Interaction Check

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Selected Drugs Clear All

MultiCheck Results - 6 Interactions

Avoid/Use Alternative
Alka-Seltzer Plus Severe Cold & Cough PowerFast Fizz (aspirin/ chlorpheniramine/ dextromethorphan/ phenylephrine) + Sudafed PE Sinus Congestion Night (diphenhydramine/ phenylephrine)
Avoid/Use Alternative phenylephrine + phenylephrine avoid combo: combo may incr. risk of HTN, tachycardia (additive effects, duplicate therapy) Caution Advised chlorpheniramine + diphenhydramine caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Monitor/Modify Tx
Alka-Seltzer Plus Severe Cold & Cough PowerFast Fizz (aspirin/ chlorpheniramine/ dextromethorphan/ phenylephrine) + Spravato (esketamine nasal)
Monitor/Modify Tx chlorpheniramine + esketamine monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects) phenylephrine + esketamine monitor BP: combo may incr. risk of HTN (additive effects)
Spravato (esketamine nasal) + Sudafed PE Sinus Congestion Night (diphenhydramine/ phenylephrine)
Monitor/Modify Tx esketamine + diphenhydramine monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects) esketamine + phenylephrine monitor BP: combo may incr. risk of HTN (additive effects)
Additional Considerations
dextromethorphan in Alka-Seltzer Plus Severe Cold & Cough PowerFast Fizz
add MAO inhibitor to Interaction Check if recent (14 days) use
phenylephrine in Alka-Seltzer Plus Severe Cold & Cough PowerFast Fizz, Sudafed PE Sinus Congestion Night
add MAO inhibitor to Interaction Check if recent (14 days) use