Symbravo

Overview

meloxicam

NSAID

• CYP2C9 substrate
• affects growth hormone diagnostic test results
• alters gallbladder contraction/motility
• antiplatelet effects
• decreases renal perfusion/fxn
• GI mucosal injury/bleeding risk
• hyperkalemia
• hypertensive effects
• hyponatremia
• lowers seizure threshold
• thrombogenic effects

rizatriptan

5-HT1 agonist

• MAO substrate
• CNS depression
• hypertensive effects
• serotonergic effects

• add MAO inhibitor to Interaction Check if recent (14 days) use

Contraindicated

• ketorolac
Symbravo (meloxicam/ rizatriptan)

+

ketorolac

1 interaction

Contraindicated

meloxicam + ketorolac

ketorolac injection, tablet: contraindicated; ketorolac nasal: avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN, hyperkalemia, renal impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

rizatriptan + ketorolac

monitor BP: combo may incr. risk of HTN (additive effects)

• methylergonovine
Symbravo (meloxicam/ rizatriptan)

+

methylergonovine

2 interactions

Contraindicated

rizatriptan + methylergonovine

contraindicated w/in 24h of use: combo may incr. risk of severe HTN, prolonged vasospasm, ischemia, serotonin syndrome (additive effects)

Monitor/Modify Tx

meloxicam + methylergonovine

monitor BP: combo may incr. risk of severe HTN, vasospasm, ischemia (additive effects)

• naratriptan
Symbravo (meloxicam/ rizatriptan)

+

naratriptan

2 interactions

Contraindicated

rizatriptan + naratriptan

contraindicated w/in 24h of use: combo may incr. risk of severe, prolonged vasospasm, HTN, serotonin syndrome, CNS depression, psychomotor impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

meloxicam + naratriptan

monitor BP: combo may incr. risk of HTN (additive effects)

• phenelzine
Symbravo (meloxicam/ rizatriptan)

+

phenelzine

1 interaction

Contraindicated

rizatriptan + phenelzine

contraindicated w/in 14 days of phenelzine use: combo may incr. rizatriptan levels, risk of serotonin syndrome, CNS depression, psychomotor impairment, other adverse effects (monoamine oxidase (MAO) inhibited, additive effects)

• procarbazine
Symbravo (meloxicam/ rizatriptan)

+

procarbazine

1 interaction

Contraindicated

rizatriptan + procarbazine

contraindicated w/in 14 days of procarbazine use: combo may incr. rizatriptan levels, risk of serotonin syndrome, CNS depression, psychomotor impairment, other adverse effects (monoamine oxidase (MAO) inhibited, additive effects)

• propranolol
Symbravo (meloxicam/ rizatriptan)

+

propranolol

2 interactions

Contraindicated

rizatriptan + propranolol

RIZATRIPTAN MELOXICAM COMBO: contraindicated; ALL OTHER RIZATRIPTAN FORMS as follows: ADULTS: monitor BP; adjust rizatriptan dose to 5 mg/dose, max 15 mg/24h; PEDS <40 kg: contraindicated with oral strip form, avoid combo with other forms; PEDS >40 kg: monitor BP; adjust rizatriptan dose to 5 mg/24h: combo may incr. rizatriptan levels, risk of adverse effects; may decr. antihypertensive agent efficacy (monoamine oxidase inhibited; antagonistic effects)

Monitor/Modify Tx

meloxicam + propranolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• rizatriptan
Symbravo (meloxicam/ rizatriptan)

+

rizatriptan

2 interactions

Contraindicated

rizatriptan + rizatriptan

contraindicated w/in 24h of use: combo may incr. risk of severe, prolonged vasospasm, HTN, serotonin syndrome, CNS depression, psychomotor impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

meloxicam + rizatriptan

monitor BP: combo may incr. risk of HTN (additive effects)

• selegiline transdermal
Symbravo (meloxicam/ rizatriptan)

+

selegiline transdermal

1 interaction

Contraindicated

rizatriptan + selegiline transdermal

contraindicated w/in 14 days of selegiline transdermal use: combo may incr. rizatriptan levels, risk of serotonin syndrome, CNS depression, psychomotor impairment, other adverse effects (monoamine oxidase (MAO) inhibited, additive effects)

• sumatriptan
Symbravo (meloxicam/ rizatriptan)

+

sumatriptan

2 interactions

Contraindicated

rizatriptan + sumatriptan

contraindicated w/in 24h of use: combo may incr. risk of severe, prolonged vasospasm, HTN, serotonin syndrome, CNS depression, psychomotor impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

meloxicam + sumatriptan

monitor BP: combo may incr. risk of HTN (additive effects)

• tranylcypromine
Symbravo (meloxicam/ rizatriptan)

+

tranylcypromine

1 interaction

Contraindicated

rizatriptan + tranylcypromine

contraindicated w/in 14 days of tranylcypromine use: combo may incr. rizatriptan levels, risk of serotonin syndrome, CNS depression, psychomotor impairment, other adverse effects (monoamine oxidase (MAO) inhibited, additive effects)

• yohimbe
Symbravo (meloxicam/ rizatriptan)

+

yohimbe

2 interactions

Contraindicated

rizatriptan + yohimbe

contraindicated w/in 14 days of yohimbe use: combo may incr. rizatriptan levels, risk of serotonin syndrome, HTN, other adverse effects (monoamine oxidase (MAO) inhibited, additive effects)

Monitor/Modify Tx

meloxicam + yohimbe

monitor BP: combo may incr. risk of HTN (additive effects)

• zolmitriptan
Symbravo (meloxicam/ rizatriptan)

+

zolmitriptan

2 interactions

Contraindicated

rizatriptan + zolmitriptan

contraindicated w/in 24h of use: combo may incr. risk of severe, prolonged vasospasm, HTN, serotonin syndrome, CNS depression, psychomotor impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

meloxicam + zolmitriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Avoid/Use Alternative

• adagrasib
Symbravo (meloxicam/ rizatriptan)

+

adagrasib

1 interaction

Avoid/Use Alternative

meloxicam + adagrasib

avoid combo if meloxicam given as fixed-dose combo w/ rizatriptan; otherwise, monitor bleeding s/sx; use lowest effective meloxicam dose, shortest duration of concomitant tx: combo may incr. meloxicam levels, risk of GI or other bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• alfentanil
Symbravo (meloxicam/ rizatriptan)

+

alfentanil

1 interaction

Avoid/Use Alternative

rizatriptan + alfentanil

use alternative or monitor BP, respiratory rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, serotonin syndrome (additive effects)

• amikacin
Symbravo (meloxicam/ rizatriptan)

+

amikacin

1 interaction

Avoid/Use Alternative

meloxicam + amikacin

use alternative or monitor amikacin levels, renal fxn, ototoxicity: combo may incr. amikacin levels, risk of nephrotoxicity, auditory, vestibular, other adverse effects (additive effects)

• amiodarone
Symbravo (meloxicam/ rizatriptan)

+

amiodarone

1 interaction

Avoid/Use Alternative

meloxicam + amiodarone

avoid combo if meloxicam given as fixed-dose combo w/ rizatriptan; otherwise, monitor bleeding s/sx; use lowest effective meloxicam dose, shortest duration of concomitant tx: combo may incr. meloxicam levels, risk of GI or other bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• amphetamine
Symbravo (meloxicam/ rizatriptan)

+

amphetamine

2 interactions

Avoid/Use Alternative

rizatriptan + amphetamine

consider alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration; decr. amphetamine start dose: combo may incr. risk of HTN, serotonin syndrome (additive effects)

Monitor/Modify Tx

meloxicam + amphetamine

monitor BP: combo may incr. risk of HTN (additive effects)

• asciminib
Symbravo (meloxicam/ rizatriptan)

+

asciminib

2 interactions

Avoid/Use Alternative

meloxicam + asciminib

avoid combo if meloxicam given as fixed-dose combo w/ rizatriptan; otherwise, monitor BP, bleeding or thrombosis s/sx, especially if asciminib 200 mg bid; use lowest effective meloxicam dose, shortest duration of concomitant tx: combo may incr. meloxicam levels, risk of GI or other bleeding (including life-threatening), HTN, thromboembolism, other adverse effects (hepatic metabolism inhibited, additive effects)

Monitor/Modify Tx

rizatriptan + asciminib

monitor BP: combo may incr. risk of HTN (additive effects)

• aspirin
Symbravo (meloxicam/ rizatriptan)

+

aspirin

1 interaction

Avoid/Use Alternative

meloxicam + aspirin

avoid aspirin >325 mg/day; otherwise, monitor bleeding s/sx, renal fxn: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), renal impairment, other adverse effects (additive effects, duplicate therapy)

• bumetanide
Symbravo (meloxicam/ rizatriptan)

+

bumetanide

2 interactions

Avoid/Use Alternative

meloxicam + bumetanide

use alternative or monitor renal fxn, BP: combo may incr. risk of renal impairment; may decr. bumetanide efficacy (additive effects; antagonistic effects)

Monitor/Modify Tx

rizatriptan + bumetanide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• buprenorphine
Symbravo (meloxicam/ rizatriptan)

+

buprenorphine

1 interaction

Avoid/Use Alternative

rizatriptan + buprenorphine

use alternative or monitor respiratory rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, serotonin syndrome (additive effects)

• buspirone
Symbravo (meloxicam/ rizatriptan)

+

buspirone

1 interaction

Avoid/Use Alternative

rizatriptan + buspirone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• butorphanol
Symbravo (meloxicam/ rizatriptan)

+

butorphanol

1 interaction

Avoid/Use Alternative

rizatriptan + butorphanol

use alternative or monitor respiratory rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of serotonin syndrome, profound CNS and respiratory depression, psychomotor impairment (additive effects)

• celecoxib
Symbravo (meloxicam/ rizatriptan)

+

celecoxib

2 interactions

Avoid/Use Alternative

meloxicam + celecoxib

avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN, hyperkalemia, renal impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

rizatriptan + celecoxib

monitor BP: combo may incr. risk of HTN (additive effects)

• citalopram
Symbravo (meloxicam/ rizatriptan)

+

citalopram

2 interactions

Avoid/Use Alternative

rizatriptan + citalopram

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

meloxicam + citalopram

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• clofarabine
Symbravo (meloxicam/ rizatriptan)

+

clofarabine

1 interaction

Avoid/Use Alternative

meloxicam + clofarabine

avoid meloxicam during 5 day clofarabine tx; monitor CBC, renal fxn, BP: combo may incr. clofarabine levels, risk of serious infection, myelosuppression, nephrotoxicity, hypotension, other adverse effects (additive effects)

• clomipramine
Symbravo (meloxicam/ rizatriptan)

+

clomipramine

1 interaction

Avoid/Use Alternative

rizatriptan + clomipramine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• clonidine
Symbravo (meloxicam/ rizatriptan)

+

clonidine

2 interactions

Avoid/Use Alternative

rizatriptan + clonidine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

Monitor/Modify Tx

meloxicam + clonidine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• codeine
Symbravo (meloxicam/ rizatriptan)

+

codeine

1 interaction

Avoid/Use Alternative

rizatriptan + codeine

avoid combo if antitussive use; otherwise, use alternative or monitor respiratory rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, serotonin syndrome (additive effects)

• cyclobenzaprine
Symbravo (meloxicam/ rizatriptan)

+

cyclobenzaprine

1 interaction

Avoid/Use Alternative

rizatriptan + cyclobenzaprine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• desipramine
Symbravo (meloxicam/ rizatriptan)

+

desipramine

1 interaction

Avoid/Use Alternative

rizatriptan + desipramine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• desvenlafaxine
Symbravo (meloxicam/ rizatriptan)

+

desvenlafaxine

2 interactions

Avoid/Use Alternative

rizatriptan + desvenlafaxine

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN (additive effects)

Monitor/Modify Tx

meloxicam + desvenlafaxine

monitor bleeding s/sx, BP: combo may incr. risk of GI or other bleeding (including life-threatening), HTN (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• dextroamphetamine
Symbravo (meloxicam/ rizatriptan)

+

dextroamphetamine

2 interactions

Avoid/Use Alternative

rizatriptan + dextroamphetamine

consider alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration; decr. dextroamphetamine start dose: combo may incr. risk of HTN, serotonin syndrome (additive effects)

Monitor/Modify Tx

meloxicam + dextroamphetamine

monitor BP: combo may incr. risk of HTN (additive effects)

• diclofenac
Symbravo (meloxicam/ rizatriptan)

+

diclofenac

2 interactions

Avoid/Use Alternative

meloxicam + diclofenac

avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN, hyperkalemia, renal impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

rizatriptan + diclofenac

monitor BP: combo may incr. risk of HTN (additive effects)

• diclofenac topical
Symbravo (meloxicam/ rizatriptan)

+

diclofenac topical

2 interactions

Avoid/Use Alternative

meloxicam + diclofenac topical

avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN, hyperkalemia, renal impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

rizatriptan + diclofenac topical

monitor BP: combo may incr. risk of HTN (additive effects)

• diflunisal
Symbravo (meloxicam/ rizatriptan)

+

diflunisal

2 interactions

Avoid/Use Alternative

meloxicam + diflunisal

avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN, hyperkalemia, renal impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

rizatriptan + diflunisal

monitor BP: combo may incr. risk of HTN (additive effects)

• dihydrocodeine
Symbravo (meloxicam/ rizatriptan)

+

dihydrocodeine

1 interaction

Avoid/Use Alternative

rizatriptan + dihydrocodeine

use alternative or monitor respiratory rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, serotonin syndrome (additive effects)

• doxylamine
Symbravo (meloxicam/ rizatriptan)

+

doxylamine

1 interaction

Avoid/Use Alternative

rizatriptan + doxylamine

avoid combo if doxylamine use for pregnancy-related nausea/vomiting; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• duloxetine
Symbravo (meloxicam/ rizatriptan)

+

duloxetine

2 interactions

Avoid/Use Alternative

rizatriptan + duloxetine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

meloxicam + duloxetine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• efavirenz
Symbravo (meloxicam/ rizatriptan)

+

efavirenz

2 interactions

Avoid/Use Alternative

meloxicam + efavirenz

avoid combo if meloxicam given as fixed-dose combo w/ rizatriptan; otherwise, monitor bleeding s/sx; use lowest effective meloxicam dose, shortest duration of concomitant tx: combo may incr. meloxicam levels, risk of GI or other bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

Caution Advised

rizatriptan + efavirenz

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• enoxaparin
Symbravo (meloxicam/ rizatriptan)

+

enoxaparin

1 interaction

Avoid/Use Alternative

meloxicam + enoxaparin

use alternative or monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• epinephrine inhaled
Symbravo (meloxicam/ rizatriptan)

+

epinephrine inhaled

2 interactions

Avoid/Use Alternative

meloxicam + epinephrine inhaled

avoid combo: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

rizatriptan + epinephrine inhaled

avoid combo: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• escitalopram
Symbravo (meloxicam/ rizatriptan)

+

escitalopram

2 interactions

Avoid/Use Alternative

rizatriptan + escitalopram

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

meloxicam + escitalopram

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ethanol (alcoholic beverage)
Symbravo (meloxicam/ rizatriptan)

+

ethanol (alcoholic beverage)

2 interactions

Avoid/Use Alternative

rizatriptan + ethanol (alcoholic beverage)

avoid combo: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, HTN (chronic alcohol use) (additive effects)

Monitor/Modify Tx

meloxicam + ethanol (alcoholic beverage)

monitor bleeding signs/symptoms, BP: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), HTN (chronic alcohol use) (additive effects)

• ethanol injection
Symbravo (meloxicam/ rizatriptan)

+

ethanol injection

1 interaction

Avoid/Use Alternative

rizatriptan + ethanol injection

use alternative or monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• etodolac
Symbravo (meloxicam/ rizatriptan)

+

etodolac

2 interactions

Avoid/Use Alternative

meloxicam + etodolac

avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN, hyperkalemia, renal impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

rizatriptan + etodolac

monitor BP: combo may incr. risk of HTN (additive effects)

• fenoprofen
Symbravo (meloxicam/ rizatriptan)

+

fenoprofen

2 interactions

Avoid/Use Alternative

meloxicam + fenoprofen

avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN, hyperkalemia, renal impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

rizatriptan + fenoprofen

monitor BP: combo may incr. risk of HTN (additive effects)

• fentanyl
Symbravo (meloxicam/ rizatriptan)

+

fentanyl

1 interaction

Avoid/Use Alternative

rizatriptan + fentanyl

use alternative or monitor respiratory rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, serotonin syndrome (additive effects)

• fluconazole
Symbravo (meloxicam/ rizatriptan)

+

fluconazole

1 interaction

Avoid/Use Alternative

meloxicam + fluconazole

avoid combo if meloxicam given as fixed-dose combo w/ rizatriptan; otherwise, monitor bleeding s/sx; use lowest effective meloxicam dose, shortest duration of concomitant tx: combo may incr. meloxicam levels, risk of GI or other bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• fluorouracil
Symbravo (meloxicam/ rizatriptan)

+

fluorouracil

1 interaction

Avoid/Use Alternative

meloxicam + fluorouracil

avoid combo if meloxicam given as fixed-dose combo w/ rizatriptan; otherwise, monitor bleeding s/sx; use lowest effective meloxicam dose, shortest duration of concomitant tx: combo may incr. meloxicam levels, risk of GI or other bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• fluoxetine
Symbravo (meloxicam/ rizatriptan)

+

fluoxetine

2 interactions

Avoid/Use Alternative

rizatriptan + fluoxetine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

meloxicam + fluoxetine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• flurbiprofen
Symbravo (meloxicam/ rizatriptan)

+

flurbiprofen

2 interactions

Avoid/Use Alternative

meloxicam + flurbiprofen

avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN, hyperkalemia, renal impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

rizatriptan + flurbiprofen

monitor BP: combo may incr. risk of HTN (additive effects)

• fluvoxamine
Symbravo (meloxicam/ rizatriptan)

+

fluvoxamine

2 interactions

Avoid/Use Alternative

rizatriptan + fluvoxamine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

meloxicam + fluvoxamine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• fondaparinux
Symbravo (meloxicam/ rizatriptan)

+

fondaparinux

1 interaction

Avoid/Use Alternative

meloxicam + fondaparinux

use alternative or monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• furosemide
Symbravo (meloxicam/ rizatriptan)

+

furosemide

2 interactions

Avoid/Use Alternative

rizatriptan + furosemide

use alternative or monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Monitor/Modify Tx

meloxicam + furosemide

monitor renal fxn, BP: combo may incr. risk of renal impairment; may decr. furosemide efficacy (additive effects; antagonistic effects)

• gepirone
Symbravo (meloxicam/ rizatriptan)

+

gepirone

1 interaction

Avoid/Use Alternative

rizatriptan + gepirone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• granisetron
Symbravo (meloxicam/ rizatriptan)

+

granisetron

1 interaction

Avoid/Use Alternative

rizatriptan + granisetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• haloperidol
Symbravo (meloxicam/ rizatriptan)

+

haloperidol

1 interaction

Avoid/Use Alternative

rizatriptan + haloperidol

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• hydrocodone
Symbravo (meloxicam/ rizatriptan)

+

hydrocodone

1 interaction

Avoid/Use Alternative

rizatriptan + hydrocodone

avoid combo if antitussive use; otherwise, use alternative or monitor respiratory rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, serotonin syndrome (additive effects)

• hydromorphone
Symbravo (meloxicam/ rizatriptan)

+

hydromorphone

1 interaction

Avoid/Use Alternative

rizatriptan + hydromorphone

use alternative or monitor respiratory rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, serotonin syndrome (additive effects)

• ibuprofen
Symbravo (meloxicam/ rizatriptan)

+

ibuprofen

2 interactions

Avoid/Use Alternative

meloxicam + ibuprofen

avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN, hyperkalemia, renal impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

rizatriptan + ibuprofen

monitor BP: combo may incr. risk of HTN (additive effects)

• ibuprofen lysine
Symbravo (meloxicam/ rizatriptan)

+

ibuprofen lysine

1 interaction

Avoid/Use Alternative

meloxicam + ibuprofen lysine

avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), renal impairment, other adverse effects (additive effects, duplicate therapy)

• indomethacin
Symbravo (meloxicam/ rizatriptan)

+

indomethacin

2 interactions

Avoid/Use Alternative

meloxicam + indomethacin

avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN, hyperkalemia, renal impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

rizatriptan + indomethacin

monitor BP: combo may incr. risk of HTN (additive effects)

• isoniazid
Symbravo (meloxicam/ rizatriptan)

+

isoniazid

1 interaction

Avoid/Use Alternative

rizatriptan + isoniazid

use alternative or monitor serotonin syndrome sx w/in 14 days of isoniazid use, especially during initiation/titration: combo may incr. rizatriptan levels, risk of serotonin syndrome, other adverse effects (monoamine oxidase (MAO) inhibited, additive effects)

• kava
Symbravo (meloxicam/ rizatriptan)

+

kava

1 interaction

Avoid/Use Alternative

rizatriptan + kava

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ketoprofen
Symbravo (meloxicam/ rizatriptan)

+

ketoprofen

2 interactions

Avoid/Use Alternative

meloxicam + ketoprofen

avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN, hyperkalemia, renal impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

rizatriptan + ketoprofen

monitor BP: combo may incr. risk of HTN (additive effects)

• kratom
Symbravo (meloxicam/ rizatriptan)

+

kratom

1 interaction

Avoid/Use Alternative

rizatriptan + kratom

use alternative or monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• levomilnacipran
Symbravo (meloxicam/ rizatriptan)

+

levomilnacipran

2 interactions

Avoid/Use Alternative

rizatriptan + levomilnacipran

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, HTN, CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

meloxicam + levomilnacipran

monitor BP, bleeding s/sx: combo may incr. risk of HTN, GI or other bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• levorphanol
Symbravo (meloxicam/ rizatriptan)

+

levorphanol

1 interaction

Avoid/Use Alternative

rizatriptan + levorphanol

use alternative or monitor respiratory rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, serotonin syndrome (additive effects)

• lisdexamfetamine
Symbravo (meloxicam/ rizatriptan)

+

lisdexamfetamine

2 interactions

Avoid/Use Alternative

rizatriptan + lisdexamfetamine

consider alternative or decr. lisdexamfetamine start dose; monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, HTN (additive effects)

Monitor/Modify Tx

meloxicam + lisdexamfetamine

monitor BP: combo may incr. risk of HTN (additive effects)

• lisinopril
Symbravo (meloxicam/ rizatriptan)

+

lisinopril

2 interactions

Avoid/Use Alternative

meloxicam + lisinopril

consider alternative or monitor potassium, renal fxn, BP: combo may incr. risk of renal impairment, hyperkalemia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

Monitor/Modify Tx

rizatriptan + lisinopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• lithium
Symbravo (meloxicam/ rizatriptan)

+

lithium

2 interactions

Avoid/Use Alternative

rizatriptan + lithium

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

meloxicam + lithium

monitor lithium levels, renal fxn: combo may incr. lithium levels, risk of nephrotoxicity, other adverse effects (additive effects)

• macimorelin
Symbravo (meloxicam/ rizatriptan)

+

macimorelin

1 interaction

Avoid/Use Alternative

meloxicam + macimorelin

avoid combo or D/C meloxicam, allowing sufficient washout time before diagnostic test: combo may interfere with test results (meloxicam may affect pituitary secretion of growth hormone)

• magnesium salicylate
Symbravo (meloxicam/ rizatriptan)

+

magnesium salicylate

2 interactions

Avoid/Use Alternative

meloxicam + magnesium salicylate

avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), renal impairment, HTN (additive effects)

Monitor/Modify Tx

rizatriptan + magnesium salicylate

monitor BP w/ high-dose magnesium salicylate: combo may incr. risk of HTN (additive effects)

