garlic + norethindrone (contraceptive)

use additional non-hormonal or alternative contraception during and x28 days after supplemental garlic tx; dietary intake OK: combo may decr. norethindrone levels, contraceptive efficacy (hepatic metab. induced)

garlic + ethinyl estradiol (contraceptive)

use additional non-hormonal or alternative contraception during and x28 days after supplemental garlic tx; dietary intake OK: combo may decr. ethinyl estradiol levels, contraceptive efficacy (hepatic metab. induced)

garlic + norethindrone (contraceptive)

use additional non-hormonal or alternative contraception during and x28 days after supplemental garlic tx; dietary intake OK: combo may decr. norethindrone levels, contraceptive efficacy (hepatic metab. induced)

clozapine + promethazine

use alternative or monitor resp. rate, BP, HR; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension (incl. orthostasis, syncope), seizures, severe constipation, paralytic ileus (incl. life-threatening), other anticholinergic adverse effects (additive effects)

tasimelteon + promethazine

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

norethindrone (contraceptive) + norethindrone (contraceptive)

avoid combo: combo may incr. risk of thromboembolism, other adverse effects (additive effects, duplicate tx)

lacosamide + promethazine

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, promethazine may decr. seizure threshold)

promethazine + cariprazine

use alternative or monitor BP, resp. rate; decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension (incl. orthostasis, syncope), extrapyramidal symptoms, hyperthermia, seizures (additive effects)

garlic + clozapine

monitor BP w/ supplemental garlic; dietary intake OK: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

garlic + promethazine

monitor BP w/ supplemental garlic; dietary intake OK: combo may incr. risk of hypotension (additive effects)

garlic + cariprazine

monitor BP w/ supplemental garlic; dietary intake OK: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

clozapine + norethindrone (contraceptive)

monitor thrombosis s/sx, especially w/ concomitant estrogen use: combo may incr. risk of thromboembolism (additive effects)

clozapine + lacosamide

monitor HR: combo may incr. risk of CNS depression, psychomotor impairment, bradycardia; may alter seizure control (additive effects; antagonistic effects, clozapine may decr. seizure threshold)

clozapine + ethinyl estradiol (contraceptive)

monitor ECG, BP, HR, thrombosis s/sx; consider decr. clozapine dose: combo may incr. clozapine levels, risk of QT prolongation, cardiac arrhythmias, hypotension, bradycardia, thromboembolism, other adverse effects (hepatic metab. inhibited, additive effects)

clozapine + norethindrone (contraceptive)

monitor thrombosis s/sx, especially w/ concomitant estrogen use: combo may incr. risk of thromboembolism (additive effects)

clozapine + cariprazine

monitor BP, HR: combo may incr. risk of CNS depression, psychomotor impairment, seizures, extrapyramidal symptoms, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects, duplicate tx)

garlic + tasimelteon

caution advised w/ supplemental garlic; dietary intake OK: combo may decr. tasimelteon levels, efficacy (hepatic metab. induced)

clozapine + cefiderocol

caution advised, especially w/ high cefiderocol doses and/or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

clozapine + tasimelteon

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

cefiderocol + lacosamide

caution advised: combo may alter seizure control (antagonistic effects, cefiderocol may decr. seizure threshold)

cefiderocol + promethazine

caution advised, especially w/ high cefiderocol doses and/or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

tasimelteon + lacosamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

tasimelteon + cariprazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

lacosamide + cariprazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, cariprazine may decr. seizure threshold)

ethinyl estradiol (contraceptive) + cariprazine

caution advised: combo may incr. cariprazine and active metabolite levels, risk of adverse effects (hepatic metab. inhibited)