epocrates logo
epocrates logo
epocrates logo
  • 0

Interaction Check

epocrates logo

Sign in to access our clinical decision support tools

Sign in Create Account

Selected Drugs Clear All

  • remove Lopressor HCT
    metoprolol tartrate/ hydrochlorothiazide
  • remove Previfem
    norgestimate/ ethinyl estradiol

multicheck MultiCheck Results - 2 Interactions

Smiley face Smiley face

Monitor/Modify Tx

Smiley face Smiley face Lopressor HCT (metoprolol tartrate/ hydrochlorothiazide) + Previfem (norgestimate/ ethinyl estradiol)

Monitor/Modify Tx


hydrochlorothiazide + ethinyl estradiol (contraceptive)

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

metoprolol + ethinyl estradiol (contraceptive)

monitor BP: combo may incr. metoprolol levels, risk of hypotension, bradycardia, AV block, other adverse effects; may decr. antihypertensive agent efficacy (hepatic metabolism inhibited; antagonistic effects)

Additional Considerations

Smiley face Smiley face metoprolol in Lopressor HCT

avoid combo with beverages or products containing ethanol and metoprolol extended-release (ER) sprinkle; combo may incr. metoprolol release rate, levels, risk of adverse effects, decr. duration of efficacy

Help
FDA Reporting Form
 
Download Epocrates from the App Store Download Epocrates from the Play Store
About Us Features Business Solutions Help & Feedback
© 2026 epocrates, Inc.    Terms of Use Privacy Policy Editorial Policy Do Not Sell or Share My Information