• meclofenamate
Symbravo (meloxicam/ rizatriptan)

+

meclofenamate

2 interactions

Avoid/Use Alternative

meloxicam + meclofenamate

avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN, hyperkalemia, renal impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

rizatriptan + meclofenamate

monitor BP: combo may incr. risk of HTN (additive effects)

• mefenamic acid
Symbravo (meloxicam/ rizatriptan)

+

mefenamic acid

2 interactions

Avoid/Use Alternative

meloxicam + mefenamic acid

avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN, hyperkalemia, renal impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

rizatriptan + mefenamic acid

monitor BP: combo may incr. risk of HTN (additive effects)

• meloxicam
Symbravo (meloxicam/ rizatriptan)

+

meloxicam

2 interactions

Avoid/Use Alternative

meloxicam + meloxicam

avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN, hyperkalemia, renal impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

rizatriptan + meloxicam

monitor BP: combo may incr. risk of HTN (additive effects)

• meperidine
Symbravo (meloxicam/ rizatriptan)

+

meperidine

1 interaction

Avoid/Use Alternative

rizatriptan + meperidine

use alternative or monitor respiratory rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of serotonin syndrome, profound CNS and respiratory depression, psychomotor impairment (additive effects)

• metaxalone
Symbravo (meloxicam/ rizatriptan)

+

metaxalone

1 interaction

Avoid/Use Alternative

rizatriptan + metaxalone

use alternative or monitor respiratory rate, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, serotonin syndrome (additive effects)

• methadone
Symbravo (meloxicam/ rizatriptan)

+

methadone

1 interaction

Avoid/Use Alternative

rizatriptan + methadone

use alternative or monitor respiratory rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of serotonin syndrome, profound CNS and respiratory depression, psychomotor impairment (additive effects)

• methamphetamine
Symbravo (meloxicam/ rizatriptan)

+

methamphetamine

2 interactions

Avoid/Use Alternative

rizatriptan + methamphetamine

consider alternative or decr. methamphetamine start dose; monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, HTN (additive effects)

Monitor/Modify Tx

meloxicam + methamphetamine

monitor BP: combo may incr. risk of HTN (additive effects)

• methotrexate
Symbravo (meloxicam/ rizatriptan)

+

methotrexate

1 interaction

Avoid/Use Alternative

meloxicam + methotrexate

use alternative if high-dose methotrexate; otherwise, monitor CBC, renal fxn, bleeding s/sx: combo may incr. methotrexate levels, risk of serious infection, myelosuppression, nephrotoxicity, GI ulceration, perforation, bleeding (including life-threatening), other adverse effects (additive effects)

• metoclopramide
Symbravo (meloxicam/ rizatriptan)

+

metoclopramide

2 interactions

Avoid/Use Alternative

rizatriptan + metoclopramide

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN, serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

meloxicam + metoclopramide

monitor BP: combo may incr. risk of HTN (additive effects)

• miconazole oropharyngeal
Symbravo (meloxicam/ rizatriptan)

+

miconazole oropharyngeal

1 interaction

Avoid/Use Alternative

meloxicam + miconazole oropharyngeal

avoid combo if meloxicam given as fixed-dose combo w/ rizatriptan; otherwise, monitor bleeding s/sx; use lowest effective meloxicam dose, shortest duration of concomitant tx: combo may incr. meloxicam levels, risk of GI or other bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• midazolam
Symbravo (meloxicam/ rizatriptan)

+

midazolam

1 interaction

Avoid/Use Alternative

rizatriptan + midazolam

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• midodrine
Symbravo (meloxicam/ rizatriptan)

+

midodrine

2 interactions

Avoid/Use Alternative

meloxicam + midodrine

use alternative or monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + midodrine

use alternative or monitor BP: combo may incr. risk of HTN (additive effects)

• milk thistle
Symbravo (meloxicam/ rizatriptan)

+

milk thistle

1 interaction

Avoid/Use Alternative

meloxicam + milk thistle

avoid combo if meloxicam given as fixed-dose combo w/ rizatriptan; otherwise, monitor bleeding s/sx; use lowest effective meloxicam dose, shortest duration of concomitant tx: combo may incr. meloxicam levels, risk of GI or other bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• milnacipran
Symbravo (meloxicam/ rizatriptan)

+

milnacipran

2 interactions

Avoid/Use Alternative

rizatriptan + milnacipran

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, HTN, CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

meloxicam + milnacipran

monitor BP, bleeding s/sx: combo may incr. risk of HTN, GI or other bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• mirtazapine
Symbravo (meloxicam/ rizatriptan)

+

mirtazapine

1 interaction

Avoid/Use Alternative

rizatriptan + mirtazapine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• morphine
Symbravo (meloxicam/ rizatriptan)

+

morphine

1 interaction

Avoid/Use Alternative

rizatriptan + morphine

use alternative or monitor respiratory rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of serotonin syndrome, profound CNS and respiratory depression, psychomotor impairment (additive effects)

• nabumetone
Symbravo (meloxicam/ rizatriptan)

+

nabumetone

2 interactions

Avoid/Use Alternative

meloxicam + nabumetone

avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN, hyperkalemia, renal impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

rizatriptan + nabumetone

monitor BP: combo may incr. risk of HTN (additive effects)

• nalbuphine
Symbravo (meloxicam/ rizatriptan)

+

nalbuphine

1 interaction

Avoid/Use Alternative

rizatriptan + nalbuphine

use alternative or monitor respiratory rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of serotonin syndrome, profound CNS and respiratory depression, psychomotor impairment (additive effects)

• naproxen
Symbravo (meloxicam/ rizatriptan)

+

naproxen

2 interactions

Avoid/Use Alternative

meloxicam + naproxen

avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN, hyperkalemia, renal impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

rizatriptan + naproxen

monitor BP: combo may incr. risk of HTN (additive effects)

• nitisinone
Symbravo (meloxicam/ rizatriptan)

+

nitisinone

1 interaction

Avoid/Use Alternative

meloxicam + nitisinone

avoid combo if meloxicam given as fixed-dose combo w/ rizatriptan; otherwise, monitor bleeding s/sx; use lowest effective meloxicam dose, shortest duration of concomitant tx: combo may incr. meloxicam levels, risk of GI or other bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• nortriptyline
Symbravo (meloxicam/ rizatriptan)

+

nortriptyline

1 interaction

Avoid/Use Alternative

rizatriptan + nortriptyline

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• oliceridine
Symbravo (meloxicam/ rizatriptan)

+

oliceridine

1 interaction

Avoid/Use Alternative

rizatriptan + oliceridine

use alternative or monitor respiratory rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, serotonin syndrome (additive effects)

• olmesartan medoxomil
Symbravo (meloxicam/ rizatriptan)

+

olmesartan medoxomil

2 interactions

Avoid/Use Alternative

meloxicam + olmesartan medoxomil

consider alternative or monitor potassium, renal fxn, BP: combo may incr. risk of renal impairment, hyperkalemia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

Monitor/Modify Tx

rizatriptan + olmesartan medoxomil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ondansetron
Symbravo (meloxicam/ rizatriptan)

+

ondansetron

1 interaction

Avoid/Use Alternative

rizatriptan + ondansetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• opium
Symbravo (meloxicam/ rizatriptan)

+

opium

1 interaction

Avoid/Use Alternative

rizatriptan + opium

use alternative or monitor respiratory rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of serotonin syndrome, profound CNS and respiratory depression, psychomotor impairment (additive effects)

• oxaprozin
Symbravo (meloxicam/ rizatriptan)

+

oxaprozin

2 interactions

Avoid/Use Alternative

meloxicam + oxaprozin

avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN, hyperkalemia, renal impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

rizatriptan + oxaprozin

monitor BP: combo may incr. risk of HTN (additive effects)

• oxybate
Symbravo (meloxicam/ rizatriptan)

+

oxybate

1 interaction

Avoid/Use Alternative

rizatriptan + oxybate

use alternative or monitor respiratory rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, syncope (additive effects)

• oxycodone
Symbravo (meloxicam/ rizatriptan)

+

oxycodone

1 interaction

Avoid/Use Alternative

rizatriptan + oxycodone

use alternative or monitor respiratory rate, serotonin syndrome sx, especially during initiation/titration; decr. oxycodone start dose by at least 50%, consider decr. rizatriptan dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, serotonin syndrome (additive effects)

• oxymorphone
Symbravo (meloxicam/ rizatriptan)

+

oxymorphone

1 interaction

Avoid/Use Alternative

rizatriptan + oxymorphone

use alternative or monitor respiratory rate, serotonin syndrome sx, especially during initiation/titration; decr. oxymorphone start dose by at least 50%, consider decr. rizatriptan dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of serotonin syndrome, profound CNS and respiratory depression, psychomotor impairment (additive effects)

• paroxetine
Symbravo (meloxicam/ rizatriptan)

+

paroxetine

2 interactions

Avoid/Use Alternative

rizatriptan + paroxetine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

meloxicam + paroxetine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pemetrexed
Symbravo (meloxicam/ rizatriptan)

+

pemetrexed

1 interaction

Avoid/Use Alternative

meloxicam + pemetrexed

avoid combo at least 5 days before, during and x2 days after pemetrexed use; monitor CBC, renal fxn, especially if concomitant renal impairment: combo may incr. pemetrexed levels, risk of myelosuppression, nephrotoxicity, other adverse effects (additive effects)

• pentazocine
Symbravo (meloxicam/ rizatriptan)

+

pentazocine

1 interaction

Avoid/Use Alternative

rizatriptan + pentazocine

use alternative or monitor respiratory rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of serotonin syndrome, profound CNS and respiratory depression, psychomotor impairment (additive effects)

• perindopril
Symbravo (meloxicam/ rizatriptan)

+

perindopril

2 interactions

Avoid/Use Alternative

meloxicam + perindopril

consider alternative or monitor potassium, renal fxn, BP: combo may incr. risk of renal impairment, hyperkalemia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

Monitor/Modify Tx

rizatriptan + perindopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• piroxicam
Symbravo (meloxicam/ rizatriptan)

+

piroxicam

2 interactions

Avoid/Use Alternative

meloxicam + piroxicam

avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN, hyperkalemia, renal impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

rizatriptan + piroxicam

monitor BP: combo may incr. risk of HTN (additive effects)

• potassium chloride
Symbravo (meloxicam/ rizatriptan)

+

potassium chloride

1 interaction

Avoid/Use Alternative

meloxicam + potassium chloride

IV potassium chloride: use alternative or monitor potassium, ECG; ORAL potassium: monitor potassium, ECG: combo may incr. risk of severe hyperkalemia, cardiac arrest (additive effects)

• potassium phosphate
Symbravo (meloxicam/ rizatriptan)

+

potassium phosphate

1 interaction

Avoid/Use Alternative

meloxicam + potassium phosphate

use alternative or monitor potassium, ECG: combo may incr. risk of severe hyperkalemia, cardiac arrest (additive effects)

• pralatrexate
Symbravo (meloxicam/ rizatriptan)

+

pralatrexate

1 interaction

Avoid/Use Alternative

meloxicam + pralatrexate

use alternative or monitor CBC: combo may incr. pralatrexate levels, risk of myelosuppression, other adverse effects (renal excretion possibly decreased)

• promethazine
Symbravo (meloxicam/ rizatriptan)

+

promethazine

1 interaction

Avoid/Use Alternative

rizatriptan + promethazine

use alternative or monitor respiratory rate, decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• rasagiline
Symbravo (meloxicam/ rizatriptan)

+

rasagiline

1 interaction

Avoid/Use Alternative

rizatriptan + rasagiline

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• remifentanil
Symbravo (meloxicam/ rizatriptan)

+

remifentanil

1 interaction

Avoid/Use Alternative

rizatriptan + remifentanil

use alternative or monitor respiratory rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of serotonin syndrome, profound CNS and respiratory depression, psychomotor impairment (additive effects)

• ropeginterferon alfa-2b
Symbravo (meloxicam/ rizatriptan)

+

ropeginterferon alfa-2b

2 interactions

Avoid/Use Alternative

rizatriptan + ropeginterferon alfa-2b

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

meloxicam + ropeginterferon alfa-2b

monitor renal fxn: combo may incr. risk of nephrotoxicity (additive effects)

• safinamide
Symbravo (meloxicam/ rizatriptan)

+

safinamide

1 interaction

Avoid/Use Alternative

rizatriptan + safinamide

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• salsalate
Symbravo (meloxicam/ rizatriptan)

+

salsalate

2 interactions

Avoid/Use Alternative

meloxicam + salsalate

avoid combo: combo may incr. risk of renal impairment, HTN, thromboembolism, GI ulceration, perforation, bleeding, including life-threatening (additive effects)

Monitor/Modify Tx

rizatriptan + salsalate

monitor BP w/ high-dose salsalate: combo may incr. risk of HTN (additive effects)

• scopolamine
Symbravo (meloxicam/ rizatriptan)

+

scopolamine

1 interaction

Avoid/Use Alternative

rizatriptan + scopolamine

use alternative: combo may increase risk of CNS depression, psychomotor impairment (additive effects)

• selegiline
Symbravo (meloxicam/ rizatriptan)

+

selegiline

1 interaction

Avoid/Use Alternative

rizatriptan + selegiline

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• sertraline
Symbravo (meloxicam/ rizatriptan)

+

sertraline

2 interactions

Avoid/Use Alternative

rizatriptan + sertraline

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

Monitor/Modify Tx

meloxicam + sertraline

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• St. John's wort
Symbravo (meloxicam/ rizatriptan)

+

St. John's wort

1 interaction

Avoid/Use Alternative

rizatriptan + St. John's wort

avoid combo: combo may incr. risk of serotonin syndrome (additive effects)

• sufentanil
Symbravo (meloxicam/ rizatriptan)

+

sufentanil

1 interaction

Avoid/Use Alternative

rizatriptan + sufentanil

use alternative or monitor respiratory rate, serotonin syndrome sx, especially during initiation/titration; decr. sufentanil start dose, consider decr. rizatriptan dose, use lowest effective doses: combo may incr. risk of serotonin syndrome, profound CNS and respiratory depression, psychomotor impairment (additive effects)

• sulindac
Symbravo (meloxicam/ rizatriptan)

+

sulindac

2 interactions

Avoid/Use Alternative

meloxicam + sulindac

avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN, hyperkalemia, renal impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

rizatriptan + sulindac

monitor BP: combo may incr. risk of HTN (additive effects)

• tacrolimus
Symbravo (meloxicam/ rizatriptan)

+

tacrolimus

2 interactions

Avoid/Use Alternative

meloxicam + tacrolimus

consider alternative or monitor tacrolimus levels, renal fxn, BP, potassium: combo may incr. tacrolimus levels, risk of nephrotoxicity, HTN, hyperkalemia, other adverse effects (additive effects)

Monitor/Modify Tx

rizatriptan + tacrolimus

monitor BP: combo may incr. risk of HTN (additive effects)

• tapentadol
Symbravo (meloxicam/ rizatriptan)

+

tapentadol

1 interaction

Avoid/Use Alternative

rizatriptan + tapentadol

use alternative or monitor respiratory rate, BP, serotonin syndrome symptoms, especially during initiation/titration; decrease dose of one or both drugs, use lowest effective doses and shortest duration of concomitant treatment: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), serotonin syndrome (additive effects)

• tedizolid
Symbravo (meloxicam/ rizatriptan)

+

tedizolid

1 interaction

Avoid/Use Alternative

rizatriptan + tedizolid

use alternative or monitor serotonin syndrome symptoms, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects, tedizolid reversibly inhibits monoamine oxidase)

• tenofovir disoproxil
Symbravo (meloxicam/ rizatriptan)

+

tenofovir disoproxil

1 interaction

Avoid/Use Alternative

meloxicam + tenofovir disoproxil

use alternative or monitor renal fxn: combo may incr. tenofovir levels, risk of nephrotoxicity, other adverse effects (additive effects)

• thalidomide
Symbravo (meloxicam/ rizatriptan)

+

thalidomide

2 interactions

Avoid/Use Alternative

rizatriptan + thalidomide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

meloxicam + thalidomide

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• tolmetin
Symbravo (meloxicam/ rizatriptan)

+

tolmetin

2 interactions

Avoid/Use Alternative

meloxicam + tolmetin

avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN, hyperkalemia, renal impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

rizatriptan + tolmetin

monitor BP: combo may incr. risk of HTN (additive effects)

• tradipitant
Symbravo (meloxicam/ rizatriptan)

+

tradipitant

1 interaction

Avoid/Use Alternative

rizatriptan + tradipitant

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tramadol
Symbravo (meloxicam/ rizatriptan)

+

tramadol

1 interaction

Avoid/Use Alternative

rizatriptan + tramadol

use alternative or monitor respiratory rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, serotonin syndrome (additive effects)

• tranexamic acid
Symbravo (meloxicam/ rizatriptan)

+

tranexamic acid

1 interaction

Avoid/Use Alternative

meloxicam + tranexamic acid

avoid combo: combo may incr. risk of thromboembolism (additive effects)

• trimethobenzamide
Symbravo (meloxicam/ rizatriptan)

+

trimethobenzamide

1 interaction

Avoid/Use Alternative

rizatriptan + trimethobenzamide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trimipramine
Symbravo (meloxicam/ rizatriptan)

+

trimipramine

1 interaction

Avoid/Use Alternative

rizatriptan + trimipramine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• vaccinia immune globulin
Symbravo (meloxicam/ rizatriptan)

+

vaccinia immune globulin

1 interaction

Avoid/Use Alternative

meloxicam + vaccinia immune globulin

use alternative or monitor thrombosis s/sx, renal fxn; use lowest vaccinia immune globulin concentration and infusion rate possible; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism, nephrotoxicity (additive effects)

• valsartan
Symbravo (meloxicam/ rizatriptan)

+

valsartan

2 interactions

Avoid/Use Alternative

meloxicam + valsartan

consider alternative or monitor potassium, renal fxn, BP: combo may incr. risk of renal impairment, hyperkalemia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

Monitor/Modify Tx

rizatriptan + valsartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• venlafaxine
Symbravo (meloxicam/ rizatriptan)

+

venlafaxine

2 interactions

Avoid/Use Alternative

rizatriptan + venlafaxine

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN (additive effects)

Monitor/Modify Tx

meloxicam + venlafaxine

monitor bleeding s/sx, BP: combo may incr. risk of GI or other bleeding (including life-threatening), HTN (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• vilazodone
Symbravo (meloxicam/ rizatriptan)

+

vilazodone

2 interactions

Avoid/Use Alternative

rizatriptan + vilazodone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

meloxicam + vilazodone

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• vortioxetine
Symbravo (meloxicam/ rizatriptan)

+

vortioxetine

2 interactions

Avoid/Use Alternative

rizatriptan + vortioxetine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

meloxicam + vortioxetine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• willow bark
Symbravo (meloxicam/ rizatriptan)

+

willow bark

1 interaction

Avoid/Use Alternative

meloxicam + willow bark

avoid combo: combo may incr. risk of renal impairment, GI ulceration, perforation, bleeding (including life-threatening), other adverse effects (additive effects, duplicate therapy, willow bark may contain salicylates)

• ziprasidone
Symbravo (meloxicam/ rizatriptan)

+

ziprasidone

1 interaction

Avoid/Use Alternative

rizatriptan + ziprasidone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• zuranolone
Symbravo (meloxicam/ rizatriptan)

+

zuranolone

1 interaction

Avoid/Use Alternative

rizatriptan + zuranolone

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

• 5-HTP
Symbravo (meloxicam/ rizatriptan)

+

5-HTP

1 interaction

Monitor/Modify Tx

rizatriptan + 5-HTP

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• abemaciclib
Symbravo (meloxicam/ rizatriptan)

+

abemaciclib

1 interaction

Monitor/Modify Tx

meloxicam + abemaciclib

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• abiraterone acetate
Symbravo (meloxicam/ rizatriptan)

+

abiraterone acetate

2 interactions

Monitor/Modify Tx

meloxicam + abiraterone acetate

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + abiraterone acetate

monitor BP: combo may incr. risk of HTN (additive effects)

• abrocitinib
Symbravo (meloxicam/ rizatriptan)

+

abrocitinib

1 interaction

Monitor/Modify Tx

meloxicam + abrocitinib

monitor platelets, bleeding or thrombosis s/sx; bleeding risk may be lower at abrocitinib doses <200 mg/day; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism, bleeding, including life-threatening (additive effects)

• acalabrutinib
Symbravo (meloxicam/ rizatriptan)

+

acalabrutinib

1 interaction

Monitor/Modify Tx

meloxicam + acalabrutinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• acebutolol
Symbravo (meloxicam/ rizatriptan)

+

acebutolol

2 interactions

Monitor/Modify Tx

meloxicam + acebutolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + acebutolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• acyclovir
Symbravo (meloxicam/ rizatriptan)

+

acyclovir

1 interaction

Monitor/Modify Tx

meloxicam + acyclovir

monitor renal fxn: combo may incr. acyclovir levels, risk of nephrotoxicity, other adverse effects (additive effects)

• adefovir dipivoxil
Symbravo (meloxicam/ rizatriptan)

+

adefovir dipivoxil

1 interaction

Monitor/Modify Tx

meloxicam + adefovir dipivoxil

monitor renal fxn: combo may incr. adefovir levels, risk of nephrotoxicity, other adverse effects (renal excretion decreased, additive effects)

• ado-trastuzumab emtansine
Symbravo (meloxicam/ rizatriptan)

+

ado-trastuzumab emtansine

1 interaction

Monitor/Modify Tx

meloxicam + ado-trastuzumab emtansine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• afatinib
Symbravo (meloxicam/ rizatriptan)

+

afatinib

1 interaction

Monitor/Modify Tx

meloxicam + afatinib

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• aflibercept
Symbravo (meloxicam/ rizatriptan)

+

aflibercept

1 interaction

Monitor/Modify Tx

meloxicam + aflibercept

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• albuterol
Symbravo (meloxicam/ rizatriptan)

+

albuterol

2 interactions

Monitor/Modify Tx

meloxicam + albuterol

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + albuterol

monitor BP: combo may incr. risk of HTN (additive effects)

• albuterol inhaled
Symbravo (meloxicam/ rizatriptan)

+

albuterol inhaled

2 interactions

Monitor/Modify Tx

meloxicam + albuterol inhaled

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + albuterol inhaled

monitor BP: combo may incr. risk of HTN (additive effects)

• aldesleukin
Symbravo (meloxicam/ rizatriptan)

+

aldesleukin

2 interactions

Monitor/Modify Tx

meloxicam + aldesleukin

monitor renal fxn: combo may incr. risk of renal impairment (additive effects)

rizatriptan + aldesleukin

withhold aldesleukin if mod-severe somnolence occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• alendronate
Symbravo (meloxicam/ rizatriptan)

+

alendronate

1 interaction

Monitor/Modify Tx

meloxicam + alendronate

monitor bleeding s/sx: combo may incr. risk of upper GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• aliskiren
Symbravo (meloxicam/ rizatriptan)

+

aliskiren

2 interactions

Monitor/Modify Tx

meloxicam + aliskiren

monitor renal fxn, potassium, BP: combo may incr. risk of renal impairment, hyperkalemia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

rizatriptan + aliskiren

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• alpha-tocopherol (vitamin E)
Symbravo (meloxicam/ rizatriptan)

+

alpha-tocopherol (vitamin E)

1 interaction

Monitor/Modify Tx

meloxicam + alpha-tocopherol (vitamin E)

monitor bleeding signs/symptoms, especially with alpha-tocopherol doses >800 units/day: combo may increase risk of bleeding, including life-threatening (additive effects)

