LidoPro Ointment

Overview

capsaicin topical

analgesic topical

1. None

lidocaine topical

topical anesthetic

1. displaces liposomal agent
2. lowers seizure threshold
3. methemoglobinemia

menthol topical

analgesic topical; antitussive topical

1. None

methyl salicylate topical

topical salicylate

1. antiplatelet effects
2. hyperuricemic effects

Contraindicated

• acetaminophen
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

acetaminophen

1 interaction

Contraindicated

lidocaine topical + acetaminophen

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• articaine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

articaine

1 interaction

Contraindicated

lidocaine topical + articaine

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• benzocaine topical
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

benzocaine topical

1 interaction

Contraindicated

lidocaine topical + benzocaine topical

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• bupivacaine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

bupivacaine

1 interaction

Contraindicated

lidocaine topical + bupivacaine

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• bupivacaine liposomal
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

bupivacaine liposomal

1 interaction

Contraindicated

lidocaine topical + bupivacaine liposomal

contraindicated if <1 yo; otherwise, monitor BP, HR; admin. bupivacaine liposomal at least 20min after lidocaine: combo may cause rapid release of free bupivacaine from liposomes, incr. risk of hypotension, bradycardia, methemoglobinemia, other adverse effects (liposomal displacement, additive effects)

• butamben
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

butamben

1 interaction

Contraindicated

lidocaine topical + butamben

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• chloroprocaine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

chloroprocaine

1 interaction

Contraindicated

lidocaine topical + chloroprocaine

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• chloroquine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

chloroquine

1 interaction

Contraindicated

lidocaine topical + chloroquine

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• cyclophosphamide
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

cyclophosphamide

1 interaction

Contraindicated

lidocaine topical + cyclophosphamide

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• dapsone
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

dapsone

1 interaction

Contraindicated

lidocaine topical + dapsone

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• dapsone topical
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

dapsone topical

1 interaction

Contraindicated

lidocaine topical + dapsone topical

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• flutamide
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

flutamide

1 interaction

Contraindicated

lidocaine topical + flutamide

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx, consider monitoring methemoglobin levels: combo may incr. risk of methemoglobinemia (additive effects)

• fosphenytoin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

fosphenytoin

1 interaction

Contraindicated

lidocaine topical + fosphenytoin

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia; may alter seizure control (additive effects; antagonistic effects, lidocaine may decr. seizure threshold)

• hydroxyurea
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

hydroxyurea

1 interaction

Contraindicated

lidocaine topical + hydroxyurea

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• ifosfamide
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

ifosfamide

1 interaction

Contraindicated

lidocaine topical + ifosfamide

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• isosorbide dinitrate
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

isosorbide dinitrate

1 interaction

Contraindicated

lidocaine topical + isosorbide dinitrate

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• isosorbide mononitrate
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

isosorbide mononitrate

1 interaction

Contraindicated

lidocaine topical + isosorbide mononitrate

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• lidocaine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

lidocaine

1 interaction

Contraindicated

lidocaine topical + lidocaine

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia, other adverse effects (additive effects, duplicate therapy)

• lidocaine topical
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

lidocaine topical

1 interaction

Contraindicated

lidocaine topical + lidocaine topical

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• mepivacaine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

mepivacaine

1 interaction

Contraindicated

lidocaine topical + mepivacaine

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• metoclopramide
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

metoclopramide

1 interaction

Contraindicated

lidocaine topical + metoclopramide

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• nitric oxide
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

nitric oxide

1 interaction

Contraindicated

lidocaine topical + nitric oxide

contraindicated if <1 yo; otherwise, monitor methemoglobin levels, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• nitrite
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

nitrite

1 interaction

Contraindicated

lidocaine topical + nitrite

contraindicated if <1 yo; otherwise, monitor methemoglobin levels, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• nitrofurantoin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

nitrofurantoin

1 interaction

Contraindicated

lidocaine topical + nitrofurantoin

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• nitroglycerin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

nitroglycerin

1 interaction

Contraindicated

lidocaine topical + nitroglycerin

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• nitroprusside
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

nitroprusside

1 interaction

Contraindicated

lidocaine topical + nitroprusside

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• phenazopyridine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

phenazopyridine

1 interaction

Contraindicated

lidocaine topical + phenazopyridine

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• phenobarbital
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

phenobarbital

1 interaction

Contraindicated

lidocaine topical + phenobarbital

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia; may alter seizure control (additive effects; antagonistic effects, lidocaine may decr. seizure threshold)

