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Lifyorli
relacorilant
Adult Dosing .
Dosage forms: CAP: 25 mg, 100 mg
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing including toxicity-related dose adjustments
ovarian CA, platinum-resistant
- [150 mg PO qd on the day before, the day of, the day after each paclitaxel albumin-bound dose]
- Info: for patients with epithelial ovarian, fallopian tube, or primary peritoneal CA who have received 1-3 lines of tx, including bevacizumab; give with food; do not open/crush/chew/dissolve cap
renal dosing
- [see below]
- CrCl >30: no adjustment; CrCl <30: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- bilirubin >1.5x ULN: avoid use
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- glucocorticoid use, concurrent (life-threatening disease use)
- bilirubin >1.5x ULN
- avoid: breastfeeding during tx and x1wk after D/C
- caution: patients of childbearing potential
- caution: male patients of reproductive potential
- caution: patients 65 yo and older
- caution: surgery within 30 days
- caution: stress
- caution: illness, acute
- caution: infection
Drug Interactions .
Overview
relacorilant
glucocorticoid antagonist
- CYP3A4 substrate
- CYP3A4 inhibitor, strong
- CYP2C8 inducer, weak
- glucocorticoid antagonist
- immunomodulatory effects
- myelosuppressive oncologic agent
Contraindicated
- adenovirus vaccine, live
- alfuzosin
- alprazolam
- BCG live intravesical
- betamethasone
- chikungunya vaccine, live
- cholera vaccine, live
- ciclesonide
- cisapride
- colchicine
- conivaptan
- cortisone
- deflazacort
- dengue vaccine, live
- dexamethasone
- dihydroergotamine
- domperidone
- dronedarone
- eliglustat
- eplerenone
- ergotamine
- finerenone
- flibanserin
- fludrocortisone
- gepirone
- hydrocortisone
- influenza nasal vaccine, live
- isavuconazonium
- ivabradine
- lomitapide
- lonafarnib
- lovastatin
- lurasidone
- measles/mumps/rubella vaccine, live
- methylprednisolone
- naloxegol
- pacritinib
- pimozide
- prednisolone
- prednisone
- ranolazine
- rotavirus vaccine, live
- silodosin
- simvastatin
- smallpox vaccine, live
- suzetrigine
- talimogene laherparepvec
- tolvaptan
- triamcinolone
- triazolam
- typhoid vaccine, live
- ubrogepant
- varicella vaccine, live
- venetoclax
- voclosporin
- yellow fever vaccine, live
Avoid/Use Alternative
- acalabrutinib
- adagrasib
- ado-trastuzumab emtansine
- alfentanil
- almotriptan
- amiodarone
- apalutamide
- apixaban
- aprepitant
- aripiprazole bimonthly injection
- aripiprazole lauroxil
- aripiprazole monthly injection
- avanafil
- avapritinib
- axitinib
- bosentan
- bosutinib
- brigatinib
- bromocriptine
- budesonide
- budesonide rectal
- buprenorphine
- buspirone
- butalbital
- cabazitaxel
- cabozantinib
- capivasertib
- carbamazepine
- cariprazine
- ceritinib
- chloramphenicol
- cladribine oral
- cobimetinib
- codeine
- copanlisib
- crizotinib
- dabrafenib
- daridorexant
- dasatinib
- defactinib
- deferiprone
- dexrazoxane
- dihydrocodeine
- disopyramide
- docetaxel
- dordaviprone
- doxorubicin
- duvelisib
- elacestrant
- elagolix
- elbasvir
- eletriptan
- elinzanetant
- encorafenib
- ensartinib
- entrectinib
- enzalutamide
- erdafitinib
- erlotinib
- estazolam
- ethinyl estradiol (contraceptive)
- etoposide
- etrasimod
- everolimus
- fedratinib
- fentanyl
- fesoterodine
- fexinidazole
