Gut
How common are IBS and functional dyspepsia following acute gastroenteritis?
After a bout of gastroenteritis, 14.5% of individuals developed postinfection irritable bowel syndrome (PI-IBS) and 12.7% postinfection functional dyspepsia (PI-FD), with greater than fourfold increased odds for IBS and threefold for FD. Proteobacteria and SARS-CoV-2 may be behind the development of PI-IBS and PI-FD.
- In this systematic review and meta-analysis, 47 observational studies comprising 28,170 subjects were used to examine the prevalence of IBS or FD after acute gastroenteritis with a >3 month follow-up. A random effects model was used to estimate prevalence and odds ratios (ORs) with 95% CIs.
- Overall prevalence of PI-IBS and PI-FD were 14.5% and 12.7%, respectively. IBS persisted in 39.8% of subjects in the long-term (>5 years follow-up) after diagnosis. Individuals experiencing acute gastroenteritis had a significantly higher odds of IBS (OR, 4.3) and FD (OR, 3.0) than non-exposed controls.
- PI-IBS was most associated with parasites (prevalence, 30.1%), but in only two studies, followed by bacteria (18.3%) and viruses (10.7%).
- In available studies, Campylobacter was associated with the highest PI-IBS prevalence (20.7%) whereas Proteobacteria and SARS-CoV-2 yielded the highest odds for PI-IBS (both OR, 5.4). Prevalence of PI-FD was 10.0% for SARS-CoV-2 and 13.6% for bacteria (Enterobacteriaceae, 19.4%).
Source:
Porcari S, et al. (2024, July 16). Gut. Prevalence of irritable bowel syndrome and functional dyspepsia after acute gastroenteritis: systematic review and meta-analysis. https://pubmed.ncbi.nlm.nih.gov/39013599/