Skysona

Overview

elivaldogene autotemcel

gene therapy

• gene therapy
• immunomodulatory effects
• lowers seizure threshold
• myelosuppressive effects

Contraindicated

• adenovirus vaccine, live
Skysona (elivaldogene autotemcel)

+

adenovirus vaccine, live

1 interaction

Contraindicated

elivaldogene autotemcel + adenovirus vaccine, live

contraindicated; vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects)

• BCG live intravesical
Skysona (elivaldogene autotemcel)

+

BCG live intravesical

1 interaction

Contraindicated

elivaldogene autotemcel + BCG live intravesical

contraindicated: combo may incr. risk of disseminated BCG infection; may decr. immune response (immunosuppressive effects)

• chikungunya vaccine, live
Skysona (elivaldogene autotemcel)

+

chikungunya vaccine, live

1 interaction

Contraindicated

elivaldogene autotemcel + chikungunya vaccine, live

contraindicated; vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects)

• cholera vaccine, live
Skysona (elivaldogene autotemcel)

+

cholera vaccine, live

1 interaction

Contraindicated

elivaldogene autotemcel + cholera vaccine, live

contraindicated; vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects)

• dengue vaccine, live
Skysona (elivaldogene autotemcel)

+

dengue vaccine, live

1 interaction

Contraindicated

elivaldogene autotemcel + dengue vaccine, live

contraindicated; vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects)

• influenza nasal vaccine, live
Skysona (elivaldogene autotemcel)

+

influenza nasal vaccine, live

1 interaction

Contraindicated

elivaldogene autotemcel + influenza nasal vaccine, live

contraindicated; vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects)

• measles/mumps/rubella vaccine, live
Skysona (elivaldogene autotemcel)

+

measles/ mumps/ rubella vaccine, live

1 interaction

Contraindicated

elivaldogene autotemcel + measles/ mumps/ rubella vaccine, live

contraindicated; vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects)

• rotavirus vaccine, live
Skysona (elivaldogene autotemcel)

+

rotavirus vaccine, live

1 interaction

Contraindicated

elivaldogene autotemcel + rotavirus vaccine, live

contraindicated; vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects)

• smallpox vaccine, live
Skysona (elivaldogene autotemcel)

+

smallpox vaccine, live

1 interaction

Contraindicated

elivaldogene autotemcel + smallpox vaccine, live

contraindicated; vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects)

• talimogene laherparepvec
Skysona (elivaldogene autotemcel)

+

talimogene laherparepvec

1 interaction

Contraindicated

elivaldogene autotemcel + talimogene laherparepvec

contraindicated: combo may incr. risk of disseminated herpetic infection; may decr. immune response (immunosuppressive effects)

• typhoid vaccine, live
Skysona (elivaldogene autotemcel)

+

typhoid vaccine, live

1 interaction

Contraindicated

elivaldogene autotemcel + typhoid vaccine, live

contraindicated; vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects)

• varicella vaccine, live
Skysona (elivaldogene autotemcel)

+

varicella vaccine, live

1 interaction

Contraindicated

elivaldogene autotemcel + varicella vaccine, live

contraindicated; vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects)

• yellow fever vaccine, live
Skysona (elivaldogene autotemcel)

+

yellow fever vaccine, live

1 interaction

Contraindicated

elivaldogene autotemcel + yellow fever vaccine, live

contraindicated; vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects)

Avoid/Use Alternative

• abacavir
Skysona (elivaldogene autotemcel)

+

abacavir

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + abacavir

avoid combo; D/C abacavir at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• aldesleukin
Skysona (elivaldogene autotemcel)

+

aldesleukin

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + aldesleukin

avoid combo: combo may incr. risk of myelosuppression, serious infection, seizures (additive effects)

• amifampridine
Skysona (elivaldogene autotemcel)

+

amifampridine

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + amifampridine

consider alternative: combo may incr. risk of seizures (additive effects)

• atazanavir
Skysona (elivaldogene autotemcel)

+

atazanavir

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + atazanavir

avoid combo; D/C atazanavir at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• bictegravir
Skysona (elivaldogene autotemcel)

+

bictegravir

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + bictegravir

avoid combo; D/C bictegravir at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• cabotegravir
Skysona (elivaldogene autotemcel)

+

cabotegravir

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + cabotegravir

avoid combo; D/C cabotegravir at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• chloramphenicol
Skysona (elivaldogene autotemcel)

+

chloramphenicol

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + chloramphenicol

use alternative or monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• cladribine oral
Skysona (elivaldogene autotemcel)

+

cladribine oral

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + cladribine oral

use alternative or monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• darunavir
Skysona (elivaldogene autotemcel)

+

darunavir

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + darunavir

avoid combo; D/C darunavir at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• deferiprone
Skysona (elivaldogene autotemcel)

+

deferiprone

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + deferiprone

use alternative or monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• dolutegravir
Skysona (elivaldogene autotemcel)

+

dolutegravir

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + dolutegravir

avoid combo; D/C dolutegravir at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• doravirine
Skysona (elivaldogene autotemcel)

+

doravirine

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + doravirine

avoid combo; D/C doravirine at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• efavirenz
Skysona (elivaldogene autotemcel)

+

efavirenz

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + efavirenz

avoid combo; D/C efavirenz at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• elvitegravir
Skysona (elivaldogene autotemcel)

+

elvitegravir

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + elvitegravir

avoid combo; D/C elvitegravir at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• emtricitabine
Skysona (elivaldogene autotemcel)

+

emtricitabine

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + emtricitabine

avoid combo; D/C emtricitabine at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• etrasimod
Skysona (elivaldogene autotemcel)

+

etrasimod

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + etrasimod

avoid combo during and x5wk after etrasimod tx: combo may incr. risk of serious infection; infection risk may be prolonged (additive effects)

• etravirine
Skysona (elivaldogene autotemcel)

+

etravirine

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + etravirine

avoid combo; D/C etravirine at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• etuvetidigene autotemcel
Skysona (elivaldogene autotemcel)

+

etuvetidigene autotemcel

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + etuvetidigene autotemcel

avoid combo: combo may incr. risk of serious infection, myelosuppression, bleeding, other adverse effects (additive effects, duplicate therapy)

• fexinidazole
Skysona (elivaldogene autotemcel)

+

fexinidazole

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + fexinidazole

use alternative or monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• fostemsavir
Skysona (elivaldogene autotemcel)

+

fostemsavir

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + fostemsavir

avoid combo; D/C fostemsavir at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• ganciclovir
Skysona (elivaldogene autotemcel)

+

ganciclovir

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + ganciclovir

use alternative or monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• human papillomavirus vaccine
Skysona (elivaldogene autotemcel)

+

human papillomavirus vaccine

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + human papillomavirus vaccine

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• ibalizumab
Skysona (elivaldogene autotemcel)

+

ibalizumab

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + ibalizumab

avoid combo; D/C ibalizumab at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• iohexol
Skysona (elivaldogene autotemcel)

+

iohexol

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + iohexol

avoid combo if intrathecal iohexol use: combo may incr. risk of seizures (additive effects)

• islatravir
Skysona (elivaldogene autotemcel)

+

islatravir

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + islatravir

avoid combo; D/C islatravir at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• lamivudine
Skysona (elivaldogene autotemcel)

+

lamivudine

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + lamivudine

avoid combo; D/C lamivudine at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• lopinavir/ritonavir
Skysona (elivaldogene autotemcel)

+

lopinavir/ ritonavir

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + lopinavir/ ritonavir

avoid combo; D/C lopinavir/ritonavir at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• maraviroc
Skysona (elivaldogene autotemcel)

+

maraviroc

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + maraviroc

avoid combo; D/C maraviroc at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• marnetegragene autotemcel
Skysona (elivaldogene autotemcel)

+

marnetegragene autotemcel

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + marnetegragene autotemcel

avoid combo: combo may incr. risk of serious infection, myelosuppression, other adverse effects (additive effects, duplicate therapy)

• natalizumab
Skysona (elivaldogene autotemcel)

+

natalizumab

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + natalizumab

avoid combo: combo may incr. risk of serious infection (additive effects)

• nevirapine
Skysona (elivaldogene autotemcel)

+

nevirapine

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + nevirapine

avoid combo; D/C nevirapine at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• penicillamine
Skysona (elivaldogene autotemcel)

+

penicillamine

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + penicillamine

consider alternative or monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• pimecrolimus topical
Skysona (elivaldogene autotemcel)

+

pimecrolimus topical

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + pimecrolimus topical

avoid combo: combo may incr. risk of serious infection (additive effects)

• poliovirus vaccine
Skysona (elivaldogene autotemcel)

+

poliovirus vaccine

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + poliovirus vaccine

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• primaquine
Skysona (elivaldogene autotemcel)

+

primaquine

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + primaquine

use alternative or monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• rabies vaccine
Skysona (elivaldogene autotemcel)

+

rabies vaccine

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + rabies vaccine

if possible, avoid immunosuppressive tx or vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• radium Ra 223 dichloride
Skysona (elivaldogene autotemcel)

+

radium Ra 223 dichloride

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + radium Ra 223 dichloride

use alternative or monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• raltegravir
Skysona (elivaldogene autotemcel)

