repotrectinib + enasidenib

avoid combo: combo may incr. or decr. repotrectinib levels, incr. risk of adverse effects or decr. efficacy (P-gp-mediated transport inhibited, hepatic metabolism induced)

repotrectinib + clobazam

monitor respiratory rate: combo may decr. repotrectinib levels, efficacy; may incr. risk of CNS and respiratory depression, psychomotor impairment (hepatic metabolism induced; additive effects)

enasidenib + clobazam

monitor respiratory rate: combo may incr. clobazam and active metabolite levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)