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Amvuttra
vutrisiran
Adult Dosing .
Dosage forms: INJ (pre-filled syringe): 25 mg per 0.5 mL
transthyretin amyloid polyneuropathy
- [25 mg SC q3mo]
- Info: for pts w/ hereditary dz; vitamin A supplementation recommended
transthyretin amyloid cardiomyopathy
- [25 mg SC q3mo]
- Info: for pts w/ hereditary or wild-type dz to reduce cardiovascular death and cardiovascular-associated hospitalization; vitamin A supplementation recommended
renal dosing
- [see below]
- eGFR >30: no adjustment; eGFR <30 or ESRD: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- mild-moderate impairment: no adjustment; severe impairment: not defined
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
Drug Interactions .
Overview
vutrisiran
transthyretin-directed siRNA
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
Serious Reactions
- AV block
Common Reactions
- extremity pain
- arthralgia
- dyspnea
- serum vitamin A decr.
- injection site rxn
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; possible risk of embryo-fetal death and decr. fetal wt based on conflicting animal data at 10-30 mg/kg/day, though no known risk of teratogenicity based on animal data at up to 30 mg/kg/day
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: liver; CYP450: none
Excretion: urine (19.4% unchanged); Half-life: 5.2h
Subclass: Cardiac Amyloidosis ; Neuropathy/Neuralgia
Mechanism of Action
binds to transthyretin (TTR) mRNA, reducing serum TTR protein and deposits in tissues (small interfering ribonucleic acid)
Formulary .
No Formulary Selected
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