• phenytoin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

phenytoin

1 interaction

Contraindicated

lidocaine topical + phenytoin

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia; may alter seizure control (additive effects; antagonistic effects, lidocaine may decr. seizure threshold)

• prilocaine topical
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

prilocaine topical

1 interaction

Contraindicated

lidocaine topical + prilocaine topical

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• primaquine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

primaquine

1 interaction

Contraindicated

lidocaine topical + primaquine

contraindicated if <1 yo; otherwise, use alternative or monitor methemoglobin levels; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• procaine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

procaine

1 interaction

Contraindicated

lidocaine topical + procaine

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• quinine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

quinine

1 interaction

Contraindicated

lidocaine topical + quinine

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• rasburicase
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

rasburicase

1 interaction

Contraindicated

lidocaine topical + rasburicase

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• resorcinol topical
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

resorcinol topical

1 interaction

Contraindicated

lidocaine topical + resorcinol topical

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• ropivacaine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

ropivacaine

1 interaction

Contraindicated

lidocaine topical + ropivacaine

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• sulfadiazine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

sulfadiazine

1 interaction

Contraindicated

lidocaine topical + sulfadiazine

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• sulfamethoxazole
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

sulfamethoxazole

1 interaction

Contraindicated

lidocaine topical + sulfamethoxazole

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• sulfasalazine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

sulfasalazine

1 interaction

Contraindicated

lidocaine topical + sulfasalazine

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• tafenoquine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

tafenoquine

1 interaction

Contraindicated

lidocaine topical + tafenoquine

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• tetracaine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

tetracaine

1 interaction

Contraindicated

lidocaine topical + tetracaine

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• varicella vaccine, live
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

varicella vaccine, live

1 interaction

Contraindicated

methyl salicylate topical + varicella vaccine, live

contraindicated w/in 6wk of varicella vaccine: combo may incr. risk of Reye syndrome; no reports with vaccine but associated with wild-type varicella infection (mechanism unknown, systemic salicylate absorption occurs from topical use)

Avoid/Use Alternative

• aldesleukin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

aldesleukin

1 interaction

Avoid/Use Alternative

lidocaine topical + aldesleukin

avoid combo: combo may incr. risk of seizures (additive effects)

• amifampridine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

amifampridine

1 interaction

Avoid/Use Alternative

lidocaine topical + amifampridine

consider alternative: combo may incr. risk of seizures (additive effects)

• enoxaparin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

enoxaparin

1 interaction

Avoid/Use Alternative

methyl salicylate topical + enoxaparin

use alternative or monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• fondaparinux
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

fondaparinux

1 interaction

Avoid/Use Alternative

methyl salicylate topical + fondaparinux

use alternative or monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• ibuprofen
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

ibuprofen

1 interaction

Avoid/Use Alternative

methyl salicylate topical + ibuprofen

avoid combo: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• indomethacin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

indomethacin

1 interaction

Avoid/Use Alternative

methyl salicylate topical + indomethacin

avoid combo: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• iohexol
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

iohexol

1 interaction

Avoid/Use Alternative

lidocaine topical + iohexol

avoid combo if intrathecal iohexol use: combo may incr. risk of seizures (additive effects)

• meclofenamate
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

meclofenamate

1 interaction

Avoid/Use Alternative

methyl salicylate topical + meclofenamate

avoid combo: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• piroxicam
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

piroxicam

1 interaction

Avoid/Use Alternative

methyl salicylate topical + piroxicam

avoid combo: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

Monitor/Modify Tx

• abrocitinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

abrocitinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + abrocitinib

monitor platelets, bleeding s/sx, especially during abrocitinib tx initiation or if abrocitinib 200 mg/day: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• acalabrutinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

acalabrutinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + acalabrutinib

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• ado-trastuzumab emtansine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

ado-trastuzumab emtansine

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ado-trastuzumab emtansine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• afatinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

afatinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + afatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• alpha-tocopherol (vitamin E)
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

alpha-tocopherol (vitamin E)

1 interaction

Monitor/Modify Tx

methyl salicylate topical + alpha-tocopherol (vitamin E)

monitor bleeding signs/symptoms, especially with alpha-tocopherol doses >800 units/day: combo may increase risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• alprostadil intracavernous
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

alprostadil intracavernous

1 interaction

Monitor/Modify Tx

methyl salicylate topical + alprostadil intracavernous

monitor injection site bleeding signs/symptoms: combo may increase risk of localized bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• alprostadil intravenous
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

alprostadil intravenous

1 interaction

Monitor/Modify Tx

methyl salicylate topical + alprostadil intravenous

monitor bleeding signs/symptoms: combo may increase risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• alteplase
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

alteplase

1 interaction

Monitor/Modify Tx

methyl salicylate topical + alteplase

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• amiodarone
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

amiodarone

1 interaction

Monitor/Modify Tx

lidocaine topical + amiodarone

consider monitoring ECG: combo may incr. risk of cardiac adverse effects (additive effects)