+

raltegravir

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + raltegravir

avoid combo; D/C raltegravir at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• rilpivirine
Skysona (elivaldogene autotemcel)

+

rilpivirine

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + rilpivirine

avoid combo; D/C rilpivirine at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• ritonavir
Skysona (elivaldogene autotemcel)

+

ritonavir

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + ritonavir

avoid combo; D/C ritonavir at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• ropeginterferon alfa-2b
Skysona (elivaldogene autotemcel)

+

ropeginterferon alfa-2b

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + ropeginterferon alfa-2b

use alternative or monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• tenofovir alafenamide
Skysona (elivaldogene autotemcel)

+

tenofovir alafenamide

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + tenofovir alafenamide

avoid combo; D/C tenofovir alafenamide at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• tenofovir disoproxil
Skysona (elivaldogene autotemcel)

+

tenofovir disoproxil

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + tenofovir disoproxil

avoid combo; D/C tenofovir disoproxil at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells (antagonistic effects)

• valganciclovir
Skysona (elivaldogene autotemcel)

+

valganciclovir

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + valganciclovir

use alternative or monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• zidovudine
Skysona (elivaldogene autotemcel)

+

zidovudine

1 interaction

Avoid/Use Alternative

elivaldogene autotemcel + zidovudine

avoid combo; D/C zidovudine at least 1mo prior to mobilization and until apheresis completed: combo may interfere with gene transfer into apheresed cells; may incr. risk of myelosuppression (antagonistic effects; additive effects)

Monitor/Modify Tx

• abemaciclib
Skysona (elivaldogene autotemcel)

+

abemaciclib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + abemaciclib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• acalabrutinib
Skysona (elivaldogene autotemcel)

+

acalabrutinib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + acalabrutinib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• ado-trastuzumab emtansine
Skysona (elivaldogene autotemcel)

+

ado-trastuzumab emtansine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + ado-trastuzumab emtansine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• afamitresgene autoleucel
Skysona (elivaldogene autotemcel)

+

afamitresgene autoleucel

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + afamitresgene autoleucel

monitor CBC, bleeding s/sx: combo may incr. risk of serious infection, myelosuppression (additive effects)

• albendazole
Skysona (elivaldogene autotemcel)

+

albendazole

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + albendazole

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• alemtuzumab
Skysona (elivaldogene autotemcel)

+

alemtuzumab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + alemtuzumab

monitor CBC, bleeding s/sx; myelosuppression risk may be lower w/ alemtuzumab doses used for MS: combo may incr. risk of myelosuppression, serious infection (additive effects)

• allopurinol
Skysona (elivaldogene autotemcel)

+

allopurinol

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + allopurinol

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• anthrax vaccine
Skysona (elivaldogene autotemcel)

+

anthrax vaccine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + anthrax vaccine

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• anti-thymocyte globulin
Skysona (elivaldogene autotemcel)

+

anti-thymocyte globulin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + anti-thymocyte globulin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• arsenic trioxide
Skysona (elivaldogene autotemcel)

+

arsenic trioxide

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + arsenic trioxide

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• asciminib
Skysona (elivaldogene autotemcel)

+

asciminib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + asciminib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• atidarsagene autotemcel
Skysona (elivaldogene autotemcel)

+

atidarsagene autotemcel

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + atidarsagene autotemcel

monitor CBC, bleeding s/sx: combo may incr. risk of serious infection, myelosuppression (additive effects)

• auranofin
Skysona (elivaldogene autotemcel)

+

auranofin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + auranofin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• avian influenza vaccine
Skysona (elivaldogene autotemcel)

+

avian influenza vaccine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + avian influenza vaccine

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• axicabtagene ciloleucel
Skysona (elivaldogene autotemcel)

+

axicabtagene ciloleucel

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + axicabtagene ciloleucel

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• azacitidine
Skysona (elivaldogene autotemcel)

+

azacitidine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + azacitidine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• azathioprine
Skysona (elivaldogene autotemcel)

+

azathioprine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + azathioprine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• balsalazide
Skysona (elivaldogene autotemcel)

+

balsalazide

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + balsalazide

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• baricitinib
Skysona (elivaldogene autotemcel)

+

baricitinib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + baricitinib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• belantamab mafodotin
Skysona (elivaldogene autotemcel)

+

belantamab mafodotin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + belantamab mafodotin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• belinostat
Skysona (elivaldogene autotemcel)

+

belinostat

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + belinostat

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• bendamustine
Skysona (elivaldogene autotemcel)

+

bendamustine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + bendamustine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• benznidazole
Skysona (elivaldogene autotemcel)

+

benznidazole

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + benznidazole

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• betibeglogene autotemcel
Skysona (elivaldogene autotemcel)

+

betibeglogene autotemcel

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + betibeglogene autotemcel

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• bevacizumab
Skysona (elivaldogene autotemcel)

+

bevacizumab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + bevacizumab

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• bexarotene
Skysona (elivaldogene autotemcel)

+

bexarotene

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + bexarotene

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• blinatumomab
Skysona (elivaldogene autotemcel)

+

blinatumomab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + blinatumomab

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• bortezomib
Skysona (elivaldogene autotemcel)

+

bortezomib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + bortezomib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• bosutinib
Skysona (elivaldogene autotemcel)

+

bosutinib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + bosutinib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• brentuximab vedotin
Skysona (elivaldogene autotemcel)

+

brentuximab vedotin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + brentuximab vedotin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• brexucabtagene autoleucel
Skysona (elivaldogene autotemcel)

+

brexucabtagene autoleucel

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + brexucabtagene autoleucel

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• bupropion
Skysona (elivaldogene autotemcel)

+

bupropion

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + bupropion

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• busulfan
Skysona (elivaldogene autotemcel)

+

busulfan

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + busulfan

monitor CBC, bleeding signs/symptoms: combo may incr. risk of seizures, myelosuppression, serious infection (additive effects)

• cabazitaxel
Skysona (elivaldogene autotemcel)

+

cabazitaxel

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + cabazitaxel

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• capecitabine
Skysona (elivaldogene autotemcel)

+

capecitabine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + capecitabine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• carboplatin
Skysona (elivaldogene autotemcel)

+

carboplatin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + carboplatin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• carfilzomib
Skysona (elivaldogene autotemcel)

+

carfilzomib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + carfilzomib

monitor CBC, bleeding s/sx; consider antiviral prophylaxis: combo may incr. risk of myelosuppression, serious infection (additive effects)

• carmustine
Skysona (elivaldogene autotemcel)

+

carmustine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + carmustine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• chikungunya vaccine
Skysona (elivaldogene autotemcel)

+

chikungunya vaccine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + chikungunya vaccine

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• chlorambucil
Skysona (elivaldogene autotemcel)

+

chlorambucil

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + chlorambucil

monitor CBC, bleeding s/sx; consider chlorambucil dose adjustment: combo may incr. risk of seizures, myelosuppression, serious infection (additive effects)

• cidofovir
Skysona (elivaldogene autotemcel)

+

cidofovir

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + cidofovir

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• ciltacabtagene autoleucel
Skysona (elivaldogene autotemcel)

+

ciltacabtagene autoleucel

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + ciltacabtagene autoleucel

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• cisplatin
Skysona (elivaldogene autotemcel)

+

cisplatin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + cisplatin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• cladribine injection
Skysona (elivaldogene autotemcel)

+

cladribine injection

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + cladribine injection

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• clofarabine
Skysona (elivaldogene autotemcel)

+

clofarabine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + clofarabine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• clozapine
Skysona (elivaldogene autotemcel)

+

clozapine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + clozapine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• colchicine
Skysona (elivaldogene autotemcel)

+

colchicine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + colchicine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• copanlisib
Skysona (elivaldogene autotemcel)

+

copanlisib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + copanlisib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• copper histidinate
Skysona (elivaldogene autotemcel)

+

copper histidinate

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + copper histidinate

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• COVID-19 vaccine
Skysona (elivaldogene autotemcel)

+

COVID-19 vaccine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + COVID-19 vaccine

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• crizotinib
Skysona (elivaldogene autotemcel)

+

crizotinib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + crizotinib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• cyclophosphamide
Skysona (elivaldogene autotemcel)

+

cyclophosphamide

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + cyclophosphamide

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• cytarabine
Skysona (elivaldogene autotemcel)

+

cytarabine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + cytarabine

monitor CBC, bleeding signs/symptoms: combo may incr. risk of myelosuppression, serious infection (additive effects)

• dacarbazine
Skysona (elivaldogene autotemcel)

+

dacarbazine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + dacarbazine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• dactinomycin
Skysona (elivaldogene autotemcel)

+

dactinomycin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + dactinomycin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• dapsone
Skysona (elivaldogene autotemcel)

+

dapsone

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + dapsone

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• daratumumab
Skysona (elivaldogene autotemcel)

+

daratumumab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + daratumumab

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• dasatinib
Skysona (elivaldogene autotemcel)

+

dasatinib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + dasatinib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• daunorubicin
Skysona (elivaldogene autotemcel)

+

daunorubicin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + daunorubicin

monitor CBC, bleeding signs/symptoms: combo may incr. risk of serious infection, myelosuppression, bleeding, including life-threatening (additive effects)

