epocrates logo
epocrates logo
epocrates logo
  • 0

Interaction Check

epocrates logo

Sign in to access our clinical decision support tools

Sign in Create Account

Selected Drugs Clear All

  • remove Lybrel
    levonorgestrel/ ethinyl estradiol
  • remove My Way
    levonorgestrel
  • remove Nexafed Sinus Pressure + Pain
    acetaminophen/ pseudoephedrine
  • remove Quartette
    levonorgestrel/ ethinyl estradiol
  • remove Vitrase
    hyaluronidase

multicheck MultiCheck Results - 6 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Lybrel (levonorgestrel/ ethinyl estradiol) + Quartette (levonorgestrel/ ethinyl estradiol)

Avoid/Use Alternative


ethinyl estradiol (contraceptive) + ethinyl estradiol (contraceptive)

avoid combo: combo may incr. risk of HTN, thromboembolism, endometrial hyperplasia, other adverse effects (additive effects, duplicate therapy)

levonorgestrel (contraceptive) + levonorgestrel (contraceptive)

avoid combo: combo may incr. risk of thromboembolism, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

Smiley face Smiley face Lybrel (levonorgestrel/ ethinyl estradiol) + Nexafed Sinus Pressure + Pain (acetaminophen/ pseudoephedrine)

Monitor/Modify Tx


ethinyl estradiol (contraceptive) + acetaminophen

monitor thrombosis s/sx: combo may incr. ethinyl estradiol levels, risk of thromboembolism, other adverse effects (mechanism unknown)

ethinyl estradiol (contraceptive) + pseudoephedrine

monitor BP: combo may incr. risk of HTN (additive effects)

Smiley face Smiley face Nexafed Sinus Pressure + Pain (acetaminophen/ pseudoephedrine) + Quartette (levonorgestrel/ ethinyl estradiol)

Monitor/Modify Tx


acetaminophen + ethinyl estradiol (contraceptive)

monitor thrombosis s/sx: combo may incr. ethinyl estradiol levels, risk of thromboembolism, other adverse effects (mechanism unknown)

pseudoephedrine + ethinyl estradiol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

Additional Considerations

Smiley face Smiley face pseudoephedrine in Nexafed Sinus Pressure + Pain

add MAO inhibitor to Interaction Check if recent (14 days) use

Help
FDA Reporting Form
 
Download Epocrates from the App Store Download Epocrates from the Play Store
About Us Features Business Solutions Help & Feedback
© 2026 epocrates, Inc.    Terms of Use Privacy Policy Editorial Policy Do Not Sell or Share My Information