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Interaction Check

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Selected Drugs Clear All

  • remove Lopressor HCT
    metoprolol tartrate/ hydrochlorothiazide
  • remove Previfem
    norgestimate/ ethinyl estradiol
  • remove thioridazine
    generic

multicheck MultiCheck Results - 5 Interactions

Smiley face Smiley face

Contraindicated

Smiley face Smiley face Previfem (norgestimate/ ethinyl estradiol) + thioridazine (generic)

Contraindicated


ethinyl estradiol (contraceptive) + thioridazine

contraindicated: combo may incr. thioridazine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

Monitor/Modify Tx

Smiley face Smiley face Lopressor HCT (metoprolol tartrate/ hydrochlorothiazide) + Previfem (norgestimate/ ethinyl estradiol)

Monitor/Modify Tx


hydrochlorothiazide + ethinyl estradiol (contraceptive)

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

metoprolol + ethinyl estradiol (contraceptive)

monitor BP: combo may incr. metoprolol levels, risk of hypotension, bradycardia, AV block, other adverse effects; may decr. antihypertensive agent efficacy (hepatic metabolism inhibited; antagonistic effects)

Smiley face Smiley face Lopressor HCT (metoprolol tartrate/ hydrochlorothiazide) + thioridazine (generic)

Monitor/Modify Tx


hydrochlorothiazide + thioridazine

monitor BP: combo may incr. hydrochlorothiazide levels, risk of hypotension (including orthostasis), other adverse effects (absorption increased, additive effects)

metoprolol + thioridazine

monitor BP, HR; consider lower metoprolol dose: combo may incr. metoprolol levels, risk of hypotension (including orthostasis), bradycardia, AV block, other adverse effects (hepatic metabolism inhibited, additive effects)

Additional Considerations

Smiley face Smiley face metoprolol in Lopressor HCT

avoid combo with beverages or products containing ethanol and metoprolol extended-release (ER) sprinkle; combo may incr. metoprolol release rate, levels, risk of adverse effects, decr. duration of efficacy

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