frovatriptan + oxybate

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, syncope (additive effects)

frovatriptan + tramadol

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

ginseng, Asian + tramadol

use alternative or monitor withdrawal sx: combo may decr. tramadol levels, efficacy (hepatic metab. induced)

hyoscyamine + oxybate

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, syncope (additive effects)

methocarbamol + oxybate

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, syncope (additive effects)

oxybate + tramadol

use alternative or monitor resp. rate; consider holding oxybate, especially if peri- or post-operative opioid analgesia required: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, syncope (additive effects)

cabotegravir + chromium

consider admin. chromium at least 2h before or 4h after oral cabotegravir: combo may decr. cabotegravir levels, efficacy (absorption decreased via chelation)

cabotegravir + ferrous sulfate

consider admin. ferrous sulfate at least 2h before or 4h after oral cabotegravir: combo may decr. cabotegravir levels, efficacy (absorption decreased via chelation)

chromium + hyoscyamine

give >2h before or >6h after chromium: combo may decr. hyoscyamine levels, efficacy (absorption decreased via chelation)

galcanezumab + frovatriptan

monitor BP: combo may incr. risk of HTN (additive effects)

galcanezumab + licorice

monitor BP w/ large amounts of licorice: combo may incr. risk of HTN (additive effects)

ferrous sulfate + hyoscyamine

separate admin. by 1h: combo may decr. hyoscyamine levels, efficacy (absorption decreased via chelation)

frovatriptan + licorice

monitor BP w/ large amounts of licorice: combo may incr. risk of HTN (additive effects)

hyoscyamine + tramadol

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

hyoscyamine + acetaminophen

caution advised w/ oral acetaminophen: combo may decr. peak acetaminophen levels, delay analgesic onset, efficacy (absorption delayed, possibly decreased)

methocarbamol + tramadol

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, seizures (additive effects)

tramadol + bethanechol

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

frovatriptan + hyoscyamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

frovatriptan + methocarbamol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

hyoscyamine + methocarbamol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

hyoscyamine + bethanechol

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

methocarbamol + bethanechol

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)