• anacaulase topical
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

anacaulase topical

1 interaction

Monitor/Modify Tx

methyl salicylate topical + anacaulase topical

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• anagrelide
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

anagrelide

1 interaction

Monitor/Modify Tx

methyl salicylate topical + anagrelide

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• antithrombin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

antithrombin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + antithrombin

monitor bleeding s/sx: combo may incr. risk of bleeding, including severe (additive effects, systemic salicylate absorption may occur from topical use)

• apixaban
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

apixaban

1 interaction

Monitor/Modify Tx

methyl salicylate topical + apixaban

monitor bleeding s/sx, especially if methyl salicylate topical applied over large surface area: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption occurs from topical use)

• asparaginase
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

asparaginase

1 interaction

Monitor/Modify Tx

methyl salicylate topical + asparaginase

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• aspirin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

aspirin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + aspirin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding (including life-threatening), other salicylate adverse effects (additive effects, duplicate therapy, systemic salicylate absorption may occur from topical use)

• avapritinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

avapritinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + avapritinib

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• axitinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

axitinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + axitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• bevacizumab
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

bevacizumab

1 interaction

Monitor/Modify Tx

methyl salicylate topical + bevacizumab

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• binimetinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

binimetinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + binimetinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• bivalirudin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

bivalirudin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + bivalirudin

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• brentuximab vedotin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

brentuximab vedotin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + brentuximab vedotin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• bromelain
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

bromelain

1 interaction

Monitor/Modify Tx

methyl salicylate topical + bromelain

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• bromfenac ophthalmic
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

bromfenac ophthalmic

1 interaction

Monitor/Modify Tx

methyl salicylate topical + bromfenac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• bupropion
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

bupropion

1 interaction

Monitor/Modify Tx

lidocaine topical + bupropion

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• cabazitaxel
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

cabazitaxel

1 interaction

Monitor/Modify Tx

methyl salicylate topical + cabazitaxel

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• cabozantinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

cabozantinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + cabozantinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• calaspargase
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

calaspargase

1 interaction

Monitor/Modify Tx

methyl salicylate topical + calaspargase

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• cangrelor
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

cangrelor

1 interaction

Monitor/Modify Tx

methyl salicylate topical + cangrelor

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• caplacizumab
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

caplacizumab

1 interaction

Monitor/Modify Tx

methyl salicylate topical + caplacizumab

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• carfilzomib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

carfilzomib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + carfilzomib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• celecoxib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

celecoxib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + celecoxib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• cilostazol
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

cilostazol

1 interaction

Monitor/Modify Tx

methyl salicylate topical + cilostazol

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• citalopram
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

citalopram

1 interaction

Monitor/Modify Tx

methyl salicylate topical + citalopram

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, systemic salicylate absorption may occur from topical use)

• clopidogrel
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

clopidogrel

1 interaction

Monitor/Modify Tx

methyl salicylate topical + clopidogrel

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• collagenase clostridium histolyticum
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

collagenase clostridium histolyticum

1 interaction

Monitor/Modify Tx

methyl salicylate topical + collagenase clostridium histolyticum

monitor injection site bleeding s/sx: combo may incr. risk of localized bleeding, including severe (additive effects)

• cysteamine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

cysteamine

1 interaction

Monitor/Modify Tx

methyl salicylate topical + cysteamine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• dabigatran
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

dabigatran

1 interaction

Monitor/Modify Tx

methyl salicylate topical + dabigatran

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• dalteparin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

dalteparin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + dalteparin

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• danshen
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

danshen

1 interaction

Monitor/Modify Tx

methyl salicylate topical + danshen

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• desvenlafaxine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

desvenlafaxine

1 interaction

Monitor/Modify Tx

methyl salicylate topical + desvenlafaxine

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, systemic salicylate absorption may occur from topical use)

• deuruxolitinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

deuruxolitinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + deuruxolitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• diclofenac
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

diclofenac

1 interaction

Monitor/Modify Tx

methyl salicylate topical + diclofenac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• diclofenac ophthalmic
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

diclofenac ophthalmic

1 interaction

Monitor/Modify Tx

methyl salicylate topical + diclofenac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• diclofenac topical
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

diclofenac topical

1 interaction

Monitor/Modify Tx

methyl salicylate topical + diclofenac topical

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• diflunisal
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

diflunisal

1 interaction

Monitor/Modify Tx

methyl salicylate topical + diflunisal

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• dimethyl fumarate
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

dimethyl fumarate

1 interaction

Monitor/Modify Tx

methyl salicylate topical + dimethyl fumarate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• diosmin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

diosmin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + diosmin

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• dipyridamole
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

dipyridamole

1 interaction

Monitor/Modify Tx

methyl salicylate topical + dipyridamole

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• diroximel fumarate
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

diroximel fumarate

1 interaction

Monitor/Modify Tx

methyl salicylate topical + diroximel fumarate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• dofetilide
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

dofetilide

1 interaction

Monitor/Modify Tx

lidocaine topical + dofetilide

consider monitoring ECG: combo may incr. risk of cardiac adverse effects (additive effects)

• duloxetine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

duloxetine

1 interaction

Monitor/Modify Tx

methyl salicylate topical + duloxetine

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• edoxaban
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

edoxaban

1 interaction

Monitor/Modify Tx

methyl salicylate topical + edoxaban

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• encorafenib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

encorafenib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + encorafenib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• epoprostenol
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

epoprostenol

1 interaction

Monitor/Modify Tx

methyl salicylate topical + epoprostenol

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• eptifibatide
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

eptifibatide

1 interaction

Monitor/Modify Tx

methyl salicylate topical + eptifibatide

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• erlotinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

erlotinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + erlotinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• escitalopram
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

escitalopram

1 interaction

Monitor/Modify Tx

methyl salicylate topical + escitalopram

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ethanol (alcoholic beverage)
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

ethanol (alcoholic beverage)

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ethanol (alcoholic beverage)

monitor bleeding signs/symptoms: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• etodolac
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

etodolac

1 interaction

Monitor/Modify Tx

methyl salicylate topical + etodolac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• evening primrose oil
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

evening primrose oil

1 interaction

Monitor/Modify Tx

methyl salicylate topical + evening primrose oil

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• fenoprofen
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

fenoprofen

1 interaction

Monitor/Modify Tx

methyl salicylate topical + fenoprofen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• fenugreek
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

fenugreek

1 interaction

Monitor/Modify Tx

methyl salicylate topical + fenugreek

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• fluoxetine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

fluoxetine

1 interaction

Monitor/Modify Tx

methyl salicylate topical + fluoxetine

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, systemic salicylate absorption may occur from topical use)

• flurbiprofen
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

flurbiprofen

1 interaction

Monitor/Modify Tx

methyl salicylate topical + flurbiprofen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• flurbiprofen ophthalmic
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

flurbiprofen ophthalmic

1 interaction

Monitor/Modify Tx

methyl salicylate topical + flurbiprofen ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• fluvoxamine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

fluvoxamine

1 interaction

Monitor/Modify Tx

methyl salicylate topical + fluvoxamine

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, systemic salicylate absorption may occur from topical use)

• fruquintinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

fruquintinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + fruquintinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• garlic
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

garlic

1 interaction

Monitor/Modify Tx

methyl salicylate topical + garlic

monitor bleeding s/sx, especially w/ supplemental garlic; dietary intake OK: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• gefitinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

gefitinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + gefitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• gemtuzumab ozogamicin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

gemtuzumab ozogamicin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + gemtuzumab ozogamicin

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• ginkgo
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

ginkgo

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ginkgo

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• heparin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

heparin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + heparin

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• hydrocortisone
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

hydrocortisone

1 interaction

Monitor/Modify Tx

methyl salicylate topical + hydrocortisone

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• ibrutinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

ibrutinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ibrutinib

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• ibuprofen lysine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

ibuprofen lysine

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ibuprofen lysine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• ibutilide
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

ibutilide

1 interaction

Monitor/Modify Tx

lidocaine topical + ibutilide

consider monitoring ECG: combo may incr. risk of cardiac adverse effects (additive effects)

• icosapent ethyl
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

icosapent ethyl

1 interaction

Monitor/Modify Tx

methyl salicylate topical + icosapent ethyl

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• imatinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

imatinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + imatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• iopamidol
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

iopamidol

1 interaction

Monitor/Modify Tx

lidocaine topical + iopamidol

caution advised if intrathecal iopamidol use; consider holding lidocaine topical at least 48h before and at least 24h after intrathecal iopamidol: combo may incr. risk of seizures (additive effects)

