Selected Drugs Clear All
MultiCheck Results
- 2
Interactions
Monitor/Modify Tx |
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BackAid Max
(acetaminophen/ pamabrom) + Bunavail
(buprenorphine/ naloxone) |
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Monitor/Modify Txpamabrom + buprenorphine monitor BP; consider incr. pamabrom dose: combo may decr. pamabrom efficacy (antagonistic effects, opioids may induce antidiuretic hormone release) |
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Bunavail
(buprenorphine/ naloxone) + Topamax
(topiramate) |
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Monitor/Modify Txbuprenorphine + topiramate monitor respiratory rate, withdrawal sx; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control; topiramate doses >200 mg/day may decr. buprenorphine levels, efficacy (additive effects; antagonistic effects, buprenorphine may decr. seizure threshold; hepatic metabolism induced) |
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Additional Considerations |
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topiramate
in Topamax
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beverages or products containing ethanol are contraindicated within 6h of topiramate extended-release (ER) capsules administration; combo may incr. topiramate release rate, levels, risk of adverse effects, decr. duration of efficacy |
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buprenorphine
in Bunavail
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consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use |
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naloxone (abuse deterrent)
in Bunavail
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no pharmacologic activity when administered as directed |
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