JAMA Otolaryng Head Neck Surg

GLP-1 RAs linked to increased chronic cough risk in patients with diabetes

December 2, 2025

A large U.S. cohort study of over 2 million adults with T2DM found that those prescribed GLP-1 receptor agonists had a significantly higher risk of developing chronic cough compared with patients on other second-line diabetes medications. This association persisted even after excluding individuals with gastroesophageal reflux disease, suggesting a mechanism independent of reflux. Researchers call for further investigation into the underlying pathways and clinical implications.

Source:

Gallagher TJ, et al. (2025, November 26). JAMA Otolaryngol Head Neck Surg. Glucagon-Like Peptide-1 Receptor Agonists and Chronic Cough. https://pubmed.ncbi.nlm.nih.gov/41296333/