• ketoprofen
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

ketoprofen

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ketoprofen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• ketorolac
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

ketorolac

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ketorolac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• ketorolac ophthalmic
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

ketorolac ophthalmic

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ketorolac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• lenvatinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

lenvatinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + lenvatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• levomilnacipran
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

levomilnacipran

1 interaction

Monitor/Modify Tx

methyl salicylate topical + levomilnacipran

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, systemic salicylate absorption may occur from topical use)

• lifileucel
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

lifileucel

1 interaction

Monitor/Modify Tx

methyl salicylate topical + lifileucel

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• magnesium salicylate
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

magnesium salicylate

1 interaction

Monitor/Modify Tx

methyl salicylate topical + magnesium salicylate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• mefenamic acid
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

mefenamic acid

1 interaction

Monitor/Modify Tx

methyl salicylate topical + mefenamic acid

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• meloxicam
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

meloxicam

1 interaction

Monitor/Modify Tx

methyl salicylate topical + meloxicam

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• methotrexate
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

methotrexate

1 interaction

Monitor/Modify Tx

methyl salicylate topical + methotrexate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• milnacipran
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

milnacipran

1 interaction

Monitor/Modify Tx

methyl salicylate topical + milnacipran

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• mitotane
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

mitotane

1 interaction

Monitor/Modify Tx

methyl salicylate topical + mitotane

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• monomethyl fumarate
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

monomethyl fumarate

1 interaction

Monitor/Modify Tx

methyl salicylate topical + monomethyl fumarate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• mycophenolate mofetil
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

mycophenolate mofetil

1 interaction

Monitor/Modify Tx

methyl salicylate topical + mycophenolate mofetil

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• mycophenolic acid
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

mycophenolic acid

1 interaction

Monitor/Modify Tx

methyl salicylate topical + mycophenolic acid

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• nabumetone
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

nabumetone

1 interaction

Monitor/Modify Tx

methyl salicylate topical + nabumetone

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• naproxen
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

naproxen

1 interaction

Monitor/Modify Tx

methyl salicylate topical + naproxen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• nattokinase
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

nattokinase

1 interaction

Monitor/Modify Tx

methyl salicylate topical + nattokinase

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• nepafenac ophthalmic
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

nepafenac ophthalmic

1 interaction

Monitor/Modify Tx

methyl salicylate topical + nepafenac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• nilotinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

nilotinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + nilotinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• nintedanib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

nintedanib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + nintedanib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• nusinersen
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

nusinersen

1 interaction

Monitor/Modify Tx

methyl salicylate topical + nusinersen

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• obinutuzumab
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

obinutuzumab

1 interaction

Monitor/Modify Tx

methyl salicylate topical + obinutuzumab

monitor platelets, bleeding s/sx; consider holding methyl salicylate topical, especially during first obinutuzumab cycle: combo may incr. risk of severe bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• omega-3-acid
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

omega-3-acid

1 interaction

Monitor/Modify Tx

methyl salicylate topical + omega-3-acid

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects)

• oxaliplatin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

oxaliplatin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + oxaliplatin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• oxaprozin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

oxaprozin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + oxaprozin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• pacritinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

pacritinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + pacritinib

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• paroxetine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

paroxetine

1 interaction

Monitor/Modify Tx

methyl salicylate topical + paroxetine

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pazopanib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

pazopanib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + pazopanib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• pegaspargase
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

pegaspargase

1 interaction

Monitor/Modify Tx

methyl salicylate topical + pegaspargase

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• penicillin G
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

penicillin G

1 interaction

Monitor/Modify Tx

methyl salicylate topical + penicillin G

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• pentosan polysulfate sodium
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

pentosan polysulfate sodium

1 interaction

Monitor/Modify Tx

methyl salicylate topical + pentosan polysulfate sodium

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• piperacillin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

piperacillin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + piperacillin

monitor bleeding s/sx, especially w/ prolonged piperacillin tx and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• pirtobrutinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

pirtobrutinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + pirtobrutinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• plasminogen, human
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

plasminogen, human

1 interaction

Monitor/Modify Tx

methyl salicylate topical + plasminogen, human

monitor bleeding s/sx, especially during and x4h after plasminogen infusion: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• ponatinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

ponatinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ponatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• porfimer
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

porfimer

1 interaction

Monitor/Modify Tx

methyl salicylate topical + porfimer

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• pralsetinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

pralsetinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + pralsetinib

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• prasugrel
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

prasugrel

1 interaction

Monitor/Modify Tx

methyl salicylate topical + prasugrel

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• probenecid
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

probenecid

1 interaction

Monitor/Modify Tx

methyl salicylate topical + probenecid

monitor uric acid levels: combo may decr. probenecid efficacy (antagonistic effects)

