NIH

Zebra of the Week: Stargardt disease

October 13, 2025

Stargardt disease is a genetic eye disorder that causes progressive vision loss. The condition involves the macula, the retinal region responsible for central visual acuity. Vision loss results from intracellular accumulation of lipofuscin within macular cells. People with Stargardt disease also have problems with night vision, and some have problems with color vision. It's most commonly caused by mutations in the ABCA4 gene and inherited in an autosomal recessive manner. Rarely, it may be caused by mutations in other genes and inherited in an autosomal dominant manner.

Source:

(Accessed 2025, October 8). NIH: Genetic and Rare Diseases Information Center. Stargardt disease. https://rarediseases.info.nih.gov/diseases/181/stargardt-disease