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Interaction Check

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Selected Drugs Clear All

  • remove Infumorph
    morphine sulfate
  • remove NitroMist
    nitroglycerin

multicheck MultiCheck Results - 1 Interaction

Smiley face Smiley face

Monitor/Modify Tx

Smiley face Smiley face Infumorph (morphine sulfate) + NitroMist (nitroglycerin)

Monitor/Modify Tx


morphine + nitroglycerin

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

Additional Considerations

Smiley face Smiley face nitroglycerin in NitroMist

if SL nitroglycerin tab use, caution advised with anticholinergic drugs, tricyclic antidepressants, other drugs that may cause xerostomia; combo may delay vasodilator onset, decr. nitroglycerin peak levels, efficacy; absorption decreased, xerostomia may alter dissolution of SL tab

Smiley face Smiley face morphine in Infumorph

consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use

add MAO inhibitor to Interaction Check if recent (14 days) use

avoid combo with beverages or products containing ethanol and some morphine extended-release (ER) capsules; combo may incr. morphine release rate, levels, risk of adverse effects, including life-threatening overdose, decr. duration of efficacy

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