Occup Environ Med

Overwork linked to structural brain changes in healthcare workers

May 16, 2025

Study details: This pilot study explored the effects of overwork on brain structure among healthcare workers. A total of 110 participants were divided into overworked (≥52 hours/week; n = 32) and non-overworked groups (n = 78). Brain volume differences were assessed using voxel-based morphometry (VBM) and atlas-based analysis, with adjustments for age, sex, and total intracranial volume.

Results: Significant structural changes were observed in the brains of overworked individuals, particularly in regions associated with executive function and emotional regulation. Notably, there was a 19% increase in the volume of the left caudal middle frontal gyrus in the overworked group (p = 0.006). VBM analysis revealed peak increases in 17 regions, including the middle frontal gyrus, insula, and superior temporal gyrus (p < 0.05). Correlation analyses indicated a positive association between weekly working hours and brain volume changes in the middle frontal gyrus and insula.

Clinical impact: These findings provide preliminary evidence that overwork is associated with structural brain changes, particularly in regions linked to cognition and emotion. This underscores the potential neurological risks of prolonged working hours and highlights the need for further research to understand the long-term cognitive and emotional implications of overwork.

Source:

Jang W, et al. (2025, May 13). Occup Environ Med. Overwork and changes in brain structure: a pilot study. https://pubmed.ncbi.nlm.nih.gov/40360285/