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Jascayd
nerandomilast
Adult Dosing .
Dosage forms: TAB: 9 mg, 18 mg
idiopathic pulmonary fibrosis
- [18 mg PO bid]
- Max: 36 mg/day; Info: may decr. dose to 9 mg PO bid if tolerability concern; do not cut/crush/chew tab, but may disperse tab in water
renal dosing
- [see below]
- eGFR >15: no adjustment; eGFR <15: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
Drug Interactions .
Overview
nerandomilast
PDE4 inhibitor
- CYP3A4 substrate
Avoid/Use Alternative
- apalutamide
- butalbital
- carbamazepine
- cenobamate
- dabrafenib
- efavirenz
- encorafenib
- enzalutamide
- etravirine
- fexinidazole
- fosphenytoin
- ivosidenib
- lopinavir/ritonavir
- lorlatinib
- lumacaftor/ivacaftor
- mavacamten
- mitapivat
- mitotane
- modafinil
- nafcillin
- pacritinib
- pentobarbital
- pexidartinib
- phenobarbital
- phenytoin
- primidone
- repotrectinib
- rifabutin
- rifampin
- rifapentine
- sotorasib
- St. John's wort
Monitor/Modify Tx
- adagrasib
- atazanavir
- ceritinib
- chloramphenicol
- clarithromycin
- cobicistat
- idelalisib
- itraconazole
- ketoconazole
- levoketoconazole
- lonafarnib
- mifepristone
- nefazodone
- nelfinavir
- posaconazole
- ribociclib
- ritonavir
- tipranavir
- tucatinib
- voriconazole
Caution Advised
- pirfenidone
Adverse Reactions .
Serious Reactions
may occur but none reported
Common Reactions
- diarrhea
- URI
- depression
- nausea
- appetite decr.
- fatigue
- weight decr.
- headache
- vomiting
- back pain
- dizziness
- asthenia
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pharmacology .
Metabolism: liver; CYP450: 3A4 substrate; UGT: substrate (enzymes not defined)
Excretion: feces 58% (14% unchanged), urine 36% (13% unchanged); Half-life: 17h
Subclass: Interstitial Lung Disease ; Phosphodiesterase 4 (PDE4) Inhibitors, Pulmonary
Mechanism of Action
inhibits phosphodiesterase type 4B (PDE4B), leading to increased intracellular cAMP levels and reduced expression of pro-fibrotic growth factors and inflammatory cytokines
Formulary .
No Formulary Selected
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