Comirnaty

Adult Dosing .

Dosage forms:  INJ

COVID-19 prevention

[immunocompetent or mildly immunocompromised patients, <65 yo]

Dose: 0.3 mL IM x1 dose; Info: give at least 8wk after last COVID-19 vaccine dose if previously vaccinated; search 'immunization' for epocrates Adult Immunization decision tool

[immunocompetent or mildly immunocompromised patients, 65 yo and older]

Dose: 0.3 mL IM x2 doses at least 6mo apart; Info: give at least 8wk after last COVID-19 vaccine dose if previously vaccinated; search 'immunization' for epocrates Adult Immunization decision tool

[moderately-severely immunocompromised patients, not previously vaccinated]

Dose: 0.3 mL IM x2 doses 3wk apart, then 0.3 mL IM x1 dose at least 4wk later, then 0.3 mL IM x1 dose at least 6mo later; Info: may give additional dose at least 2mo after last dose and consider further doses based on shared clinical decision-making; search 'immunization' for epocrates Adult Immunization decision tool

[moderately-severely immunocompromised patients, previously received 1 Pfizer-BioNTech vaccine dose]

Dose: 0.3 mL IM x2 doses at least 4wk apart, then 0.3 mL IM x1 dose at least 6mo later; Start: 3wk after last dose; Info: may give additional dose at least 2mo after last dose and consider further doses based on shared clinical decision-making; search 'immunization' for epocrates Adult Immunization decision tool

[moderately-severely immunocompromised patients, previously received 2 Pfizer-BioNTech vaccine doses]

Dose: 0.3 mL IM x2 doses at least 6mo apart; Start: at least 4wk after last dose; Info: may give additional dose at least 2mo after last dose and consider further doses based on shared clinical decision-making; search 'immunization' for epocrates Adult Immunization decision tool

[moderately-severely immunocompromised patients, previously received 3 or more mRNA vaccine doses]

Dose: 0.3 mL IM x2 doses at least 6mo apart; Start: at least 8wk after last dose; Info: may give additional dose at least 2mo after last dose and consider further doses based on shared clinical decision-making; search 'immunization' for epocrates Adult Immunization decision tool

[moderately-severely immunocompromised patients, previously received 2 or more Novavax vaccine doses]

Dose: 0.3 mL IM x2 doses at least 6mo apart; Start: at least 8wk after last dose; Info: may give additional dose at least 2mo after last dose and consider further doses based on shared clinical decision-making; search 'immunization' for epocrates Adult Immunization decision tool

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  INJ

Special Note

[formulation clarification]

Info: pre-filled syringes = 30 mcg/0.3 mL, use in patients 12 yo and older; blue cap vials = 10 mcg/0.3 mL, use in patients 5-11 yo

COVID-19 prevention

[5 yo and older, immunocompetent or mildly immunocompromised patients]

Dose: 0.3 mL IM x1 dose; Info: give at least 8wk after last COVID-19 vaccine dose if previously vaccinated; give based on shared clinical decision-making; search 'immunization' for epocrates Child/Adolescent Immunization decision tool

[5 yo and older, moderately-severely immunocompromised patients, not previously vaccinated]

Dose: 0.3 mL IM x2 doses 3wk apart, then 0.3 mL IM x1 dose at least 4wk later, then 0.3 mL IM x1 dose at least 6mo later; Info: may give additional dose at least 2mo after last dose and consider further doses based on shared clinical decision-making; search 'immunization' for epocrates Child/Adolescent Immunization decision tool

[5 yo and older, moderately-severely immunocompromised patients, previously received 1 Pfizer-BioNTech vaccine dose]

Dose: 0.3 mL IM x2 doses at least 4wk apart, then 0.3 mL IM x1 dose at least 6mo later; Start: 3wk after last dose; Info: may give additional dose at least 2mo after last dose and consider further doses based on shared clinical decision-making; search 'immunization' for epocrates Child/Adolescent Immunization decision tool

[5 yo and older, moderately-severely immunocompromised patients, previously received 2 Pfizer-BioNTech vaccine doses]

Dose: 0.3 mL IM x2 doses at least 6mo apart; Start: at least 4wk after last dose; Info: may give additional dose at least 2mo after last dose and consider further doses based on shared clinical decision-making; search 'immunization' for epocrates Child/Adolescent Immunization decision tool

[5 yo and older, moderately-severely immunocompromised patients, previously received 3 or more mRNA vaccine doses]

Dose: 0.3 mL IM x2 doses at least 6mo apart; Start: at least 8wk after last dose; Info: may give additional dose at least 2mo after last dose and consider further doses based on shared clinical decision-making; search 'immunization' for epocrates Child/Adolescent Immunization decision tool

[5 yo and older, moderately-severely immunocompromised patients, previously received 2 or more Novavax vaccine doses]

Dose: 0.3 mL IM x2 doses at least 6mo apart; Start: at least 8wk after last dose; Info: may give additional dose at least 2mo after last dose and consider further doses based on shared clinical decision-making; search 'immunization' for epocrates Child/Adolescent Immunization decision tool

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[no adjustment]