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Interaction Check

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Selected Drugs Clear All

  • remove Arnuity Ellipta
    fluticasone furoate inhaled
  • remove Corynanthe johimbe
    yohimbe (Pausinystalia yohimbe)
  • remove Excedrin Migraine
    acetaminophen/ aspirin/ caffeine
  • remove Janumet XR
    sitagliptin/ metformin
  • remove Nextstellis
    drospirenone/ estetrol
  • remove Psorcon E
    diflorasone topical
  • remove Votrient
    pazopanib

multicheck MultiCheck Results - 16 Interactions

Smiley face Smiley face

Monitor/Modify Tx

Smiley face Smiley face Corynanthe johimbe (yohimbe (Pausinystalia yohimbe)) + Excedrin Migraine (acetaminophen/ aspirin/ caffeine)

Monitor/Modify Tx


yohimbe + caffeine

monitor BP, HR; avoid excessive caffeine intake: combo may incr. risk of HTN, tachycardia (additive effects)

Smiley face Smiley face Corynanthe johimbe (yohimbe (Pausinystalia yohimbe)) + Nextstellis (drospirenone/ estetrol)

Monitor/Modify Tx


yohimbe + estetrol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

Smiley face Smiley face Corynanthe johimbe (yohimbe (Pausinystalia yohimbe)) + Votrient (pazopanib)

Monitor/Modify Tx


yohimbe + pazopanib

monitor BP: combo may incr. risk of HTN (additive effects)

Smiley face Smiley face Excedrin Migraine (acetaminophen/ aspirin/ caffeine) + Janumet XR (sitagliptin/ metformin)

Monitor/Modify Tx


aspirin + sitagliptin

monitor renal fxn, glucose, especially w/ high-dose aspirin: combo may incr. risk of nephrotoxicity, hypoglycemia (additive effects)

Smiley face Smiley face Excedrin Migraine (acetaminophen/ aspirin/ caffeine) + Nextstellis (drospirenone/ estetrol)

Monitor/Modify Tx


caffeine + estetrol (contraceptive)

monitor BP; avoid excessive caffeine intake: combo may incr. risk of HTN (additive effects)

Smiley face Smiley face Excedrin Migraine (acetaminophen/ aspirin/ caffeine) + Votrient (pazopanib)

Monitor/Modify Tx


aspirin + pazopanib

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

caffeine + pazopanib

monitor BP; avoid excessive caffeine intake: combo may incr. risk of HTN (additive effects)

Smiley face Smiley face Janumet XR (sitagliptin/ metformin) + Nextstellis (drospirenone/ estetrol)

Monitor/Modify Tx


metformin + drospirenone (contraceptive)

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

metformin + estetrol (contraceptive)

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

sitagliptin + drospirenone (contraceptive)

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

sitagliptin + estetrol (contraceptive)

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

Smiley face Smiley face Janumet XR (sitagliptin/ metformin) + Psorcon E (diflorasone topical)

Monitor/Modify Tx


metformin + diflorasone topical

monitor glucose w/ prolonged topical corticosteroid use: combo may decr. antidiabetic agent efficacy (antagonistic effects)

sitagliptin + diflorasone topical

monitor glucose w/ prolonged topical corticosteroid use: combo may decr. antidiabetic agent efficacy (antagonistic effects)

Smiley face Smiley face Janumet XR (sitagliptin/ metformin) + Votrient (pazopanib)

Monitor/Modify Tx


sitagliptin + pazopanib

monitor renal, cardiac fxn: combo may incr. risk of nephrotoxicity, cardiotoxicity (additive effects)

Smiley face Smiley face Nextstellis (drospirenone/ estetrol) + Votrient (pazopanib)

Monitor/Modify Tx


drospirenone (contraceptive) + pazopanib

monitor thrombosis s/sx, especially w/ concomitant estrogen use: combo may incr. risk of thromboembolism (additive effects)

estetrol (contraceptive) + pazopanib

monitor BP, thrombosis s/sx: combo may incr. risk of HTN, thromboembolism (additive effects)

Additional Considerations

Smiley face Smiley face yohimbe in Corynanthe johimbe

yohimbe products may contain varying amounts of yohimbine, other alkaloids

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