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Abrysvo
respiratory syncytial virus vaccine (RSV)
Adult Dosing .
Dosage forms: INJ
RSV dz prevention
- [pregnant pts, 32-36 wk gestation]
- Dose: 0.5 mL IM x1; Start: before start of RSV season; Info: for prevention of RSV dz in infants 0-6 mo; see CDC Adult Immunizations schedule in Guidelines > Specialties > Infectious Diseases
- [non-pregnant pts, 18-59 yo, pts w/ high infection risk]
- Dose: 0.5 mL IM x1
- [60-74 yo, pts w/ high infection risk]
- Dose: 0.5 mL IM x1; Start: before start of RSV season; Info: see CDC Adult Immunizations schedule in Guidelines > Specialties > Infectious Diseases
- [75 yo and older]
- Dose: 0.5 mL IM x1; Start: before start of RSV season; Info: see CDC Adult Immunizations schedule in Guidelines > Specialties > Infectious Diseases
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ
RSV dz prevention
- [pregnant pts, 10 yo and older, 32-36 wk gestation]
- Dose: 0.5 mL IM x1; Start: before start of RSV season; Info: for prevention of RSV dz in infants 0-6 mo; see CDC Child/Adolescent Immunizations schedule in Guidelines > Specialties > Infectious Diseases
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- caution: immunocompromised pts
- caution: illness, acute moderate-severe
Drug Interactions .
Overview
respiratory syncytial virus vaccine
vaccine
- non-live vaccine
Avoid/Use Alternative
- interferon gamma 1b
Monitor/Modify Tx
- abatacept
- abemaciclib
- abrocitinib
- acalabrutinib
- adalimumab
- afamitresgene autoleucel
- aldesleukin
- alemtuzumab
- anakinra
- anifrolumab
- anti-thymocyte globulin
- atezolizumab
- atidarsagene autotemcel
- avelumab
- axicabtagene ciloleucel
- azacitidine
- azathioprine
- baricitinib
- basiliximab
- belatacept
- belimumab
- belinostat
- bendamustine
- betamethasone
- bimekizumab
- blinatumomab
- bortezomib
- brentuximab vedotin
- brexucabtagene autoleucel
- brodalumab
- budesonide
- budesonide rectal
- busulfan
- cabazitaxel
- canakinumab
- capecitabine
- carboplatin
- carfilzomib
- carmustine
- cemiplimab
- certolizumab pegol
- chlorambucil
- ciltacabtagene autoleucel
- cisplatin
- cladribine injection
- cladribine oral
- clofarabine
- copanlisib
- corticotropin
- cortisone
- cosibelimab
- cyclophosphamide
- cyclosporine
- cytarabine
- dactinomycin
- daratumumab
- dasatinib
- daunorubicin
- decitabine
- deflazacort
- deucravacitinib
- deuruxolitinib
- dexamethasone
- dimethyl fumarate
- dinutuximab
- diroximel fumarate
- docetaxel
- dostarlimab
- doxorubicin
- dupilumab
- durvalumab
- duvelisib
- efgartigimod alfa
- elivaldogene autotemcel
- elotuzumab
- elranatamab
- emapalumab
- epcoritamab
- epirubicin
- eribulin
- etanercept
- etoposide
- etrasimod
- everolimus
- fingolimod
- floxuridine
- fludarabine
- fludrocortisone
- fluorouracil
- fruquintinib
- gemcitabine
- gemtuzumab ozogamicin
- glofitamab
- golimumab
- guselkumab
- hydrocortisone
- hydroxyurea
- ibritumomab tiuxetan
- ibrutinib
- idarubicin
- idecabtagene vicleucel
- idelalisib
- ifosfamide
- imatinib
- inebilizumab
- infliximab
- inotuzumab ozogamicin
- ipilimumab
- irinotecan
- isatuximab
- ixabepilone
- ixekizumab
- lebrikizumab
- leflunomide
- lenalidomide
- lisocabtagene maraleucel
- lomustine
- loncastuximab tesirine
- lymphocyte immune globulin, anti-thymocyte globulin
- melphalan
- mercaptopurine
- methotrexate
- methylprednisolone
- mirikizumab
- mitoxantrone
- mogamulizumab
- momelotinib
- monomethyl fumarate
- mosunetuzumab
- mycophenolate mofetil
- mycophenolic acid
- natalizumab
- nelarabine
- nemolizumab
- nivolumab
- obecabtagene autoleucel
- obinutuzumab
- ocrelizumab
- ofatumumab
- oxaliplatin
- ozanimod
- paclitaxel
- palbociclib
- panobinostat
- peginterferon alfa 2a
- pembrolizumab
- pentostatin
- pirtobrutinib
- polatuzumab vedotin
- pomalidomide
- ponatinib
- ponesimod
- prednisolone
- prednisone
- procarbazine
- regorafenib
- retifanlimab
- rilonacept
- risankizumab
- ritlecitinib
- rituximab
- romidepsin
- ropeginterferon alfa-2b
- rozanolixizumab
- ruxolitinib
- sarilumab
- satralizumab
- secukinumab
- selinexor
- siltuximab
- siponimod
- sirolimus
- sirolimus albumin-bound
- sirolimus topical
- spesolimab
- sunitinib
- tacrolimus
- tafasitamab
- talquetamab
- tarlatamab
- teclistamab
- temozolomide
- temsirolimus
- teplizumab
- teriflunomide
- thioguanine
- thiotepa
- tildrakizumab
- tisagenlecleucel
- tislelizumab
- tocilizumab
- tofacitinib
- topotecan
- toripalimab
- tralokinumab
- tremelimumab
- triamcinolone
- ublituximab
- upadacitinib
- ustekinumab
- vamorolone
- vedolizumab
- venetoclax
- vinblastine
- vincristine
- vinorelbine
- voclosporin
- zanubrutinib
Adverse Reactions .
Serious Reactions
- hypersensitivity rxn
- anaphylaxis
- Guillain-Barre syndrome
Common Reactions
- fatigue
- headache
- injection site rxn
- myalgia
- arthralgia
- diarrhea
- nausea
- vomiting
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy, indicated for immunization at 32-36 wk gestation to prevent RSV dz in infants 0-6 mo; no known risk of fetal harm based on human data; possible risk of preterm birth if given at <32 wk gestation based on limited human data
Pregnancy Registry
enroll pts or encourage pts to enroll in Abrysvo Pregnancy Registry at 1-800-616-3791
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: other; CYP450: unknown
Excretion: other; Half-life: unknown
Subclass: Respiratory Syncytial Virus (RSV) Vaccines ; Routine Adult Vaccines ; Routine Pediatric Vaccines
Mechanism of Action
exact mechanism of action unknown; induces antibody formation; confers immunity to infants through transplacental antibody transfer
Formulary .
No Formulary Selected
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