• decitabine
Skysona (elivaldogene autotemcel)

+

decitabine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + decitabine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• deferasirox
Skysona (elivaldogene autotemcel)

+

deferasirox

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + deferasirox

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• deuruxolitinib
Skysona (elivaldogene autotemcel)

+

deuruxolitinib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + deuruxolitinib

monitor CBC: combo may incr. risk of myelosuppression, serious infection (additive effects)

• dexrazoxane
Skysona (elivaldogene autotemcel)

+

dexrazoxane

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + dexrazoxane

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• dinutuximab
Skysona (elivaldogene autotemcel)

+

dinutuximab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + dinutuximab

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• diphtheria/tetanus vaccine
Skysona (elivaldogene autotemcel)

+

diphtheria/ tetanus vaccine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + diphtheria/ tetanus vaccine

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• diphtheria/tetanus/pertussis vaccine
Skysona (elivaldogene autotemcel)

+

diphtheria/ tetanus/ pertussis vaccine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + diphtheria/ tetanus/ pertussis vaccine

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• docetaxel
Skysona (elivaldogene autotemcel)

+

docetaxel

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + docetaxel

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• dostarlimab
Skysona (elivaldogene autotemcel)

+

dostarlimab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + dostarlimab

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• doxorubicin
Skysona (elivaldogene autotemcel)

+

doxorubicin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + doxorubicin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• duvelisib
Skysona (elivaldogene autotemcel)

+

duvelisib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + duvelisib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• ebola vaccine, live
Skysona (elivaldogene autotemcel)

+

ebola vaccine, live

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + ebola vaccine, live

consider vaccinating at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response; may incr. risk of mild vesicular stomatitis virus infection (immunosuppressive effects, recombinant vaccine with vesicular stomatitis virus vector)

• eflornithine
Skysona (elivaldogene autotemcel)

+

eflornithine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + eflornithine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• elranatamab
Skysona (elivaldogene autotemcel)

+

elranatamab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + elranatamab

monitor CBC, bleeding s/sx: combo may incr. risk of serious infection, myelosuppression (additive effects)

• enfortumab vedotin
Skysona (elivaldogene autotemcel)

+

enfortumab vedotin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + enfortumab vedotin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• entrectinib
Skysona (elivaldogene autotemcel)

+

entrectinib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + entrectinib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• epcoritamab
Skysona (elivaldogene autotemcel)

+

epcoritamab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + epcoritamab

monitor CBC, bleeding s/sx: combo may incr. risk of serious infection, myelosuppression (additive effects)

• epirubicin
Skysona (elivaldogene autotemcel)

+

epirubicin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + epirubicin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• eribulin
Skysona (elivaldogene autotemcel)

+

eribulin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + eribulin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• etoposide
Skysona (elivaldogene autotemcel)

+

etoposide

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + etoposide

monitor CBC, bleeding signs/symptoms: combo may incr. risk of myelosuppression, serious infection (additive effects)

• everolimus
Skysona (elivaldogene autotemcel)

+

everolimus

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + everolimus

monitor CBC, bleeding s/sx; admin. PCP prophylaxis: combo may incr. risk of myelosuppression, serious infection (additive effects)

• fam-trastuzumab deruxtecan
Skysona (elivaldogene autotemcel)

+

fam-trastuzumab deruxtecan

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + fam-trastuzumab deruxtecan

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• fedratinib
Skysona (elivaldogene autotemcel)

+

fedratinib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + fedratinib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• floxuridine
Skysona (elivaldogene autotemcel)

+

floxuridine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + floxuridine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• flucytosine
Skysona (elivaldogene autotemcel)

+

flucytosine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + flucytosine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• fludarabine
Skysona (elivaldogene autotemcel)

+

fludarabine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + fludarabine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• fluorouracil
Skysona (elivaldogene autotemcel)

+

fluorouracil

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + fluorouracil

monitor CBC, bleeding signs/symptoms: combo may incr. risk of myelosuppression (additive effects)

• fluphenazine
Skysona (elivaldogene autotemcel)

+

fluphenazine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + fluphenazine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• foscarnet
Skysona (elivaldogene autotemcel)

+

foscarnet

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + foscarnet

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• fosfomycin injection
Skysona (elivaldogene autotemcel)

+

fosfomycin injection

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + fosfomycin injection

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• fostamatinib
Skysona (elivaldogene autotemcel)

+

fostamatinib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + fostamatinib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• gemcitabine
Skysona (elivaldogene autotemcel)

+

gemcitabine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + gemcitabine

monitor CBC, bleeding s/sx; risk may be lower w/ intravesical gemcitabine administration: combo may incr. risk of myelosuppression (additive effects)

• gemtuzumab ozogamicin
Skysona (elivaldogene autotemcel)

+

gemtuzumab ozogamicin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + gemtuzumab ozogamicin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• givinostat
Skysona (elivaldogene autotemcel)

+

givinostat

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + givinostat

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• glasdegib
Skysona (elivaldogene autotemcel)

+

glasdegib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + glasdegib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• glofitamab
Skysona (elivaldogene autotemcel)

+

glofitamab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + glofitamab

monitor CBC, bleeding s/sx: combo may incr. risk of serious infection, myelosuppression (additive effects)

• Haemophilus b vaccine
Skysona (elivaldogene autotemcel)

+

Haemophilus b vaccine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + Haemophilus b vaccine

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• hepatitis A vaccine
Skysona (elivaldogene autotemcel)

+

hepatitis A vaccine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + hepatitis A vaccine

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• hepatitis B vaccine
Skysona (elivaldogene autotemcel)

+

hepatitis B vaccine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + hepatitis B vaccine

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• hydroxychloroquine
Skysona (elivaldogene autotemcel)

+

hydroxychloroquine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + hydroxychloroquine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, seizures (additive effects)

• hydroxyurea
Skysona (elivaldogene autotemcel)

+

hydroxyurea

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + hydroxyurea

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• ibritumomab tiuxetan
Skysona (elivaldogene autotemcel)

+

ibritumomab tiuxetan

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + ibritumomab tiuxetan

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• ibrutinib
Skysona (elivaldogene autotemcel)

+

ibrutinib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + ibrutinib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• idarubicin
Skysona (elivaldogene autotemcel)

+

idarubicin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + idarubicin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• idecabtagene vicleucel
Skysona (elivaldogene autotemcel)

+

idecabtagene vicleucel

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + idecabtagene vicleucel

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• idelalisib
Skysona (elivaldogene autotemcel)

+

idelalisib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + idelalisib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• ifosfamide
Skysona (elivaldogene autotemcel)

+

ifosfamide

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + ifosfamide

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• imatinib
Skysona (elivaldogene autotemcel)

+

imatinib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + imatinib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• imetelstat
Skysona (elivaldogene autotemcel)

+

imetelstat

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + imetelstat

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• influenza vaccine
Skysona (elivaldogene autotemcel)

+

influenza vaccine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + influenza vaccine

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• inotuzumab ozogamicin
Skysona (elivaldogene autotemcel)

+

inotuzumab ozogamicin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + inotuzumab ozogamicin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• interferon beta 1a
Skysona (elivaldogene autotemcel)

+

interferon beta 1a

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + interferon beta 1a

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• interferon beta 1b
Skysona (elivaldogene autotemcel)

+

interferon beta 1b

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + interferon beta 1b

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• interferon gamma 1b
Skysona (elivaldogene autotemcel)

+

interferon gamma 1b

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + interferon gamma 1b

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• iopamidol
Skysona (elivaldogene autotemcel)

+

iopamidol

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + iopamidol

caution advised if intrathecal iopamidol use: combo may incr. risk of seizures (additive effects)

• irinotecan
Skysona (elivaldogene autotemcel)

+

irinotecan

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + irinotecan

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• isatuximab
Skysona (elivaldogene autotemcel)

+

isatuximab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + isatuximab

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• ivosidenib
Skysona (elivaldogene autotemcel)

+

ivosidenib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + ivosidenib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• ixabepilone
Skysona (elivaldogene autotemcel)

+

ixabepilone

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + ixabepilone

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• Japanese encephalitis vaccine
Skysona (elivaldogene autotemcel)

+

Japanese encephalitis vaccine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + Japanese encephalitis vaccine

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery; consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• leflunomide
Skysona (elivaldogene autotemcel)

+

leflunomide

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + leflunomide

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• lenalidomide
Skysona (elivaldogene autotemcel)

+

lenalidomide

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + lenalidomide

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• lifileucel
Skysona (elivaldogene autotemcel)

+

lifileucel

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + lifileucel

monitor CBC, bleeding s/sx: combo may incr. risk of serious infection, myelosuppression (additive effects)

• linezolid
Skysona (elivaldogene autotemcel)

+

linezolid

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + linezolid

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• linvoseltamab
Skysona (elivaldogene autotemcel)

+

linvoseltamab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + linvoseltamab

monitor CBC, bleeding s/sx: combo may incr. risk of serious infection, myelosuppression (additive effects)

• lisocabtagene maraleucel
Skysona (elivaldogene autotemcel)

