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Zycubo
copper histidinate
Adult Dosing .
Adult dosing is currently unavailable or not applicable for this drug.
Peds Dosing .
- Dosage forms: INJ
Menkes disease
- [<1 yo]
- Dose: 1.45 mg SC bid
- [1-16 yo]
- Dose: 1.45 mg SC qd
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
Drug Interactions .
Overview
copper histidinate
- heavy metal
- myelosuppressive effects
- nephrotoxicity
Contraindicated
- cidofovir
Avoid/Use Alternative
- aldesleukin
- amikacin
- amikacin inhaled
- bumetanide
- chloramphenicol
- cladribine oral
- clofarabine
- deferiprone
- fexinidazole
- foscarnet
- ganciclovir
- gentamicin
- mannitol
- methotrexate
- oxaliplatin
- penicillamine
- pentamidine
- polymyxin B
- primaquine
- radium Ra 223 dichloride
- ropeginterferon alfa-2b
- streptomycin
- streptozocin
- tenofovir disoproxil
- tobramycin inhaled
- valganciclovir
Monitor/Modify Tx
- abemaciclib
- acalabrutinib
- acyclovir
- adefovir dipivoxil
- ado-trastuzumab emtansine
- afamitresgene autoleucel
- albendazole
- alectinib
- alemtuzumab
- aliskiren
- allopurinol
- amiloride
- amphotericin
- anthrax immune globulin
- anti-thymocyte globulin
- arsenic trioxide
- asciminib
- aspirin
- atidarsagene autotemcel
- auranofin
- axicabtagene ciloleucel
- axitinib
- azacitidine
- azathioprine
- azilsartan medoxomil
- balsalazide
- baricitinib
- belantamab mafodotin
- belinostat
- benazepril
- bendamustine
- benznidazole
- betibeglogene autotemcel
- bevacizumab
- bexarotene
- bleomycin
- blinatumomab
- bortezomib
- bosutinib
- botulism immune globulin
- brentuximab vedotin
- brexucabtagene autoleucel
- busulfan
- cabazitaxel
- cabozantinib
- candesartan cilexetil
- capecitabine
- captopril
- carboplatin
- carfilzomib
- carmustine
- celecoxib
- chlorambucil
- chlorothiazide
- chlorthalidone
- ciltacabtagene autoleucel
- cisplatin
- cladribine injection
- clindamycin
- clozapine
- colchicine
- colistimethate
- copanlisib
- creatine
- crizotinib
- cyclophosphamide
- cyclosporine
- cytarabine
- cytomegalovirus immune globulin
- dacarbazine
- dactinomycin
- dapsone
- daratumumab
- dasatinib
- daunorubicin
- decitabine
- deferasirox
- deferoxamine
- deuruxolitinib
- dexrazoxane
- diclofenac
- diclofenac topical
- diflunisal
- dinutuximab
- docetaxel
- dostarlimab
- doxorubicin
- duvelisib
- eflornithine
- elivaldogene autotemcel
- elranatamab
- enalapril
- enalaprilat
- enfortumab vedotin
- entrectinib
- epcoritamab
- epirubicin
- eribulin
- ethacrynic acid
- etodolac
- etoposide
- etuvetidigene autotemcel
- everolimus
- exagamglogene autotemcel
- fam-trastuzumab deruxtecan
- fedratinib
- fenoprofen
- floxuridine
- flucytosine
- fludarabine
- fluorouracil
- fluphenazine
- flurbiprofen
- fosfomycin injection
- fosinopril
- fostamatinib
- furosemide
- gemcitabine
- gemtuzumab ozogamicin
- givinostat
- glasdegib
- glofitamab
- hydrochlorothiazide
- hydroxocobalamin IV
- hydroxychloroquine
- hydroxyurea
- ibritumomab tiuxetan
- ibrutinib
- ibuprofen
- ibuprofen lysine
- idarubicin
- idecabtagene vicleucel
- idelalisib
- ifosfamide
- imatinib
- imetelstat
- immune globulin
- indapamide
- indomethacin
- inotuzumab ozogamicin
- interferon beta 1a
- interferon beta 1b
- interferon gamma 1b
- iodixanol
- iohexol
- iomeprol
- iopamidol
- iopromide
- iothalamate meglumine
- ioversol
- irbesartan
- irinotecan
- isatuximab
- ivosidenib
- ixabepilone
- ketoprofen
- ketorolac
- leflunomide
- lenalidomide
- lenvatinib
- lifileucel
- linezolid
- linvoseltamab
- lisinopril
