NIH

Zebra of the Week: Epidermodysplasia verruciformis

August 11, 2025

Epidermodysplasia verruciformis is a rare inherited genodermatosis characterized by chronic infection with human papillomavirus (HPV) leading to polymorphous cutaneous lesions and high risk of developing non melanoma skin cancer.

Symptoms include persistent, widespread flat wart-like lesions and scaly macules primarily on sun-exposed areas, often beginning in childhood, with a predisposition to cutaneous squamous cell carcinoma due to persistent HPV infection.

Source:

(Accessed 2025, August 8). NIH: Genetic and Rare Diseases Information Center. Epidermodysplasia verruciformis. https://rarediseases.info.nih.gov/diseases/6357/epidermodysplasia-verruciformis