+

lisocabtagene maraleucel

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + lisocabtagene maraleucel

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• lomustine
Skysona (elivaldogene autotemcel)

+

lomustine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + lomustine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• lonafarnib
Skysona (elivaldogene autotemcel)

+

lonafarnib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + lonafarnib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• loncastuximab tesirine
Skysona (elivaldogene autotemcel)

+

loncastuximab tesirine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + loncastuximab tesirine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• lovotibeglogene autotemcel
Skysona (elivaldogene autotemcel)

+

lovotibeglogene autotemcel

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + lovotibeglogene autotemcel

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, bleeding (additive effects)

• lurbinectedin
Skysona (elivaldogene autotemcel)

+

lurbinectedin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + lurbinectedin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• lutetium Lu 177 dotatate
Skysona (elivaldogene autotemcel)

+

lutetium Lu 177 dotatate

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + lutetium Lu 177 dotatate

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• lutetium Lu 177 vipivotide tetraxetan
Skysona (elivaldogene autotemcel)

+

lutetium Lu 177 vipivotide tetraxetan

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + lutetium Lu 177 vipivotide tetraxetan

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• lymphocyte immune globulin, anti-thymocyte globulin
Skysona (elivaldogene autotemcel)

+

lymphocyte immune globulin, anti-thymocyte globulin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + lymphocyte immune globulin, anti-thymocyte globulin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• melphalan
Skysona (elivaldogene autotemcel)

+

melphalan

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + melphalan

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• meningococcal vaccine
Skysona (elivaldogene autotemcel)

+

meningococcal vaccine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + meningococcal vaccine

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• mercaptopurine
Skysona (elivaldogene autotemcel)

+

mercaptopurine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + mercaptopurine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• mesalamine
Skysona (elivaldogene autotemcel)

+

mesalamine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + mesalamine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• mesalamine rectal
Skysona (elivaldogene autotemcel)

+

mesalamine rectal

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + mesalamine rectal

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• methotrexate
Skysona (elivaldogene autotemcel)

+

methotrexate

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + methotrexate

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• midostaurin
Skysona (elivaldogene autotemcel)

+

midostaurin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + midostaurin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• mitomycin
Skysona (elivaldogene autotemcel)

+

mitomycin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + mitomycin

monitor CBC, bleeding s/sx; risk may be lower w/ intravesical mitomycin administration: combo may incr. risk of serious infection, myelosuppression (additive effects)

• mitotane
Skysona (elivaldogene autotemcel)

+

mitotane

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + mitotane

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• mitoxantrone
Skysona (elivaldogene autotemcel)

+

mitoxantrone

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + mitoxantrone

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• mogamulizumab
Skysona (elivaldogene autotemcel)

+

mogamulizumab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + mogamulizumab

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• momelotinib
Skysona (elivaldogene autotemcel)

+

momelotinib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + momelotinib

monitor CBC, bleeding s/sx: combo may incr. risk of serious infection, myelosuppression (additive effects)

• mosunetuzumab
Skysona (elivaldogene autotemcel)

+

mosunetuzumab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + mosunetuzumab

monitor CBC, bleeding s/sx: combo may incr. risk of serious infection, myelosuppression (additive effects)

• mycophenolate mofetil
Skysona (elivaldogene autotemcel)

+

mycophenolate mofetil

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + mycophenolate mofetil

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• mycophenolic acid
Skysona (elivaldogene autotemcel)

+

mycophenolic acid

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + mycophenolic acid

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• nelarabine
Skysona (elivaldogene autotemcel)

+

nelarabine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + nelarabine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• nilotinib
Skysona (elivaldogene autotemcel)

+

nilotinib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + nilotinib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• niraparib
Skysona (elivaldogene autotemcel)

+

niraparib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + niraparib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• obecabtagene autoleucel
Skysona (elivaldogene autotemcel)

+

obecabtagene autoleucel

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + obecabtagene autoleucel

monitor CBC: combo may incr. risk of serious infection, myelosuppression (additive effects)

• obinutuzumab
Skysona (elivaldogene autotemcel)

+

obinutuzumab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + obinutuzumab

monitor CBC, bleeding s/sx: combo may incr. risk of serious infection, myelosuppression (additive effects)

• ofatumumab
Skysona (elivaldogene autotemcel)

+

ofatumumab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + ofatumumab

monitor CBC, bleeding s/sx; myelosuppression risk may be lower w/ ofatumumab doses used for MS: combo may incr. risk of myelosuppression, serious infection (additive effects)

• olaparib
Skysona (elivaldogene autotemcel)

+

olaparib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + olaparib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• olsalazine
Skysona (elivaldogene autotemcel)

+

olsalazine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + olsalazine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• oxaliplatin
Skysona (elivaldogene autotemcel)

+

oxaliplatin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + oxaliplatin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• paclitaxel
Skysona (elivaldogene autotemcel)

+

paclitaxel

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + paclitaxel

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• pacritinib
Skysona (elivaldogene autotemcel)

+

pacritinib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + pacritinib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• palbociclib
Skysona (elivaldogene autotemcel)

+

palbociclib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + palbociclib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• peginterferon alfa 2a
Skysona (elivaldogene autotemcel)

+

peginterferon alfa 2a

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + peginterferon alfa 2a

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• peginterferon beta 1a
Skysona (elivaldogene autotemcel)

+

peginterferon beta 1a

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + peginterferon beta 1a

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• pemetrexed
Skysona (elivaldogene autotemcel)

+

pemetrexed

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + pemetrexed

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• pentamidine
Skysona (elivaldogene autotemcel)

+

pentamidine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + pentamidine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• pentostatin
Skysona (elivaldogene autotemcel)

+

pentostatin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + pentostatin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• pirtobrutinib
Skysona (elivaldogene autotemcel)

+

pirtobrutinib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + pirtobrutinib

monitor CBC, bleeding s/sx: combo may incr. risk of serious infection, myelosuppression (additive effects)

• pneumococcal vaccine
Skysona (elivaldogene autotemcel)

+

pneumococcal vaccine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + pneumococcal vaccine

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• polatuzumab vedotin
Skysona (elivaldogene autotemcel)

+

polatuzumab vedotin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + polatuzumab vedotin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• pomalidomide
Skysona (elivaldogene autotemcel)

+

pomalidomide

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + pomalidomide

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• ponatinib
Skysona (elivaldogene autotemcel)

+

ponatinib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + ponatinib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• pralatrexate
Skysona (elivaldogene autotemcel)

+

pralatrexate

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + pralatrexate

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• procarbazine
Skysona (elivaldogene autotemcel)

+

procarbazine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + procarbazine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• proguanil
Skysona (elivaldogene autotemcel)

+

proguanil

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + proguanil

monitor CBC, bleeding s/sx, especially if concomitant renal impairment: combo may incr. risk of myelosuppression (additive effects)

• pyrimethamine
Skysona (elivaldogene autotemcel)

+

pyrimethamine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + pyrimethamine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• quizartinib
Skysona (elivaldogene autotemcel)

+

quizartinib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + quizartinib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• relacorilant
Skysona (elivaldogene autotemcel)

+

relacorilant

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + relacorilant

monitor CBC, bleeding s/sx: combo may incr. risk of serious infection, myelosuppression (additive effects)

• respiratory syncytial virus vaccine
Skysona (elivaldogene autotemcel)

+

respiratory syncytial virus vaccine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + respiratory syncytial virus vaccine

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• ribavirin
Skysona (elivaldogene autotemcel)

+

ribavirin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + ribavirin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• ribociclib
Skysona (elivaldogene autotemcel)

+

ribociclib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + ribociclib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• rifabutin
Skysona (elivaldogene autotemcel)

+

rifabutin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + rifabutin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• rituximab
Skysona (elivaldogene autotemcel)

+

rituximab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + rituximab

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• romidepsin
Skysona (elivaldogene autotemcel)

+

romidepsin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + romidepsin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• rucaparib
Skysona (elivaldogene autotemcel)

+

rucaparib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + rucaparib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• ruxolitinib
Skysona (elivaldogene autotemcel)

+

ruxolitinib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + ruxolitinib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• ruxolitinib topical
Skysona (elivaldogene autotemcel)

+

ruxolitinib topical

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + ruxolitinib topical

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• sacituzumab govitecan
Skysona (elivaldogene autotemcel)

+

sacituzumab govitecan

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + sacituzumab govitecan

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• sarilumab
Skysona (elivaldogene autotemcel)

+

sarilumab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + sarilumab

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• satralizumab
Skysona (elivaldogene autotemcel)

+

satralizumab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + satralizumab

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• selinexor
Skysona (elivaldogene autotemcel)

+

selinexor

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + selinexor

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• sipuleucel-T
Skysona (elivaldogene autotemcel)

+

sipuleucel-T

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + sipuleucel-T

consider decr. elivaldogene autotemcel dose or D/C during leukapheresis and sipuleucel-T admin.: combo may decr. efficacy of sipuleucel-T; may incr. risk of adverse effects (antagonistic effects; additive effects)

• sirolimus
Skysona (elivaldogene autotemcel)

+

sirolimus

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + sirolimus

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• sirolimus albumin-bound
Skysona (elivaldogene autotemcel)

