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Hemiclor
chlorthalidone
Adult Dosing .
Dosage forms: TAB: 12.5 mg
Special Note
- [equivalency or interchangeability info]
- Info: not interchangeable with Thalitone; do not substitute on a mg to mg basis
HTN
- [12.5-25 mg PO qam]
- Info: give with food
renal dosing
- [see below]
- renal impairment: not defined, caution advised; anuria: contraindicated
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment/progressive hepatic disease: not defined, caution advised
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- anuria
- avoid: sun exposure
- avoid: UV light exposure, artificial
- caution: hypersensitivity to sulfonamides
- caution: renal impairment
- caution: hepatic impairment
- caution: hepatic disease, progressive
- caution: electrolyte abnormalities
- caution: volume depletion
- caution: seizure disorder
- caution: arrhythmia
- caution: post-sympathectomy
- caution: diabetes mellitus
- caution: SLE
- caution: gout history
- caution: pancreatitis history
- caution: HTN, gestational
- caution: elderly patients
Drug Interactions .
Overview
chlorthalidone
thiazide diuretic
- antihypertensive agent
- binds to anion exchange resin/polymer
- decreases renal perfusion/fxn
- diuretic
- hypercalcemia
- hyperglycemic effects
- hyperuricemic effects
- hypokalemia
- hypomagnesemia
- hyponatremia
- photosensitivity
- urine alkalinizer
Contraindicated
Avoid/Use Alternative
Monitor/Modify Tx
Caution Advised
Adverse Reactions .
Serious Reactions
- hypokalemia, severe
- electrolyte imbalance
- arrhythmia
- pancreatitis
- cholestatic jaundice
- anaphylaxis
- necrotizing angiitis
- erythema multiforme
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
- exfoliative dermatitis
- photosensitivity
- renal failure
- interstitial nephritis
- aplastic anemia
- agranulocytosis
- leukopenia
- hemolytic anemia
- thrombocytopenia
Common Reactions
- hypokalemia
- hypochloremia
- hyponatremia
- hypomagnesemia
- hypercalcemia
- hyperuricemia
- hyperglycemia
- hyperlipidemia
- hypotension, orthostatic
- anorexia
- nausea
- vertigo
- constipation
- dizziness
- photosensitivity
- rash
- urticaria
- paresthesia
- headache
- muscle spasm
- weakness
- impotence
Safety/Monitoring .
Monitoring Parameters
BUN/Cr; electrolytes at baseline, then periodically
Look/Sound-Alike Drug Names
chlorthalidone confused with: chlorothiazide; chlorproMAZINE; clomiPRAMINE
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy if on chronic tx before conception, otherwise weigh risk/benefit; no known risk of teratogenicity based on human data; possible risk of decr. placental perfusion and neonatal adverse effects, including hypoglycemia, thrombocytopenia, and electrolyte abnormalities, based on limited or conflicting human data; risks not observed if chronic use before conception
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; possible risk of infant harm based on limited human data and drug properties; possible decr. milk production based on conflicting human data
Pharmacology .
Metabolism: for chlorthalidone: liver; CYP450: unknown
Excretion: for chlorthalidone: urine 50-75% (primarily unchanged); Half-life: 40-60h
Subclass: Diuretics, Thiazides
Mechanism of Action
for chlorthalidone: inhibits distal convoluted tubule sodium and chloride reabsorption
Formulary .
No Formulary Selected
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