• ramucirumab
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

ramucirumab

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ramucirumab

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• ranibizumab
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

ranibizumab

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ranibizumab

monitor bleeding s/sx: combo may incr. risk of ocular hemorrhage (additive effects, systemic salicylate absorption may occur from topical use)

• regorafenib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

regorafenib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + regorafenib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• remibrutinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

remibrutinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + remibrutinib

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• resveratrol
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

resveratrol

1 interaction

Monitor/Modify Tx

methyl salicylate topical + resveratrol

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• reteplase
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

reteplase

1 interaction

Monitor/Modify Tx

methyl salicylate topical + reteplase

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• revakinagene taroretcel
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

revakinagene taroretcel

1 interaction

Monitor/Modify Tx

methyl salicylate topical + revakinagene taroretcel

monitor bleeding s/sx: combo may incr. risk of ocular hemorrhage (additive effects, systemic salicylate absorption may occur from topical use)

• rivaroxaban
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

rivaroxaban

1 interaction

Monitor/Modify Tx

methyl salicylate topical + rivaroxaban

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• saw palmetto
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

saw palmetto

1 interaction

Monitor/Modify Tx

methyl salicylate topical + saw palmetto

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• selpercatinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

selpercatinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + selpercatinib

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• selumetinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

selumetinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + selumetinib

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, antiplatelet and anticoagulant effects augmented by vitamin E content in selumetinib capsules; systemic salicylate absorption may occur from topical use)

• sepiapterin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

sepiapterin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + sepiapterin

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• sertraline
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

sertraline

1 interaction

Monitor/Modify Tx

methyl salicylate topical + sertraline

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, systemic salicylate absorption may occur from topical use)

• sirolimus albumin-bound
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

sirolimus albumin-bound

1 interaction

Monitor/Modify Tx

methyl salicylate topical + sirolimus albumin-bound

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• sorafenib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

sorafenib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + sorafenib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• sotalol
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

sotalol

1 interaction

Monitor/Modify Tx

lidocaine topical + sotalol

consider monitoring ECG: combo may incr. risk of cardiac adverse effects (additive effects)

• sotatercept
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

sotatercept

1 interaction

Monitor/Modify Tx

methyl salicylate topical + sotatercept

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding, including severe (additive effects, systemic salicylate absorption may occur from topical use)

• sulindac
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

sulindac

1 interaction

Monitor/Modify Tx

methyl salicylate topical + sulindac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• sunitinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

sunitinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + sunitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• temsirolimus
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

temsirolimus

1 interaction

Monitor/Modify Tx

methyl salicylate topical + temsirolimus

monitor bleeding signs/symptoms: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• tenecteplase
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

tenecteplase

1 interaction

Monitor/Modify Tx

methyl salicylate topical + tenecteplase

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• ticagrelor
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

ticagrelor

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ticagrelor

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• tipranavir
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

tipranavir

1 interaction

Monitor/Modify Tx

methyl salicylate topical + tipranavir

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• tirofiban
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

tirofiban

1 interaction

Monitor/Modify Tx

methyl salicylate topical + tirofiban

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• tisotumab vedotin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

tisotumab vedotin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + tisotumab vedotin

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• tivozanib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

tivozanib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + tivozanib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• tolmetin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

tolmetin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + tolmetin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• tovorafenib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

tovorafenib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + tovorafenib

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• trametinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

trametinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + trametinib

monitor bleeding s/sx, especially w/ concomitant dabrafenib use: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• trazodone
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

trazodone

1 interaction

Monitor/Modify Tx

methyl salicylate topical + trazodone

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, systemic salicylate absorption may occur from topical use)

• treprostinil
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

treprostinil

1 interaction

Monitor/Modify Tx

methyl salicylate topical + treprostinil

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• upadacitinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

upadacitinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + upadacitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• vadadustat
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

vadadustat

1 interaction

Monitor/Modify Tx

methyl salicylate topical + vadadustat

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• valproic acid
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

valproic acid

2 interactions

Monitor/Modify Tx

methyl salicylate topical + valproic acid

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

Caution Advised

lidocaine topical + valproic acid

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• vandetanib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

vandetanib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + vandetanib

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• venlafaxine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

venlafaxine

1 interaction

Monitor/Modify Tx

methyl salicylate topical + venlafaxine

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• vilazodone
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

vilazodone

1 interaction

Monitor/Modify Tx

methyl salicylate topical + vilazodone

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, systemic salicylate absorption may occur from topical use)