+

sirolimus albumin-bound

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + sirolimus albumin-bound

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• smallpox/mpox vaccine, live
Skysona (elivaldogene autotemcel)

+

smallpox/ mpox vaccine, live

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + smallpox/ mpox vaccine, live

consider vaccinating at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• stiripentol
Skysona (elivaldogene autotemcel)

+

stiripentol

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + stiripentol

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression; may alter seizure control (additive effects; antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• streptozocin
Skysona (elivaldogene autotemcel)

+

streptozocin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + streptozocin

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• succimer
Skysona (elivaldogene autotemcel)

+

succimer

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + succimer

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• sulfasalazine
Skysona (elivaldogene autotemcel)

+

sulfasalazine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + sulfasalazine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• tafasitamab
Skysona (elivaldogene autotemcel)

+

tafasitamab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + tafasitamab

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• tagraxofusp
Skysona (elivaldogene autotemcel)

+

tagraxofusp

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + tagraxofusp

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• talazoparib
Skysona (elivaldogene autotemcel)

+

talazoparib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + talazoparib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• talquetamab
Skysona (elivaldogene autotemcel)

+

talquetamab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + talquetamab

monitor CBC, bleeding s/sx: combo may incr. risk of serious infection, myelosuppression (additive effects)

• tarlatamab
Skysona (elivaldogene autotemcel)

+

tarlatamab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + tarlatamab

monitor CBC, bleeding s/sx: combo may incr. risk of serious infection, myelosuppression (additive effects)

• tazemetostat
Skysona (elivaldogene autotemcel)

+

tazemetostat

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + tazemetostat

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• teclistamab
Skysona (elivaldogene autotemcel)

+

teclistamab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + teclistamab

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• temozolomide
Skysona (elivaldogene autotemcel)

+

temozolomide

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + temozolomide

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• temsirolimus
Skysona (elivaldogene autotemcel)

+

temsirolimus

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + temsirolimus

monitor CBC, bleeding signs/symptoms: combo may incr. risk of myelosuppression, serious infection (additive effects)

• teriflunomide
Skysona (elivaldogene autotemcel)

+

teriflunomide

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + teriflunomide

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• thalidomide
Skysona (elivaldogene autotemcel)

+

thalidomide

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + thalidomide

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• thioguanine
Skysona (elivaldogene autotemcel)

+

thioguanine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + thioguanine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• thiotepa
Skysona (elivaldogene autotemcel)

+

thiotepa

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + thiotepa

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• tick-borne encephalitis vaccine
Skysona (elivaldogene autotemcel)

+

tick-borne encephalitis vaccine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + tick-borne encephalitis vaccine

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• tisagenlecleucel
Skysona (elivaldogene autotemcel)

+

tisagenlecleucel

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + tisagenlecleucel

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• tocilizumab
Skysona (elivaldogene autotemcel)

+

tocilizumab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + tocilizumab

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• tofacitinib
Skysona (elivaldogene autotemcel)

+

tofacitinib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + tofacitinib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• topotecan
Skysona (elivaldogene autotemcel)

+

topotecan

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + topotecan

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• trabectedin
Skysona (elivaldogene autotemcel)

+

trabectedin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + trabectedin

monitor CBC, bleeding signs/symptoms: combo may incr. risk of serious infection, myelosuppression (additive effects)

• trastuzumab
Skysona (elivaldogene autotemcel)

+

trastuzumab

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + trastuzumab

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• treosulfan
Skysona (elivaldogene autotemcel)

+

treosulfan

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + treosulfan

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, seizures (additive effects)

• trifluridine
Skysona (elivaldogene autotemcel)

+

trifluridine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + trifluridine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• trimethoprim
Skysona (elivaldogene autotemcel)

+

trimethoprim

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + trimethoprim

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• typhoid vaccine
Skysona (elivaldogene autotemcel)

+

typhoid vaccine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + typhoid vaccine

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• upadacitinib
Skysona (elivaldogene autotemcel)

+

upadacitinib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + upadacitinib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• valproic acid
Skysona (elivaldogene autotemcel)

+

valproic acid

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + valproic acid

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression; may alter seizure control (additive effects; antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• vancomycin
Skysona (elivaldogene autotemcel)

+

vancomycin

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + vancomycin

VANCOMYCIN IV: monitor CBC, bleeding s/sx, especially w/ long-term vancomycin; VANCOMYCIN PO use OK: combo may incr. risk of myelosuppression (additive effects)

• venetoclax
Skysona (elivaldogene autotemcel)

+

venetoclax

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + venetoclax

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• vinblastine
Skysona (elivaldogene autotemcel)

+

vinblastine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + vinblastine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• vincristine
Skysona (elivaldogene autotemcel)

+

vincristine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + vincristine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• vinorelbine
Skysona (elivaldogene autotemcel)

+

vinorelbine

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + vinorelbine

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• zanubrutinib
Skysona (elivaldogene autotemcel)

+

zanubrutinib

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + zanubrutinib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, serious infection (additive effects)

• ziv-aflibercept
Skysona (elivaldogene autotemcel)

+

ziv-aflibercept

1 interaction

Monitor/Modify Tx

elivaldogene autotemcel + ziv-aflibercept

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

Caution Advised

• abatacept
Skysona (elivaldogene autotemcel)

+

abatacept

1 interaction

Caution Advised

elivaldogene autotemcel + abatacept

caution advised: combo may incr. risk of serious infection (additive effects)

• abrocitinib
Skysona (elivaldogene autotemcel)

+

abrocitinib

1 interaction

Caution Advised

elivaldogene autotemcel + abrocitinib

caution advised: combo may incr. risk of serious infection (additive effects)

• acetazolamide
Skysona (elivaldogene autotemcel)

+

acetazolamide

1 interaction

Caution Advised

elivaldogene autotemcel + acetazolamide

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• adalimumab
Skysona (elivaldogene autotemcel)

+

adalimumab

1 interaction

Caution Advised

elivaldogene autotemcel + adalimumab

caution advised: combo may incr. risk of serious infection (additive effects)

• anakinra
Skysona (elivaldogene autotemcel)

+

anakinra

1 interaction

Caution Advised

elivaldogene autotemcel + anakinra

caution advised: combo may incr. risk of serious infection (additive effects)

• anifrolumab
Skysona (elivaldogene autotemcel)

+

anifrolumab

1 interaction

Caution Advised

elivaldogene autotemcel + anifrolumab

caution advised: combo may incr. risk of serious infection (additive effects)

• avacopan
Skysona (elivaldogene autotemcel)

+

avacopan

1 interaction

Caution Advised

elivaldogene autotemcel + avacopan

caution advised: combo may incr. risk of serious infection (additive effects)

• basiliximab
Skysona (elivaldogene autotemcel)

+

basiliximab

1 interaction

Caution Advised

elivaldogene autotemcel + basiliximab

caution advised: combo may incr. risk of serious infection (additive effects)

• beclomethasone inhaled
Skysona (elivaldogene autotemcel)

+

beclomethasone inhaled

1 interaction

Caution Advised

elivaldogene autotemcel + beclomethasone inhaled

caution advised: combo may incr. risk of serious infection (additive effects)

• beclomethasone nasal
Skysona (elivaldogene autotemcel)

+

beclomethasone nasal

1 interaction

Caution Advised

elivaldogene autotemcel + beclomethasone nasal

caution advised: combo may incr. risk of serious infection (additive effects)

• belatacept
Skysona (elivaldogene autotemcel)

+

belatacept

1 interaction

Caution Advised

elivaldogene autotemcel + belatacept

caution advised: combo may incr. risk of serious infection (additive effects)

• belimumab
Skysona (elivaldogene autotemcel)

+

belimumab

1 interaction

Caution Advised

elivaldogene autotemcel + belimumab

caution advised: combo may incr. risk of serious infection (additive effects)

• betamethasone
Skysona (elivaldogene autotemcel)

+

betamethasone

1 interaction

Caution Advised

elivaldogene autotemcel + betamethasone

caution advised: combo may incr. risk of serious infection (additive effects)

• bimekizumab
Skysona (elivaldogene autotemcel)

+

bimekizumab

1 interaction

Caution Advised

elivaldogene autotemcel + bimekizumab

caution advised: combo may incr. risk of serious infection (additive effects)

• brivaracetam
Skysona (elivaldogene autotemcel)

+

brivaracetam

1 interaction

Caution Advised

elivaldogene autotemcel + brivaracetam

caution advised: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• brodalumab
Skysona (elivaldogene autotemcel)

+

brodalumab

1 interaction

Caution Advised

elivaldogene autotemcel + brodalumab

caution advised: combo may incr. risk of serious infection (additive effects)

• budesonide
Skysona (elivaldogene autotemcel)

+

budesonide

1 interaction

Caution Advised

elivaldogene autotemcel + budesonide

caution advised: combo may incr. risk of serious infection (additive effects)

• budesonide inhaled
Skysona (elivaldogene autotemcel)

+

budesonide inhaled

1 interaction

Caution Advised

elivaldogene autotemcel + budesonide inhaled

caution advised: combo may incr. risk of serious infection (additive effects)

• budesonide nasal
Skysona (elivaldogene autotemcel)

