L-methylfolate—a safe and effective adjunctive treatment for depression

According to a review of two RCTs, an open-label extension of these RCTs, and a real-world prospective study, l-methylfolate (LMF) is an effective adjunctive therapy for MDD, with 15 mg/day the most effective dose tested. Treatment response was higher in those with a higher BMI and elevated inflammatory biomarkers. LMF isn't associated with adverse reactions typically seen with other adjunctive MDD therapies.