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Interaction Check

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Selected Drugs Clear All

  • remove Alfenta
    alfentanil
  • remove fentanyl transmucosal
    generic
  • remove kava (Piper methysticum)
    common name
  • remove oxymetazoline nasal
    generic
  • remove Pamprin Max Pain + Energy
    acetaminophen/ aspirin/ caffeine
  • remove Tasmar
    tolcapone
  • remove Viread
    tenofovir disoproxil

multicheck MultiCheck Results - 9 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Alfenta (alfentanil) + fentanyl transmucosal (generic)

Avoid/Use Alternative


alfentanil + fentanyl

use alternative or monitor respiratory rate, BP, HR, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, serotonin syndrome, bradycardia, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus (additive effects)

Smiley face Smiley face Alfenta (alfentanil) + kava (Piper methysticum) (common name)

Avoid/Use Alternative


alfentanil + kava

avoid combo: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension (additive effects)

Smiley face Smiley face fentanyl transmucosal (generic) + kava (Piper methysticum) (common name)

Avoid/Use Alternative


fentanyl + kava

avoid combo: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

Smiley face Smiley face fentanyl transmucosal (generic) + oxymetazoline nasal (generic)

Avoid/Use Alternative


fentanyl + oxymetazoline nasal

avoid combo during fentanyl nasal dose titration, otherwise caution advised: combo may decr. fentanyl levels, efficacy (absorption decreased)

Smiley face Smiley face kava (Piper methysticum) (common name) + Tasmar (tolcapone)

Avoid/Use Alternative


kava + tolcapone

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Smiley face Smiley face Pamprin Max Pain + Energy (acetaminophen/ aspirin/ caffeine) + Viread (tenofovir disoproxil)

Avoid/Use Alternative


aspirin + tenofovir disoproxil

use alternative or monitor renal fxn: combo may incr. tenofovir levels, risk of nephrotoxicity, other adverse effects (additive effects)

Monitor/Modify Tx

Smiley face Smiley face Alfenta (alfentanil) + Tasmar (tolcapone)

Monitor/Modify Tx


alfentanil + tolcapone

monitor respiratory rate, BP; decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

Smiley face Smiley face fentanyl transmucosal (generic) + Tasmar (tolcapone)

Monitor/Modify Tx


fentanyl + tolcapone

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

Smiley face Smiley face oxymetazoline nasal (generic) + Pamprin Max Pain + Energy (acetaminophen/ aspirin/ caffeine)

Monitor/Modify Tx


oxymetazoline nasal + caffeine

monitor BP; avoid excessive caffeine intake: combo may incr. risk of HTN (additive effects)

Additional Considerations

Smiley face Smiley face fentanyl in fentanyl transmucosal

consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use

add MAO inhibitor to Interaction Check if recent (14 days) use

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