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Brinsupri
brensocatib
Adult Dosing .
Dosage forms: TAB: 10 mg, 25 mg
non-cystic fibrosis bronchiectasis
- [10-25 mg PO qd]
renal dosing
- [see below]
- eGFR >15: no adjustment; eGFR <15: not defined
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Peds Dosing .
- Dosage forms: TAB: 10 mg, 25 mg
non-cystic fibrosis bronchiectasis
- [12 yo and older]
- Dose: 10-25 mg PO qd
renal dosing
- [see below]
- eGFR >15: no adjustment; eGFR <15: not defined
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
Drug Interactions .
Overview
brensocatib
DPP-1 inhibitor
- immunomodulatory effects
Contraindicated
Monitor/Modify Tx
Adverse Reactions .
Serious Reactions
- skin CA
Common Reactions
- URI
- gingival reaction
- periodontal reaction
- headache
- rash
- alk phos elevated
- xerosis
- hyperkeratosis
- HTN
- alopecia
- ALT or AST incr.
Safety/Monitoring .
Monitoring Parameters
dental exams regularly; dermatologic exams
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; no known risk of fetal harm based on animal data at 20x and 42x MRHD; possible risk of fetal malformations based on animal data at 128x MRHD
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: for brensocatib: liver; CYP450: 2C8, 2D6, 3A (primary) substrate
Excretion: for brensocatib: urine 54.2% (22.8% unchanged), feces 28.3% (2.4% unchanged); Half-life: 25-39h
Subclass: Dipeptidyl Peptidase-1 (DPP-1) Inhibitors
Mechanism of Action
for brensocatib: inhibits dipeptidyl peptidase-1, reducing neutrophil serine proteases activity
Formulary .
No Formulary Selected
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