+

budesonide nasal

1 interaction

Caution Advised

elivaldogene autotemcel + budesonide nasal

caution advised: combo may incr. risk of serious infection (additive effects)

• budesonide rectal
Skysona (elivaldogene autotemcel)

+

budesonide rectal

1 interaction

Caution Advised

elivaldogene autotemcel + budesonide rectal

caution advised: combo may incr. risk of serious infection (additive effects)

• canakinumab
Skysona (elivaldogene autotemcel)

+

canakinumab

1 interaction

Caution Advised

elivaldogene autotemcel + canakinumab

caution advised: combo may incr. risk of serious infection (additive effects)

• cannabidiol
Skysona (elivaldogene autotemcel)

+

cannabidiol

1 interaction

Caution Advised

elivaldogene autotemcel + cannabidiol

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• carbamazepine
Skysona (elivaldogene autotemcel)

+

carbamazepine

1 interaction

Caution Advised

elivaldogene autotemcel + carbamazepine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• cenobamate
Skysona (elivaldogene autotemcel)

+

cenobamate

1 interaction

Caution Advised

elivaldogene autotemcel + cenobamate

caution advised: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• certolizumab pegol
Skysona (elivaldogene autotemcel)

+

certolizumab pegol

1 interaction

Caution Advised

elivaldogene autotemcel + certolizumab pegol

caution advised: combo may incr. risk of serious infection (additive effects)

• ciclesonide
Skysona (elivaldogene autotemcel)

+

ciclesonide

1 interaction

Caution Advised

elivaldogene autotemcel + ciclesonide

caution advised: combo may incr. risk of serious infection (additive effects)

• clobazam
Skysona (elivaldogene autotemcel)

+

clobazam

1 interaction

Caution Advised

elivaldogene autotemcel + clobazam

caution advised: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• clobetasol ophthalmic
Skysona (elivaldogene autotemcel)

+

clobetasol ophthalmic

1 interaction

Caution Advised

elivaldogene autotemcel + clobetasol ophthalmic

caution advised: combo may incr. risk of serious infection (additive effects)

• clomipramine
Skysona (elivaldogene autotemcel)

+

clomipramine

1 interaction

Caution Advised

elivaldogene autotemcel + clomipramine

caution advised: combo may incr. risk of seizures (additive effects)

• clonazepam
Skysona (elivaldogene autotemcel)

+

clonazepam

1 interaction

Caution Advised

elivaldogene autotemcel + clonazepam

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• clorazepate
Skysona (elivaldogene autotemcel)

+

clorazepate

1 interaction

Caution Advised

elivaldogene autotemcel + clorazepate

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• coccidioides immitis skin test antigen
Skysona (elivaldogene autotemcel)

+

coccidioides immitis skin test antigen

1 interaction

Caution Advised

elivaldogene autotemcel + coccidioides immitis skin test antigen

caution advised: combo may interfere with test results (antagonistic effects)

• corticotropin
Skysona (elivaldogene autotemcel)

+

corticotropin

1 interaction

Caution Advised

elivaldogene autotemcel + corticotropin

caution advised: combo may incr. risk of serious infection (additive effects)

• cortisone
Skysona (elivaldogene autotemcel)

+

cortisone

1 interaction

Caution Advised

elivaldogene autotemcel + cortisone

caution advised: combo may incr. risk of serious infection (additive effects)

• crovalimab
Skysona (elivaldogene autotemcel)

+

crovalimab

1 interaction

Caution Advised

elivaldogene autotemcel + crovalimab

caution advised: combo may incr. risk of serious infection (additive effects)

• cyclosporine
Skysona (elivaldogene autotemcel)

+

cyclosporine

1 interaction

Caution Advised

elivaldogene autotemcel + cyclosporine

caution advised: combo may incr. risk of serious infection (additive effects)

• danicopan
Skysona (elivaldogene autotemcel)

+

danicopan

1 interaction

Caution Advised

elivaldogene autotemcel + danicopan

caution advised: combo may incr. risk of serious infection (additive effects)

• deflazacort
Skysona (elivaldogene autotemcel)

+

deflazacort

1 interaction

Caution Advised

elivaldogene autotemcel + deflazacort

caution advised: combo may incr. risk of serious infection (additive effects)

• delgocitinib topical
Skysona (elivaldogene autotemcel)

+

delgocitinib topical

1 interaction

Caution Advised

elivaldogene autotemcel + delgocitinib topical

caution advised: combo may incr. risk of serious infection (additive effects)

• deucravacitinib
Skysona (elivaldogene autotemcel)

+

deucravacitinib

1 interaction

Caution Advised

elivaldogene autotemcel + deucravacitinib

caution advised: combo may incr. risk of serious infection (additive effects)

• dexamethasone
Skysona (elivaldogene autotemcel)

+

dexamethasone

1 interaction

Caution Advised

elivaldogene autotemcel + dexamethasone

caution advised: combo may incr. risk of serious infection (additive effects)

• dexamethasone ophthalmic
Skysona (elivaldogene autotemcel)

+

dexamethasone ophthalmic

1 interaction

Caution Advised

elivaldogene autotemcel + dexamethasone ophthalmic

caution advised: combo may incr. risk of serious infection (additive effects)

• diazepam
Skysona (elivaldogene autotemcel)

+

diazepam

1 interaction

Caution Advised

elivaldogene autotemcel + diazepam

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• difluprednate ophthalmic
Skysona (elivaldogene autotemcel)

+

difluprednate ophthalmic

1 interaction

Caution Advised

elivaldogene autotemcel + difluprednate ophthalmic

caution advised: combo may incr. risk of serious infection (additive effects)

• dimethyl fumarate
Skysona (elivaldogene autotemcel)

+

dimethyl fumarate

1 interaction

Caution Advised

elivaldogene autotemcel + dimethyl fumarate

caution advised: combo may incr. risk of serious infection (additive effects)

• diroximel fumarate
Skysona (elivaldogene autotemcel)

+

diroximel fumarate

1 interaction

Caution Advised

elivaldogene autotemcel + diroximel fumarate

caution advised: combo may incr. risk of serious infection (additive effects)

• dupilumab
Skysona (elivaldogene autotemcel)

+

dupilumab

1 interaction

Caution Advised

elivaldogene autotemcel + dupilumab

caution advised: combo may incr. risk of serious infection (additive effects)

• eculizumab
Skysona (elivaldogene autotemcel)

+

eculizumab

1 interaction

Caution Advised

elivaldogene autotemcel + eculizumab

caution advised: combo may incr. risk of serious infection (additive effects)

• efgartigimod alfa
Skysona (elivaldogene autotemcel)

+

efgartigimod alfa

1 interaction

Caution Advised

elivaldogene autotemcel + efgartigimod alfa

caution advised: combo may incr. risk of serious infection (additive effects)

• elotuzumab
Skysona (elivaldogene autotemcel)

+

elotuzumab

1 interaction

Caution Advised

elivaldogene autotemcel + elotuzumab

caution advised: combo may incr. risk of serious infection (additive effects)

• emapalumab
Skysona (elivaldogene autotemcel)

+

emapalumab

1 interaction

Caution Advised

elivaldogene autotemcel + emapalumab

caution advised: combo may incr. risk of serious infection (additive effects)

• eslicarbazepine acetate
Skysona (elivaldogene autotemcel)

+

eslicarbazepine acetate

1 interaction

Caution Advised

elivaldogene autotemcel + eslicarbazepine acetate

caution advised: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• etanercept
Skysona (elivaldogene autotemcel)

+

etanercept

1 interaction

Caution Advised

elivaldogene autotemcel + etanercept

caution advised: combo may incr. risk of serious infection (additive effects)

• ethosuximide
Skysona (elivaldogene autotemcel)

+

ethosuximide

1 interaction

Caution Advised

elivaldogene autotemcel + ethosuximide

caution advised: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• felbamate
Skysona (elivaldogene autotemcel)

+

felbamate

1 interaction

Caution Advised

elivaldogene autotemcel + felbamate

caution advised: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• fenfluramine
Skysona (elivaldogene autotemcel)

+

fenfluramine

1 interaction

Caution Advised

elivaldogene autotemcel + fenfluramine

caution advised: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• fingolimod
Skysona (elivaldogene autotemcel)

+

fingolimod

1 interaction

Caution Advised

elivaldogene autotemcel + fingolimod

caution advised during and x2mo after fingolimod tx: combo may incr. risk of serious infection; infection risk may be prolonged (additive effects)

• fludrocortisone
Skysona (elivaldogene autotemcel)

+

fludrocortisone

1 interaction

Caution Advised

elivaldogene autotemcel + fludrocortisone

caution advised: combo may incr. risk of serious infection (additive effects)

• flunisolide nasal
Skysona (elivaldogene autotemcel)

+

flunisolide nasal

1 interaction

Caution Advised

elivaldogene autotemcel + flunisolide nasal

caution advised: combo may incr. risk of serious infection (additive effects)

• fluocinolone intravitreal
Skysona (elivaldogene autotemcel)

+

fluocinolone intravitreal

1 interaction

Caution Advised

elivaldogene autotemcel + fluocinolone intravitreal

caution advised: combo may incr. risk of serious infection (additive effects)

• fluorometholone ophthalmic
Skysona (elivaldogene autotemcel)