• vinpocetine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

vinpocetine

1 interaction

Monitor/Modify Tx

methyl salicylate topical + vinpocetine

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• vorapaxar
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

vorapaxar

1 interaction

Monitor/Modify Tx

methyl salicylate topical + vorapaxar

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• vortioxetine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

vortioxetine

1 interaction

Monitor/Modify Tx

methyl salicylate topical + vortioxetine

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, systemic salicylate absorption may occur from topical use)

• warfarin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

warfarin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + warfarin

monitor INR, bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (synergistic effects, systemic salicylate absorption occurs from topical use)

• willow bark
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

willow bark

1 interaction

Monitor/Modify Tx

methyl salicylate topical + willow bark

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, willow bark may contain salicylates, systemic salicylate absorption occurs from methyl salicylate topical use)

• zanubrutinib
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

zanubrutinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + zanubrutinib

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• ziv-aflibercept
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

ziv-aflibercept

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ziv-aflibercept

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

Caution Advised

• acetazolamide
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

acetazolamide

1 interaction

Caution Advised

lidocaine topical + acetazolamide

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• bismuth subsalicylate
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

bismuth subsalicylate

1 interaction

Caution Advised

methyl salicylate topical + bismuth subsalicylate

caution advised: combo may incr. salicylate levels, risk of adverse effects (additive effects, systemic salicylate absorption occurs from topical use)

• brivaracetam
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

brivaracetam

1 interaction

Caution Advised

lidocaine topical + brivaracetam

caution advised: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• busulfan
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

busulfan

1 interaction

Caution Advised

lidocaine topical + busulfan

caution advised: combo may incr. risk of seizures (additive effects)

• cannabidiol
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

cannabidiol

1 interaction

Caution Advised

lidocaine topical + cannabidiol

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• carbamazepine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

carbamazepine

1 interaction

Caution Advised

lidocaine topical + carbamazepine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• cenobamate
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

cenobamate

1 interaction

Caution Advised

lidocaine topical + cenobamate

caution advised: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• chlorambucil
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

chlorambucil

1 interaction

Caution Advised

lidocaine topical + chlorambucil

caution advised: combo may incr. risk of seizures (additive effects)

• clobazam
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

clobazam

1 interaction

Caution Advised

lidocaine topical + clobazam

caution advised: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• clomipramine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

clomipramine

1 interaction

Caution Advised

lidocaine topical + clomipramine

caution advised: combo may incr. risk of seizures (additive effects)

• clonazepam
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

clonazepam

1 interaction

Caution Advised

lidocaine topical + clonazepam

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• clorazepate
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

clorazepate

1 interaction

Caution Advised

lidocaine topical + clorazepate

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• clozapine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

clozapine

1 interaction

Caution Advised

lidocaine topical + clozapine

caution advised: combo may incr. risk of seizures (additive effects)

• cocaine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

cocaine

1 interaction

Caution Advised

lidocaine topical + cocaine

caution advised, consider cumulative doses/potential systemic exposure from all topical or local anesthetic formulations used concurrently: combo may incr. risk of adverse effects (additive effects)

• diazepam
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

diazepam

1 interaction

Caution Advised

lidocaine topical + diazepam

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• disopyramide
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

disopyramide

1 interaction

Caution Advised

lidocaine topical + disopyramide

caution advised: combo may incr. risk of adverse effects (additive effects)

• eslicarbazepine acetate
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

eslicarbazepine acetate

1 interaction

Caution Advised

lidocaine topical + eslicarbazepine acetate

caution advised: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• ethosuximide
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

ethosuximide

1 interaction

Caution Advised

lidocaine topical + ethosuximide

caution advised: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• felbamate
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

felbamate

1 interaction

Caution Advised

lidocaine topical + felbamate

caution advised: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• fenfluramine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

fenfluramine

1 interaction

Caution Advised

lidocaine topical + fenfluramine

caution advised: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• flecainide
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

flecainide

1 interaction

Caution Advised

lidocaine topical + flecainide

caution advised: combo may incr. risk of adverse effects (additive effects)

• gabapentin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

gabapentin

1 interaction

Caution Advised

lidocaine topical + gabapentin

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• ganaxolone
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

ganaxolone

1 interaction

Caution Advised

lidocaine topical + ganaxolone

caution advised: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• hydroxychloroquine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

hydroxychloroquine

1 interaction

Caution Advised

lidocaine topical + hydroxychloroquine

caution advised: combo may incr. risk of seizures (additive effects)

