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Vtama
tapinarof topical
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
Drug Interactions .
Overview
tapinarof topical
AhR agonist topical
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
Serious Reactions
may occur but none reported
Common Reactions
- folliculitis
- respiratory infection
- nasopharyngitis
- contact dermatitis
- headache
- pruritus
- influenza
- asthma
- vomiting
- ear infection
- extremity pain
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; no human data available, though risk of fetal harm not expected based on insignificant systemic absorption
Lactation
Clinical Summary
may use while breastfeeding; no human data available, though risk of infant harm and adverse effects on milk production not expected based on insignificant systemic absorption in breastfeeding pts
Pharmacology .
Metabolism: liver; CYP450: unknown; Info: minimal systemic absorption
Excretion: unknown; Half-life: unknown
Subclass: Psoriasis, Topical Nonsteroidal Agents
Mechanism of Action
exact mechanism of action unknown; activates aryl hydrocarbon receptor (AhR), inhibiting pro-inflammatory cytokines, incl. IL-17, and promoting skin barrier normalization (aryl hydrocarbon receptor agonist)
Formulary .
No Formulary Selected
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