+

fluorometholone ophthalmic

1 interaction

Caution Advised

elivaldogene autotemcel + fluorometholone ophthalmic

caution advised: combo may incr. risk of serious infection (additive effects)

• fluticasone furoate
Skysona (elivaldogene autotemcel)

+

fluticasone furoate

1 interaction

Caution Advised

elivaldogene autotemcel + fluticasone furoate

caution advised: combo may incr. risk of serious infection (additive effects)

• fluticasone propionate
Skysona (elivaldogene autotemcel)

+

fluticasone propionate

1 interaction

Caution Advised

elivaldogene autotemcel + fluticasone propionate

caution advised: combo may incr. risk of serious infection (additive effects)

• fosphenytoin
Skysona (elivaldogene autotemcel)

+

fosphenytoin

1 interaction

Caution Advised

elivaldogene autotemcel + fosphenytoin

caution advised: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• fruquintinib
Skysona (elivaldogene autotemcel)

+

fruquintinib

1 interaction

Caution Advised

elivaldogene autotemcel + fruquintinib

caution advised: combo may incr. risk of serious infection (additive effects)

• gabapentin
Skysona (elivaldogene autotemcel)

+

gabapentin

1 interaction

Caution Advised

elivaldogene autotemcel + gabapentin

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• ganaxolone
Skysona (elivaldogene autotemcel)

+

ganaxolone

1 interaction

Caution Advised

elivaldogene autotemcel + ganaxolone

caution advised: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• golimumab
Skysona (elivaldogene autotemcel)

+

golimumab

1 interaction

Caution Advised

elivaldogene autotemcel + golimumab

caution advised: combo may incr. risk of serious infection (additive effects)

• guselkumab
Skysona (elivaldogene autotemcel)

+

guselkumab

1 interaction

Caution Advised

elivaldogene autotemcel + guselkumab

caution advised: combo may incr. risk of serious infection (additive effects)

• hydrocortisone
Skysona (elivaldogene autotemcel)

+

hydrocortisone

1 interaction

Caution Advised

elivaldogene autotemcel + hydrocortisone

caution advised: combo may incr. risk of serious infection (additive effects)

• hydrocortisone ophthalmic
Skysona (elivaldogene autotemcel)

+

hydrocortisone ophthalmic

1 interaction

Caution Advised

elivaldogene autotemcel + hydrocortisone ophthalmic

caution advised: combo may incr. risk of serious infection (additive effects)

• icotrokinra
Skysona (elivaldogene autotemcel)

+

icotrokinra

1 interaction

Caution Advised

elivaldogene autotemcel + icotrokinra

caution advised: combo may incr. risk of serious infection (additive effects)

• inebilizumab
Skysona (elivaldogene autotemcel)

+

inebilizumab

1 interaction

Caution Advised

elivaldogene autotemcel + inebilizumab

caution advised: combo may incr. risk of serious infection (additive effects)

• infliximab
Skysona (elivaldogene autotemcel)

+

infliximab

1 interaction

Caution Advised

elivaldogene autotemcel + infliximab

caution advised: combo may incr. risk of serious infection (additive effects)

• iptacopan
Skysona (elivaldogene autotemcel)

+

iptacopan

1 interaction

Caution Advised

elivaldogene autotemcel + iptacopan

caution advised: combo may incr. risk of serious infection (additive effects)

• ixekizumab
Skysona (elivaldogene autotemcel)

+

ixekizumab

1 interaction

Caution Advised

elivaldogene autotemcel + ixekizumab

caution advised: combo may incr. risk of serious infection (additive effects)

• lacosamide
Skysona (elivaldogene autotemcel)

+

lacosamide

1 interaction

Caution Advised

elivaldogene autotemcel + lacosamide

caution advised: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• lamotrigine
Skysona (elivaldogene autotemcel)

+

lamotrigine

1 interaction

Caution Advised

elivaldogene autotemcel + lamotrigine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• lebrikizumab
Skysona (elivaldogene autotemcel)

+

lebrikizumab

1 interaction

Caution Advised

elivaldogene autotemcel + lebrikizumab

caution advised: combo may incr. risk of serious infection (additive effects)

• levetiracetam
Skysona (elivaldogene autotemcel)

+

levetiracetam

1 interaction

Caution Advised

elivaldogene autotemcel + levetiracetam

caution advised: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• lorazepam
Skysona (elivaldogene autotemcel)

+

lorazepam

1 interaction

Caution Advised

elivaldogene autotemcel + lorazepam

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• loteprednol ophthalmic
Skysona (elivaldogene autotemcel)

+

loteprednol ophthalmic

1 interaction

Caution Advised

elivaldogene autotemcel + loteprednol ophthalmic

caution advised: combo may incr. risk of serious infection (additive effects)

• magnesium citrate
Skysona (elivaldogene autotemcel)

+

magnesium citrate

1 interaction

Caution Advised

elivaldogene autotemcel + magnesium citrate

caution advised, especially if magnesium citrate bowel prep use: combo may incr. risk of seizures (additive effects)

• methsuximide
Skysona (elivaldogene autotemcel)

+

methsuximide

1 interaction

Caution Advised

elivaldogene autotemcel + methsuximide

caution advised: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• methylprednisolone
Skysona (elivaldogene autotemcel)

+

methylprednisolone

1 interaction

Caution Advised

elivaldogene autotemcel + methylprednisolone

caution advised: combo may incr. risk of serious infection (additive effects)

• midazolam
Skysona (elivaldogene autotemcel)

+

midazolam

1 interaction

Caution Advised

elivaldogene autotemcel + midazolam

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• mirikizumab
Skysona (elivaldogene autotemcel)

+

mirikizumab

1 interaction

Caution Advised

elivaldogene autotemcel + mirikizumab

caution advised: combo may incr. risk of serious infection (additive effects)

• mometasone implant
Skysona (elivaldogene autotemcel)

+

mometasone implant

1 interaction

Caution Advised

elivaldogene autotemcel + mometasone implant

caution advised: combo may incr. risk of serious infection (additive effects)

• mometasone inhaled
Skysona (elivaldogene autotemcel)

+

mometasone inhaled

1 interaction

Caution Advised

elivaldogene autotemcel + mometasone inhaled

caution advised: combo may incr. risk of serious infection (additive effects)

• mometasone nasal
Skysona (elivaldogene autotemcel)

+

mometasone nasal

1 interaction

Caution Advised

elivaldogene autotemcel + mometasone nasal

caution advised: combo may incr. risk of serious infection (additive effects)

• monomethyl fumarate
Skysona (elivaldogene autotemcel)

+

monomethyl fumarate

1 interaction

Caution Advised

elivaldogene autotemcel + monomethyl fumarate

caution advised: combo may incr. risk of serious infection (additive effects)

• nadofaragene firadenovec intravesical
Skysona (elivaldogene autotemcel)

+

nadofaragene firadenovec intravesical

1 interaction

Caution Advised

elivaldogene autotemcel + nadofaragene firadenovec intravesical

caution advised: combo may incr. risk of disseminated adenovirus infection (immunosuppressive effects)

• narsoplimab
Skysona (elivaldogene autotemcel)

+

narsoplimab

1 interaction

Caution Advised

elivaldogene autotemcel + narsoplimab

caution advised: combo may incr. risk of serious infection (additive effects)

• nipocalimab
Skysona (elivaldogene autotemcel)

+

nipocalimab

1 interaction

Caution Advised

elivaldogene autotemcel + nipocalimab

caution advised: combo may incr. risk of serious infection (additive effects)

• ocrelizumab
Skysona (elivaldogene autotemcel)

+

ocrelizumab

1 interaction

Caution Advised

elivaldogene autotemcel + ocrelizumab

caution advised: combo may incr. risk of serious infection (additive effects)

• oxcarbazepine
Skysona (elivaldogene autotemcel)

+

oxcarbazepine

1 interaction

Caution Advised

elivaldogene autotemcel + oxcarbazepine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• ozanimod
Skysona (elivaldogene autotemcel)

+

ozanimod

1 interaction

Caution Advised

elivaldogene autotemcel + ozanimod

caution advised during and x3mo after ozanimod tx: combo may incr. risk of serious infection; infection risk may be prolonged (additive effects)

• pegcetacoplan
Skysona (elivaldogene autotemcel)

+

pegcetacoplan

1 interaction

Caution Advised

elivaldogene autotemcel + pegcetacoplan

caution advised: combo may incr. risk of serious infection (additive effects)

• perampanel
Skysona (elivaldogene autotemcel)

+

perampanel

1 interaction

Caution Advised

elivaldogene autotemcel + perampanel

caution advised: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• phenobarbital
Skysona (elivaldogene autotemcel)

+

phenobarbital

1 interaction

Caution Advised

elivaldogene autotemcel + phenobarbital

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• phenytoin
Skysona (elivaldogene autotemcel)

+

phenytoin

1 interaction

Caution Advised

elivaldogene autotemcel + phenytoin

caution advised: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• polyethylene glycol
Skysona (elivaldogene autotemcel)

+

polyethylene glycol

1 interaction

Caution Advised

elivaldogene autotemcel + polyethylene glycol

caution advised, especially if magnesium citrate bowel prep use: combo may incr. risk of seizures (additive effects)

• polyethylene glycol/electrolytes
Skysona (elivaldogene autotemcel)