• alprazolam
Symbravo (meloxicam/ rizatriptan)

+

alprazolam

1 interaction

Monitor/Modify Tx

rizatriptan + alprazolam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• alprostadil intracavernous
Symbravo (meloxicam/ rizatriptan)

+

alprostadil intracavernous

1 interaction

Monitor/Modify Tx

meloxicam + alprostadil intracavernous

monitor injection site bleeding signs/symptoms: combo may increase risk of localized bleeding (additive effects)

• alprostadil intravenous
Symbravo (meloxicam/ rizatriptan)

+

alprostadil intravenous

1 interaction

Monitor/Modify Tx

meloxicam + alprostadil intravenous

monitor bleeding signs/symptoms: combo may increase risk of bleeding, including life-threatening (additive effects)

• alteplase
Symbravo (meloxicam/ rizatriptan)

+

alteplase

1 interaction

Monitor/Modify Tx

meloxicam + alteplase

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• amikacin inhaled
Symbravo (meloxicam/ rizatriptan)

+

amikacin inhaled

1 interaction

Monitor/Modify Tx

meloxicam + amikacin inhaled

monitor renal fxn, ototoxicity: combo may incr. amikacin levels, risk of nephrotoxicity, auditory, vestibular, other adverse effects (additive effects)

• amiloride
Symbravo (meloxicam/ rizatriptan)

+

amiloride

2 interactions

Monitor/Modify Tx

meloxicam + amiloride

monitor renal fxn, potassium, BP: combo may incr. risk of renal impairment, hyperkalemia; may decr. amiloride efficacy (additive effects; antagonistic effects)

rizatriptan + amiloride

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• aminocaproic acid
Symbravo (meloxicam/ rizatriptan)

+

aminocaproic acid

1 interaction

Monitor/Modify Tx

meloxicam + aminocaproic acid

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• amitriptyline
Symbravo (meloxicam/ rizatriptan)

+

amitriptyline

1 interaction

Monitor/Modify Tx

rizatriptan + amitriptyline

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• amlodipine
Symbravo (meloxicam/ rizatriptan)

+

amlodipine

2 interactions

Monitor/Modify Tx

meloxicam + amlodipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + amlodipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• amoxapine
Symbravo (meloxicam/ rizatriptan)

+

amoxapine

1 interaction

Monitor/Modify Tx

rizatriptan + amoxapine

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• amphotericin
Symbravo (meloxicam/ rizatriptan)

+

amphotericin

1 interaction

Monitor/Modify Tx

meloxicam + amphotericin

monitor renal fxn: combo may incr. risk of nephrotoxicity (additive effects)

• anacaulase topical
Symbravo (meloxicam/ rizatriptan)

+

anacaulase topical

1 interaction

Monitor/Modify Tx

meloxicam + anacaulase topical

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• anagrelide
Symbravo (meloxicam/ rizatriptan)

+

anagrelide

1 interaction

Monitor/Modify Tx

meloxicam + anagrelide

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• angiotensin II
Symbravo (meloxicam/ rizatriptan)

+

angiotensin II

2 interactions

Monitor/Modify Tx

meloxicam + angiotensin II

monitor BP, thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

rizatriptan + angiotensin II

monitor BP: combo may incr. risk of HTN (additive effects)

• anthrax immune globulin
Symbravo (meloxicam/ rizatriptan)

+

anthrax immune globulin

1 interaction

Monitor/Modify Tx

meloxicam + anthrax immune globulin

monitor renal fxn, thrombosis s/sx; use lowest anthrax immune globulin infusion rate possible; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of nephrotoxicity, thromboembolism (additive effects)

• anti-inhibitor coagulant complex
Symbravo (meloxicam/ rizatriptan)

+

anti-inhibitor coagulant complex

1 interaction

Monitor/Modify Tx

meloxicam + anti-inhibitor coagulant complex

monitor thrombosis s/sx, especially w/ anti-inhibitor coagulant complex dose >100 units/kg; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• antihemophilic factor (factor VIII)/von Willebrand factor complex
Symbravo (meloxicam/ rizatriptan)

+

antihemophilic factor (factor VIII)/ von Willebrand factor complex

1 interaction

Monitor/Modify Tx

meloxicam + antihemophilic factor (factor VIII)/ von Willebrand factor complex

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• antithrombin
Symbravo (meloxicam/ rizatriptan)

+

antithrombin

1 interaction

Monitor/Modify Tx

meloxicam + antithrombin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• apixaban
Symbravo (meloxicam/ rizatriptan)

+

apixaban

1 interaction

Monitor/Modify Tx

meloxicam + apixaban

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• aprocitentan
Symbravo (meloxicam/ rizatriptan)

+

aprocitentan

2 interactions

Monitor/Modify Tx

meloxicam + aprocitentan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + aprocitentan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• arformoterol inhaled
Symbravo (meloxicam/ rizatriptan)

+

arformoterol inhaled

2 interactions

Monitor/Modify Tx

meloxicam + arformoterol inhaled

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + arformoterol inhaled

monitor BP: combo may incr. risk of HTN (additive effects)

• argatroban
Symbravo (meloxicam/ rizatriptan)

+

argatroban

1 interaction

Monitor/Modify Tx

meloxicam + argatroban

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• armodafinil
Symbravo (meloxicam/ rizatriptan)

+

armodafinil

2 interactions

Monitor/Modify Tx

meloxicam + armodafinil

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + armodafinil

monitor BP: combo may incr. risk of HTN (additive effects)

• asparaginase
Symbravo (meloxicam/ rizatriptan)

+

asparaginase

1 interaction

Monitor/Modify Tx

meloxicam + asparaginase

monitor bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of GI or other bleeding (including life-threatening), thromboembolism (additive effects)

• atenolol
Symbravo (meloxicam/ rizatriptan)

+

atenolol

2 interactions

Monitor/Modify Tx

meloxicam + atenolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + atenolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• atidarsagene autotemcel
Symbravo (meloxicam/ rizatriptan)

+

atidarsagene autotemcel

1 interaction

Monitor/Modify Tx

meloxicam + atidarsagene autotemcel

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• atogepant
Symbravo (meloxicam/ rizatriptan)

+

atogepant

2 interactions

Monitor/Modify Tx

meloxicam + atogepant

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + atogepant

monitor BP: combo may incr. risk of HTN (additive effects)

• atomoxetine
Symbravo (meloxicam/ rizatriptan)

+

atomoxetine

2 interactions

Monitor/Modify Tx

meloxicam + atomoxetine

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + atomoxetine

monitor BP: combo may incr. risk of HTN (additive effects)

• atropine ophthalmic
Symbravo (meloxicam/ rizatriptan)

+

atropine ophthalmic

2 interactions

Monitor/Modify Tx

meloxicam + atropine ophthalmic

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + atropine ophthalmic

monitor BP: combo may incr. risk of HTN (additive effects)

• auranofin
Symbravo (meloxicam/ rizatriptan)

+

auranofin

1 interaction

Monitor/Modify Tx

meloxicam + auranofin

monitor renal fxn: combo may incr. auranofin levels, risk of nephrotoxicity, other adverse effects (additive effects)

• avapritinib
Symbravo (meloxicam/ rizatriptan)

+

avapritinib

1 interaction

Monitor/Modify Tx

meloxicam + avapritinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• avatrombopag
Symbravo (meloxicam/ rizatriptan)

+

avatrombopag

1 interaction

Monitor/Modify Tx

meloxicam + avatrombopag

monitor platelets, thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• axitinib
Symbravo (meloxicam/ rizatriptan)

+

axitinib

2 interactions

Monitor/Modify Tx

meloxicam + axitinib

monitor BP, bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN (additive effects)

rizatriptan + axitinib

monitor BP: combo may incr. risk of HTN (additive effects)

• azilsartan medoxomil
Symbravo (meloxicam/ rizatriptan)

+

azilsartan medoxomil

2 interactions

Monitor/Modify Tx

meloxicam + azilsartan medoxomil

monitor renal fxn, BP: combo may incr. risk of renal impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

rizatriptan + azilsartan medoxomil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• baclofen intrathecal
Symbravo (meloxicam/ rizatriptan)

+

baclofen intrathecal

1 interaction

Monitor/Modify Tx

rizatriptan + baclofen intrathecal

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• balsalazide
Symbravo (meloxicam/ rizatriptan)

+

balsalazide

1 interaction

Monitor/Modify Tx

meloxicam + balsalazide

monitor renal fxn: combo may incr. risk of nephrotoxicity (additive effects)

• baricitinib
Symbravo (meloxicam/ rizatriptan)

+

baricitinib

1 interaction

Monitor/Modify Tx

meloxicam + baricitinib

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• bazedoxifene
Symbravo (meloxicam/ rizatriptan)

+

bazedoxifene

1 interaction

Monitor/Modify Tx

meloxicam + bazedoxifene

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• benazepril
Symbravo (meloxicam/ rizatriptan)

+

benazepril

2 interactions

Monitor/Modify Tx

meloxicam + benazepril

monitor renal fxn, potassium, BP: combo may incr. risk of renal impairment, hyperkalemia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

rizatriptan + benazepril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• benzphetamine
Symbravo (meloxicam/ rizatriptan)

+

benzphetamine

2 interactions

Monitor/Modify Tx

meloxicam + benzphetamine

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + benzphetamine

monitor BP: combo may incr. risk of HTN (additive effects)

• betamethasone
Symbravo (meloxicam/ rizatriptan)

+

betamethasone

2 interactions

Monitor/Modify Tx

meloxicam + betamethasone

monitor BP, bleeding s/sx: combo may incr. risk of HTN, GI ulceration, perforation, bleeding, including life-threatening (additive effects)

rizatriptan + betamethasone

monitor BP: combo may incr. risk of HTN (additive effects)

• betaxolol
Symbravo (meloxicam/ rizatriptan)

+

betaxolol

2 interactions

Monitor/Modify Tx

meloxicam + betaxolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + betaxolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• bevacizumab
Symbravo (meloxicam/ rizatriptan)

+

bevacizumab

2 interactions

Monitor/Modify Tx

meloxicam + bevacizumab

monitor BP, bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism, GI ulceration, perforation, bleeding, including life-threatening (additive effects)

rizatriptan + bevacizumab

monitor BP: combo may incr. risk of HTN (additive effects)

• binimetinib
Symbravo (meloxicam/ rizatriptan)

+

binimetinib

1 interaction

Monitor/Modify Tx

meloxicam + binimetinib

monitor bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism, GI or other bleeding, including life-threatening (additive effects)

• bismuth subsalicylate
Symbravo (meloxicam/ rizatriptan)

+

bismuth subsalicylate

2 interactions

Monitor/Modify Tx

meloxicam + bismuth subsalicylate

monitor BP w/ high-dose bismuth subsalicylate: combo may incr. risk of HTN (additive effects)

rizatriptan + bismuth subsalicylate

monitor BP w/ high-dose bismuth subsalicylate: combo may incr. risk of HTN (additive effects)

• bisoprolol
Symbravo (meloxicam/ rizatriptan)

+

bisoprolol

2 interactions

Monitor/Modify Tx

meloxicam + bisoprolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + bisoprolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• bivalirudin
Symbravo (meloxicam/ rizatriptan)

+

bivalirudin

1 interaction

Monitor/Modify Tx

meloxicam + bivalirudin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• black cohosh
Symbravo (meloxicam/ rizatriptan)

+

black cohosh

1 interaction

Monitor/Modify Tx

rizatriptan + black cohosh

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• botulism immune globulin
Symbravo (meloxicam/ rizatriptan)

+

botulism immune globulin

1 interaction

Monitor/Modify Tx

meloxicam + botulism immune globulin

monitor renal fxn, thrombosis s/sx; use lowest botulism immune globulin concentration and infusion rate possible; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of nephrotoxicity, thromboembolism (additive effects)

• brentuximab vedotin
Symbravo (meloxicam/ rizatriptan)

+

brentuximab vedotin

1 interaction

Monitor/Modify Tx

meloxicam + brentuximab vedotin

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• brigatinib
Symbravo (meloxicam/ rizatriptan)

+

brigatinib

2 interactions

Monitor/Modify Tx

meloxicam + brigatinib

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + brigatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• brolucizumab
Symbravo (meloxicam/ rizatriptan)

+

brolucizumab

1 interaction

Monitor/Modify Tx

meloxicam + brolucizumab

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• bromelain
Symbravo (meloxicam/ rizatriptan)

+

bromelain

1 interaction

Monitor/Modify Tx

meloxicam + bromelain

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• bromfenac ophthalmic
Symbravo (meloxicam/ rizatriptan)

+

bromfenac ophthalmic

1 interaction

Monitor/Modify Tx

meloxicam + bromfenac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects)

• bromocriptine
Symbravo (meloxicam/ rizatriptan)

+

bromocriptine

1 interaction

Monitor/Modify Tx

rizatriptan + bromocriptine

avoid combo: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• budesonide
Symbravo (meloxicam/ rizatriptan)

+

budesonide

2 interactions

Monitor/Modify Tx

meloxicam + budesonide

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + budesonide

monitor BP: combo may incr. risk of HTN (additive effects)

• bupropion
Symbravo (meloxicam/ rizatriptan)

+

bupropion

2 interactions

Monitor/Modify Tx

meloxicam + bupropion

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + bupropion

monitor BP: combo may incr. risk of HTN (additive effects)

• butalbital
Symbravo (meloxicam/ rizatriptan)

+

butalbital

1 interaction

Monitor/Modify Tx

rizatriptan + butalbital

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• C1 esterase inhibitor
Symbravo (meloxicam/ rizatriptan)

+

C1 esterase inhibitor

1 interaction

Monitor/Modify Tx

meloxicam + C1 esterase inhibitor

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• cabazitaxel
Symbravo (meloxicam/ rizatriptan)

+

cabazitaxel

1 interaction

Monitor/Modify Tx

meloxicam + cabazitaxel

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• cabozantinib
Symbravo (meloxicam/ rizatriptan)

+

cabozantinib

2 interactions

Monitor/Modify Tx

meloxicam + cabozantinib

monitor BP, bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of HTN, GI ulceration, perforation, bleeding (including life-threatening), thromboembolism (additive effects)

rizatriptan + cabozantinib

monitor BP: combo may incr. risk of HTN (additive effects)

• caffeine
Symbravo (meloxicam/ rizatriptan)

+

caffeine

2 interactions

Monitor/Modify Tx

meloxicam + caffeine

monitor BP; avoid excessive caffeine intake: combo may incr. risk of HTN (additive effects)

rizatriptan + caffeine

monitor BP; avoid excessive caffeine intake: combo may incr. risk of HTN (additive effects)

• caffeine citrate
Symbravo (meloxicam/ rizatriptan)

+

caffeine citrate

2 interactions

Monitor/Modify Tx

meloxicam + caffeine citrate

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + caffeine citrate

monitor BP: combo may incr. risk of HTN (additive effects)

• calaspargase
Symbravo (meloxicam/ rizatriptan)

+

calaspargase

1 interaction

Monitor/Modify Tx

meloxicam + calaspargase

monitor bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of GI or other bleeding (including life-threatening), thromboembolism (additive effects)

• candesartan cilexetil
Symbravo (meloxicam/ rizatriptan)

+

candesartan cilexetil

2 interactions

Monitor/Modify Tx

meloxicam + candesartan cilexetil

monitor renal fxn, potassium, BP: combo may incr. risk of renal impairment, hyperkalemia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

rizatriptan + candesartan cilexetil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• cangrelor
Symbravo (meloxicam/ rizatriptan)

+

cangrelor

1 interaction

Monitor/Modify Tx

meloxicam + cangrelor

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• cannabis
Symbravo (meloxicam/ rizatriptan)

+

cannabis

2 interactions

Monitor/Modify Tx

meloxicam + cannabis

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + cannabis

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, HTN (additive effects)

• capecitabine
Symbravo (meloxicam/ rizatriptan)

+

capecitabine

1 interaction

Monitor/Modify Tx

meloxicam + capecitabine

monitor renal fxn: combo may incr. risk of nephrotoxicity (additive effects)

• caplacizumab
Symbravo (meloxicam/ rizatriptan)

+

caplacizumab

1 interaction

Monitor/Modify Tx

meloxicam + caplacizumab

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• captopril
Symbravo (meloxicam/ rizatriptan)

+

captopril

2 interactions

Monitor/Modify Tx

meloxicam + captopril

monitor renal fxn, BP, potassium: combo may incr. risk of renal impairment, hyperkalemia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

rizatriptan + captopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• carbamazepine
Symbravo (meloxicam/ rizatriptan)

+

carbamazepine

1 interaction

Monitor/Modify Tx

rizatriptan + carbamazepine

monitor serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• carboplatin
Symbravo (meloxicam/ rizatriptan)

+

carboplatin

1 interaction

Monitor/Modify Tx

meloxicam + carboplatin

monitor CBC, renal fxn, ototoxicity: combo may incr. carboplatin levels, risk of serious infection, myelosuppression, nephrotoxicity, auditory, vestibular, other adverse effects (additive effects)

• carfilzomib
Symbravo (meloxicam/ rizatriptan)

+

carfilzomib

2 interactions

Monitor/Modify Tx

meloxicam + carfilzomib

monitor BP, bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of GI or other bleeding (including life-threatening), thromboembolism, HTN (additive effects)

rizatriptan + carfilzomib

monitor BP: combo may incr. risk of HTN (additive effects)

• carvedilol
Symbravo (meloxicam/ rizatriptan)

+

carvedilol

2 interactions

Monitor/Modify Tx

meloxicam + carvedilol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + carvedilol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• chlordiazepoxide
Symbravo (meloxicam/ rizatriptan)

+

chlordiazepoxide

1 interaction

Monitor/Modify Tx

rizatriptan + chlordiazepoxide

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• chlorothiazide
Symbravo (meloxicam/ rizatriptan)

+

chlorothiazide

2 interactions

Monitor/Modify Tx

meloxicam + chlorothiazide

monitor renal fxn, BP: combo may incr. risk of renal impairment; may decr. chlorothiazide efficacy (additive effects; antagonistic effects)

rizatriptan + chlorothiazide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• chlorpromazine
Symbravo (meloxicam/ rizatriptan)

+

chlorpromazine

1 interaction

Monitor/Modify Tx

rizatriptan + chlorpromazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlorthalidone
Symbravo (meloxicam/ rizatriptan)

+

chlorthalidone

2 interactions

Monitor/Modify Tx

meloxicam + chlorthalidone

monitor renal fxn, BP: combo may incr. risk of renal impairment; may decr. chlorthalidone efficacy (additive effects; antagonistic effects)

rizatriptan + chlorthalidone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• chorionic gonadotropin
Symbravo (meloxicam/ rizatriptan)

+

chorionic gonadotropin

1 interaction

Monitor/Modify Tx

meloxicam + chorionic gonadotropin

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• cidofovir
Symbravo (meloxicam/ rizatriptan)

+

cidofovir

1 interaction

Monitor/Modify Tx

meloxicam + cidofovir

monitor CBC, renal fxn: combo may incr. cidofovir levels, risk of myelosuppression, nephrotoxicity, other adverse effects (additive effects)

• cilostazol
Symbravo (meloxicam/ rizatriptan)

+

cilostazol

1 interaction

Monitor/Modify Tx

meloxicam + cilostazol

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• cinacalcet
Symbravo (meloxicam/ rizatriptan)

+

cinacalcet

1 interaction

Monitor/Modify Tx

meloxicam + cinacalcet

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• cisplatin
Symbravo (meloxicam/ rizatriptan)

+

cisplatin

1 interaction

Monitor/Modify Tx

meloxicam + cisplatin

monitor CBC, renal fxn, ototoxicity: combo may incr. cisplatin levels, risk of serious infection, myelosuppression, nephrotoxicity, auditory, vestibular, other adverse effects (additive effects)

• clevidipine
Symbravo (meloxicam/ rizatriptan)

+

clevidipine

2 interactions

Monitor/Modify Tx

meloxicam + clevidipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + clevidipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• clindamycin
Symbravo (meloxicam/ rizatriptan)

+

clindamycin

1 interaction

Monitor/Modify Tx

meloxicam + clindamycin

monitor renal fxn: combo may incr. risk of nephrotoxicity (additive effects)

• clobazam
Symbravo (meloxicam/ rizatriptan)

+

clobazam

1 interaction

Monitor/Modify Tx

rizatriptan + clobazam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• clonazepam
Symbravo (meloxicam/ rizatriptan)

+

clonazepam

1 interaction

Monitor/Modify Tx

rizatriptan + clonazepam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• clopidogrel
Symbravo (meloxicam/ rizatriptan)

+

clopidogrel

1 interaction

Monitor/Modify Tx

meloxicam + clopidogrel

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• clorazepate
Symbravo (meloxicam/ rizatriptan)

+

clorazepate

1 interaction

Monitor/Modify Tx

rizatriptan + clorazepate

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• clozapine
Symbravo (meloxicam/ rizatriptan)

+

clozapine

2 interactions

Monitor/Modify Tx

meloxicam + clozapine

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

Caution Advised

rizatriptan + clozapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• coagulation factor IX
Symbravo (meloxicam/ rizatriptan)

+

coagulation factor IX

1 interaction

Monitor/Modify Tx

meloxicam + coagulation factor IX

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• coagulation factor VIIa
Symbravo (meloxicam/ rizatriptan)

+

coagulation factor VIIa

1 interaction

Monitor/Modify Tx

meloxicam + coagulation factor VIIa

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• coagulation factor XIII A-subunit
Symbravo (meloxicam/ rizatriptan)

+

coagulation factor XIII A-subunit

1 interaction

Monitor/Modify Tx

meloxicam + coagulation factor XIII A-subunit

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• cocaine
Symbravo (meloxicam/ rizatriptan)

+

cocaine

2 interactions

Monitor/Modify Tx

meloxicam + cocaine

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + cocaine

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN, serotonin syndrome (additive effects)

• colistimethate
Symbravo (meloxicam/ rizatriptan)

+

colistimethate

1 interaction

Monitor/Modify Tx

meloxicam + colistimethate

monitor renal fxn: combo may incr. colistimethate levels, risk of nephrotoxicity, other adverse effects (additive effects)

• collagenase clostridium histolyticum
Symbravo (meloxicam/ rizatriptan)

+

collagenase clostridium histolyticum

1 interaction

Monitor/Modify Tx

meloxicam + collagenase clostridium histolyticum

monitor injection site bleeding s/sx: combo may incr. risk of localized bleeding, including severe (additive effects)

• concizumab
Symbravo (meloxicam/ rizatriptan)

+

concizumab

1 interaction

Monitor/Modify Tx

meloxicam + concizumab

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• copanlisib
Symbravo (meloxicam/ rizatriptan)

+

copanlisib

2 interactions

Monitor/Modify Tx

meloxicam + copanlisib

monitor BP: combo may incr. risk of HTN (additive effects, copanlisib may cause infusion-related HTN)

rizatriptan + copanlisib

monitor BP: combo may incr. risk of HTN (additive effects, copanlisib may cause infusion-related HTN)

• copper histidinate
Symbravo (meloxicam/ rizatriptan)

+

copper histidinate

1 interaction

Monitor/Modify Tx

meloxicam + copper histidinate

monitor renal fxn, electrolytes: combo may incr. risk of nephrotoxicity (additive effects)

• corticotropin
Symbravo (meloxicam/ rizatriptan)

+

corticotropin

2 interactions

Monitor/Modify Tx

meloxicam + corticotropin

monitor bleeding s/sx, BP: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), HTN (additive effects)

rizatriptan + corticotropin

monitor BP: combo may incr. risk of HTN (additive effects)

• cortisone
Symbravo (meloxicam/ rizatriptan)