• lacosamide
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

lacosamide

1 interaction

Caution Advised

lidocaine topical + lacosamide

caution advised: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• lamotrigine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

lamotrigine

1 interaction

Caution Advised

lidocaine topical + lamotrigine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• levetiracetam
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

levetiracetam

1 interaction

Caution Advised

lidocaine topical + levetiracetam

caution advised: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• lorazepam
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

lorazepam

1 interaction

Caution Advised

lidocaine topical + lorazepam

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• magnesium citrate
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

magnesium citrate

1 interaction

Caution Advised

lidocaine topical + magnesium citrate

caution advised, especially if magnesium citrate bowel prep use: combo may incr. risk of seizures (additive effects)

• methsuximide
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

methsuximide

1 interaction

Caution Advised

lidocaine topical + methsuximide

caution advised: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• mexiletine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

mexiletine

1 interaction

Caution Advised

lidocaine topical + mexiletine

caution advised: combo may incr. risk of adverse effects (additive effects)

• midazolam
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

midazolam

1 interaction

Caution Advised

lidocaine topical + midazolam

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• oxcarbazepine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

oxcarbazepine

1 interaction

Caution Advised

lidocaine topical + oxcarbazepine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• perampanel
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

perampanel

1 interaction

Caution Advised

lidocaine topical + perampanel

caution advised: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• polyethylene glycol
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

polyethylene glycol

1 interaction

Caution Advised

lidocaine topical + polyethylene glycol

caution advised, especially if polyethylene glycol bowel prep use: combo may incr. risk of seizures (additive effects)

• polyethylene glycol/electrolytes
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

polyethylene glycol/ electrolytes

1 interaction

Caution Advised

lidocaine topical + polyethylene glycol/ electrolytes

caution advised: combo may incr. risk of seizures (additive effects)

• pregabalin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

pregabalin

1 interaction

Caution Advised

lidocaine topical + pregabalin

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• primidone
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

primidone

1 interaction

Caution Advised

lidocaine topical + primidone

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• procainamide
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

procainamide

1 interaction

Caution Advised

lidocaine topical + procainamide

caution advised: combo may incr. risk of adverse effects (additive effects)

• promethazine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

promethazine

1 interaction

Caution Advised

lidocaine topical + promethazine

caution advised: combo may incr. risk of seizures (additive effects)

• propafenone
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

propafenone

1 interaction

Caution Advised

lidocaine topical + propafenone

caution advised: combo may incr. risk of adverse effects (additive effects)

• quinidine (antiarrhythmic)
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

quinidine (antiarrhythmic)

1 interaction

Caution Advised

lidocaine topical + quinidine (antiarrhythmic)

caution advised: combo may incr. risk of adverse effects (additive effects)

• rufinamide
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

rufinamide

1 interaction

Caution Advised

lidocaine topical + rufinamide

caution advised: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• salicylic acid topical
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

salicylic acid topical

1 interaction

Caution Advised

methyl salicylate topical + salicylic acid topical

caution advised: combo may incr. risk of local adverse effects if applied to overlapping area; may incr. salicylate levels, risk of systemic adverse effects (additive effects, systemic salicylate absorption occurs from topical use)

• salsalate
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

salsalate

1 interaction

Caution Advised

methyl salicylate topical + salsalate

caution advised: combo may incr. salicylate levels, risk of adverse effects (additive effects, systemic salicylate absorption occurs from topical use)

• sodium picosulfate
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

sodium picosulfate

1 interaction

Caution Advised

lidocaine topical + sodium picosulfate

caution advised: combo may incr. risk of seizures (additive effects)

• stiripentol
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

stiripentol

1 interaction

Caution Advised

lidocaine topical + stiripentol

caution advised: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• sulfate bowel prep
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

sulfate bowel prep

1 interaction

Caution Advised

lidocaine topical + sulfate bowel prep

caution advised: combo may incr. risk of seizures (additive effects)

• tiagabine
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

tiagabine

1 interaction

Caution Advised

lidocaine topical + tiagabine

caution advised: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• topiramate
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

topiramate

1 interaction

Caution Advised

lidocaine topical + topiramate

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• tramadol
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

tramadol

1 interaction

Caution Advised

lidocaine topical + tramadol

caution advised: combo may incr. risk of seizures (additive effects)

• treosulfan
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

treosulfan

1 interaction

Caution Advised

lidocaine topical + treosulfan

caution advised: combo may incr. risk of seizures (additive effects)

• vigabatrin
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

vigabatrin

1 interaction

Caution Advised

lidocaine topical + vigabatrin

caution advised: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• zonisamide
LidoPro Ointment (lidocaine/ menthol/ capsaicin/ methyl salicylate topical)

+

zonisamide

1 interaction

Caution Advised

lidocaine topical + zonisamide

caution advised: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)