Select a medication above to begin.
Brinsupri
brensocatib
Adult Dosing .
Dosage forms: TAB: 10 mg, 25 mg
non-cystic fibrosis bronchiectasis
- [10-25 mg PO qd]
renal dosing
- [see below]
- eGFR >15: no adjustment; eGFR <15: not defined
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Peds Dosing .
- Dosage forms: TAB: 10 mg, 25 mg
non-cystic fibrosis bronchiectasis
- [12 yo and older]
- Dose: 10-25 mg PO qd
renal dosing
- [see below]
- eGFR >15: no adjustment; eGFR <15: not defined
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
Drug Interactions .
Overview
brensocatib
DPP-1 inhibitor
- immunosuppressive effects
Contraindicated
- adenovirus vaccine, live
- chikungunya vaccine, live
- cholera vaccine, live
- dengue vaccine, live
- influenza nasal vaccine, live
- measles/mumps/rubella vaccine, live
- rotavirus vaccine, live
- smallpox vaccine, live
- typhoid vaccine, live
- varicella vaccine, live
- yellow fever vaccine, live
Monitor/Modify Tx
- ebola vaccine, live
- smallpox/mpox vaccine, live
Adverse Reactions .
Serious Reactions
- skin CA
Common Reactions
- URI
- gingival reaction
- periodontal reaction
- headache
- rash
- alk phos elevated
- xerosis
- hyperkeratosis
- HTN
- alopecia
- ALT or AST incr.
Safety/Monitoring .
Monitoring Parameters
dental exams regularly; dermatologic exams
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; no known risk of fetal harm based on animal data at 20x and 42x MRHD; possible risk of fetal malformations based on animal data at 128x MRHD
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: liver; CYP450: 2C8, 2D6, 3A (primary) substrate
Excretion: urine 54.2% (22.8% unchanged), feces 28.3% (2.4% unchanged); Half-life: 25-39h
Subclass: Dipeptidyl Peptidase-1 (DPP-1) Inhibitors
Mechanism of Action
inhibits dipeptidyl peptidase-1, reducing neutrophil serine proteases activity
Formulary .
No Formulary Selected
Join Now to View Patient Handouts!
Create a FREE epocrates Online account to access patient medication instructions. Your patients and caregivers will appreciate you printing these friendly handouts, available in English and Spanish. Each handout addresses common concerns such as how to take the medication, and possible side effects.
Current Members: Sign In.
Pill Pictures
Join Now to View Pill Pictures!
Create a FREE epocrates Online account to access full-color images of medications within the drug monograph.
Current Members: Sign In.