+

cortisone

2 interactions

Monitor/Modify Tx

meloxicam + cortisone

monitor bleeding s/sx, BP: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), HTN (additive effects)

rizatriptan + cortisone

monitor BP: combo may incr. risk of HTN (additive effects)

• creatine
Symbravo (meloxicam/ rizatriptan)

+

creatine

1 interaction

Monitor/Modify Tx

meloxicam + creatine

monitor renal fxn: combo may incr. risk of nephrotoxicity (additive effects)

• cyclophosphamide
Symbravo (meloxicam/ rizatriptan)

+

cyclophosphamide

1 interaction

Monitor/Modify Tx

meloxicam + cyclophosphamide

monitor CBC, renal, cardiac fxn: combo may incr. cyclophosphamide levels, risk of serious infection, myelosuppression, nephrotoxicity, cardiotoxicity, other adverse effects (additive effects)

• cyclosporine
Symbravo (meloxicam/ rizatriptan)

+

cyclosporine

2 interactions

Monitor/Modify Tx

meloxicam + cyclosporine

monitor renal fxn, BP, potassium: combo may incr. risk of nephrotoxicity, HTN, hyperkalemia (additive effects)

rizatriptan + cyclosporine

monitor BP: combo may incr. risk of HTN (additive effects)

• cysteamine
Symbravo (meloxicam/ rizatriptan)

+

cysteamine

1 interaction

Monitor/Modify Tx

meloxicam + cysteamine

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• cytomegalovirus immune globulin
Symbravo (meloxicam/ rizatriptan)

+

cytomegalovirus immune globulin

1 interaction

Monitor/Modify Tx

meloxicam + cytomegalovirus immune globulin

monitor renal fxn, thrombosis s/sx; use lowest cytomegalovirus immune globulin concentration and infusion rate possible; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of nephrotoxicity, thromboembolism (additive effects)

• dabigatran
Symbravo (meloxicam/ rizatriptan)

+

dabigatran

1 interaction

Monitor/Modify Tx

meloxicam + dabigatran

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• dalteparin
Symbravo (meloxicam/ rizatriptan)

+

dalteparin

1 interaction

Monitor/Modify Tx

meloxicam + dalteparin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• danazol
Symbravo (meloxicam/ rizatriptan)

+

danazol

2 interactions

Monitor/Modify Tx

meloxicam + danazol

monitor BP, thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

rizatriptan + danazol

monitor BP: combo may incr. risk of HTN (additive effects)

• danshen
Symbravo (meloxicam/ rizatriptan)

+

danshen

1 interaction

Monitor/Modify Tx

meloxicam + danshen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• darbepoetin alfa
Symbravo (meloxicam/ rizatriptan)

+

darbepoetin alfa

2 interactions

Monitor/Modify Tx

meloxicam + darbepoetin alfa

monitor BP, thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

rizatriptan + darbepoetin alfa

monitor BP: combo may incr. risk of HTN (additive effects)

• daridorexant
Symbravo (meloxicam/ rizatriptan)

+

daridorexant

1 interaction

Monitor/Modify Tx

rizatriptan + daridorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dasatinib
Symbravo (meloxicam/ rizatriptan)

+

dasatinib

1 interaction

Monitor/Modify Tx

meloxicam + dasatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• decitabine
Symbravo (meloxicam/ rizatriptan)

+

decitabine

1 interaction

Monitor/Modify Tx

meloxicam + decitabine

monitor potassium w/ IV decitabine use: combo may incr. risk of hyperkalemia (additive effects)

• deferasirox
Symbravo (meloxicam/ rizatriptan)

+

deferasirox

1 interaction

Monitor/Modify Tx

meloxicam + deferasirox

monitor CBC, renal fxn, bleeding s/sx, ototoxicity: combo may incr. deferasirox levels, risk of myelosuppression, nephrotoxicity, GI ulceration, perforation, bleeding (including life-threatening), auditory, vestibular, other adverse effects (additive effects)

• deferoxamine
Symbravo (meloxicam/ rizatriptan)

+

deferoxamine

1 interaction

Monitor/Modify Tx

meloxicam + deferoxamine

monitor renal fxn: combo may incr. risk of nephrotoxicity (additive effects)

• defibrotide
Symbravo (meloxicam/ rizatriptan)

+

defibrotide

1 interaction

Monitor/Modify Tx

meloxicam + defibrotide

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• deflazacort
Symbravo (meloxicam/ rizatriptan)

+

deflazacort

2 interactions

Monitor/Modify Tx

meloxicam + deflazacort

monitor BP, bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN (additive effects)

rizatriptan + deflazacort

monitor BP: combo may incr. risk of HTN (additive effects)

• desflurane
Symbravo (meloxicam/ rizatriptan)

+

desflurane

1 interaction

Monitor/Modify Tx

rizatriptan + desflurane

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• desmopressin
Symbravo (meloxicam/ rizatriptan)

+

desmopressin

2 interactions

Monitor/Modify Tx

meloxicam + desmopressin

monitor BP, sodium: combo may incr. risk of HTN, hyponatremia, including life-threatening (additive effects)

rizatriptan + desmopressin

monitor BP: combo may incr. risk of HTN (additive effects)

• desogestrel (contraceptive)
Symbravo (meloxicam/ rizatriptan)

+

desogestrel (contraceptive)

1 interaction

Monitor/Modify Tx

meloxicam + desogestrel (contraceptive)

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• deuruxolitinib
Symbravo (meloxicam/ rizatriptan)

+

deuruxolitinib

1 interaction

Monitor/Modify Tx

meloxicam + deuruxolitinib

monitor bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism, GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• dexamethasone
Symbravo (meloxicam/ rizatriptan)

+

dexamethasone

2 interactions

Monitor/Modify Tx

meloxicam + dexamethasone

monitor BP, bleeding or thrombosis s/sx, especially if multiple myeloma use; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of HTN, GI ulceration, perforation, bleeding (including life-threatening), thromboembolism (additive effects)

rizatriptan + dexamethasone

monitor BP: combo may incr. risk of HTN (additive effects)

• dexmedetomidine
Symbravo (meloxicam/ rizatriptan)

+

dexmedetomidine

1 interaction

Monitor/Modify Tx

rizatriptan + dexmedetomidine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexmedetomidine injection
Symbravo (meloxicam/ rizatriptan)

+

dexmedetomidine injection

1 interaction

Monitor/Modify Tx

rizatriptan + dexmedetomidine injection

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• dexmethylphenidate
Symbravo (meloxicam/ rizatriptan)

+

dexmethylphenidate

2 interactions

Monitor/Modify Tx

meloxicam + dexmethylphenidate

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + dexmethylphenidate

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, HTN (additive effects)

• dextromethorphan
Symbravo (meloxicam/ rizatriptan)

+

dextromethorphan

1 interaction

Monitor/Modify Tx

rizatriptan + dextromethorphan

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• diazepam
Symbravo (meloxicam/ rizatriptan)

+

diazepam

1 interaction

Monitor/Modify Tx

rizatriptan + diazepam

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• diclofenac ophthalmic
Symbravo (meloxicam/ rizatriptan)

+

diclofenac ophthalmic

1 interaction

Monitor/Modify Tx

meloxicam + diclofenac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects)

• dienogest (contraceptive)
Symbravo (meloxicam/ rizatriptan)

+

dienogest (contraceptive)

1 interaction

Monitor/Modify Tx

meloxicam + dienogest (contraceptive)

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• diethylpropion
Symbravo (meloxicam/ rizatriptan)

+

diethylpropion

2 interactions

Monitor/Modify Tx

meloxicam + diethylpropion

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + diethylpropion

monitor BP: combo may incr. risk of HTN (additive effects)

• diltiazem
Symbravo (meloxicam/ rizatriptan)

+

diltiazem

2 interactions

Monitor/Modify Tx

meloxicam + diltiazem

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + diltiazem

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• dimethyl fumarate
Symbravo (meloxicam/ rizatriptan)

+

dimethyl fumarate

1 interaction

Monitor/Modify Tx

meloxicam + dimethyl fumarate

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• diosmin
Symbravo (meloxicam/ rizatriptan)

+

diosmin

1 interaction

Monitor/Modify Tx

meloxicam + diosmin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• dipyridamole
Symbravo (meloxicam/ rizatriptan)

+

dipyridamole

1 interaction

Monitor/Modify Tx

meloxicam + dipyridamole

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• diroximel fumarate
Symbravo (meloxicam/ rizatriptan)

+

diroximel fumarate

1 interaction

Monitor/Modify Tx

meloxicam + diroximel fumarate

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• dobutamine
Symbravo (meloxicam/ rizatriptan)

+

dobutamine

2 interactions

Monitor/Modify Tx

meloxicam + dobutamine

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + dobutamine

monitor BP: combo may incr. risk of HTN (additive effects)

• donepezil
Symbravo (meloxicam/ rizatriptan)

+

donepezil

1 interaction

Monitor/Modify Tx

meloxicam + donepezil

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• dopamine
Symbravo (meloxicam/ rizatriptan)

+

dopamine

2 interactions

Monitor/Modify Tx

meloxicam + dopamine

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + dopamine

monitor BP: combo may incr. risk of HTN (additive effects)

• doxapram
Symbravo (meloxicam/ rizatriptan)

+

doxapram

2 interactions

Monitor/Modify Tx

meloxicam + doxapram

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + doxapram

monitor BP: combo may incr. risk of HTN (additive effects)

• doxazosin
Symbravo (meloxicam/ rizatriptan)

+

doxazosin

2 interactions

Monitor/Modify Tx

meloxicam + doxazosin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + doxazosin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• doxepin
Symbravo (meloxicam/ rizatriptan)

+

doxepin

1 interaction

Monitor/Modify Tx

rizatriptan + doxepin

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• doxepin topical
Symbravo (meloxicam/ rizatriptan)

+

doxepin topical

1 interaction

Monitor/Modify Tx

rizatriptan + doxepin topical

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• dronabinol
Symbravo (meloxicam/ rizatriptan)

+

dronabinol

2 interactions

Monitor/Modify Tx

meloxicam + dronabinol

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + dronabinol

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, HTN (additive effects)

• droperidol
Symbravo (meloxicam/ rizatriptan)

+

droperidol

1 interaction

Monitor/Modify Tx

rizatriptan + droperidol

decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• drospirenone (contraceptive)
Symbravo (meloxicam/ rizatriptan)

+

drospirenone (contraceptive)

1 interaction

Monitor/Modify Tx

meloxicam + drospirenone (contraceptive)

monitor potassium, thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of hyperkalemia, thromboembolism (additive effects)

• drospirenone (hormone replacement)
Symbravo (meloxicam/ rizatriptan)

+

drospirenone (hormone replacement)

1 interaction

Monitor/Modify Tx

meloxicam + drospirenone (hormone replacement)

monitor potassium, thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of hyperkalemia, thromboembolism (additive effects)

• droxidopa
Symbravo (meloxicam/ rizatriptan)

+

droxidopa

2 interactions

Monitor/Modify Tx

meloxicam + droxidopa

monitor BP: combo may incr. risk of supine HTN (additive effects)

rizatriptan + droxidopa

monitor BP: combo may incr. risk of supine HTN (additive effects)

• edoxaban
Symbravo (meloxicam/ rizatriptan)

+

edoxaban

1 interaction

Monitor/Modify Tx

meloxicam + edoxaban

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• eltrombopag
Symbravo (meloxicam/ rizatriptan)

+

eltrombopag

1 interaction

Monitor/Modify Tx

meloxicam + eltrombopag

monitor platelets, thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• enalapril
Symbravo (meloxicam/ rizatriptan)

+

enalapril

2 interactions

Monitor/Modify Tx

meloxicam + enalapril

monitor renal fxn, BP, potassium: combo may incr. risk of renal impairment, hyperkalemia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

rizatriptan + enalapril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• enalaprilat
Symbravo (meloxicam/ rizatriptan)

+

enalaprilat

2 interactions

Monitor/Modify Tx

meloxicam + enalaprilat

monitor renal fxn, BP, potassium: combo may incr. risk of renal impairment, hyperkalemia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

rizatriptan + enalaprilat

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• encorafenib
Symbravo (meloxicam/ rizatriptan)

+

encorafenib

1 interaction

Monitor/Modify Tx

meloxicam + encorafenib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• ephedra
Symbravo (meloxicam/ rizatriptan)

+

ephedra

2 interactions

Monitor/Modify Tx

meloxicam + ephedra

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + ephedra

monitor BP: combo may incr. risk of HTN (additive effects)

• ephedrine injection
Symbravo (meloxicam/ rizatriptan)

+

ephedrine injection

2 interactions

Monitor/Modify Tx

meloxicam + ephedrine injection

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + ephedrine injection

monitor BP: combo may incr. risk of HTN (additive effects)

• ephedrine oral
Symbravo (meloxicam/ rizatriptan)

+

ephedrine oral

2 interactions

Monitor/Modify Tx

meloxicam + ephedrine oral

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + ephedrine oral

monitor BP: combo may incr. risk of HTN (additive effects)

• epinephrine
Symbravo (meloxicam/ rizatriptan)

+

epinephrine

2 interactions

Monitor/Modify Tx

meloxicam + epinephrine

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + epinephrine

monitor BP: combo may incr. risk of HTN (additive effects)

• epirubicin
Symbravo (meloxicam/ rizatriptan)

+

epirubicin

1 interaction

Monitor/Modify Tx

meloxicam + epirubicin

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• eplerenone
Symbravo (meloxicam/ rizatriptan)

+

eplerenone

2 interactions

Monitor/Modify Tx

meloxicam + eplerenone

monitor potassium, BP: combo may incr. risk of hyperkalemia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

rizatriptan + eplerenone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• epoetin alfa
Symbravo (meloxicam/ rizatriptan)

+

epoetin alfa

2 interactions

Monitor/Modify Tx

meloxicam + epoetin alfa

monitor BP, thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

rizatriptan + epoetin alfa

monitor BP: combo may incr. risk of HTN (additive effects)

• epoprostenol
Symbravo (meloxicam/ rizatriptan)

+

epoprostenol

1 interaction

Monitor/Modify Tx

meloxicam + epoprostenol

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• eptifibatide
Symbravo (meloxicam/ rizatriptan)

+

eptifibatide

1 interaction

Monitor/Modify Tx

meloxicam + eptifibatide

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• eptinezumab
Symbravo (meloxicam/ rizatriptan)

+

eptinezumab

2 interactions

Monitor/Modify Tx

meloxicam + eptinezumab

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + eptinezumab

monitor BP: combo may incr. risk of HTN (additive effects)

• erenumab
Symbravo (meloxicam/ rizatriptan)

+

erenumab

2 interactions

Monitor/Modify Tx

meloxicam + erenumab

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + erenumab

monitor BP: combo may incr. risk of HTN (additive effects)

• erlotinib
Symbravo (meloxicam/ rizatriptan)

+

erlotinib

1 interaction

Monitor/Modify Tx

meloxicam + erlotinib

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• esketamine
Symbravo (meloxicam/ rizatriptan)

+

esketamine

2 interactions

Monitor/Modify Tx

meloxicam + esketamine

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + esketamine

monitor BP, respiratory rate: combo may incr. risk of HTN, CNS and respiratory depression, psychomotor impairment (additive effects)

• esmolol
Symbravo (meloxicam/ rizatriptan)

+

esmolol

2 interactions

Monitor/Modify Tx

meloxicam + esmolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + esmolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• estazolam
Symbravo (meloxicam/ rizatriptan)

+

estazolam

1 interaction

Monitor/Modify Tx

rizatriptan + estazolam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• estetrol (contraceptive)
Symbravo (meloxicam/ rizatriptan)

+

estetrol (contraceptive)

2 interactions

Monitor/Modify Tx

meloxicam + estetrol (contraceptive)

monitor BP, thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

rizatriptan + estetrol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

• estradiol (contraceptive)
Symbravo (meloxicam/ rizatriptan)

+

estradiol (contraceptive)

2 interactions

Monitor/Modify Tx

meloxicam + estradiol (contraceptive)

monitor BP, thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

rizatriptan + estradiol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

• estradiol (hormone replacement)
Symbravo (meloxicam/ rizatriptan)

+

estradiol (hormone replacement)

1 interaction

Monitor/Modify Tx

meloxicam + estradiol (hormone replacement)

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• estrogens, conjugated (hormone replacement)
Symbravo (meloxicam/ rizatriptan)

+

estrogens, conjugated (hormone replacement)

1 interaction

Monitor/Modify Tx

meloxicam + estrogens, conjugated (hormone replacement)

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• estrogens, esterified (hormone replacement)
Symbravo (meloxicam/ rizatriptan)

+

estrogens, esterified (hormone replacement)

1 interaction

Monitor/Modify Tx

meloxicam + estrogens, esterified (hormone replacement)

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• eszopiclone
Symbravo (meloxicam/ rizatriptan)

+

eszopiclone

1 interaction

Monitor/Modify Tx

rizatriptan + eszopiclone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• etelcalcetide
Symbravo (meloxicam/ rizatriptan)

+

etelcalcetide

1 interaction

Monitor/Modify Tx

meloxicam + etelcalcetide

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• ethacrynic acid
Symbravo (meloxicam/ rizatriptan)

+

ethacrynic acid

2 interactions

Monitor/Modify Tx

meloxicam + ethacrynic acid

monitor renal fxn, BP: combo may incr. risk of renal impairment; may decr. ethacrynic acid efficacy (additive effects; antagonistic effects)

rizatriptan + ethacrynic acid

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ethanol (in some formulations)
Symbravo (meloxicam/ rizatriptan)

+

ethanol (in some formulations)

1 interaction

Monitor/Modify Tx

rizatriptan + ethanol (in some formulations)

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• ethinyl estradiol (contraceptive)
Symbravo (meloxicam/ rizatriptan)

+

ethinyl estradiol (contraceptive)

2 interactions

Monitor/Modify Tx

meloxicam + ethinyl estradiol (contraceptive)

monitor BP, thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

rizatriptan + ethinyl estradiol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

• ethinyl estradiol (hormone replacement)
Symbravo (meloxicam/ rizatriptan)

+

ethinyl estradiol (hormone replacement)

1 interaction

Monitor/Modify Tx

meloxicam + ethinyl estradiol (hormone replacement)

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• ethynodiol (contraceptive)
Symbravo (meloxicam/ rizatriptan)

+

ethynodiol (contraceptive)

1 interaction

Monitor/Modify Tx

meloxicam + ethynodiol (contraceptive)

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• etomidate
Symbravo (meloxicam/ rizatriptan)

+

etomidate

1 interaction

Monitor/Modify Tx

rizatriptan + etomidate

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• etonogestrel (contraceptive)
Symbravo (meloxicam/ rizatriptan)

+

etonogestrel (contraceptive)

1 interaction

Monitor/Modify Tx

meloxicam + etonogestrel (contraceptive)

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• etrasimod
Symbravo (meloxicam/ rizatriptan)

+

etrasimod

2 interactions

Monitor/Modify Tx

meloxicam + etrasimod

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + etrasimod

monitor BP: combo may incr. risk of HTN (additive effects)

• evening primrose oil
Symbravo (meloxicam/ rizatriptan)

+

evening primrose oil

1 interaction

Monitor/Modify Tx

meloxicam + evening primrose oil

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• everolimus
Symbravo (meloxicam/ rizatriptan)

+

everolimus

1 interaction

Monitor/Modify Tx

meloxicam + everolimus

monitor thrombosis s/sx, especially if immunosuppressant use; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• factor XIII concentrate
Symbravo (meloxicam/ rizatriptan)

+

factor XIII concentrate

1 interaction

Monitor/Modify Tx

meloxicam + factor XIII concentrate

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• faricimab
Symbravo (meloxicam/ rizatriptan)

+

faricimab

1 interaction

Monitor/Modify Tx

meloxicam + faricimab

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• fedratinib
Symbravo (meloxicam/ rizatriptan)

+

fedratinib

1 interaction

Monitor/Modify Tx

meloxicam + fedratinib

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• felodipine
Symbravo (meloxicam/ rizatriptan)

+

felodipine

2 interactions

Monitor/Modify Tx

meloxicam + felodipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + felodipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• fenfluramine
Symbravo (meloxicam/ rizatriptan)

+

fenfluramine

2 interactions

Monitor/Modify Tx

meloxicam + fenfluramine

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

rizatriptan + fenfluramine

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN (including hypertensive crisis), serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• fenofibrate
Symbravo (meloxicam/ rizatriptan)

+

fenofibrate

1 interaction

Monitor/Modify Tx

meloxicam + fenofibrate

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• fenofibric acid
Symbravo (meloxicam/ rizatriptan)

+

fenofibric acid

1 interaction

Monitor/Modify Tx

meloxicam + fenofibric acid

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• fenoldopam
Symbravo (meloxicam/ rizatriptan)

+

fenoldopam

2 interactions

Monitor/Modify Tx

meloxicam + fenoldopam

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + fenoldopam

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• fenugreek
Symbravo (meloxicam/ rizatriptan)

+

fenugreek

1 interaction

Monitor/Modify Tx

meloxicam + fenugreek

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• fibrinogen (human)
Symbravo (meloxicam/ rizatriptan)

+

fibrinogen (human)

1 interaction

Monitor/Modify Tx

meloxicam + fibrinogen (human)

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• finerenone
Symbravo (meloxicam/ rizatriptan)

+

finerenone

1 interaction

Monitor/Modify Tx

meloxicam + finerenone

monitor potassium: combo may incr. risk of hyperkalemia (additive effects)

• fingolimod
Symbravo (meloxicam/ rizatriptan)

+

fingolimod

2 interactions

Monitor/Modify Tx

meloxicam + fingolimod

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + fingolimod

monitor BP: combo may incr. risk of HTN (additive effects)

• fitusiran
Symbravo (meloxicam/ rizatriptan)

+

fitusiran

1 interaction

Monitor/Modify Tx

meloxicam + fitusiran

monitor antithrombin activity level, thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• flucytosine
Symbravo (meloxicam/ rizatriptan)

+

flucytosine

1 interaction

Monitor/Modify Tx

meloxicam + flucytosine

monitor CBC, renal fxn, flucytosine levels: combo may incr. flucytosine levels, risk of myelosuppression, nephrotoxicity, other adverse effects (additive effects)

• fludrocortisone
Symbravo (meloxicam/ rizatriptan)

+

fludrocortisone

2 interactions

Monitor/Modify Tx

meloxicam + fludrocortisone

monitor bleeding s/sx, BP: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), HTN (additive effects)

rizatriptan + fludrocortisone

monitor BP: combo may incr. risk of HTN (additive effects)

• fluphenazine
Symbravo (meloxicam/ rizatriptan)

+

fluphenazine

1 interaction

Monitor/Modify Tx

rizatriptan + fluphenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• flurazepam
Symbravo (meloxicam/ rizatriptan)

+

flurazepam

1 interaction

Monitor/Modify Tx

rizatriptan + flurazepam

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• flurbiprofen ophthalmic
Symbravo (meloxicam/ rizatriptan)

+

flurbiprofen ophthalmic

1 interaction

Monitor/Modify Tx

meloxicam + flurbiprofen ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects)

• follitropin
Symbravo (meloxicam/ rizatriptan)

+

follitropin

1 interaction

Monitor/Modify Tx

meloxicam + follitropin

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• formoterol inhaled
Symbravo (meloxicam/ rizatriptan)

+

formoterol inhaled

2 interactions

Monitor/Modify Tx

meloxicam + formoterol inhaled

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + formoterol inhaled

monitor BP: combo may incr. risk of HTN (additive effects)

• foscarnet
Symbravo (meloxicam/ rizatriptan)

