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In a large real-world cohort study, women with breast cancer and obesity or type 2 diabetes who used GLP-1 receptor agonists had substantially lower ten-year all-cause mortality and cancer recurrence than matched patients on other treatments. . .

A pragmatic trial of genotype-guided SSRI prescribing found no benefit at three months but higher remission rates at six months, suggesting the value of pharmacogenetic testing emerges over time rather than immediately. . .

A study of 33 wealthy countries from 1990 to 2022 found that fewer hours worked track with lower adult obesity, with men showing the strongest effect. . .

Patients achieving ≥15% weight loss by 24 weeks on semaglutide 7.2 mg averaged 27.7% weight reduction at 72 weeks, with most weight loss driven by fat mass reduction. . .

A new, mRNA-based influenza vaccine reduced flu by 27% compared with standard-dose vaccines in adults 50 and older, but with notably higher rates of fatigue, headache, myalgia, and injection-site pain. . .

A global consensus retired polycystic ovary syndrome in favor of polyendocrine metabolic ovarian syndrome, a name built around the endocrine and cardiometabolic features at the core of the disease. . .

A new committee statement sets consistent ethical standards for how ob-gyns should counsel patients on pregnancy options, with patient autonomy at the center regardless of practice setting, personal beliefs, or local legal restrictions. . .

Ultra-processed food intake should be treated as a distinct cardiovascular risk factor, not just a marker of poor nutrient content, according to a new European cardiology consensus statement. . .

In selected ischemic stroke patients with poor early response to tenecteplase, tirofiban improved 90-day functional outcomes. . .