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Nereus
tradipitant
Adult Dosing .
Dosage forms: CAP: 85 mg
motion sickness prevention
- [85-170 mg PO x1]
- Start: approximately 60min before vomit-inducing event; Max: 1 dose/24h; Info: use lowest effective dose; give 1h before or 2h after meals
renal dosing
- [see below]
- eGFR >30: no adjustment; eGFR <30: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- caution: CNS depressant use, concurrent
Drug Interactions .
Overview
tradipitant
substance P/NK-1 antagonist
- CYP3A4 substrate
- CNS depression
Avoid/Use Alternative
- 5-HTP
- aldesleukin
- alfentanil
- allopurinol
- almotriptan
- alprazolam
- amantadine
- amitriptyline
- amoxapine
- apomorphine
- apraclonidine ophthalmic
- aripiprazole bimonthly injection
- aripiprazole lauroxil
- aripiprazole monthly injection
- aripiprazole oral
- asenapine
- baclofen
- baclofen intrathecal
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- buprenorphine
- buspirone
- butalbital
- butorphanol
- cannabidiol
- cannabis
- carbamazepine
- carbinoxamine
- cariprazine
- carisoprodol
- cenobamate
- cetirizine
- chamomile, German
- chlophedianol
- chlorcyclizine
- chlordiazepoxide
- chlorpheniramine
- chlorpromazine
- chlorzoxazone
- citalopram
- clemastine
- clobazam
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- codeine
- cyclobenzaprine
- cyproheptadine
- dantrolene
- daridorexant
- darifenacin
- desflurane
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- dexmedetomidine
- dexmedetomidine injection
- diazepam
- dichlorphenamide
- difelikefalin
- difenoxin
- dihydrocodeine
- dimenhydrinate
- diphenhydramine
- diphenoxylate
- domperidone
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- droperidol
- duloxetine
- efavirenz
- eletriptan
- elinzanetant
- entacapone
- entrectinib
- escitalopram
- esketamine
- eslicarbazepine acetate
- estazolam
- eszopiclone
- ethanol (alcoholic beverage)
- ethanol (in some formulations)
- ethanol injection
- ethosuximide
- etomidate
- felbamate
- fenfluramine
- fentanyl
- fesoterodine
- flibanserin
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- foslevodopa
- fosphenytoin
- frovatriptan
- gabapentin
- gabapentin enacarbil
- ganaxolone
- glofitamab
- glycopyrrolate
- guanfacine
- haloperidol
- hydrocodone
- hydromorphone
- hydroxyzine
- hyoscyamine
- ifosfamide
- iloperidone
- imipramine
- isocarboxazid
- isoflurane
- kava
- ketamine
- kratom
- lacosamide
- lamotrigine
- lemborexant
- levetiracetam
- levocetirizine
- levodopa
- levomilnacipran
- levorphanol
- linvoseltamab
- lofexidine
- lorazepam
- loxapine
- lumateperone
- lurasidone
- meclizine
- melatonin
- meperidine
- meprobamate
- metaxalone
- methadone
- methocarbamol
- methohexital
- methsuximide
- methyldopa
- metoclopramide
- metyrapone
- metyrosine
- midazolam
- milnacipran
- milsaperidone
- mirtazapine
- mitotane
- molindone
- morphine
- mosunetuzumab
- mycophenolate mofetil
- nalbuphine
- naltrexone
- naratriptan
- nefazodone
- nelarabine
- nortriptyline
- olanzapine
- oliceridine
- opicapone
- opium
- orphenadrine
- oxazepam
- oxcarbazepine
- oxybate
- oxybutynin
- oxycodone
- oxymorphone
- paliperidone
- paroxetine
- passion flower
- pentazocine
- pentobarbital
- perampanel
- perphenazine
- phenelzine
- pheniramine
- phenobarbital
- phenytoin
- pimozide
- pramipexole
- pregabalin
- primidone
- procarbazine
- prochlorperazine
- promethazine
- propofol
- protriptyline
- pyrilamine
- quazepam
- quetiapine
- ramelteon
- rasagiline
- remifentanil
- remimazolam
- repotrectinib
- risperidone
- rizatriptan
- ropeginterferon alfa-2b
- ropinirole
- rotigotine transdermal
- rufinamide
- safinamide
- scopolamine
- selegiline
- selegiline transdermal
- selinexor
- sertraline
- sevoflurane
- solifenacin
- stiripentol
- sufentanil
- sumatriptan
- suvorexant
- tapentadol
- tasimelteon
- temazepam
- tetrabenazine
- thalidomide
- thioridazine
- thiotepa
- thiothixene
- tiagabine
- tizanidine
- tolcapone
- tolterodine
- topiramate
- tramadol
- tranylcypromine
- trazodone
- triazolam
- trifluoperazine
- trihexyphenidyl
- trimethobenzamide
- trimipramine
- triprolidine
- trospium
- valbenazine
- valerian
- valproic acid
- venlafaxine
- vigabatrin
- vilazodone
- viloxazine
- zaleplon
- ziconotide
- ziprasidone
- zolmitriptan
- zolpidem
- zonisamide
- zuranolone
Caution Advised
- adagrasib
- atazanavir
- ceritinib
- chloramphenicol
- clarithromycin
- cobicistat
- idelalisib
- itraconazole
- ketoconazole
- levoketoconazole
- lonafarnib
- lopinavir/ritonavir
- mifepristone
- nelfinavir
- posaconazole
- ribociclib
- ritonavir
- tipranavir
- tucatinib
- voriconazole
Adverse Reactions .
Serious Reactions
may occur but none reported
Common Reactions
- somnolence
- headache
- fatigue
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; inadequate human data available; no known risk of fetal harm based on animal data at 1.4x and 3.3x MRHD
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: for tradipitant: liver; CYP450: 2C8 (minor), 2C19, 3A4 substrate; UGT: 1A4, 2B7 substrate
Excretion: for tradipitant: feces 80% (minimally unchanged), urine 7% (none unchanged); Half-life: 34h
Subclass: Antiemetics, Neurokinin-1 Receptor Antagonists
Mechanism of Action
for tradipitant: exact mechanism of action unknown; selectively antagonizes human substance P/neurokinin 1 receptors
Formulary .
No Formulary Selected
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