J Allergy Clin Immunol Pract

Nasal sprays or oral meds: Which are more effective for allergic rhinitis?

January 27, 2025

Intranasal corticosteroids or antihistamines are superior to oral options for managing allergic rhinitis. This evidence can guide clinicians in optimizing treatment strategies, ultimately improving patient outcomes.

Study details: This systematic review and meta-analysis compared the effectiveness of intranasal corticosteroids or antihistamines vs. oral antihistamines or leukotriene receptor antagonists in improving allergic rhinitis symptoms and quality of life. The analysis included 35 randomized controlled trials involving patients ≥12 years with seasonal or perennial allergic rhinitis. Outcomes of interest included Total Nasal Symptom Score (TNSS), Total Ocular Symptom Score, and Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ).

Results: Relative to oral medications, intranasal corticosteroids significantly improved TNSS, Total Ocular Symptom Score, and RQLQ. Intranasal antihistamines also showed superiority over oral antihistamines in improving TNSS and RQLQ.

Source:

Torres MI, et al; Allergic Rhinitis and its Impact on Asthma 2024 Guideline Panel. (2024, December). J Allergy Clin Immunol Pract. Intranasal Versus Oral Treatments for Allergic Rhinitis: A Systematic Review With Meta-Analysis. https://pubmed.ncbi.nlm.nih.gov/39251016/