagulation factor VIIa (recombinant)-jncw
congenital hemophilia A or B w/ inhibitors
- [bleeding episode, minor-moderate]
- Dose: 75 mcg/kg/dose IV q3h until hemostasis; Alt: 225 mcg/kg/dose IV x1; if hemostasis not achieved w/in 9h, may give additional 75 mcg/kg/dose IV q3h until hemostasis; Info: individualize dose, frequency; consider alternative tx if hemostasis not achieved w/in 24h
- [bleeding episode, major]
- Dose: 225 mcg/kg/dose IV x1; if hemostasis not achieved after 6h, give 75 mcg/kg/dose IV q2h until hemostasis; Info: individualize dose, frequency
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ
Special Note
- [formulation clarification]
- Info: nonproprietary name = coagulation factor VIIa (recombinant)-jncw
congenital hemophilia A or B w/ inhibitors
- [bleeding episode, minor-moderate, 12 yo and older]
- Dose: 75 mcg/kg/dose IV q3h until hemostasis; Alt: 225 mcg/kg/dose IV x1; if hemostasis not achieved w/in 9h, may give additional 75 mcg/kg/dose IV q3h until hemostasis; Info: individualize dose, frequency; consider alternative tx if hemostasis not achieved w/in 24h
- [bleeding episode, major, 12 yo and older]
- Dose: 225 mcg/kg/dose IV x1; if hemostasis not achieved after 6h, give 75 mcg/kg/dose IV q2h until hemostasis; Info: individualize dose, frequency
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]