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Tezspire (tezepelumab-ekko)
tezepelumab
Adult Dosing .
Dosage forms: INJ (pen): 210 mg per 1.91 mL; INJ (pre-filled syringe): 210 mg per 1.91 mL; INJ (vial): 210 mg per 1.91 mL
Special Note
- [drug name clarification]
- Info: nonproprietary name = tezepelumab-ekko
severe asthma, maintenance tx
- [210 mg SC q4wk]
- Info: for add-on tx
renal dosing
- [see below]
- CrCl >30: no adjustment; CrCl <30: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ (pen): 210 mg per 1.91 mL; INJ (pre-filled syringe): 210 mg per 1.91 mL; INJ (vial): 210 mg per 1.91 mL
Special Note
- [drug name clarification]
- Info: nonproprietary name = tezepelumab-ekko
severe asthma, maintenance tx
- [12 yo and older]
- Dose: 210 mg SC q4wk; Info: for add-on tx
renal dosing
- [see below]
- CrCl >30: no adjustment; CrCl <30: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- asthma, acute
- bronchospasm, acute
- status asthmaticus
- avoid: abrupt corticosteroid D/C
- caution: helminth infection risk
Drug Interactions .
Overview
tezepelumab
TSLP antagonist
- immunosuppressive effects
Avoid/Use Alternative
- adenovirus vaccine, live
- chikungunya vaccine, live
- cholera vaccine, live
- dengue vaccine, live
- influenza nasal vaccine, live
- measles/mumps/rubella vaccine, live
- rotavirus vaccine, live
- smallpox vaccine, live
- typhoid vaccine, live
- varicella vaccine, live
- yellow fever vaccine, live
Monitor/Modify Tx
- carfilzomib
- ebola vaccine, live
- everolimus
- smallpox/mpox vaccine, live
- temsirolimus
Caution Advised
- abemaciclib
- acalabrutinib
- afamitresgene autoleucel
- aldesleukin
- alemtuzumab
- anti-thymocyte globulin
- atidarsagene autotemcel
- axicabtagene ciloleucel
- azacitidine
- azathioprine
- basiliximab
- belatacept
- belinostat
- bendamustine
- betamethasone
- blinatumomab
- bortezomib
- brentuximab vedotin
- brexucabtagene autoleucel
- budesonide
- busulfan
- cabazitaxel
- carboplatin
- carmustine
- chlorambucil
- ciltacabtagene autoleucel
- cisplatin
- cladribine injection
- clofarabine
- copanlisib
- cortisone
- cyclophosphamide
- cyclosporine
- cytarabine
- dactinomycin
- daratumumab
- daunorubicin
- decitabine
- deflazacort
- dexamethasone
- dinutuximab
- docetaxel
- doxorubicin
- duvelisib
- elotuzumab
- elranatamab
- epcoritamab
- epirubicin
- eribulin
- etoposide
- floxuridine
- fludarabine
- fludrocortisone
- fluorouracil
- fruquintinib
- gemtuzumab ozogamicin
- glofitamab
- hydrocortisone
- hydroxyurea
- ibritumomab tiuxetan
- ibrutinib
- idarubicin
- idecabtagene vicleucel
- idelalisib
- ifosfamide
- inotuzumab ozogamicin
- irinotecan
- isatuximab
- ixabepilone
- lenalidomide
- lisocabtagene maraleucel
- lomustine
- loncastuximab tesirine
- lymphocyte immune globulin, anti-thymocyte globulin
- melphalan
- mercaptopurine
- methylprednisolone
- mogamulizumab
- momelotinib
- mosunetuzumab
- mycophenolate mofetil
- mycophenolic acid
- nelarabine
- obecabtagene autoleucel
- obinutuzumab
- ofatumumab
- oxaliplatin
- paclitaxel
- panobinostat
- pentostatin
- pirtobrutinib
- polatuzumab vedotin
- pomalidomide
- ponatinib
- prednisolone
- prednisone
- procarbazine
- quizartinib
- regorafenib
- rituximab
- romidepsin
- ruxolitinib
- selinexor
- sirolimus
- sirolimus albumin-bound
- tacrolimus
- tafasitamab
- talquetamab
- tarlatamab
- teclistamab
- temozolomide
- thioguanine
- thiotepa
- tisagenlecleucel
- topotecan
- triamcinolone
- vamorolone
- venetoclax
- vinblastine
- vincristine
- vinorelbine
- voclosporin
- zanubrutinib
Adverse Reactions .
Serious Reactions
- cardiovascular event
- hypersensitivity rxn
- anaphylaxis
- helminth infection risk
Common Reactions
- injection site rxn
- pharyngitis
- arthralgia
- back pain
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy, esp. in 3rd trimester; no human data available, though likely to cross placenta in 3rd trimester based on human data w/ other monoclonal antibodies; no known risk of fetal harm based on animal data up to 168x MRHD
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: proteolytic degradation; CYP450: none
Excretion: unknown; Half-life: 26 days
Subclass: Thymic Stromal Lymphopoietin (TSLP) Antagonists
Mechanism of Action
exact mechanism of action unknown; binds thymic stromal lymphopoietin (TSLP), reducing inflammatory biomarkers and cytokines, incl. eosinophils, IgE, FeNO, IL-5, IL-13 (monoclonal antibody)
Formulary .
No Formulary Selected
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