- fluticasone propionate
- fosaprepitant
- fosphenytoin
- futibatinib
- ganciclovir
- gepotidacin
- gilteritinib
- glasdegib
- grazoprevir
- hydrocodone
- ibrutinib
- idelalisib
- imlunestrant
- irinotecan
- ivacaftor
- ivosidenib
- ixabepilone
- lapatinib
- larotrectinib
- lefamulin
- lemborexant
- lenacapavir
- leniolisib
- levoketoconazole
- lorlatinib
- lumacaftor/ivacaftor
- lurbinectedin
- macitentan
- mefloquine
- meperidine
- methadone
- methylergonovine
- midazolam
- midostaurin
- mifepristone
- mitapivat
- mitotane
- mobocertinib
- natalizumab
- neratinib
- nilotinib
- nimodipine
- nirogacestat
- nisoldipine
- olaparib
- oliceridine
- omaveloxolone
- orforglipron
- oxycodone
- palbociclib
- palifermin
- palovarotene
- pazopanib
- pemigatinib
- penicillamine
- pentobarbital
- pexidartinib
- phenobarbital
- phenytoin
- pimecrolimus topical
- pirtobrutinib
- ponatinib
- pralsetinib
- primaquine
- primidone
- propafenone
- quizartinib
- rabies vaccine
- radium Ra 223 dichloride
- red yeast rice
- regorafenib
- remibrutinib
- repotrectinib
- retapamulin topical
- ribociclib
- rifabutin
- rifampin
- rilzabrutinib
- rimegepant
- rivaroxaban
- ropeginterferon alfa-2b
- ruxolitinib
- ruxolitinib topical
- salmeterol inhaled
- sebetralstat
- selpercatinib
- selumetinib
- sevabertinib
- sildenafil
- siponimod
- sipuleucel-T
- sirolimus
- sirolimus albumin-bound
- sonidegib
- sparsentan
- St. John's wort
- sufentanil
- sunitinib
- sunvozertinib
- suvorexant
- tadalafil
- taletrectinib
- tamsulosin
- tazemetostat
- temsirolimus
- thiotepa
- ticagrelor
- toremifene
- trabectedin
- tramadol
- trazodone
- tretinoin
- valganciclovir
- vamorolone
- vardenafil
- vemurafenib
- vinblastine
- vincristine
- vinorelbine
- vorapaxar
Monitor/Modify Tx
- abemaciclib
- aficamten
- albendazole
- alemtuzumab
- allopurinol
- aminophylline
- amlodipine
- anthrax vaccine
- anti-thymocyte globulin
- aripiprazole oral
- artemether/lumefantrine
- asciminib
- atazanavir
- atidarsagene autotemcel
- atogepant
- atorvastatin
- auranofin
- avacopan
- avatrombopag
- azathioprine
- balsalazide
- baricitinib
- bedaquiline
- benznidazole
- betibeglogene autotemcel
- bortezomib
- brentuximab vedotin
- brexpiprazole
- butorphanol
- chikungunya vaccine
- cidofovir
- cilostazol
- cinacalcet
- clarithromycin
- clonazepam
- clorazepate
- clozapine
- copper histidinate
- COVID-19 vaccine
- cyclophosphamide
- cyclosporine
- dapsone
- darifenacin
- deferasirox
- deuruxolitinib
- diazepam
- diazoxide
- diltiazem
- diphtheria/tetanus vaccine
- diphtheria/tetanus/pertussis vaccine
- dofetilide
- doxercalciferol
- drospirenone (contraceptive)
- drospirenone (hormone replacement)
- ebola vaccine, live
- efavirenz
- efbemalenograstim alfa
- eflapegrastim (G-CSF)
- elexacaftor/tezacaftor/ivacaftor
- elivaldogene autotemcel
- enfortumab vedotin
- erythromycin
- esomeprazole
- estradiol (contraceptive)
- eszopiclone
- etuvetidigene autotemcel
- exagamglogene autotemcel
- felodipine
- filgrastim (G-CSF)
- flucytosine
- fluphenazine
- foscarnet
- fosfomycin injection
- fostamatinib
- givinostat
- guanfacine
- Haemophilus b vaccine
- haloperidol
- hepatitis A vaccine
- hepatitis B vaccine
- human papillomavirus vaccine
- hydroxychloroquine
- hydroxyurea
- ibrexafungerp
- iloperidone
- imatinib
- influenza H5N1 vaccine
- influenza vaccine