+

foscarnet

1 interaction

Monitor/Modify Tx

meloxicam + foscarnet

monitor CBC, renal fxn: combo may incr. foscarnet levels, risk of myelosuppression, nephrotoxicity, other adverse effects (additive effects)

• fosinopril
Symbravo (meloxicam/ rizatriptan)

+

fosinopril

2 interactions

Monitor/Modify Tx

meloxicam + fosinopril

monitor renal fxn, BP, potassium: combo may incr. risk of renal impairment, hyperkalemia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

rizatriptan + fosinopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• fostamatinib
Symbravo (meloxicam/ rizatriptan)

+

fostamatinib

2 interactions

Monitor/Modify Tx

meloxicam + fostamatinib

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + fostamatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• fremanezumab
Symbravo (meloxicam/ rizatriptan)

+

fremanezumab

2 interactions

Monitor/Modify Tx

meloxicam + fremanezumab

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + fremanezumab

monitor BP: combo may incr. risk of HTN (additive effects)

• fruquintinib
Symbravo (meloxicam/ rizatriptan)

+

fruquintinib

2 interactions

Monitor/Modify Tx

meloxicam + fruquintinib

monitor BP, bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of HTN (including hypertensive crisis), thromboembolism, GI ulceration, perforation, bleeding, including life-threatening (additive effects)

rizatriptan + fruquintinib

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• gabapentin
Symbravo (meloxicam/ rizatriptan)

+

gabapentin

1 interaction

Monitor/Modify Tx

rizatriptan + gabapentin

monitor respiratory rate; consider decreasing gabapentin dose: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• gabapentin enacarbil
Symbravo (meloxicam/ rizatriptan)

+

gabapentin enacarbil

1 interaction

Monitor/Modify Tx

rizatriptan + gabapentin enacarbil

monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• galantamine
Symbravo (meloxicam/ rizatriptan)

+

galantamine

1 interaction

Monitor/Modify Tx

meloxicam + galantamine

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• galcanezumab
Symbravo (meloxicam/ rizatriptan)

+

galcanezumab

2 interactions

Monitor/Modify Tx

meloxicam + galcanezumab

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + galcanezumab

monitor BP: combo may incr. risk of HTN (additive effects)

• ganciclovir
Symbravo (meloxicam/ rizatriptan)

+

ganciclovir

1 interaction

Monitor/Modify Tx

meloxicam + ganciclovir

monitor CBC, renal fxn: combo may incr. ganciclovir levels, risk of myelosuppression, nephrotoxicity, other adverse effects (additive effects)

• garlic
Symbravo (meloxicam/ rizatriptan)

+

garlic

1 interaction

Monitor/Modify Tx

meloxicam + garlic

monitor bleeding s/sx, especially w/ supplemental garlic; dietary intake OK: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• gefitinib
Symbravo (meloxicam/ rizatriptan)

+

gefitinib

1 interaction

Monitor/Modify Tx

meloxicam + gefitinib

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• gemtuzumab ozogamicin
Symbravo (meloxicam/ rizatriptan)

+

gemtuzumab ozogamicin

1 interaction

Monitor/Modify Tx

meloxicam + gemtuzumab ozogamicin

monitor platelets, bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• gentamicin
Symbravo (meloxicam/ rizatriptan)

+

gentamicin

1 interaction

Monitor/Modify Tx

meloxicam + gentamicin

monitor gentamicin levels, renal fxn, ototoxicity: combo may incr. gentamicin levels, risk of nephrotoxicity, auditory, vestibular, other adverse effects (additive effects)

• ginkgo
Symbravo (meloxicam/ rizatriptan)

+

ginkgo

1 interaction

Monitor/Modify Tx

meloxicam + ginkgo

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• guanfacine
Symbravo (meloxicam/ rizatriptan)

+

guanfacine

2 interactions

Monitor/Modify Tx

meloxicam + guanfacine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + guanfacine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• heparin
Symbravo (meloxicam/ rizatriptan)

+

heparin

1 interaction

Monitor/Modify Tx

meloxicam + heparin

monitor bleeding s/sx, potassium: combo may incr. risk of GI or other bleeding (including life-threatening), hyperkalemia (additive effects)

• hepatitis B immune globulin
Symbravo (meloxicam/ rizatriptan)

+

hepatitis B immune globulin

1 interaction

Monitor/Modify Tx

meloxicam + hepatitis B immune globulin

monitor thrombosis s/sx; use lowest hepatitis B immune globulin infusion rate possible; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• hoodia
Symbravo (meloxicam/ rizatriptan)

+

hoodia

2 interactions

Monitor/Modify Tx

meloxicam + hoodia

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + hoodia

monitor BP: combo may incr. risk of HTN (additive effects)

• hydralazine
Symbravo (meloxicam/ rizatriptan)

+

hydralazine

2 interactions

Monitor/Modify Tx

meloxicam + hydralazine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + hydralazine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• hydrochlorothiazide
Symbravo (meloxicam/ rizatriptan)

+

hydrochlorothiazide

2 interactions

Monitor/Modify Tx

meloxicam + hydrochlorothiazide

monitor renal fxn, BP: combo may incr. risk of renal impairment; may decr. hydrochlorothiazide efficacy (additive effects; antagonistic effects)

rizatriptan + hydrochlorothiazide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• hydrocortisone
Symbravo (meloxicam/ rizatriptan)

+

hydrocortisone

2 interactions

Monitor/Modify Tx

meloxicam + hydrocortisone

monitor bleeding s/sx, BP: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), HTN (additive effects)

rizatriptan + hydrocortisone

monitor BP: combo may incr. risk of HTN (additive effects)

• hydroxocobalamin IV
Symbravo (meloxicam/ rizatriptan)

+

hydroxocobalamin IV

2 interactions

Monitor/Modify Tx

meloxicam + hydroxocobalamin IV

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + hydroxocobalamin IV

monitor BP: combo may incr. risk of HTN (additive effects)

• hydroxyzine
Symbravo (meloxicam/ rizatriptan)

+

hydroxyzine

1 interaction

Monitor/Modify Tx

rizatriptan + hydroxyzine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ibandronate
Symbravo (meloxicam/ rizatriptan)

+

ibandronate

1 interaction

Monitor/Modify Tx

meloxicam + ibandronate

monitor bleeding s/sx if oral ibandronate use: combo may incr. risk of upper GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• ibrutinib
Symbravo (meloxicam/ rizatriptan)

+

ibrutinib

2 interactions

Monitor/Modify Tx

meloxicam + ibrutinib

monitor bleeding s/sx, BP: combo may incr. risk of GI or other bleeding (including life-threatening), HTN (additive effects)

rizatriptan + ibrutinib

monitor BP: combo may incr. risk of HTN (additive effects)

• icosapent ethyl
Symbravo (meloxicam/ rizatriptan)

+

icosapent ethyl

1 interaction

Monitor/Modify Tx

meloxicam + icosapent ethyl

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• ifosfamide
Symbravo (meloxicam/ rizatriptan)

+

ifosfamide

2 interactions

Monitor/Modify Tx

meloxicam + ifosfamide

monitor CBC, renal, cardiac fxn: combo may incr. ifosfamide levels, risk of myelosuppression, serious infection, encephalopathy, nephrotoxicity, cardiotoxicity, other adverse effects (additive effects)

rizatriptan + ifosfamide

D/C one or both drugs if encephalopathy occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• imatinib
Symbravo (meloxicam/ rizatriptan)

+

imatinib

1 interaction

Monitor/Modify Tx

meloxicam + imatinib

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• imipramine
Symbravo (meloxicam/ rizatriptan)

+

imipramine

1 interaction

Monitor/Modify Tx

rizatriptan + imipramine

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• immune globulin
Symbravo (meloxicam/ rizatriptan)

+

immune globulin

1 interaction

Monitor/Modify Tx

meloxicam + immune globulin

monitor renal fxn, thrombosis s/sx; use lowest immune globulin dose, concentration and infusion rate possible; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of nephrotoxicity, thromboembolism (additive effects)

• indapamide
Symbravo (meloxicam/ rizatriptan)

+

indapamide

2 interactions

Monitor/Modify Tx

meloxicam + indapamide

monitor renal fxn, BP: combo may incr. risk of renal impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

rizatriptan + indapamide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• iodixanol
Symbravo (meloxicam/ rizatriptan)

+

iodixanol

1 interaction

Monitor/Modify Tx

meloxicam + iodixanol

monitor renal function, thrombosis signs/symptoms; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of nephrotoxicity, thromboembolism (additive effects)

• iohexol
Symbravo (meloxicam/ rizatriptan)

+

iohexol

1 interaction

Monitor/Modify Tx

meloxicam + iohexol

monitor renal fxn, thrombosis s/sx if IV iohexol use; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of nephrotoxicity, thromboembolism (additive effects)

• iomeprol
Symbravo (meloxicam/ rizatriptan)

+

iomeprol

1 interaction

Monitor/Modify Tx

meloxicam + iomeprol

monitor renal fxn, thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of nephrotoxicity, thromboembolism (additive effects)

• iopamidol
Symbravo (meloxicam/ rizatriptan)

+

iopamidol

1 interaction

Monitor/Modify Tx

meloxicam + iopamidol

if IV iopamidol use, monitor renal fxn, thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of nephrotoxicity, thromboembolism (additive effects)

• iopromide
Symbravo (meloxicam/ rizatriptan)

+

iopromide

1 interaction

Monitor/Modify Tx

meloxicam + iopromide

monitor renal function, thrombosis signs/symptoms; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of nephrotoxicity, thromboembolism (additive effects)

• iothalamate meglumine
Symbravo (meloxicam/ rizatriptan)

+

iothalamate meglumine

1 interaction

Monitor/Modify Tx

meloxicam + iothalamate meglumine

if IV iothalamate meglumine use, monitor renal function, thrombosis signs/symptoms; use lowest effective meloxicam dose, shortest effective tx duration; retrograde cystography and cystourethrography use OK: combo may incr. risk of nephrotoxicity, thromboembolism (additive effects)

• ioversol
Symbravo (meloxicam/ rizatriptan)

+

ioversol

1 interaction

Monitor/Modify Tx

meloxicam + ioversol

monitor renal function, thrombosis signs/symptoms; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of nephrotoxicity, thromboembolism (additive effects)

• irbesartan
Symbravo (meloxicam/ rizatriptan)

+

irbesartan

2 interactions

Monitor/Modify Tx

meloxicam + irbesartan

monitor renal fxn, potassium, BP: combo may incr. risk of renal impairment, hyperkalemia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

rizatriptan + irbesartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• isoflurane
Symbravo (meloxicam/ rizatriptan)

+

isoflurane

1 interaction

Monitor/Modify Tx

rizatriptan + isoflurane

monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• isradipine
Symbravo (meloxicam/ rizatriptan)

+

isradipine

2 interactions

Monitor/Modify Tx

meloxicam + isradipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + isradipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• itraconazole
Symbravo (meloxicam/ rizatriptan)

+

itraconazole

1 interaction

Monitor/Modify Tx

meloxicam + itraconazole

consider incr. meloxicam dose: combo may decr. meloxicam levels, efficacy (mechanism unknown, GI absorption possibly impaired)

• ketamine
Symbravo (meloxicam/ rizatriptan)

+

ketamine

2 interactions

Monitor/Modify Tx

meloxicam + ketamine

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + ketamine

monitor respiratory rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression (including life-threatening), psychomotor impairment, HTN (additive effects)

• ketorolac ophthalmic
Symbravo (meloxicam/ rizatriptan)

+

ketorolac ophthalmic

1 interaction

Monitor/Modify Tx

meloxicam + ketorolac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects)

• labetalol
Symbravo (meloxicam/ rizatriptan)

+

labetalol

2 interactions

Monitor/Modify Tx

meloxicam + labetalol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + labetalol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• landiolol
Symbravo (meloxicam/ rizatriptan)

+

landiolol

1 interaction

Monitor/Modify Tx

meloxicam + landiolol

monitor potassium, especially if renal impairment: combo may incr. risk of hyperkalemia (additive effects)

• lanreotide
Symbravo (meloxicam/ rizatriptan)

+

lanreotide

2 interactions

Monitor/Modify Tx

meloxicam + lanreotide

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + lanreotide

monitor BP: combo may incr. risk of HTN (additive effects)

• lanthanum
Symbravo (meloxicam/ rizatriptan)

+

lanthanum

1 interaction

Monitor/Modify Tx

meloxicam + lanthanum

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• lazertinib
Symbravo (meloxicam/ rizatriptan)

+

lazertinib

1 interaction

Monitor/Modify Tx

meloxicam + lazertinib

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• leflunomide
Symbravo (meloxicam/ rizatriptan)

+

leflunomide

2 interactions

Monitor/Modify Tx

meloxicam + leflunomide

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + leflunomide

monitor BP: combo may incr. risk of HTN (additive effects)

• lemborexant
Symbravo (meloxicam/ rizatriptan)

+

lemborexant

1 interaction

Monitor/Modify Tx

rizatriptan + lemborexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lenalidomide
Symbravo (meloxicam/ rizatriptan)

+

lenalidomide

1 interaction

Monitor/Modify Tx

meloxicam + lenalidomide

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• lenvatinib
Symbravo (meloxicam/ rizatriptan)

+

lenvatinib

2 interactions

Monitor/Modify Tx

meloxicam + lenvatinib

monitor BP, bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN (additive effects)

rizatriptan + lenvatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• levalbuterol inhaled
Symbravo (meloxicam/ rizatriptan)

+

levalbuterol inhaled

2 interactions

Monitor/Modify Tx

meloxicam + levalbuterol inhaled

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + levalbuterol inhaled

monitor BP: combo may incr. risk of HTN (additive effects)

• levonorgestrel (contraceptive)
Symbravo (meloxicam/ rizatriptan)

+

levonorgestrel (contraceptive)

1 interaction

Monitor/Modify Tx

meloxicam + levonorgestrel (contraceptive)

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• levonorgestrel (hormone replacement)
Symbravo (meloxicam/ rizatriptan)

+

levonorgestrel (hormone replacement)

1 interaction

Monitor/Modify Tx

meloxicam + levonorgestrel (hormone replacement)

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• licorice
Symbravo (meloxicam/ rizatriptan)

+

licorice

2 interactions

Monitor/Modify Tx

meloxicam + licorice

monitor BP w/ large amounts of licorice: combo may incr. risk of HTN (additive effects)

rizatriptan + licorice

monitor BP w/ large amounts of licorice: combo may incr. risk of HTN (additive effects)

• lifileucel
Symbravo (meloxicam/ rizatriptan)

+

lifileucel

1 interaction

Monitor/Modify Tx

meloxicam + lifileucel

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• lomustine
Symbravo (meloxicam/ rizatriptan)

+

lomustine

1 interaction

Monitor/Modify Tx

meloxicam + lomustine

monitor CBC, renal fxn: combo may incr. lomustine levels, risk of serious infection, myelosuppression, nephrotoxicity, other adverse effects (additive effects)

• lorazepam
Symbravo (meloxicam/ rizatriptan)

+

lorazepam

1 interaction

Monitor/Modify Tx

rizatriptan + lorazepam

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• lorlatinib
Symbravo (meloxicam/ rizatriptan)

+

lorlatinib

2 interactions

Monitor/Modify Tx

meloxicam + lorlatinib

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + lorlatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• losartan
Symbravo (meloxicam/ rizatriptan)

+

losartan

2 interactions

Monitor/Modify Tx

meloxicam + losartan

monitor renal fxn, potassium, BP: combo may incr. risk of renal impairment, hyperkalemia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

rizatriptan + losartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• lumacaftor/ivacaftor
Symbravo (meloxicam/ rizatriptan)

+

lumacaftor/ ivacaftor

2 interactions

Monitor/Modify Tx

meloxicam + lumacaftor/ ivacaftor

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + lumacaftor/ ivacaftor

monitor BP: combo may incr. risk of HTN (additive effects)

• lumateperone
Symbravo (meloxicam/ rizatriptan)

+

lumateperone

1 interaction

Monitor/Modify Tx

rizatriptan + lumateperone

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• luspatercept
Symbravo (meloxicam/ rizatriptan)

+

luspatercept

2 interactions

Monitor/Modify Tx

meloxicam + luspatercept

monitor BP; if beta thalassemia use, monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

rizatriptan + luspatercept

monitor BP: combo may incr. risk of HTN (additive effects)

• lusutrombopag
Symbravo (meloxicam/ rizatriptan)

+

lusutrombopag

1 interaction

Monitor/Modify Tx

meloxicam + lusutrombopag

monitor platelets, thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• lutetium Lu 177 vipivotide tetraxetan
Symbravo (meloxicam/ rizatriptan)

+

lutetium Lu 177 vipivotide tetraxetan

1 interaction

Monitor/Modify Tx

meloxicam + lutetium Lu 177 vipivotide tetraxetan

monitor renal fxn: combo may incr. risk of nephrotoxicity (additive effects)

• magnesium citrate
Symbravo (meloxicam/ rizatriptan)

+

magnesium citrate

1 interaction

Monitor/Modify Tx

meloxicam + magnesium citrate

monitor renal fxn, especially if magnesium citrate bowel prep use: combo may incr. risk of renal impairment (additive effects)

• mannitol
Symbravo (meloxicam/ rizatriptan)

+

mannitol

1 interaction

Monitor/Modify Tx

meloxicam + mannitol

monitor renal fxn: combo may incr. mannitol levels, risk of renal impairment, neurotoxicity (including life-threatening), other adverse effects (additive effects)

• medroxyprogesterone (contraceptive)
Symbravo (meloxicam/ rizatriptan)

+

medroxyprogesterone (contraceptive)

1 interaction

Monitor/Modify Tx

meloxicam + medroxyprogesterone (contraceptive)

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• medroxyprogesterone (hormone replacement)
Symbravo (meloxicam/ rizatriptan)

+

medroxyprogesterone (hormone replacement)

1 interaction

Monitor/Modify Tx

meloxicam + medroxyprogesterone (hormone replacement)

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• megestrol
Symbravo (meloxicam/ rizatriptan)

+

megestrol

1 interaction

Monitor/Modify Tx

meloxicam + megestrol

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• menotropins
Symbravo (meloxicam/ rizatriptan)

+

menotropins

1 interaction

Monitor/Modify Tx

meloxicam + menotropins

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• mesalamine
Symbravo (meloxicam/ rizatriptan)

+

mesalamine

1 interaction

Monitor/Modify Tx

meloxicam + mesalamine

monitor renal fxn: combo may incr. risk of nephrotoxicity (additive effects)

• mesalamine rectal
Symbravo (meloxicam/ rizatriptan)

+

mesalamine rectal

1 interaction

Monitor/Modify Tx

meloxicam + mesalamine rectal

monitor renal fxn: combo may incr. risk of nephrotoxicity (additive effects)

• methohexital
Symbravo (meloxicam/ rizatriptan)

+

methohexital

1 interaction

Monitor/Modify Tx

rizatriptan + methohexital

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• methoxy polyethylene glycol-epoetin beta
Symbravo (meloxicam/ rizatriptan)

+

methoxy polyethylene glycol-epoetin beta

2 interactions

Monitor/Modify Tx

meloxicam + methoxy polyethylene glycol-epoetin beta

monitor BP, thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

rizatriptan + methoxy polyethylene glycol-epoetin beta

monitor BP: combo may incr. risk of HTN (additive effects)

• methyl salicylate topical
Symbravo (meloxicam/ rizatriptan)

+

methyl salicylate topical

1 interaction

Monitor/Modify Tx

meloxicam + methyl salicylate topical

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• methyldopa
Symbravo (meloxicam/ rizatriptan)

+

methyldopa

2 interactions

Monitor/Modify Tx

meloxicam + methyldopa

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + methyldopa

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• methylene blue injection
Symbravo (meloxicam/ rizatriptan)

+

methylene blue injection

1 interaction

Monitor/Modify Tx

rizatriptan + methylene blue injection

hold rizatriptan if emergency use; monitor serotonin syndrome sx up to 4h after last methylene blue dose; may resume rizatriptan 72h after last methylene blue dose: combo may incr. rizatriptan levels, risk of serotonin syndrome, other adverse effects (monoamine oxidase (MAO) possibly inhibited, additive effects)

• methylphenidate
Symbravo (meloxicam/ rizatriptan)

+

methylphenidate

2 interactions

Monitor/Modify Tx

meloxicam + methylphenidate

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + methylphenidate

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN, serotonin syndrome (additive effects)

• methylprednisolone
Symbravo (meloxicam/ rizatriptan)

+

methylprednisolone

2 interactions

Monitor/Modify Tx

meloxicam + methylprednisolone

monitor bleeding s/sx, BP: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), HTN (additive effects)

rizatriptan + methylprednisolone

monitor BP: combo may incr. risk of HTN (additive effects)

• methyltestosterone
Symbravo (meloxicam/ rizatriptan)

+

methyltestosterone

2 interactions

Monitor/Modify Tx

meloxicam + methyltestosterone

monitor BP, thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

rizatriptan + methyltestosterone

monitor BP: combo may incr. risk of HTN (additive effects)

• metolazone
Symbravo (meloxicam/ rizatriptan)

+

metolazone

2 interactions

Monitor/Modify Tx

meloxicam + metolazone

monitor renal fxn, BP: combo may incr. risk of renal impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

rizatriptan + metolazone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• metoprolol
Symbravo (meloxicam/ rizatriptan)

+

metoprolol

2 interactions

Monitor/Modify Tx

meloxicam + metoprolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + metoprolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• minoxidil
Symbravo (meloxicam/ rizatriptan)

+

minoxidil

2 interactions

Monitor/Modify Tx

meloxicam + minoxidil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + minoxidil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• mirabegron
Symbravo (meloxicam/ rizatriptan)

+

mirabegron

2 interactions

Monitor/Modify Tx

meloxicam + mirabegron

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + mirabegron

monitor BP: combo may incr. risk of HTN (additive effects)

• mitomycin
Symbravo (meloxicam/ rizatriptan)

+

mitomycin

1 interaction

Monitor/Modify Tx

meloxicam + mitomycin

monitor renal fxn; risk may be lower w/ intravesical mitomycin administration: combo may incr. risk of nephrotoxicity (additive effects)

• mitotane
Symbravo (meloxicam/ rizatriptan)

+

mitotane

2 interactions

Monitor/Modify Tx

meloxicam + mitotane

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

Caution Advised

rizatriptan + mitotane

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• modafinil
Symbravo (meloxicam/ rizatriptan)

+

modafinil

2 interactions

Monitor/Modify Tx

meloxicam + modafinil

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + modafinil

monitor BP: combo may incr. risk of HTN (additive effects)

• moexipril
Symbravo (meloxicam/ rizatriptan)

+

moexipril

2 interactions

Monitor/Modify Tx

meloxicam + moexipril

monitor renal fxn, BP, potassium: combo may incr. risk of renal impairment, hyperkalemia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

rizatriptan + moexipril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• momelotinib
Symbravo (meloxicam/ rizatriptan)

+

momelotinib

1 interaction

Monitor/Modify Tx

meloxicam + momelotinib

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• monomethyl fumarate
Symbravo (meloxicam/ rizatriptan)

+

monomethyl fumarate

1 interaction

Monitor/Modify Tx

meloxicam + monomethyl fumarate

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• mycophenolate mofetil
Symbravo (meloxicam/ rizatriptan)

+

mycophenolate mofetil

2 interactions

Monitor/Modify Tx

meloxicam + mycophenolate mofetil

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

Caution Advised

rizatriptan + mycophenolate mofetil

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• mycophenolic acid
Symbravo (meloxicam/ rizatriptan)

