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Enflonsia (clesrovimab-cfor)
clesrovimab
Adult Dosing .
Adult dosing is currently unavailable or not applicable for this drug.
Peds Dosing .
- Dosage forms: INJ
Special Note
- [drug name clarification]
- Info: nonproprietary name = clesrovimab-cfor
RSV dz prevention
- [<13 mo]
- Dose: 105 mg IM x1 dose; Start: before start of RSV season; Info: give after birth if born during or entering RSV season; consider additional dose if pt undergoing cardiac surgery w/ cardiopulmonary bypass
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [no adjustment]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
Drug Interactions .
Overview
clesrovimab
antiviral monoclonal antibody
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
Serious Reactions
- hypersensitivity rxn
- anaphylaxis
Common Reactions
- injection site rxn
- rash
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
N/A; drug unlikely to be used during pregnancy based on indication
Lactation
Clinical Summary
N/A; drug unlikely to be used while breastfeeding based on indication
Pharmacology .
Metabolism: other; CYP450: none
Excretion: other; Half-life: 44 days
Subclass: Respiratory Syncytial Virus (RSV)
Mechanism of Action
binds to RSV F protein, inhibiting conformational changes necessary for viral fusion and entry (monoclonal antibody)
Formulary .
No Formulary Selected
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