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Interaction Check

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Selected Drugs Clear All

  • remove Constulose
    lactulose
  • remove Gilotrif
    afatinib
  • remove naproxen/ esomeprazole
    generic
  • remove Pedia-Lax Enema
    sodium phosphate rectal
  • remove Pizensy
    lactitol

multicheck MultiCheck Results - 1 Interaction

Smiley face Smiley face

Monitor/Modify Tx

Smiley face Smiley face Gilotrif (afatinib) + naproxen/esomeprazole (generic)

Monitor/Modify Tx


afatinib + naproxen

monitor bleeding s/sx; decr. afatinib dose by 10 mg/day if not tolerated: combo may incr. afatinib levels, risk of GI ulceration, perforation, bleeding (including life-threatening), other adverse effects (P-gp-mediated transport inhibited, additive effects)

Additional Considerations

Smiley face Smiley face lactitol in Pizensy

Discontinued in US

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