- interferon beta 1a
- interferon beta 1b
- interferon gamma 1b
- istradefylline
- itraconazole
- Japanese encephalitis vaccine
- ketoconazole
- lacosamide
- leflunomide
- levomilnacipran
- lidocaine
- linezolid
- loperamide
- lovotibeglogene autotemcel
- lumateperone
- lymphocyte immune globulin, anti-thymocyte globulin
- maraviroc
- marnetegragene autotemcel
- mavacamten
- mavorixafor
- meningococcal vaccine
- mercaptopurine
- mesalamine
- mesalamine rectal
- methotrexate
- milsaperidone
- mirtazapine
- mycophenolate mofetil
- mycophenolic acid
- nerandomilast
- nicardipine
- nifedipine
- nintedanib
- nortriptyline
- olsalazine
- omeprazole
- osilodrostat
- paclitaxel
- paricalcitol
- pegfilgrastim (G-CSF)
- peginterferon alfa 2a
- peginterferon beta 1a
- pentamidine
- pimavanserin
- pneumococcal vaccine
- polatuzumab vedotin
- poliovirus vaccine
- proguanil
- pyrimethamine
- quetiapine
- quinidine (antiarrhythmic)
- quinidine (CYP2D6 inhibitor)
- quinine
- repaglinide
- respiratory syncytial virus vaccine
- revumenib
- ribavirin
- rilpivirine
- riociguat
- rituximab
- romidepsin
- sargramostim (GM-CSF)
- sarilumab
- satralizumab
- saxagliptin
- sertraline
- smallpox/mpox vaccine, live
- solifenacin
- stiripentol
- succimer
- sulfasalazine
- tacrolimus
- teplizumab
- teriflunomide
- tezacaftor/ivacaftor
- thalidomide
- theophylline
- tick-borne encephalitis vaccine
- tocilizumab
- tofacitinib
- tolterodine
- trimethoprim
- typhoid vaccine
- upadacitinib
- valbenazine
- valproic acid
- vancomycin
- vanzacaftor/tezacaftor/deutivacaftor
- verapamil
- vilanterol inhaled
- vilazodone
- voriconazole
- warfarin
- zanubrutinib
- zidovudine
- ziftomenib
- zolpidem
- zuranolone
Caution Advised
- abatacept
- abrocitinib
- adalimumab
- afamitresgene autoleucel
- aldesleukin
- aliskiren
- alosetron
- anakinra
- anifrolumab
- armodafinil
- axicabtagene ciloleucel
- azacitidine
- basiliximab
- beclomethasone inhaled
- beclomethasone nasal
- belatacept
- belimumab
- belinostat
- bendamustine
- bictegravir
- bimekizumab
- blinatumomab
- brexucabtagene autoleucel
- brodalumab
- budesonide inhaled
- budesonide nasal
- busulfan
- canakinumab
- cannabis
- capmatinib
- carboplatin
- carfilzomib
- carmustine
- cenobamate
- certolizumab pegol
- chlorambucil
- chlordiazepoxide
- ciltacabtagene autoleucel
- cisplatin
- cladribine injection
- clindamycin
- clobetasol ophthalmic
- clofarabine
- cobicistat
- coccidioides immitis skin test antigen
- corticotropin
- crovalimab
- cytarabine
- dacarbazine
- dactinomycin
- danicopan
- daratumumab
- darolutamide
- darunavir
- daunorubicin
- delgocitinib topical
- deucravacitinib
- dexamethasone ophthalmic
- difluprednate ophthalmic
- dimethyl fumarate
- dinutuximab
- diroximel fumarate
- doravirine
- doxazosin
- dronabinol
- dupilumab
- dutasteride
- eculizumab
- efgartigimod alfa
- elotuzumab
- elranatamab
- elvitegravir
- emapalumab
- epcoritamab
- epirubicin
- eravacycline
- eribulin
- estradiol (hormone replacement)
- estrogens, esterified (hormone replacement)
- etanercept
- ethinyl estradiol (hormone replacement)
- etravirine
- fingolimod
- floxuridine
- fludarabine
- flunisolide nasal
- fluocinolone intravitreal
- fluorometholone ophthalmic
- fluticasone furoate
- fruquintinib
- gefitinib
- gemtuzumab ozogamicin
- glofitamab
- golimumab
- guselkumab
