BMJ Evid Based Med
Curcumin and omeprazole compared in functional dyspepsia patients
Patients with functional dyspepsia treated with curcumin, omeprazole, or a combination of the two had similar symptomatic improvement.
- This randomized trial enrolled 206 patients with a diagnosis of functional dyspepsia who were randomly assigned to one of the three groups: curcumin alone (C), omeprazole alone (O), or curcumin plus omeprazole (C+O). Curcumin dose was two 250 mg capsuled qid, and omeprazole dose was 20 mg once daily for 28 days. A total of 151 patients completed the study. Severity of Dyspepsia Assessment (SODA) score was used to assess functional dyspepsia symptoms on days 28 and 56.
- SODA scores were improved significantly on day 28 in the pain (-4.83, -5.46 and -6.22), non-pain (-2.22, -2.32 and -2.31) and satisfaction (0.39, 0.79 and 0.60) domains for the C+O, C, and O groups, respectively. Improvements were enhanced on day 56 in the pain (-7.19, -8.07 and -8.85), non-pain (-4.09, -4.12 and -3.71) and satisfaction (0.78, 1.07, and 0.81) domains in the C+O, C, and O groups, respectively. No significant differences were observed among the three groups, and no serious adverse events were reported.
- No synergistic effect between omeprazole and curcumin was observed.
Source
Kongkam P, et al. (2023, September 11). BMJ Evid Based Med. Curcumin and proton pump inhibitors for functional dyspepsia: a randomised, double blind controlled trial. https://pubmed.ncbi.nlm.nih.gov/37696679/