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Zebra of the Week: Ichthyosis vulgaris

February 3, 2025

Ichthyosis vulgaris is a genetic skin disorder characterized by dry, scaly skin, particularly on the extensor surfaces of the limbs, scalp, central face, and trunk. Other associated features include keratosis pilaris and hyperlinearity of the palms and soles. There is no cure for ichthyosis vulgaris, but symptoms can be managed with regular skin care. Treatment includes frequent moisturizing, exfoliation, and the use of emollients and keratolytic agents such as lactic acid and glycolic acid. In severe cases, retinoids may be prescribed.

About Ichthyosis vulgaris

• Population estimate: Approximately 1 in 250 people are affected by this condition.
• Signs/symptoms: Symptoms typically appear in early childhood, often between 2 months and 5 years of age.
• Cause: Ichthyosis vulgaris is primarily caused by genetic mutations in the FLG gene, leading to defective production of filaggrin.

Sources:

American Academy of Dermatology Association. (Accessed January 31, 2025). Ichthyosis vulgaris. https://www.aad.org/public/diseases/a-z/ichthyosis-vulgaris-overview

NIH: Genetic and Rare Diseases Information Center. (Accessed January 31, 2025). Ichthyosis vulgaris. https://rarediseases.info.nih.gov/diseases/6752/ichthyosis-vulgaris