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Zycubo
copper histidinate
Adult Dosing .
Adult dosing is currently unavailable or not applicable for this drug.
Peds Dosing .
- Dosage forms: INJ
Menkes disease
- [<1 yo]
- Dose: 1.45 mg SC bid
- [1-16 yo]
- Dose: 1.45 mg SC qd
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
Drug Interactions .
Overview
copper histidinate
- heavy metal
- myelosuppressive effects
- nephrotoxicity
Contraindicated
Avoid/Use Alternative
Monitor/Modify Tx
Adverse Reactions .
Serious Reactions
- renal tubular toxicity
- hepatotoxicity
- bone marrow dysfunction
- spleen dysfunction
- seizures
- respiratory infection
- respiratory failure
- cardiopulmonary failure
- hypovolemia
Common Reactions
- pneumonia
- infection
- respiratory failure
- seizures
- hemorrhage
- hypotension
- vomiting
- tachycardia
- fever
- volume depletion
- fracture
- dyspnea
- transaminase elevation
- diarrhea
- anemia
- injection site reaction
Safety/Monitoring .
Monitoring Parameters
BUN/Cr, electrolytes, CBC, LFTs, serum copper and ceruloplasmin levels at baseline, then q6wk x6mo, then q3mo x18mo, then q6mo
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human or animal data available
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: for copper histidinate: unknown; CYP450: unknown
Excretion: for copper histidinate: bile; Half-life: 75h
Subclass: Inherited Metabolic Disorders
Mechanism of Action
for copper histidinate: directly supplies bioavailable copper ions, increasing serum copper and ceruloplasmin concentrations
Formulary .
No Formulary Selected
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