- hydrocortisone ophthalmic
- ibritumomab tiuxetan
- icotrokinra
- idarubicin
- idecabtagene vicleucel
- ifosfamide
- inebilizumab
- infliximab
- inotuzumab ozogamicin
- iptacopan
- isatuximab
- isradipine
- ixekizumab
- lebrikizumab
- lenalidomide
- lifileucel
- linvoseltamab
- lisocabtagene maraleucel
- lomustine
- loncastuximab tesirine
- lopinavir/ritonavir
- loteprednol ophthalmic
- melphalan
- mirikizumab
- mirvetuximab soravtansine
- mitomycin
- mitoxantrone
- modafinil
- mogamulizumab
- momelotinib
- mometasone implant
- mometasone inhaled
- mometasone nasal
- monomethyl fumarate
- mosunetuzumab
- nadofaragene firadenovec intravesical
- nafcillin
- naldemedine
- narsoplimab
- nelarabine
- nipocalimab
- obecabtagene autoleucel
- obinutuzumab
- ocrelizumab
- ofatumumab
- ospemifene
- oxaliplatin
- oxybutynin
- ozanimod
- pegcetacoplan
- pentostatin
- ponesimod
- pozelimab
- prednisolone ophthalmic
- procarbazine
- ramelteon
- ravulizumab
- rifapentine
- rilonacept
- ripretinib
- risankizumab
- risperidone
- ritlecitinib
- roflumilast
- roflumilast topical
- rozanolixizumab
- secukinumab
- seladelpar
- selinexor
- sibeprenlimab
- siltuximab
- sirolimus topical
- sotorasib
- spesolimab
- sutimlimab
- tacrolimus topical
- tafasitamab
- talquetamab
- tamoxifen
- tarlatamab
- teclistamab
- telisotuzumab vedotin
- temozolomide
- tezepelumab
- thioguanine
- tildrakizumab
- tinidazole
- tisagenlecleucel
- tisotumab vedotin
- topiramate
- topotecan
- tradipitant
- tralokinumab
- tuberculin purified protein derivative
- tucatinib
- ublituximab
- ustekinumab
- vedolizumab
- velpatasvir
- venlafaxine
- vilobelimab
- voxilaprevir
- zaleplon
- zileuton
- zilucoplan
Adverse Reactions .
Serious Reactions
- neutropenia
- febrile neutropenia
- infection, severe
- adrenal insufficiency
- glucocorticoid-treated condition exacerbation
- pleural effusion
Common Reactions
- Hgb decr.
- neutrophils decr.
- fatigue
- nausea
- diarrhea
- Plt decr.
- rash
- appetite decr.
- stomatitis
- cough
- edema
- nail disorder
- fever
- dizziness
- dysgeusia
- dry eyes
- hypotension
- HTN
- acute kidney injury
- febrile neutropenia
- syncope
Safety/Monitoring .
Monitoring Parameters
pregnancy test at baseline; CBC with diff before each paclitaxel albumin-bound dose and as clinically indicated; signs/symptoms of adrenal insufficiency
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; risk of embryo-fetal death and structural abnormalities based on animal data at 0.6x systemic exposure
Individuals of Reproductive Potential
obtain pregnancy test before tx start; avoid pregnancy by using effective contraception during tx and x1wk after D/C in patients of childbearing potential and male patients
Lactation
Clinical Summary
avoid breastfeeding during tx and x1wk after D/C; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: for relacorilant: liver primarily; CYP450: 3A substrate
Excretion: for relacorilant: feces 73% (<1% unchanged), urine 17% (<2% unchanged); Half-life: 27h
Subclass: Glucocorticoid Receptor Antagonists
Mechanism of Action
for relacorilant: inhibits cortisol-induced reduction of tumor necrosis factor alpha and interferon gamma, enhancing apoptosis and antitumor activity when administered with chemotherapy
Formulary .
No Formulary Selected
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