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Vizz
aceclidine ophthalmic
Adult Dosing .
Dosage forms: SOLUTION: 1.44%
presbyopia
- [2 drops in eye(s) qd]
- Info: wait 2min between each drop
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- caution: iritis history
- caution: retinal disorder
Drug Interactions .
Overview
aceclidine ophthalmic
cholinergic ophthalmic
- cholinergic effects
Caution Advised
- aclidinium inhaled
- amantadine
- amitriptyline
- amoxapine
- atropine
- atropine ophthalmic
- belladonna alkaloids
- benztropine
- brompheniramine
- carbinoxamine
- chlophedianol
- chlorcyclizine
- chlorpheniramine
- chlorpromazine
- clemastine
- clidinium
- clomipramine
- clozapine
- cyclobenzaprine
- cyclopentolate ophthalmic
- cyproheptadine
- darifenacin
- desipramine
- dexbrompheniramine
- dexchlorpheniramine
- dicyclomine
- dimenhydrinate
- diphenhydramine
- disopyramide
- doxepin
- doxepin topical
- doxylamine
- fesoterodine
- flavoxate
- fluphenazine
- glycopyrrolate
- glycopyrrolate inhaled
- glycopyrronium topical
- homatropine
- hydroxyzine
- hyoscyamine
- imipramine
- ipratropium inhaled
- loxapine
- meclizine
- methocarbamol
- methscopolamine
- mirtazapine
- molindone
- nortriptyline
- olanzapine
- orphenadrine
- oxybutynin
- perphenazine
- pheniramine
- pimozide
- procainamide
- prochlorperazine
- promethazine
- protriptyline
- pyrilamine
- quetiapine
- quinidine (antiarrhythmic)
- quinidine (CYP2D6 inhibitor)
- revefenacin inhaled
- scopolamine
- sofpironium topical
- solifenacin
- thioridazine
- thiothixene
- tiotropium inhaled
- tolterodine
- trifluoperazine
- trihexyphenidyl
- trimipramine
- triprolidine
- tropicamide ophthalmic
- trospium
- umeclidinium inhaled
Adverse Reactions .
Serious Reactions
- retinal tear
- retinal detachment
- iritis exacerbation
Common Reactions
- ocular irritation
- blurred vision
- headache
- conjunctival hyperemia
- ocular hyperemia
Safety/Monitoring .
Monitoring Parameters
retinal exam at baseline
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; no human data available, though risk of fetal harm not expected based on limited systemic absorption; no known risk of fetal harm based on animal data with PO route at 70x and 110x MRHD
Lactation
Clinical Summary
may use while breastfeeding; no human data available, though risk of infant harm and adverse effects on milk production not expected based on limited systemic absorption in breastfeeding patients
Pharmacology .
Metabolism: for aceclidine: hydrolysis; CYP450: unknown; Info: limited systemic absorption
Excretion: for aceclidine: unknown; Half-life: unknown
Subclass: Cholinergics/Miotics
Mechanism of Action
for aceclidine: stimulates cholinergic receptors, selectively contracting the iris sphincter muscle
Formulary .
No Formulary Selected
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