J Am Geriatr Soc

Should statins be used for primary prevention after age 80?

March 12, 2026

In a population-based cohort of 15,745 adults aged ≥80 years without prior cardiovascular disease, persistent statin use was associated with 31% lower all-cause mortality (hazard ratio [HR], 0.69; 95% confidence interval [CI], 0.34-0.74; p < 0.001) and 20% fewer new coronary events (HR, 0.80; 95% CI, 0.68-0.94; p = 0.008) over four years, with no increased risk of myopathy, diabetes, or dementia. Benefits weren't observed in patients who discontinued statin therapy before age 80.

Clinical takeaway: For adults ≥80, consider statins for primary prevention when life expectancy, functional status, and patient goals suggest meaningful potential benefit—an individualized, shared decision-making approach remains essential.

Source:

Lavon O, et al. (2026, March 7). J Am Geriatr Soc. Statin Therapy for Primary Prevention and Clinical Outcomes in Adults Aged 80 and Older: A Retrospective Comparative Cohort Study. https://pubmed.ncbi.nlm.nih.gov/41793188/