+

mycophenolic acid

1 interaction

Monitor/Modify Tx

meloxicam + mycophenolic acid

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• nadolol
Symbravo (meloxicam/ rizatriptan)

+

nadolol

2 interactions

Monitor/Modify Tx

meloxicam + nadolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + nadolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nattokinase
Symbravo (meloxicam/ rizatriptan)

+

nattokinase

1 interaction

Monitor/Modify Tx

meloxicam + nattokinase

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• naxitamab
Symbravo (meloxicam/ rizatriptan)

+

naxitamab

2 interactions

Monitor/Modify Tx

meloxicam + naxitamab

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + naxitamab

monitor BP: combo may incr. risk of HTN (additive effects)

• nebivolol
Symbravo (meloxicam/ rizatriptan)

+

nebivolol

2 interactions

Monitor/Modify Tx

meloxicam + nebivolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + nebivolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• necitumumab
Symbravo (meloxicam/ rizatriptan)

+

necitumumab

1 interaction

Monitor/Modify Tx

meloxicam + necitumumab

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• nefazodone
Symbravo (meloxicam/ rizatriptan)

+

nefazodone

1 interaction

Monitor/Modify Tx

rizatriptan + nefazodone

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• nelarabine
Symbravo (meloxicam/ rizatriptan)

+

nelarabine

1 interaction

Monitor/Modify Tx

rizatriptan + nelarabine

withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• neomycin
Symbravo (meloxicam/ rizatriptan)

+

neomycin

1 interaction

Monitor/Modify Tx

meloxicam + neomycin

if compromised gut wall allows for neomycin absorption, monitor renal fxn, ototoxicity: combo may incr. neomycin levels, risk of nephrotoxicity, auditory, vestibular, other adverse effects (additive effects)

• nepafenac ophthalmic
Symbravo (meloxicam/ rizatriptan)

+

nepafenac ophthalmic

1 interaction

Monitor/Modify Tx

meloxicam + nepafenac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects)

• niacin (vitamin B3)
Symbravo (meloxicam/ rizatriptan)

+

niacin (vitamin B3)

1 interaction

Monitor/Modify Tx

meloxicam + niacin (vitamin B3)

monitor platelets, bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• nicardipine
Symbravo (meloxicam/ rizatriptan)

+

nicardipine

2 interactions

Monitor/Modify Tx

meloxicam + nicardipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + nicardipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nifedipine
Symbravo (meloxicam/ rizatriptan)

+

nifedipine

2 interactions

Monitor/Modify Tx

meloxicam + nifedipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + nifedipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nilotinib
Symbravo (meloxicam/ rizatriptan)

+

nilotinib

1 interaction

Monitor/Modify Tx

meloxicam + nilotinib

monitor potassium, bleeding s/sx: combo may incr. risk of hyperkalemia, GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• nimodipine
Symbravo (meloxicam/ rizatriptan)

+

nimodipine

2 interactions

Monitor/Modify Tx

meloxicam + nimodipine

monitor BP: combo may decr. nimodipine efficacy (antagonistic effects)

rizatriptan + nimodipine

monitor BP: combo may decr. nimodipine efficacy (antagonistic effects)

• nintedanib
Symbravo (meloxicam/ rizatriptan)

+

nintedanib

1 interaction

Monitor/Modify Tx

meloxicam + nintedanib

monitor bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism (additive effects)

• niraparib
Symbravo (meloxicam/ rizatriptan)

+

niraparib

2 interactions

Monitor/Modify Tx

meloxicam + niraparib

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + niraparib

monitor BP: combo may incr. risk of HTN (additive effects)

• nisoldipine
Symbravo (meloxicam/ rizatriptan)

+

nisoldipine

2 interactions

Monitor/Modify Tx

meloxicam + nisoldipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + nisoldipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• norelgestromin (contraceptive)
Symbravo (meloxicam/ rizatriptan)

+

norelgestromin (contraceptive)

1 interaction

Monitor/Modify Tx

meloxicam + norelgestromin (contraceptive)

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• norepinephrine
Symbravo (meloxicam/ rizatriptan)

+

norepinephrine

2 interactions

Monitor/Modify Tx

meloxicam + norepinephrine

monitor BP: combo may incr. risk of severe HTN (additive effects)

rizatriptan + norepinephrine

monitor BP: combo may incr. risk of severe HTN (additive effects)

• norethindrone (contraceptive)
Symbravo (meloxicam/ rizatriptan)

+

norethindrone (contraceptive)

1 interaction

Monitor/Modify Tx

meloxicam + norethindrone (contraceptive)

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• norethindrone (hormone replacement)
Symbravo (meloxicam/ rizatriptan)

+

norethindrone (hormone replacement)

1 interaction

Monitor/Modify Tx

meloxicam + norethindrone (hormone replacement)

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• norgestimate (contraceptive)
Symbravo (meloxicam/ rizatriptan)

+

norgestimate (contraceptive)

1 interaction

Monitor/Modify Tx

meloxicam + norgestimate (contraceptive)

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• norgestrel (contraceptive)
Symbravo (meloxicam/ rizatriptan)

+

norgestrel (contraceptive)

1 interaction

Monitor/Modify Tx

meloxicam + norgestrel (contraceptive)

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• nusinersen
Symbravo (meloxicam/ rizatriptan)

+

nusinersen

1 interaction

Monitor/Modify Tx

meloxicam + nusinersen

monitor platelets, bleeding s/sx, renal fxn: combo may incr. risk of nephrotoxicity, GI or other bleeding, including life-threatening (additive effects)

• obinutuzumab
Symbravo (meloxicam/ rizatriptan)

+

obinutuzumab

2 interactions

Monitor/Modify Tx

meloxicam + obinutuzumab

monitor BP, platelets, bleeding or thrombosis s/sx; consider holding meloxicam, especially during first obinutuzumab cycle: combo may incr. risk of HTN (including hypertensive crisis), thromboembolism, severe bleeding, including life-threatening (additive effects)

rizatriptan + obinutuzumab

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• olanzapine
Symbravo (meloxicam/ rizatriptan)

+

olanzapine

1 interaction

Monitor/Modify Tx

rizatriptan + olanzapine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• olaparib
Symbravo (meloxicam/ rizatriptan)

+

olaparib

1 interaction

Monitor/Modify Tx

meloxicam + olaparib

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• olodaterol inhaled
Symbravo (meloxicam/ rizatriptan)

+

olodaterol inhaled

2 interactions

Monitor/Modify Tx

meloxicam + olodaterol inhaled

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + olodaterol inhaled

monitor BP: combo may incr. risk of HTN (additive effects)

• olsalazine
Symbravo (meloxicam/ rizatriptan)

+

olsalazine

1 interaction

Monitor/Modify Tx

meloxicam + olsalazine

monitor renal fxn: combo may incr. risk of nephrotoxicity (additive effects)

• omega-3-acid
Symbravo (meloxicam/ rizatriptan)

+

omega-3-acid

1 interaction

Monitor/Modify Tx

meloxicam + omega-3-acid

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• opicapone
Symbravo (meloxicam/ rizatriptan)

+

opicapone

1 interaction

Monitor/Modify Tx

rizatriptan + opicapone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• osilodrostat
Symbravo (meloxicam/ rizatriptan)

+

osilodrostat

2 interactions

Monitor/Modify Tx

meloxicam + osilodrostat

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + osilodrostat

monitor BP: combo may incr. risk of HTN (additive effects)

• ospemifene
Symbravo (meloxicam/ rizatriptan)

+

ospemifene

1 interaction

Monitor/Modify Tx

meloxicam + ospemifene

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• oxaliplatin
Symbravo (meloxicam/ rizatriptan)

+

oxaliplatin

1 interaction

Monitor/Modify Tx

meloxicam + oxaliplatin

monitor ECG, CBC, renal fxn, bleeding s/sx, ototoxicity: combo may incr. oxaliplatin levels, risk of QT prolongation, cardiac arrhythmias, serious infection, myelosuppression, nephrotoxicity, GI or other bleeding (including life-threatening), auditory, vestibular, other adverse effects (additive effects)

• oxazepam
Symbravo (meloxicam/ rizatriptan)

+

oxazepam

1 interaction

Monitor/Modify Tx

rizatriptan + oxazepam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• oxybutynin
Symbravo (meloxicam/ rizatriptan)

+

oxybutynin

1 interaction

Monitor/Modify Tx

rizatriptan + oxybutynin

decr. dose of one or both drugs or consider oxybutynin transdermal patch: combo may incr. risk of CNS depression, psychomotor impairment; somnolence less likely with oxybutynin transdermal patch (additive effects)

• oxymetazoline nasal
Symbravo (meloxicam/ rizatriptan)

+

oxymetazoline nasal

2 interactions

Monitor/Modify Tx

meloxicam + oxymetazoline nasal

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + oxymetazoline nasal

monitor BP: combo may incr. risk of HTN (additive effects)

• oxytocin
Symbravo (meloxicam/ rizatriptan)

+

oxytocin

2 interactions

Monitor/Modify Tx

meloxicam + oxytocin

monitor BP: combo may incr. risk of HTN, including life-threatening (additive effects)

rizatriptan + oxytocin

monitor BP: combo may incr. risk of HTN, including life-threatening (additive effects)

• ozanimod
Symbravo (meloxicam/ rizatriptan)

+

ozanimod

2 interactions

Monitor/Modify Tx

meloxicam + ozanimod

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

rizatriptan + ozanimod

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• pacritinib
Symbravo (meloxicam/ rizatriptan)

+

pacritinib

1 interaction

Monitor/Modify Tx

meloxicam + pacritinib

monitor platelets, bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism, GI or other bleeding, including life-threatening (additive effects)

• palonosetron
Symbravo (meloxicam/ rizatriptan)

+

palonosetron

1 interaction

Monitor/Modify Tx

rizatriptan + palonosetron

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• pamidronate
Symbravo (meloxicam/ rizatriptan)

+

pamidronate

1 interaction

Monitor/Modify Tx

meloxicam + pamidronate

monitor renal fxn: combo may incr. pamidronate levels, risk of nephrotoxicity, other adverse effects (additive effects)

• paromomycin
Symbravo (meloxicam/ rizatriptan)

+

paromomycin

1 interaction

Monitor/Modify Tx

meloxicam + paromomycin

if compromised gut wall allows for paromomycin absorption, monitor renal fxn, ototoxicity: combo may incr. paromomycin levels, risk of nephrotoxicity, auditory, vestibular, other adverse effects (additive effects)

• pazopanib
Symbravo (meloxicam/ rizatriptan)

+

pazopanib

2 interactions

Monitor/Modify Tx

meloxicam + pazopanib

monitor BP, bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of HTN, GI ulceration, perforation, bleeding (including life-threatening), thromboembolism (additive effects)

rizatriptan + pazopanib

monitor BP: combo may incr. risk of HTN (additive effects)

• pegaspargase
Symbravo (meloxicam/ rizatriptan)

+

pegaspargase

1 interaction

Monitor/Modify Tx

meloxicam + pegaspargase

monitor bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of GI or other bleeding (including life-threatening), thromboembolism (additive effects)

• penicillamine
Symbravo (meloxicam/ rizatriptan)

+

penicillamine

1 interaction

Monitor/Modify Tx

meloxicam + penicillamine

monitor CBC, renal fxn: combo may incr. penicillamine levels, risk of myelosuppression, nephrotoxicity, other adverse effects (additive effects)

• penicillin G
Symbravo (meloxicam/ rizatriptan)

+

penicillin G

1 interaction

Monitor/Modify Tx

meloxicam + penicillin G

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• pentamidine
Symbravo (meloxicam/ rizatriptan)

+

pentamidine

1 interaction

Monitor/Modify Tx

meloxicam + pentamidine

monitor renal fxn: combo may incr. risk of nephrotoxicity (additive effects)

• pentobarbital
Symbravo (meloxicam/ rizatriptan)

+

pentobarbital

1 interaction

Monitor/Modify Tx

rizatriptan + pentobarbital

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• pentosan polysulfate sodium
Symbravo (meloxicam/ rizatriptan)

+

pentosan polysulfate sodium

1 interaction

Monitor/Modify Tx

meloxicam + pentosan polysulfate sodium

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• pentostatin
Symbravo (meloxicam/ rizatriptan)

+

pentostatin

1 interaction

Monitor/Modify Tx

meloxicam + pentostatin

monitor CBC, renal fxn: combo may incr. pentostatin levels, risk of serious infection, myelosuppression, nephrotoxicity, other adverse effects (additive effects)

• pentoxifylline
Symbravo (meloxicam/ rizatriptan)

+

pentoxifylline

1 interaction

Monitor/Modify Tx

meloxicam + pentoxifylline

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• perphenazine
Symbravo (meloxicam/ rizatriptan)

+

perphenazine

1 interaction

Monitor/Modify Tx

rizatriptan + perphenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pexidartinib
Symbravo (meloxicam/ rizatriptan)

+

pexidartinib

2 interactions

Monitor/Modify Tx

meloxicam + pexidartinib

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + pexidartinib

monitor BP: combo may incr. risk of HTN (additive effects)

• phendimetrazine
Symbravo (meloxicam/ rizatriptan)

+

phendimetrazine

2 interactions

Monitor/Modify Tx

meloxicam + phendimetrazine

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + phendimetrazine

monitor BP: combo may incr. risk of HTN (additive effects)

• phenobarbital
Symbravo (meloxicam/ rizatriptan)

+

phenobarbital

1 interaction

Monitor/Modify Tx

rizatriptan + phenobarbital

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• phenoxybenzamine
Symbravo (meloxicam/ rizatriptan)

+

phenoxybenzamine

2 interactions

Monitor/Modify Tx

meloxicam + phenoxybenzamine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + phenoxybenzamine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• phentermine
Symbravo (meloxicam/ rizatriptan)

+

phentermine

2 interactions

Monitor/Modify Tx

meloxicam + phentermine

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + phentermine

monitor BP: combo may incr. risk of HTN (additive effects)

• phentolamine
Symbravo (meloxicam/ rizatriptan)

+

phentolamine

2 interactions

Monitor/Modify Tx

meloxicam + phentolamine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + phentolamine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• phenylephrine
Symbravo (meloxicam/ rizatriptan)

+

phenylephrine

2 interactions

Monitor/Modify Tx

meloxicam + phenylephrine

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + phenylephrine

monitor BP: combo may incr. risk of HTN (additive effects)

• phenylephrine injection
Symbravo (meloxicam/ rizatriptan)

+

phenylephrine injection

2 interactions

Monitor/Modify Tx

meloxicam + phenylephrine injection

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + phenylephrine injection

monitor BP: combo may incr. risk of HTN (additive effects)

• phenylephrine nasal
Symbravo (meloxicam/ rizatriptan)

+

phenylephrine nasal

2 interactions

Monitor/Modify Tx

meloxicam + phenylephrine nasal

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + phenylephrine nasal

monitor BP: combo may incr. risk of HTN (additive effects)

• phenylephrine ophthalmic
Symbravo (meloxicam/ rizatriptan)

+

phenylephrine ophthalmic

2 interactions

Monitor/Modify Tx

meloxicam + phenylephrine ophthalmic

monitor BP; HTN risk may be lower w/ phenylephrine ophthalmic 2.5%: combo may incr. risk of HTN (additive effects)

rizatriptan + phenylephrine ophthalmic

monitor BP; HTN risk may be lower w/ phenylephrine ophthalmic 2.5%: combo may incr. risk of HTN (additive effects)

• phenylephrine rectal
Symbravo (meloxicam/ rizatriptan)

+

phenylephrine rectal

2 interactions

Monitor/Modify Tx

meloxicam + phenylephrine rectal

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + phenylephrine rectal

monitor BP: combo may incr. risk of HTN (additive effects)

• pindolol
Symbravo (meloxicam/ rizatriptan)

+

pindolol

2 interactions

Monitor/Modify Tx

meloxicam + pindolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + pindolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• piperacillin
Symbravo (meloxicam/ rizatriptan)

+

piperacillin

1 interaction

Monitor/Modify Tx

meloxicam + piperacillin

monitor bleeding s/sx, especially w/ prolonged piperacillin tx and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• pirtobrutinib
Symbravo (meloxicam/ rizatriptan)

+

pirtobrutinib

1 interaction

Monitor/Modify Tx

meloxicam + pirtobrutinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• plasminogen, human
Symbravo (meloxicam/ rizatriptan)

+

plasminogen, human

1 interaction

Monitor/Modify Tx

meloxicam + plasminogen, human

monitor bleeding s/sx, especially during and x4h after plasminogen infusion: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• plazomicin
Symbravo (meloxicam/ rizatriptan)

+

plazomicin

1 interaction

Monitor/Modify Tx

meloxicam + plazomicin

monitor plazomicin levels, renal fxn, ototoxicity: combo may incr. plazomicin levels, risk of nephrotoxicity, auditory, vestibular, other adverse effects (additive effects)

• polyethylene glycol
Symbravo (meloxicam/ rizatriptan)

+

polyethylene glycol

1 interaction

Monitor/Modify Tx

meloxicam + polyethylene glycol

monitor renal fxn, especially if polyethylene glycol bowel prep use: combo may incr. risk of renal impairment (additive effects)

• polyethylene glycol/electrolytes
Symbravo (meloxicam/ rizatriptan)

+

polyethylene glycol/ electrolytes

1 interaction

Monitor/Modify Tx

meloxicam + polyethylene glycol/ electrolytes

monitor renal fxn: combo may incr. risk of renal impairment (additive effects)

• polymyxin B
Symbravo (meloxicam/ rizatriptan)

+

polymyxin B

1 interaction

Monitor/Modify Tx

meloxicam + polymyxin B

monitor renal fxn: combo may incr. risk of nephrotoxicity (additive effects)

• pomalidomide
Symbravo (meloxicam/ rizatriptan)

+

pomalidomide

1 interaction

Monitor/Modify Tx

meloxicam + pomalidomide

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• ponatinib
Symbravo (meloxicam/ rizatriptan)

+

ponatinib

2 interactions

Monitor/Modify Tx

meloxicam + ponatinib

monitor BP, bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN (additive effects)

rizatriptan + ponatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• ponesimod
Symbravo (meloxicam/ rizatriptan)

+

ponesimod

2 interactions

Monitor/Modify Tx

meloxicam + ponesimod

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + ponesimod

monitor BP: combo may incr. risk of HTN (additive effects)

• porfimer
Symbravo (meloxicam/ rizatriptan)

+

porfimer

1 interaction

Monitor/Modify Tx

meloxicam + porfimer

monitor bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism, GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• potassium acid phosphate
Symbravo (meloxicam/ rizatriptan)

+

potassium acid phosphate

1 interaction

Monitor/Modify Tx

meloxicam + potassium acid phosphate

monitor potassium: combo may incr. risk of hyperkalemia (additive effects)

• potassium bicarbonate
Symbravo (meloxicam/ rizatriptan)

+

potassium bicarbonate

1 interaction

Monitor/Modify Tx

meloxicam + potassium bicarbonate

monitor potassium, ECG: combo may incr. risk of severe hyperkalemia, cardiac arrest (additive effects)

• potassium citrate
Symbravo (meloxicam/ rizatriptan)

+

potassium citrate

1 interaction

Monitor/Modify Tx

meloxicam + potassium citrate

monitor potassium, ECG: combo may incr. risk of severe hyperkalemia, cardiac arrest (additive effects)

• potassium iodide
Symbravo (meloxicam/ rizatriptan)

+

potassium iodide

1 interaction

Monitor/Modify Tx

meloxicam + potassium iodide

monitor potassium, ECG: combo may incr. risk of severe hyperkalemia, cardiac arrest (additive effects)

• pralsetinib
Symbravo (meloxicam/ rizatriptan)

+

pralsetinib

2 interactions

Monitor/Modify Tx

meloxicam + pralsetinib

monitor BP, bleeding s/sx: combo may incr. risk of HTN, GI or other bleeding, including life-threatening (additive effects)

rizatriptan + pralsetinib

monitor BP: combo may incr. risk of HTN (additive effects)

• prasugrel
Symbravo (meloxicam/ rizatriptan)

+

prasugrel

1 interaction

Monitor/Modify Tx

meloxicam + prasugrel

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• prazosin
Symbravo (meloxicam/ rizatriptan)

+

prazosin

2 interactions

Monitor/Modify Tx

meloxicam + prazosin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + prazosin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• prednisolone
Symbravo (meloxicam/ rizatriptan)

+

prednisolone

2 interactions

Monitor/Modify Tx

meloxicam + prednisolone

monitor bleeding s/sx, BP: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), HTN (additive effects)

rizatriptan + prednisolone

monitor BP: combo may incr. risk of HTN (additive effects)

• prednisone
Symbravo (meloxicam/ rizatriptan)

+

prednisone

2 interactions

Monitor/Modify Tx

meloxicam + prednisone

monitor bleeding s/sx, BP: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), HTN (additive effects)

rizatriptan + prednisone

monitor BP: combo may incr. risk of HTN (additive effects)

• pregabalin
Symbravo (meloxicam/ rizatriptan)

+

pregabalin

1 interaction

Monitor/Modify Tx

rizatriptan + pregabalin

monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• primidone
Symbravo (meloxicam/ rizatriptan)

+

primidone

1 interaction

Monitor/Modify Tx

rizatriptan + primidone

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• progesterone (hormone replacement)
Symbravo (meloxicam/ rizatriptan)

+

progesterone (hormone replacement)

1 interaction

Monitor/Modify Tx

meloxicam + progesterone (hormone replacement)

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• progesterone vaginal (hormone replacement)
Symbravo (meloxicam/ rizatriptan)

+

progesterone vaginal (hormone replacement)

1 interaction

Monitor/Modify Tx

meloxicam + progesterone vaginal (hormone replacement)

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• propofol
Symbravo (meloxicam/ rizatriptan)

+

propofol

1 interaction

Monitor/Modify Tx

rizatriptan + propofol

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• prothrombin complex concentrate (human)
Symbravo (meloxicam/ rizatriptan)

+

prothrombin complex concentrate (human)

1 interaction

Monitor/Modify Tx

meloxicam + prothrombin complex concentrate (human)

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• protriptyline
Symbravo (meloxicam/ rizatriptan)

+

protriptyline

1 interaction

Monitor/Modify Tx

rizatriptan + protriptyline

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• pseudoephedrine
Symbravo (meloxicam/ rizatriptan)

+

pseudoephedrine

2 interactions

Monitor/Modify Tx

meloxicam + pseudoephedrine

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + pseudoephedrine

monitor BP: combo may incr. risk of HTN (additive effects)

• pyridostigmine
Symbravo (meloxicam/ rizatriptan)

+

pyridostigmine

1 interaction

Monitor/Modify Tx

meloxicam + pyridostigmine

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• quazepam
Symbravo (meloxicam/ rizatriptan)

+

quazepam

1 interaction

Monitor/Modify Tx

rizatriptan + quazepam

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• quetiapine
Symbravo (meloxicam/ rizatriptan)

+

quetiapine

2 interactions

Monitor/Modify Tx

meloxicam + quetiapine

monitor BP, especially in pts <18 yo: combo may incr. risk of HTN (additive effects)

rizatriptan + quetiapine

monitor BP, especially in pts <18 yo: combo may incr. risk of HTN, CNS depression, psychomotor impairment (additive effects)

• quinapril
Symbravo (meloxicam/ rizatriptan)

+

quinapril

2 interactions

Monitor/Modify Tx

meloxicam + quinapril

monitor renal fxn, BP, potassium: combo may incr. risk of renal impairment, hyperkalemia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

rizatriptan + quinapril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• raloxifene
Symbravo (meloxicam/ rizatriptan)

+

raloxifene

1 interaction

Monitor/Modify Tx

meloxicam + raloxifene

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• ramipril
Symbravo (meloxicam/ rizatriptan)