- lisocabtagene maraleucel
- lithium
- lomustine
- lonafarnib
- loncastuximab tesirine
- losartan
- lovotibeglogene autotemcel
- lurbinectedin
- lutetium Lu 177 dotatate
- lutetium Lu 177 vipivotide tetraxetan
- lymphocyte immune globulin, anti-thymocyte globulin
- magnesium citrate
- magnesium salicylate
- marnetegragene autotemcel
- meclofenamate
- mefenamic acid
- meloxicam
- melphalan
- mercaptopurine
- mesalamine
- mesalamine rectal
- metolazone
- midostaurin
- mitomycin
- mitotane
- mitoxantrone
- moexipril
- mogamulizumab
- momelotinib
- mosunetuzumab
- mycophenolate mofetil
- mycophenolic acid
- nabumetone
- naproxen
- nelarabine
- neomycin
- nilotinib
- niraparib
- nusinersen
- obecabtagene autoleucel
- obinutuzumab
- ofatumumab
- olaparib
- olmesartan medoxomil
- olsalazine
- oxaprozin
- paclitaxel
- pacritinib
- palbociclib
- pamidronate
- paromomycin
- pazopanib
- peginterferon alfa 2a
- peginterferon beta 1a
- pemetrexed
- pentostatin
- perindopril
- piroxicam
- pirtobrutinib
- plazomicin
- polatuzumab vedotin
- polyethylene glycol
- polyethylene glycol/electrolytes
- pomalidomide
- ponatinib
- pralatrexate
- procarbazine
- proguanil
- pyrimethamine
- quinapril
- quizartinib
- ramipril
- ramucirumab
- relacorilant
- Rho(D) immune globulin
- ribavirin
- ribociclib
- rifabutin
- rituximab
- romidepsin
- rucaparib
- ruxolitinib
- ruxolitinib topical
- sacituzumab govitecan
- salsalate
- sarilumab
- satralizumab
- selinexor
- sirolimus
- sirolimus albumin-bound
- sitagliptin
- sodium picosulfate
- sparsentan
- spironolactone
- stiripentol
- succimer
- sulfasalazine
- sulfate bowel prep
- sulindac
- sunitinib
- tacrolimus
- tafasitamab
- tagraxofusp
- talazoparib
- talquetamab
- tarlatamab
- tazemetostat
- teclistamab
- telavancin
- telmisartan
- temozolomide
- temsirolimus
- tenofovir alafenamide
- teplizumab
- teriflunomide
- thalidomide
- thioguanine
- thiotepa
- tiopronin
- tisagenlecleucel
- tivozanib
- tobramycin
- tocilizumab
- tofacitinib
- tolmetin
- topotecan
- torsemide
- trabectedin
- trandolapril
- trastuzumab
- treosulfan
- triamterene
- trifluridine
- trimethoprim
- upadacitinib
- vaccinia immune globulin
- valacyclovir
- valproic acid
- valsartan
- vancomycin
- venetoclax
- vinblastine
- vincristine
- vinorelbine
- voclosporin
- willow bark
- zanubrutinib
- zidovudine
- ziv-aflibercept
- zoledronic acid
- zonisamide
Adverse Reactions .
Serious Reactions
- renal tubular toxicity
- hepatotoxicity
- bone marrow dysfunction
- spleen dysfunction
- seizures
- respiratory infection
- respiratory failure
- cardiopulmonary failure
- hypovolemia
Common Reactions
- pneumonia
- infection
- respiratory failure
- seizures
- hemorrhage
- hypotension
- vomiting
- tachycardia
- fever
- volume depletion
- fracture
- dyspnea
- transaminase elevation
- diarrhea
- anemia
- injection site reaction
Safety/Monitoring .
Monitoring Parameters
BUN/Cr, electrolytes, CBC, LFTs, serum copper and ceruloplasmin levels at baseline, then q6wk x6mo, then q3mo x18mo, then q6mo
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human or animal data available
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: for copper histidinate: unknown; CYP450: unknown
Excretion: for copper histidinate: bile; Half-life: 75h
Subclass: Inherited Metabolic Disorders
Mechanism of Action
for copper histidinate: directly supplies bioavailable copper ions, increasing serum copper and ceruloplasmin concentrations
Formulary .
No Formulary Selected
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