J Am Heart Assoc

Men face double the mortality risk in 'broken heart syndrome'

May 16, 2025

Study details: This study utilized the Nationwide Inpatient Sample database to evaluate trends, mortality, and complications in patients admitted with Takotsubo cardiomyopathy from 2016 to 2020. The cohort included 199,890 patients, predominantly female (83%), with a higher prevalence among older adults, White race, and those with higher income.

Results: The overall mortality rate was 6.5%, with no significant improvement over the study period. Major complications included cardiogenic shock (6.6%), afib (20.7%), cardiac arrest (3.4%), CHF (35.9%), and stroke (5.3%). Notably, mortality was more than double in men compared with women (11.2% vs. 5.5%).

Clinical impact: Findings underscore the persistent high mortality and complication rates associated with Takotsubo cardiomyopathy, particularly among men. These results highlight the need for enhanced clinical strategies and interventions to improve outcomes in this patient population.

Source:

Movahed MR, et al. (2025, May 14). J Am Heart Assoc. High Mortality and Complications in Patients Admitted With Takotsubo Cardiomyopathy With More Than Double Mortality in Men Without Improvement in Outcome Over the Years. https://pubmed.ncbi.nlm.nih.gov/40365782/