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Interaction Check

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Selected Drugs Clear All

  • remove Benlysta
    belimumab
  • remove Nuedexta
    dextromethorphan/ quinidine
  • remove Safyral
    drospirenone/ ethinyl estradiol/ levomefolate
  • remove Savella
    milnacipran

multicheck MultiCheck Results - 2 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Nuedexta (dextromethorphan/ quinidine) + Savella (milnacipran)

Avoid/Use Alternative


dextromethorphan + milnacipran

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

Smiley face Smiley face Safyral (drospirenone/ ethinyl estradiol/ levomefolate) + Savella (milnacipran)

Monitor/Modify Tx


ethinyl estradiol (contraceptive) + milnacipran

monitor BP: combo may incr. risk of HTN (additive effects)

Additional Considerations

Smiley face Smiley face quinidine (CYP2D6 inhibitor) in Nuedexta

low dose quinidine used as CYP2D6 'booster' has different interaction characteristics vs. antiarrhythmic dose quinidine

Smiley face Smiley face dextromethorphan in Nuedexta

add MAO inhibitor to Interaction Check if recent (14 days) use

Smiley face Smiley face milnacipran in Savella

add MAO inhibitor to Interaction Check if recent (14 days) use

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