+

polyethylene glycol/ electrolytes

1 interaction

Caution Advised

elivaldogene autotemcel + polyethylene glycol/ electrolytes

caution advised: combo may incr. risk of seizures (additive effects)

• ponesimod
Skysona (elivaldogene autotemcel)

+

ponesimod

1 interaction

Caution Advised

elivaldogene autotemcel + ponesimod

caution advised during and x1-2wk after ponesimod tx: combo may incr. risk of serious infection; infection risk may be prolonged (additive effects)

• pozelimab
Skysona (elivaldogene autotemcel)

+

pozelimab

1 interaction

Caution Advised

elivaldogene autotemcel + pozelimab

caution advised: combo may incr. risk of serious infection (additive effects)

• prednisolone
Skysona (elivaldogene autotemcel)

+

prednisolone

1 interaction

Caution Advised

elivaldogene autotemcel + prednisolone

caution advised: combo may incr. risk of serious infection (additive effects)

• prednisolone ophthalmic
Skysona (elivaldogene autotemcel)

+

prednisolone ophthalmic

1 interaction

Caution Advised

elivaldogene autotemcel + prednisolone ophthalmic

caution advised: combo may incr. risk of serious infection (additive effects)

• prednisone
Skysona (elivaldogene autotemcel)

+

prednisone

1 interaction

Caution Advised

elivaldogene autotemcel + prednisone

caution advised: combo may incr. risk of serious infection (additive effects)

• pregabalin
Skysona (elivaldogene autotemcel)

+

pregabalin

1 interaction

Caution Advised

elivaldogene autotemcel + pregabalin

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• primidone
Skysona (elivaldogene autotemcel)

+

primidone

1 interaction

Caution Advised

elivaldogene autotemcel + primidone

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• promethazine
Skysona (elivaldogene autotemcel)

+

promethazine

1 interaction

Caution Advised

elivaldogene autotemcel + promethazine

caution advised: combo may incr. risk of seizures (additive effects)

• ravulizumab
Skysona (elivaldogene autotemcel)

+

ravulizumab

1 interaction

Caution Advised

elivaldogene autotemcel + ravulizumab

caution advised: combo may incr. risk of serious infection (additive effects)

• regorafenib
Skysona (elivaldogene autotemcel)

+

regorafenib

1 interaction

Caution Advised

elivaldogene autotemcel + regorafenib

caution advised: combo may incr. risk of serious infection (additive effects)

• rilonacept
Skysona (elivaldogene autotemcel)

+

rilonacept

1 interaction

Caution Advised

elivaldogene autotemcel + rilonacept

caution advised: combo may incr. risk of serious infection (additive effects)

• rilzabrutinib
Skysona (elivaldogene autotemcel)

+

rilzabrutinib

1 interaction

Caution Advised

elivaldogene autotemcel + rilzabrutinib

caution advised: combo may incr. risk of serious infection (additive effects)

• risankizumab
Skysona (elivaldogene autotemcel)

+

risankizumab

1 interaction

Caution Advised

elivaldogene autotemcel + risankizumab

caution advised: combo may incr. risk of serious infection (additive effects)

• ritlecitinib
Skysona (elivaldogene autotemcel)

+

ritlecitinib

1 interaction

Caution Advised

elivaldogene autotemcel + ritlecitinib

caution advised: combo may incr. risk of serious infection (additive effects)

• rozanolixizumab
Skysona (elivaldogene autotemcel)

+

rozanolixizumab

1 interaction

Caution Advised

elivaldogene autotemcel + rozanolixizumab

caution advised: combo may incr. risk of serious infection (additive effects)

• rufinamide
Skysona (elivaldogene autotemcel)

+

rufinamide

1 interaction

Caution Advised

elivaldogene autotemcel + rufinamide

caution advised: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• secukinumab
Skysona (elivaldogene autotemcel)

+

secukinumab

1 interaction

Caution Advised

elivaldogene autotemcel + secukinumab

caution advised: combo may incr. risk of serious infection (additive effects)

• sibeprenlimab
Skysona (elivaldogene autotemcel)

+

sibeprenlimab

1 interaction

Caution Advised

elivaldogene autotemcel + sibeprenlimab

caution advised: combo may incr. risk of serious infection (additive effects)

• siltuximab
Skysona (elivaldogene autotemcel)

+

siltuximab

1 interaction

Caution Advised

elivaldogene autotemcel + siltuximab

caution advised: combo may incr. risk of serious infection (additive effects)

• siponimod
Skysona (elivaldogene autotemcel)

+

siponimod

1 interaction

Caution Advised

elivaldogene autotemcel + siponimod

caution advised during and x3-4wk after siponimod tx: combo may incr. risk of serious infection; infection risk may be prolonged (additive effects)

• sodium picosulfate
Skysona (elivaldogene autotemcel)

+

sodium picosulfate

1 interaction

Caution Advised

elivaldogene autotemcel + sodium picosulfate

caution advised: combo may incr. risk of seizures (additive effects)

• spesolimab
Skysona (elivaldogene autotemcel)

+

spesolimab

1 interaction

Caution Advised

elivaldogene autotemcel + spesolimab

caution advised: combo may incr. risk of serious infection (additive effects)

• sulfate bowel prep
Skysona (elivaldogene autotemcel)

+

sulfate bowel prep

1 interaction

Caution Advised

elivaldogene autotemcel + sulfate bowel prep

caution advised: combo may incr. risk of seizures (additive effects)

• sutimlimab
Skysona (elivaldogene autotemcel)

+

sutimlimab

1 interaction

Caution Advised

elivaldogene autotemcel + sutimlimab

caution advised: combo may incr. risk of serious infection (additive effects)

• tacrolimus
Skysona (elivaldogene autotemcel)

+

tacrolimus

1 interaction

Caution Advised

elivaldogene autotemcel + tacrolimus

caution advised: combo may incr. risk of serious infection (additive effects)

• tiagabine
Skysona (elivaldogene autotemcel)

+

tiagabine

1 interaction

Caution Advised

elivaldogene autotemcel + tiagabine

caution advised: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• tildrakizumab
Skysona (elivaldogene autotemcel)

+

tildrakizumab

1 interaction

Caution Advised

elivaldogene autotemcel + tildrakizumab

caution advised: combo may incr. risk of serious infection (additive effects)

• topiramate
Skysona (elivaldogene autotemcel)

+

topiramate

1 interaction

Caution Advised

elivaldogene autotemcel + topiramate

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• tralokinumab
Skysona (elivaldogene autotemcel)

+

tralokinumab

1 interaction

Caution Advised

elivaldogene autotemcel + tralokinumab

caution advised: combo may incr. risk of serious infection (additive effects)

• tramadol
Skysona (elivaldogene autotemcel)

+

tramadol

1 interaction

Caution Advised

elivaldogene autotemcel + tramadol

caution advised: combo may incr. risk of seizures (additive effects)

• triamcinolone
Skysona (elivaldogene autotemcel)

+

triamcinolone

1 interaction

Caution Advised

elivaldogene autotemcel + triamcinolone

caution advised: combo may incr. risk of serious infection (additive effects)

• tuberculin purified protein derivative
Skysona (elivaldogene autotemcel)

+

tuberculin purified protein derivative

1 interaction

Caution Advised

elivaldogene autotemcel + tuberculin purified protein derivative

caution advised during and x5-6wk after elivaldogene autotemcel tx: combo may interfere with test results (antagonistic effects)

• ublituximab
Skysona (elivaldogene autotemcel)

+

ublituximab

1 interaction

Caution Advised

elivaldogene autotemcel + ublituximab

caution advised: combo may incr. risk of serious infection (additive effects)

• ustekinumab
Skysona (elivaldogene autotemcel)

+

ustekinumab

1 interaction

Caution Advised

elivaldogene autotemcel + ustekinumab

caution advised: combo may incr. risk of serious infection (additive effects)

• vamorolone
Skysona (elivaldogene autotemcel)

+

vamorolone

1 interaction

Caution Advised

elivaldogene autotemcel + vamorolone

caution advised: combo may incr. risk of serious infection (additive effects)

• vedolizumab
Skysona (elivaldogene autotemcel)

+

vedolizumab

1 interaction

Caution Advised

elivaldogene autotemcel + vedolizumab

caution advised: combo may incr. risk of serious infection (additive effects)

• vigabatrin
Skysona (elivaldogene autotemcel)

+

vigabatrin

1 interaction

Caution Advised

elivaldogene autotemcel + vigabatrin

caution advised: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• vilobelimab
Skysona (elivaldogene autotemcel)

+

vilobelimab

1 interaction

Caution Advised

elivaldogene autotemcel + vilobelimab

caution advised: combo may incr. risk of serious infection (additive effects)

• voclosporin
Skysona (elivaldogene autotemcel)

+

voclosporin

1 interaction

Caution Advised

elivaldogene autotemcel + voclosporin

caution advised: combo may incr. risk of serious infection (additive effects)

• zilucoplan
Skysona (elivaldogene autotemcel)

+

zilucoplan

1 interaction

Caution Advised

elivaldogene autotemcel + zilucoplan

caution advised: combo may incr. risk of serious infection (additive effects)

• zonisamide
Skysona (elivaldogene autotemcel)

+

zonisamide

1 interaction

Caution Advised

elivaldogene autotemcel + zonisamide

caution advised: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)