Select a medication above to begin.
Leqvio
inclisiran
Adult Dosing .
Dosage forms: INJ (pre-filled syringe): 284 mg per 1.5 mL
hypercholesterolemia
- [284 mg SC q6mo]
- Start: 284 mg SC q3mo x2, then 284 mg SC q6mo; Info: restart dosing schedule if missed dose >3mo
heterozygous familial hypercholesterolemia
- [284 mg SC q6mo]
- Start: 284 mg SC q3mo x2, then 284 mg SC q6mo; Info: restart dosing schedule if missed dose >3mo
renal dosing
- [see below]
- renal impairment: no adjustment; ESRD: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- mild-moderate impairment: no adjustment; severe impairment: not defined
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
Drug Interactions .
Overview
inclisiran
PCSK9 siRNA
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
Serious Reactions
- hypersensitivity rxn, severe
- angioedema
Common Reactions
- injection site rxn
- arthralgia
- bronchitis
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; no known risk of embryo-fetal toxicity or teratogenicity based on animal data at 5x and 10x MRHD, respectively
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: other; CYP450: none
Excretion: urine 16%; Half-life: 9h
Subclass: Dyslipidemia: PCSK9 Small Interfering Ribonucleic Acids (siRNAs)
Mechanism of Action
small interfering ribonucleic acid (siRNA) directs catalytic breakdown of mRNA for proprotein convertase subtilisin kexin type 9 (PCSK9) synthesis and subsequent binding to LDL receptors, increasing LDL receptor recycling and decreasing circulating LDL
Formulary .
No Formulary Selected
Join Now to View Patient Handouts!
Create a FREE epocrates Online account to access patient medication instructions. Your patients and caregivers will appreciate you printing these friendly handouts, available in English and Spanish. Each handout addresses common concerns such as how to take the medication, and possible side effects.
Current Members: Sign In.
Pill Pictures
Join Now to View Pill Pictures!
Create a FREE epocrates Online account to access full-color images of medications within the drug monograph.
Current Members: Sign In.