epocrates logo
epocrates logo
epocrates logo
  • 0

Interaction Check

epocrates logo

Sign in to access our clinical decision support tools

Sign in Create Account

Selected Drugs Clear All

  • remove Aralen
    chloroquine phosphate
  • remove Clarinex Reditabs
    desloratadine
  • remove Jascayd
    nerandomilast
  • remove Lariam
    mefloquine hydrochloride

multicheck MultiCheck Results - 1 Interaction

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Aralen (chloroquine phosphate) + Lariam (mefloquine hydrochloride)

Avoid/Use Alternative


chloroquine + mefloquine

avoid combo; give mefloquine at least 12h after last dose of chloroquine: combo may incr. risk of QT prolongation, cardiac arrhythmias, seizures (additive effects)

Additional Considerations

Smiley face Smiley face chloroquine in Aralen

consider monitoring ECG in combo with other drugs that prolong QT interval; combo may incr. risk of QT prolongation, cardiac arrhythmias, even after chloroquine D/C due to long half-life (1-2mo)

Help
FDA Reporting Form
 
Download Epocrates from the App Store Download Epocrates from the Play Store
About Us Features Business Solutions Help & Feedback
© 2026 epocrates, Inc.    Terms of Use Privacy Policy Editorial Policy Do Not Sell or Share My Information