+

ramipril

2 interactions

Monitor/Modify Tx

meloxicam + ramipril

monitor renal fxn, BP, potassium: combo may incr. risk of renal impairment, hyperkalemia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

rizatriptan + ramipril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ramucirumab
Symbravo (meloxicam/ rizatriptan)

+

ramucirumab

2 interactions

Monitor/Modify Tx

meloxicam + ramucirumab

monitor BP, bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN (additive effects)

rizatriptan + ramucirumab

monitor BP: combo may incr. risk of HTN (additive effects)

• ranibizumab
Symbravo (meloxicam/ rizatriptan)

+

ranibizumab

1 interaction

Monitor/Modify Tx

meloxicam + ranibizumab

monitor bleeding or thrombosis s/sx; thrombosis risk may be lower if ocular implant use; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of ocular hemorrhage, thromboembolism (additive effects)

• regorafenib
Symbravo (meloxicam/ rizatriptan)

+

regorafenib

2 interactions

Monitor/Modify Tx

meloxicam + regorafenib

monitor bleeding s/sx, BP: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), HTN (additive effects)

rizatriptan + regorafenib

monitor BP: combo may incr. risk of HTN (additive effects)

• remibrutinib
Symbravo (meloxicam/ rizatriptan)

+

remibrutinib

1 interaction

Monitor/Modify Tx

meloxicam + remibrutinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• remimazolam
Symbravo (meloxicam/ rizatriptan)

+

remimazolam

1 interaction

Monitor/Modify Tx

rizatriptan + remimazolam

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• resveratrol
Symbravo (meloxicam/ rizatriptan)

+

resveratrol

1 interaction

Monitor/Modify Tx

meloxicam + resveratrol

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• reteplase
Symbravo (meloxicam/ rizatriptan)

+

reteplase

1 interaction

Monitor/Modify Tx

meloxicam + reteplase

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• revakinagene taroretcel
Symbravo (meloxicam/ rizatriptan)

+

revakinagene taroretcel

1 interaction

Monitor/Modify Tx

meloxicam + revakinagene taroretcel

monitor bleeding s/sx; hold meloxicam prior to implant insertion: combo may incr. risk of ocular hemorrhage (additive effects)

• Rho(D) immune globulin
Symbravo (meloxicam/ rizatriptan)

+

Rho(D) immune globulin

1 interaction

Monitor/Modify Tx

meloxicam + Rho(D) immune globulin

monitor renal fxn, thrombosis s/sx; use lowest Rho(D) immune globulin infusion rate possible; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of nephrotoxicity, thromboembolism (additive effects)

• rimegepant
Symbravo (meloxicam/ rizatriptan)

+

rimegepant

2 interactions

Monitor/Modify Tx

meloxicam + rimegepant

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + rimegepant

monitor BP: combo may incr. risk of HTN (additive effects)

• ripretinib
Symbravo (meloxicam/ rizatriptan)

+

ripretinib

2 interactions

Monitor/Modify Tx

meloxicam + ripretinib

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + ripretinib

monitor BP: combo may incr. risk of HTN (additive effects)

• risedronate
Symbravo (meloxicam/ rizatriptan)

+

risedronate

1 interaction

Monitor/Modify Tx

meloxicam + risedronate

monitor bleeding s/sx: combo may incr. risk of upper GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• ritlecitinib
Symbravo (meloxicam/ rizatriptan)

+

ritlecitinib

1 interaction

Monitor/Modify Tx

meloxicam + ritlecitinib

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• rituximab
Symbravo (meloxicam/ rizatriptan)

+

rituximab

1 interaction

Monitor/Modify Tx

meloxicam + rituximab

monitor renal fxn: combo may incr. risk of nephrotoxicity (additive effects)

• rivaroxaban
Symbravo (meloxicam/ rizatriptan)

+

rivaroxaban

1 interaction

Monitor/Modify Tx

meloxicam + rivaroxaban

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• rivastigmine
Symbravo (meloxicam/ rizatriptan)

+

rivastigmine

1 interaction

Monitor/Modify Tx

meloxicam + rivastigmine

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• romiplostim
Symbravo (meloxicam/ rizatriptan)

+

romiplostim

1 interaction

Monitor/Modify Tx

meloxicam + romiplostim

monitor platelets, thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• ropinirole
Symbravo (meloxicam/ rizatriptan)

+

ropinirole

2 interactions

Monitor/Modify Tx

meloxicam + ropinirole

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + ropinirole

monitor BP: combo may incr. risk of HTN, CNS depression, psychomotor impairment (additive effects)

• rotigotine transdermal
Symbravo (meloxicam/ rizatriptan)

+

rotigotine transdermal

2 interactions

Monitor/Modify Tx

meloxicam + rotigotine transdermal

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + rotigotine transdermal

monitor BP, HR: combo may incr. risk of HTN, tachycardia, CNS depression, psychomotor impairment (additive effects)

• ruxolitinib
Symbravo (meloxicam/ rizatriptan)

+

ruxolitinib

1 interaction

Monitor/Modify Tx

meloxicam + ruxolitinib

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• ruxolitinib topical
Symbravo (meloxicam/ rizatriptan)

+

ruxolitinib topical

1 interaction

Monitor/Modify Tx

meloxicam + ruxolitinib topical

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• salmeterol inhaled
Symbravo (meloxicam/ rizatriptan)

+

salmeterol inhaled

2 interactions

Monitor/Modify Tx

meloxicam + salmeterol inhaled

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + salmeterol inhaled

monitor BP: combo may incr. risk of HTN (additive effects)

• SAMe
Symbravo (meloxicam/ rizatriptan)

+

SAMe

1 interaction

Monitor/Modify Tx

rizatriptan + SAMe

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• saw palmetto
Symbravo (meloxicam/ rizatriptan)

+

saw palmetto

1 interaction

Monitor/Modify Tx

meloxicam + saw palmetto

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• segesterone (contraceptive)
Symbravo (meloxicam/ rizatriptan)

+

segesterone (contraceptive)

1 interaction

Monitor/Modify Tx

meloxicam + segesterone (contraceptive)

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• selpercatinib
Symbravo (meloxicam/ rizatriptan)

+

selpercatinib

2 interactions

Monitor/Modify Tx

meloxicam + selpercatinib

monitor BP, bleeding s/sx: combo may incr. risk of HTN, GI or other bleeding, including life-threatening (additive effects)

rizatriptan + selpercatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• selumetinib
Symbravo (meloxicam/ rizatriptan)

+

selumetinib

1 interaction

Monitor/Modify Tx

meloxicam + selumetinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, antiplatelet and anticoagulant effects augmented by vitamin E content in selumetinib capsules)

• sepiapterin
Symbravo (meloxicam/ rizatriptan)

+

sepiapterin

1 interaction

Monitor/Modify Tx

meloxicam + sepiapterin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• sevoflurane
Symbravo (meloxicam/ rizatriptan)

+

sevoflurane

1 interaction

Monitor/Modify Tx

rizatriptan + sevoflurane

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• sincalide
Symbravo (meloxicam/ rizatriptan)

+

sincalide

1 interaction

Monitor/Modify Tx

meloxicam + sincalide

if sincalide gallbladder contraction stimulation use, consider D/C meloxicam prior to sincalide admin.: combo may alter sincalide efficacy, interfere with test results (gallbladder motility/contractility altered)

• siponimod
Symbravo (meloxicam/ rizatriptan)

+

siponimod

2 interactions

Monitor/Modify Tx

meloxicam + siponimod

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + siponimod

monitor BP: combo may incr. risk of HTN (additive effects)

• sipuleucel-T
Symbravo (meloxicam/ rizatriptan)

+

sipuleucel-T

1 interaction

Monitor/Modify Tx

meloxicam + sipuleucel-T

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• sirolimus
Symbravo (meloxicam/ rizatriptan)

+

sirolimus

1 interaction

Monitor/Modify Tx

meloxicam + sirolimus

monitor renal fxn: combo may incr. risk of nephrotoxicity (additive effects)

• sirolimus albumin-bound
Symbravo (meloxicam/ rizatriptan)

+

sirolimus albumin-bound

1 interaction

Monitor/Modify Tx

meloxicam + sirolimus albumin-bound

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• sitagliptin
Symbravo (meloxicam/ rizatriptan)

+

sitagliptin

1 interaction

Monitor/Modify Tx

meloxicam + sitagliptin

monitor renal fxn: combo may incr. risk of nephrotoxicity (additive effects)

• sodium tetradecyl sulfate
Symbravo (meloxicam/ rizatriptan)

+

sodium tetradecyl sulfate

1 interaction

Monitor/Modify Tx

meloxicam + sodium tetradecyl sulfate

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• solriamfetol
Symbravo (meloxicam/ rizatriptan)

+

solriamfetol

2 interactions

Monitor/Modify Tx

meloxicam + solriamfetol

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + solriamfetol

monitor BP: combo may incr. risk of HTN (additive effects)

• sorafenib
Symbravo (meloxicam/ rizatriptan)

+

sorafenib

2 interactions

Monitor/Modify Tx

meloxicam + sorafenib

monitor bleeding s/sx, BP: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), HTN (additive effects)

rizatriptan + sorafenib

monitor BP: combo may incr. risk of HTN (additive effects)

• sotatercept
Symbravo (meloxicam/ rizatriptan)

+

sotatercept

1 interaction

Monitor/Modify Tx

meloxicam + sotatercept

monitor Hgb, platelets, bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of GI or other bleeding (including severe or life-threatening), thromboembolism (additive effects)

• sparsentan
Symbravo (meloxicam/ rizatriptan)

+

sparsentan

1 interaction

Monitor/Modify Tx

meloxicam + sparsentan

monitor renal fxn, potassium: combo may incr. risk of nephrotoxicity, hyperkalemia (additive effects)

• spironolactone
Symbravo (meloxicam/ rizatriptan)

+

spironolactone

2 interactions

Monitor/Modify Tx

meloxicam + spironolactone

monitor renal fxn, potassium, BP: combo may incr. risk of renal impairment, severe hyperkalemia; may decr. spironolactone efficacy (additive effects; antagonistic effects)

rizatriptan + spironolactone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• streptomycin
Symbravo (meloxicam/ rizatriptan)

+

streptomycin

1 interaction

Monitor/Modify Tx

meloxicam + streptomycin

monitor renal fxn, ototoxicity: combo may incr. streptomycin levels, risk of nephrotoxicity, auditory, vestibular, other adverse effects (additive effects)

• streptozocin
Symbravo (meloxicam/ rizatriptan)

+

streptozocin

1 interaction

Monitor/Modify Tx

meloxicam + streptozocin

monitor renal fxn: combo may incr. risk of nephrotoxicity (additive effects)

• sulfate bowel prep
Symbravo (meloxicam/ rizatriptan)

+

sulfate bowel prep

1 interaction

Monitor/Modify Tx

meloxicam + sulfate bowel prep

monitor renal fxn: combo may incr. risk of renal impairment (additive effects)

• sunitinib
Symbravo (meloxicam/ rizatriptan)

+

sunitinib

2 interactions

Monitor/Modify Tx

meloxicam + sunitinib

monitor bleeding s/sx, BP: combo may incr. risk of HTN, GI ulceration, perforation, bleeding, including life-threatening (additive effects)

rizatriptan + sunitinib

monitor BP: combo may incr. risk of HTN (additive effects)

• suvorexant
Symbravo (meloxicam/ rizatriptan)

+

suvorexant

1 interaction

Monitor/Modify Tx

rizatriptan + suvorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tagraxofusp
Symbravo (meloxicam/ rizatriptan)

+

tagraxofusp

2 interactions

Monitor/Modify Tx

meloxicam + tagraxofusp

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + tagraxofusp

monitor BP: combo may incr. risk of HTN (additive effects)

• tamoxifen
Symbravo (meloxicam/ rizatriptan)

+

tamoxifen

1 interaction

Monitor/Modify Tx

meloxicam + tamoxifen

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• telavancin
Symbravo (meloxicam/ rizatriptan)

+

telavancin

1 interaction

Monitor/Modify Tx

meloxicam + telavancin

monitor ECG, renal fxn: combo may incr. telavancin levels, risk of QT prolongation, cardiac arrhythmias, nephrotoxicity, other adverse effects (additive effects)

• telmisartan
Symbravo (meloxicam/ rizatriptan)

+

telmisartan

2 interactions

Monitor/Modify Tx

meloxicam + telmisartan

monitor renal fxn, potassium, BP: combo may incr. risk of renal impairment, hyperkalemia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

rizatriptan + telmisartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• temazepam
Symbravo (meloxicam/ rizatriptan)

+

temazepam

1 interaction

Monitor/Modify Tx

rizatriptan + temazepam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• temsirolimus
Symbravo (meloxicam/ rizatriptan)

+

temsirolimus

1 interaction

Monitor/Modify Tx

meloxicam + temsirolimus

monitor renal function, bleeding signs/symptoms: combo may incr. risk of nephrotoxicity, GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• tenecteplase
Symbravo (meloxicam/ rizatriptan)

+

tenecteplase

1 interaction

Monitor/Modify Tx

meloxicam + tenecteplase

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• tenofovir alafenamide
Symbravo (meloxicam/ rizatriptan)

+

tenofovir alafenamide

1 interaction

Monitor/Modify Tx

meloxicam + tenofovir alafenamide

monitor renal fxn: combo may incr. tenofovir levels, risk of nephrotoxicity, other adverse effects (additive effects)

• terazosin
Symbravo (meloxicam/ rizatriptan)

+

terazosin

2 interactions

Monitor/Modify Tx

meloxicam + terazosin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + terazosin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• terbutaline
Symbravo (meloxicam/ rizatriptan)

+

terbutaline

2 interactions

Monitor/Modify Tx

meloxicam + terbutaline

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + terbutaline

monitor BP: combo may incr. risk of HTN (additive effects)

• teriflunomide
Symbravo (meloxicam/ rizatriptan)

+

teriflunomide

2 interactions

Monitor/Modify Tx

meloxicam + teriflunomide

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + teriflunomide

monitor BP: combo may incr. risk of HTN (additive effects)

• testosterone
Symbravo (meloxicam/ rizatriptan)

+

testosterone

2 interactions

Monitor/Modify Tx

meloxicam + testosterone

monitor BP, thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

rizatriptan + testosterone

monitor BP: combo may incr. risk of HTN (additive effects)

• thioridazine
Symbravo (meloxicam/ rizatriptan)

+

thioridazine

1 interaction

Monitor/Modify Tx

rizatriptan + thioridazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• thiothixene
Symbravo (meloxicam/ rizatriptan)

+

thiothixene

1 interaction

Monitor/Modify Tx

rizatriptan + thiothixene

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ticagrelor
Symbravo (meloxicam/ rizatriptan)

+

ticagrelor

1 interaction

Monitor/Modify Tx

meloxicam + ticagrelor

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• timolol
Symbravo (meloxicam/ rizatriptan)

+

timolol

2 interactions

Monitor/Modify Tx

meloxicam + timolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + timolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• tiopronin
Symbravo (meloxicam/ rizatriptan)

+

tiopronin

1 interaction

Monitor/Modify Tx

meloxicam + tiopronin

monitor renal fxn: combo may incr. risk of nephrotoxicity (additive effects)

• tipranavir
Symbravo (meloxicam/ rizatriptan)

+

tipranavir

1 interaction

Monitor/Modify Tx

meloxicam + tipranavir

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• tirofiban
Symbravo (meloxicam/ rizatriptan)

+

tirofiban

1 interaction

Monitor/Modify Tx

meloxicam + tirofiban

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• tisotumab vedotin
Symbravo (meloxicam/ rizatriptan)

+

tisotumab vedotin

1 interaction

Monitor/Modify Tx

meloxicam + tisotumab vedotin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• tivozanib
Symbravo (meloxicam/ rizatriptan)

+

tivozanib

2 interactions

Monitor/Modify Tx

meloxicam + tivozanib

monitor BP, bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk HTN (including hypertensive crisis), thromboembolism, GI ulceration, perforation, bleeding, including life-threatening (additive effects)

rizatriptan + tivozanib

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• tobramycin
Symbravo (meloxicam/ rizatriptan)

+

tobramycin

1 interaction

Monitor/Modify Tx

meloxicam + tobramycin

monitor tobramycin levels, renal fxn, ototoxicity: combo may incr. tobramycin levels, risk of nephrotoxicity, auditory, vestibular, other adverse effects (additive effects)

• tobramycin inhaled
Symbravo (meloxicam/ rizatriptan)

+

tobramycin inhaled

1 interaction

Monitor/Modify Tx

meloxicam + tobramycin inhaled

monitor renal fxn, ototoxicity: combo may incr. tobramycin levels, risk of nephrotoxicity, auditory, vestibular, other adverse effects (additive effects)

• tocilizumab
Symbravo (meloxicam/ rizatriptan)

+

tocilizumab

1 interaction

Monitor/Modify Tx

meloxicam + tocilizumab

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• tofacitinib
Symbravo (meloxicam/ rizatriptan)

+

tofacitinib

1 interaction

Monitor/Modify Tx

meloxicam + tofacitinib

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• tolvaptan
Symbravo (meloxicam/ rizatriptan)

+

tolvaptan

1 interaction

Monitor/Modify Tx

meloxicam + tolvaptan

monitor potassium: combo may incr. risk of hyperkalemia (additive effects)

• toremifene
Symbravo (meloxicam/ rizatriptan)

+

toremifene

1 interaction

Monitor/Modify Tx

meloxicam + toremifene

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• torsemide
Symbravo (meloxicam/ rizatriptan)

+

torsemide

2 interactions

Monitor/Modify Tx

meloxicam + torsemide

monitor renal fxn, BP: combo may incr. risk of renal impairment; may decr. torsemide efficacy (additive effects; antagonistic effects)

rizatriptan + torsemide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• tovorafenib
Symbravo (meloxicam/ rizatriptan)

+

tovorafenib

1 interaction

Monitor/Modify Tx

meloxicam + tovorafenib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• trametinib
Symbravo (meloxicam/ rizatriptan)

+

trametinib

2 interactions

Monitor/Modify Tx

meloxicam + trametinib

monitor BP, bleeding or thrombosis s/sx, especially w/ concomitant dabrafenib use; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism, GI ulceration, perforation, bleeding, including life-threatening (additive effects)

rizatriptan + trametinib

monitor BP: combo may incr. risk of HTN (additive effects)

• trandolapril
Symbravo (meloxicam/ rizatriptan)

+

trandolapril

2 interactions

Monitor/Modify Tx

meloxicam + trandolapril

monitor renal fxn, BP, potassium: combo may incr. risk of renal impairment, hyperkalemia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

rizatriptan + trandolapril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• trazodone
Symbravo (meloxicam/ rizatriptan)

+

trazodone

2 interactions

Monitor/Modify Tx

meloxicam + trazodone

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

rizatriptan + trazodone

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• treprostinil
Symbravo (meloxicam/ rizatriptan)

+

treprostinil

1 interaction

Monitor/Modify Tx

meloxicam + treprostinil

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• tretinoin
Symbravo (meloxicam/ rizatriptan)

+

tretinoin

1 interaction

Monitor/Modify Tx

meloxicam + tretinoin

monitor thrombosis s/sx, especially during 1st month of tretinoin use; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• triamcinolone
Symbravo (meloxicam/ rizatriptan)

+

triamcinolone

2 interactions

Monitor/Modify Tx

meloxicam + triamcinolone

monitor BP, bleeding s/sx: combo may incr. risk of HTN, GI ulceration, perforation, bleeding, including life-threatening (additive effects)

rizatriptan + triamcinolone

monitor BP: combo may incr. risk of HTN (additive effects)

• triamterene
Symbravo (meloxicam/ rizatriptan)

+

triamterene

2 interactions

Monitor/Modify Tx

meloxicam + triamterene

monitor renal fxn, potassium, BP: combo may incr. risk of renal impairment, severe hyperkalemia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

rizatriptan + triamterene

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• triazolam
Symbravo (meloxicam/ rizatriptan)

+

triazolam

1 interaction

Monitor/Modify Tx

rizatriptan + triazolam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• trimethoprim
Symbravo (meloxicam/ rizatriptan)

+

trimethoprim

1 interaction

Monitor/Modify Tx

meloxicam + trimethoprim

monitor potassium: combo may incr. risk of hyperkalemia (additive effects)

• ubrogepant
Symbravo (meloxicam/ rizatriptan)

+

ubrogepant

2 interactions

Monitor/Modify Tx

meloxicam + ubrogepant

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + ubrogepant

monitor BP: combo may incr. risk of HTN (additive effects)

• upadacitinib
Symbravo (meloxicam/ rizatriptan)

+

upadacitinib

1 interaction

Monitor/Modify Tx

meloxicam + upadacitinib

monitor bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism (additive effects)

• vadadustat
Symbravo (meloxicam/ rizatriptan)

+

vadadustat

2 interactions

Monitor/Modify Tx

meloxicam + vadadustat

monitor BP, Hgb, bleeding or thrombosis s/sx; use lowest effective vadadustat dose; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of HTN (including hypertensive crisis), thromboembolism, GI ulceration, perforation, bleeding, including life-threatening (additive effects)

rizatriptan + vadadustat

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• valacyclovir
Symbravo (meloxicam/ rizatriptan)

+

valacyclovir

1 interaction

Monitor/Modify Tx

meloxicam + valacyclovir

monitor renal fxn: combo may incr. acyclovir levels, risk of nephrotoxicity, other adverse effects (additive effects)

• valganciclovir
Symbravo (meloxicam/ rizatriptan)

+

valganciclovir

1 interaction

Monitor/Modify Tx

meloxicam + valganciclovir

monitor CBC, renal fxn: combo may incr. ganciclovir levels, risk of myelosuppression, nephrotoxicity, other adverse effects (additive effects)

• valoctocogene roxaparvovec
Symbravo (meloxicam/ rizatriptan)

+

valoctocogene roxaparvovec

1 interaction

Monitor/Modify Tx

meloxicam + valoctocogene roxaparvovec

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• valproic acid
Symbravo (meloxicam/ rizatriptan)

+

valproic acid

2 interactions

Monitor/Modify Tx

meloxicam + valproic acid

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

Caution Advised

rizatriptan + valproic acid

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• vamorolone
Symbravo (meloxicam/ rizatriptan)

+

vamorolone

2 interactions

Monitor/Modify Tx

meloxicam + vamorolone

monitor BP, bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism, GI ulceration, perforation, bleeding, including life-threatening (additive effects)

rizatriptan + vamorolone

monitor BP: combo may incr. risk of HTN (additive effects)

• vancomycin
Symbravo (meloxicam/ rizatriptan)

+

vancomycin

1 interaction

Monitor/Modify Tx

meloxicam + vancomycin

VANCOMYCIN IV: monitor renal fxn, vancomycin levels, ototoxicity; VANCOMYCIN PO: consider monitoring renal fxn, vancomycin levels, ototoxicity in pts w/ severe renal impairment, severe intestinal inflammation, or prolonged course >2 g/day: combo may incr. vancomycin levels, risk of nephrotoxicity, auditory, vestibular, other adverse effects (additive effects; incr. oral vancomycin absorption if inflamed or compromised gut mucosa)

• vandetanib
Symbravo (meloxicam/ rizatriptan)

+

vandetanib

2 interactions

Monitor/Modify Tx

meloxicam + vandetanib

monitor BP, bleeding s/sx: combo may incr. risk of HTN, GI or other bleeding, including life-threatening (additive effects)

rizatriptan + vandetanib

monitor BP: combo may incr. risk of HTN (additive effects)

• varicella zoster immune globulin
Symbravo (meloxicam/ rizatriptan)

