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Interaction Check

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Selected Drugs Clear All

  • remove Depo-Provera CI
    medroxyprogesterone acetate
  • remove Enhertu (fam-trastuzumab deruxtecan-nxki)
    fam-trastuzumab deruxtecan
  • remove RabAvert
    rabies vaccine
  • remove Zyban
    bupropion hydrochloride

multicheck MultiCheck Results - 1 Interaction

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Enhertu (fam-trastuzumab deruxtecan-nxki) (fam-trastuzumab deruxtecan) + RabAvert (rabies vaccine)

Avoid/Use Alternative


fam-trastuzumab deruxtecan + rabies vaccine

if possible, avoid immunosuppressive tx or vaccinate at least 2wk before starting fam-trastuzumab deruxtecan tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

Additional Considerations

Smiley face Smiley face bupropion in Zyban

caution advised with concomitant drugs if smoking cessation use; dose adjustments may be necessary; smoking cessation may alter pharmacokinetics or pharmacodynamics of certain drugs

add MAO inhibitor to Interaction Check if recent (14 days) use

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