+

varicella zoster immune globulin

1 interaction

Monitor/Modify Tx

meloxicam + varicella zoster immune globulin

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• vasopressin
Symbravo (meloxicam/ rizatriptan)

+

vasopressin

2 interactions

Monitor/Modify Tx

meloxicam + vasopressin

monitor BP, sodium: combo may incr. risk of HTN, hyponatremia (additive effects)

rizatriptan + vasopressin

monitor BP: combo may incr. risk of HTN (additive effects)

• verapamil
Symbravo (meloxicam/ rizatriptan)

+

verapamil

2 interactions

Monitor/Modify Tx

meloxicam + verapamil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

rizatriptan + verapamil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• vilanterol inhaled
Symbravo (meloxicam/ rizatriptan)

+

vilanterol inhaled

2 interactions

Monitor/Modify Tx

meloxicam + vilanterol inhaled

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + vilanterol inhaled

monitor BP: combo may incr. risk of HTN (additive effects)

• viloxazine
Symbravo (meloxicam/ rizatriptan)

+

viloxazine

2 interactions

Monitor/Modify Tx

meloxicam + viloxazine

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + viloxazine

monitor BP: combo may incr. risk of HTN, CNS depression, psychomotor impairment (additive effects)

• vinpocetine
Symbravo (meloxicam/ rizatriptan)

+

vinpocetine

1 interaction

Monitor/Modify Tx

meloxicam + vinpocetine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• voclosporin
Symbravo (meloxicam/ rizatriptan)

+

voclosporin

2 interactions

Monitor/Modify Tx

meloxicam + voclosporin

monitor potassium, renal fxn, BP: combo may incr. risk of severe hyperkalemia, nephrotoxicity, HTN (additive effects)

rizatriptan + voclosporin

monitor BP: combo may incr. risk of HTN (additive effects)

• von Willebrand factor
Symbravo (meloxicam/ rizatriptan)

+

von Willebrand factor

1 interaction

Monitor/Modify Tx

meloxicam + von Willebrand factor

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• vorapaxar
Symbravo (meloxicam/ rizatriptan)

+

vorapaxar

1 interaction

Monitor/Modify Tx

meloxicam + vorapaxar

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• voriconazole
Symbravo (meloxicam/ rizatriptan)

+

voriconazole

1 interaction

Monitor/Modify Tx

meloxicam + voriconazole

monitor bleeding s/sx; use lowest effective meloxicam dose, shortest duration of concomitant tx: combo may incr. meloxicam levels, risk of GI or other bleeding (including life-threatening), other adverse effects (hepatic metabolism possibly inhibited)

• vorinostat
Symbravo (meloxicam/ rizatriptan)

+

vorinostat

1 interaction

Monitor/Modify Tx

meloxicam + vorinostat

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

• warfarin
Symbravo (meloxicam/ rizatriptan)

+

warfarin

1 interaction

Monitor/Modify Tx

meloxicam + warfarin

monitor INR, bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (synergistic effects)

• zaleplon
Symbravo (meloxicam/ rizatriptan)

+

zaleplon

1 interaction

Monitor/Modify Tx

rizatriptan + zaleplon

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zanubrutinib
Symbravo (meloxicam/ rizatriptan)

+

zanubrutinib

1 interaction

Monitor/Modify Tx

meloxicam + zanubrutinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• zavegepant
Symbravo (meloxicam/ rizatriptan)

+

zavegepant

2 interactions

Monitor/Modify Tx

meloxicam + zavegepant

monitor BP: combo may incr. risk of HTN (additive effects)

rizatriptan + zavegepant

monitor BP: combo may incr. risk of HTN (additive effects)

• ziconotide
Symbravo (meloxicam/ rizatriptan)

+

ziconotide

1 interaction

Monitor/Modify Tx

rizatriptan + ziconotide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ziv-aflibercept
Symbravo (meloxicam/ rizatriptan)

+

ziv-aflibercept

2 interactions

Monitor/Modify Tx

meloxicam + ziv-aflibercept

monitor BP, bleeding or thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN (additive effects)

rizatriptan + ziv-aflibercept

monitor BP: combo may incr. risk of HTN (additive effects)

• zoledronic acid
Symbravo (meloxicam/ rizatriptan)

+

zoledronic acid

1 interaction

Monitor/Modify Tx

meloxicam + zoledronic acid

monitor renal fxn: combo may incr. zoledronic acid levels, risk of nephrotoxicity, other adverse effects (additive effects)

• zolpidem
Symbravo (meloxicam/ rizatriptan)

+

zolpidem

1 interaction

Monitor/Modify Tx

rizatriptan + zolpidem

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zonisamide
Symbravo (meloxicam/ rizatriptan)

+

zonisamide

2 interactions

Monitor/Modify Tx

meloxicam + zonisamide

monitor renal fxn: combo may incr. risk of renal impairment (additive effects)

Caution Advised

rizatriptan + zonisamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zopapogene imadenovec
Symbravo (meloxicam/ rizatriptan)

+

zopapogene imadenovec

1 interaction

Monitor/Modify Tx

meloxicam + zopapogene imadenovec

monitor thrombosis s/sx; use lowest effective meloxicam dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

Caution Advised

• allopurinol
Symbravo (meloxicam/ rizatriptan)

+

allopurinol

1 interaction

Caution Advised

rizatriptan + allopurinol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• amantadine
Symbravo (meloxicam/ rizatriptan)

+

amantadine

1 interaction

Caution Advised

rizatriptan + amantadine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• apomorphine
Symbravo (meloxicam/ rizatriptan)

+

apomorphine

1 interaction

Caution Advised

rizatriptan + apomorphine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• apraclonidine ophthalmic
Symbravo (meloxicam/ rizatriptan)

+

apraclonidine ophthalmic

1 interaction

Caution Advised

rizatriptan + apraclonidine ophthalmic

caution advised if apraclonidine IOP adjunct use; postop use OK: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• aripiprazole bimonthly injection
Symbravo (meloxicam/ rizatriptan)

+

aripiprazole bimonthly injection

1 interaction

Caution Advised

rizatriptan + aripiprazole bimonthly injection

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• aripiprazole lauroxil
Symbravo (meloxicam/ rizatriptan)

+

aripiprazole lauroxil

1 interaction

Caution Advised

rizatriptan + aripiprazole lauroxil

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• aripiprazole monthly injection
Symbravo (meloxicam/ rizatriptan)

+

aripiprazole monthly injection

1 interaction

Caution Advised

rizatriptan + aripiprazole monthly injection

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• aripiprazole oral
Symbravo (meloxicam/ rizatriptan)

+

aripiprazole oral

1 interaction

Caution Advised

rizatriptan + aripiprazole oral

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• asenapine
Symbravo (meloxicam/ rizatriptan)

+

asenapine

1 interaction

Caution Advised

rizatriptan + asenapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• baclofen
Symbravo (meloxicam/ rizatriptan)

+

baclofen

1 interaction

Caution Advised

rizatriptan + baclofen

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• brexpiprazole
Symbravo (meloxicam/ rizatriptan)

+

brexpiprazole

1 interaction

Caution Advised

rizatriptan + brexpiprazole

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• brimonidine ophthalmic
Symbravo (meloxicam/ rizatriptan)

+

brimonidine ophthalmic

1 interaction

Caution Advised

rizatriptan + brimonidine ophthalmic

caution advised if elevated IOP or presbyopia use; OTC ocular redness use OK: combo may increase risk of CNS depression, psychomotor impairment (additive effects)

• brimonidine topical
Symbravo (meloxicam/ rizatriptan)

+

brimonidine topical

1 interaction

Caution Advised

rizatriptan + brimonidine topical

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• brivaracetam
Symbravo (meloxicam/ rizatriptan)

+

brivaracetam

1 interaction

Caution Advised

rizatriptan + brivaracetam

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• brompheniramine
Symbravo (meloxicam/ rizatriptan)

+

brompheniramine

1 interaction

Caution Advised

rizatriptan + brompheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cannabidiol
Symbravo (meloxicam/ rizatriptan)

+

cannabidiol

1 interaction

Caution Advised

rizatriptan + cannabidiol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• carbinoxamine
Symbravo (meloxicam/ rizatriptan)

+

carbinoxamine

1 interaction

Caution Advised

rizatriptan + carbinoxamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cariprazine
Symbravo (meloxicam/ rizatriptan)

+

cariprazine

1 interaction

Caution Advised

rizatriptan + cariprazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• carisoprodol
Symbravo (meloxicam/ rizatriptan)

+

carisoprodol

1 interaction

Caution Advised

rizatriptan + carisoprodol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cenobamate
Symbravo (meloxicam/ rizatriptan)

+

cenobamate

1 interaction

Caution Advised

rizatriptan + cenobamate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cetirizine
Symbravo (meloxicam/ rizatriptan)

+

cetirizine

1 interaction

Caution Advised

rizatriptan + cetirizine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chamomile, German
Symbravo (meloxicam/ rizatriptan)

+

chamomile, German

1 interaction

Caution Advised

rizatriptan + chamomile, German

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlophedianol
Symbravo (meloxicam/ rizatriptan)

+

chlophedianol

1 interaction

Caution Advised

rizatriptan + chlophedianol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlorcyclizine
Symbravo (meloxicam/ rizatriptan)

+

chlorcyclizine

1 interaction

Caution Advised

rizatriptan + chlorcyclizine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlorpheniramine
Symbravo (meloxicam/ rizatriptan)

+

chlorpheniramine

1 interaction

Caution Advised

rizatriptan + chlorpheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlorzoxazone
Symbravo (meloxicam/ rizatriptan)

+

chlorzoxazone

1 interaction

Caution Advised

rizatriptan + chlorzoxazone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ciprofloxacin
Symbravo (meloxicam/ rizatriptan)

+

ciprofloxacin

1 interaction

Caution Advised

meloxicam + ciprofloxacin

caution advised: combo may incr. risk of CNS stimulation, seizures (mechanism unknown)

• clemastine
Symbravo (meloxicam/ rizatriptan)

+

clemastine

1 interaction

Caution Advised

rizatriptan + clemastine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cyproheptadine
Symbravo (meloxicam/ rizatriptan)

+

cyproheptadine

1 interaction

Caution Advised

rizatriptan + cyproheptadine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dantrolene
Symbravo (meloxicam/ rizatriptan)

+

dantrolene

1 interaction

Caution Advised

rizatriptan + dantrolene

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• darifenacin
Symbravo (meloxicam/ rizatriptan)

+

darifenacin

1 interaction

Caution Advised

rizatriptan + darifenacin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• delafloxacin
Symbravo (meloxicam/ rizatriptan)

+

delafloxacin

1 interaction

Caution Advised

meloxicam + delafloxacin

caution advised: combo may incr. risk of CNS stimulation, seizures (mechanism unknown)

• deutetrabenazine
Symbravo (meloxicam/ rizatriptan)

+

deutetrabenazine

1 interaction

Caution Advised

rizatriptan + deutetrabenazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexbrompheniramine
Symbravo (meloxicam/ rizatriptan)

+

dexbrompheniramine

1 interaction

Caution Advised

rizatriptan + dexbrompheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexchlorpheniramine
Symbravo (meloxicam/ rizatriptan)

+

dexchlorpheniramine

1 interaction

Caution Advised

rizatriptan + dexchlorpheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dichlorphenamide
Symbravo (meloxicam/ rizatriptan)

+

dichlorphenamide

1 interaction

Caution Advised

rizatriptan + dichlorphenamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• difelikefalin
Symbravo (meloxicam/ rizatriptan)

+

difelikefalin

1 interaction

Caution Advised

rizatriptan + difelikefalin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• difenoxin
Symbravo (meloxicam/ rizatriptan)

+

difenoxin

1 interaction

Caution Advised

rizatriptan + difenoxin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dimenhydrinate
Symbravo (meloxicam/ rizatriptan)

+

dimenhydrinate

1 interaction

Caution Advised

rizatriptan + dimenhydrinate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• diphenhydramine
Symbravo (meloxicam/ rizatriptan)

+

diphenhydramine

1 interaction

Caution Advised

rizatriptan + diphenhydramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• diphenoxylate
Symbravo (meloxicam/ rizatriptan)

+

diphenoxylate

1 interaction

Caution Advised

rizatriptan + diphenoxylate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• domperidone
Symbravo (meloxicam/ rizatriptan)

+

domperidone

1 interaction

Caution Advised

rizatriptan + domperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• elinzanetant
Symbravo (meloxicam/ rizatriptan)

+

elinzanetant

1 interaction

Caution Advised

rizatriptan + elinzanetant

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• emtricitabine
Symbravo (meloxicam/ rizatriptan)

+

emtricitabine

1 interaction

Caution Advised

meloxicam + emtricitabine

caution advised, especially w/ high-dose meloxicam: combo may incr. levels of both drugs, risk of adverse effects (renal secretion possibly inhibited)

• entacapone
Symbravo (meloxicam/ rizatriptan)

+

entacapone

1 interaction

Caution Advised

rizatriptan + entacapone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• entrectinib
Symbravo (meloxicam/ rizatriptan)

+

entrectinib

1 interaction

Caution Advised

rizatriptan + entrectinib

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• eslicarbazepine acetate
Symbravo (meloxicam/ rizatriptan)

+

eslicarbazepine acetate

1 interaction

Caution Advised

rizatriptan + eslicarbazepine acetate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ethosuximide
Symbravo (meloxicam/ rizatriptan)

+

ethosuximide

1 interaction

Caution Advised

rizatriptan + ethosuximide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• felbamate
Symbravo (meloxicam/ rizatriptan)

+

felbamate

1 interaction

Caution Advised

rizatriptan + felbamate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fesoterodine
Symbravo (meloxicam/ rizatriptan)

+

fesoterodine

1 interaction

Caution Advised

rizatriptan + fesoterodine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• flibanserin
Symbravo (meloxicam/ rizatriptan)

+

flibanserin

1 interaction

Caution Advised

rizatriptan + flibanserin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• foslevodopa
Symbravo (meloxicam/ rizatriptan)

+

foslevodopa

1 interaction

Caution Advised

rizatriptan + foslevodopa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fosphenytoin
Symbravo (meloxicam/ rizatriptan)

+

fosphenytoin

1 interaction

Caution Advised

rizatriptan + fosphenytoin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ganaxolone
Symbravo (meloxicam/ rizatriptan)

+

ganaxolone

1 interaction

Caution Advised

rizatriptan + ganaxolone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• glofitamab
Symbravo (meloxicam/ rizatriptan)

+

glofitamab

1 interaction

Caution Advised

rizatriptan + glofitamab

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• glycopyrrolate
Symbravo (meloxicam/ rizatriptan)

+

glycopyrrolate

1 interaction

Caution Advised

rizatriptan + glycopyrrolate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• hyoscyamine
Symbravo (meloxicam/ rizatriptan)

+

hyoscyamine

1 interaction

Caution Advised

rizatriptan + hyoscyamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• iloperidone
Symbravo (meloxicam/ rizatriptan)

+

iloperidone

1 interaction

Caution Advised

rizatriptan + iloperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lacosamide
Symbravo (meloxicam/ rizatriptan)

+

lacosamide

1 interaction

Caution Advised

rizatriptan + lacosamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lamotrigine
Symbravo (meloxicam/ rizatriptan)

+

lamotrigine

1 interaction

Caution Advised

rizatriptan + lamotrigine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levetiracetam
Symbravo (meloxicam/ rizatriptan)

+

levetiracetam

1 interaction

Caution Advised

rizatriptan + levetiracetam

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levocetirizine
Symbravo (meloxicam/ rizatriptan)

+

levocetirizine

1 interaction

Caution Advised

rizatriptan + levocetirizine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levodopa
Symbravo (meloxicam/ rizatriptan)

+

levodopa

1 interaction

Caution Advised

rizatriptan + levodopa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levofloxacin
Symbravo (meloxicam/ rizatriptan)

+

levofloxacin

1 interaction

Caution Advised

meloxicam + levofloxacin

caution advised: combo may incr. risk of CNS stimulation, seizures (mechanism unknown)

• linvoseltamab
Symbravo (meloxicam/ rizatriptan)

+

linvoseltamab

1 interaction

Caution Advised

rizatriptan + linvoseltamab

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lofexidine
Symbravo (meloxicam/ rizatriptan)

+

lofexidine

1 interaction

Caution Advised

rizatriptan + lofexidine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• loxapine
Symbravo (meloxicam/ rizatriptan)

+

loxapine

1 interaction

Caution Advised

rizatriptan + loxapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lurasidone
Symbravo (meloxicam/ rizatriptan)

+

lurasidone

1 interaction

Caution Advised

rizatriptan + lurasidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• meclizine
Symbravo (meloxicam/ rizatriptan)

+

meclizine

1 interaction

Caution Advised

rizatriptan + meclizine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• melatonin
Symbravo (meloxicam/ rizatriptan)

+

melatonin

1 interaction

Caution Advised

rizatriptan + melatonin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• meprobamate
Symbravo (meloxicam/ rizatriptan)

+

meprobamate

1 interaction

Caution Advised

rizatriptan + meprobamate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methocarbamol
Symbravo (meloxicam/ rizatriptan)

+

methocarbamol

1 interaction

Caution Advised

rizatriptan + methocarbamol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methsuximide
Symbravo (meloxicam/ rizatriptan)

+

methsuximide

1 interaction

Caution Advised

rizatriptan + methsuximide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• metyrapone
Symbravo (meloxicam/ rizatriptan)

+

metyrapone

1 interaction

Caution Advised

rizatriptan + metyrapone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• metyrosine
Symbravo (meloxicam/ rizatriptan)

+

metyrosine

1 interaction

Caution Advised

rizatriptan + metyrosine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• milsaperidone
Symbravo (meloxicam/ rizatriptan)

+

milsaperidone

1 interaction

Caution Advised

rizatriptan + milsaperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• molindone
Symbravo (meloxicam/ rizatriptan)

+

molindone

1 interaction

Caution Advised

rizatriptan + molindone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• mosunetuzumab
Symbravo (meloxicam/ rizatriptan)

+

mosunetuzumab

1 interaction

Caution Advised

rizatriptan + mosunetuzumab

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• moxifloxacin
Symbravo (meloxicam/ rizatriptan)

+

moxifloxacin

1 interaction

Caution Advised

meloxicam + moxifloxacin

caution advised: combo may incr. risk of CNS stimulation, seizures (mechanism unknown)

• naltrexone
Symbravo (meloxicam/ rizatriptan)

+

naltrexone

1 interaction

Caution Advised

rizatriptan + naltrexone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ofloxacin
Symbravo (meloxicam/ rizatriptan)

+

ofloxacin

1 interaction

Caution Advised

meloxicam + ofloxacin

caution advised: combo may incr. risk of CNS stimulation, seizures (mechanism unknown)

• orphenadrine
Symbravo (meloxicam/ rizatriptan)

+

orphenadrine

1 interaction

Caution Advised

rizatriptan + orphenadrine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• oxcarbazepine
Symbravo (meloxicam/ rizatriptan)

+

oxcarbazepine

1 interaction

Caution Advised

rizatriptan + oxcarbazepine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• paliperidone
Symbravo (meloxicam/ rizatriptan)

+

paliperidone

1 interaction

Caution Advised

rizatriptan + paliperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• passion flower
Symbravo (meloxicam/ rizatriptan)

+

passion flower

1 interaction

Caution Advised

rizatriptan + passion flower

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• perampanel
Symbravo (meloxicam/ rizatriptan)

+

perampanel

1 interaction

Caution Advised

rizatriptan + perampanel

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pheniramine
Symbravo (meloxicam/ rizatriptan)

+

pheniramine

1 interaction

Caution Advised

rizatriptan + pheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• phenytoin
Symbravo (meloxicam/ rizatriptan)

+

phenytoin

1 interaction

Caution Advised

rizatriptan + phenytoin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pimozide
Symbravo (meloxicam/ rizatriptan)

+

pimozide

1 interaction

Caution Advised

rizatriptan + pimozide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pramipexole
Symbravo (meloxicam/ rizatriptan)

+

pramipexole

1 interaction

Caution Advised

rizatriptan + pramipexole

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• prochlorperazine
Symbravo (meloxicam/ rizatriptan)

+

prochlorperazine

1 interaction

Caution Advised

rizatriptan + prochlorperazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pyrilamine
Symbravo (meloxicam/ rizatriptan)

+

pyrilamine

1 interaction

Caution Advised

rizatriptan + pyrilamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ramelteon
Symbravo (meloxicam/ rizatriptan)

+

ramelteon

1 interaction

Caution Advised

rizatriptan + ramelteon

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• repotrectinib
Symbravo (meloxicam/ rizatriptan)

+

repotrectinib

1 interaction

Caution Advised

rizatriptan + repotrectinib

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• risperidone
Symbravo (meloxicam/ rizatriptan)

+

risperidone

1 interaction

Caution Advised

rizatriptan + risperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• rufinamide
Symbravo (meloxicam/ rizatriptan)

+

rufinamide

1 interaction

Caution Advised

rizatriptan + rufinamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• selinexor
Symbravo (meloxicam/ rizatriptan)

+

selinexor

1 interaction

Caution Advised

rizatriptan + selinexor

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• solifenacin
Symbravo (meloxicam/ rizatriptan)

+

solifenacin

1 interaction

Caution Advised

rizatriptan + solifenacin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• stiripentol
Symbravo (meloxicam/ rizatriptan)

+

stiripentol

1 interaction

Caution Advised

rizatriptan + stiripentol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tasimelteon
Symbravo (meloxicam/ rizatriptan)

+

tasimelteon

1 interaction

Caution Advised

rizatriptan + tasimelteon

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tetrabenazine
Symbravo (meloxicam/ rizatriptan)

+

tetrabenazine

1 interaction

Caution Advised

rizatriptan + tetrabenazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• thiotepa
Symbravo (meloxicam/ rizatriptan)

+

thiotepa

1 interaction

Caution Advised

rizatriptan + thiotepa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tiagabine
Symbravo (meloxicam/ rizatriptan)

+

tiagabine

1 interaction

Caution Advised

rizatriptan + tiagabine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tizanidine
Symbravo (meloxicam/ rizatriptan)

+

tizanidine

1 interaction

Caution Advised

rizatriptan + tizanidine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tolcapone
Symbravo (meloxicam/ rizatriptan)

+

tolcapone

1 interaction

Caution Advised

rizatriptan + tolcapone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tolterodine
Symbravo (meloxicam/ rizatriptan)

+

tolterodine

1 interaction

Caution Advised

rizatriptan + tolterodine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• topiramate
Symbravo (meloxicam/ rizatriptan)

+

topiramate

1 interaction

Caution Advised

rizatriptan + topiramate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trifluoperazine
Symbravo (meloxicam/ rizatriptan)

+

trifluoperazine

1 interaction

Caution Advised

rizatriptan + trifluoperazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trihexyphenidyl
Symbravo (meloxicam/ rizatriptan)

+

trihexyphenidyl

1 interaction

Caution Advised

rizatriptan + trihexyphenidyl

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• triprolidine
Symbravo (meloxicam/ rizatriptan)

+

triprolidine

1 interaction

Caution Advised

rizatriptan + triprolidine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trospium
Symbravo (meloxicam/ rizatriptan)

+

trospium

1 interaction

Caution Advised

rizatriptan + trospium

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valbenazine
Symbravo (meloxicam/ rizatriptan)

+

valbenazine

1 interaction

Caution Advised

rizatriptan + valbenazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valerian
Symbravo (meloxicam/ rizatriptan)

+

valerian

1 interaction

Caution Advised

rizatriptan + valerian

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• vigabatrin
Symbravo (meloxicam/ rizatriptan)

+

vigabatrin

1 interaction

Caution Advised

rizatriptan + vigabatrin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)