Advil Targeted Relief Cream

Overview

camphor topical

antipruritic topical; antitussive topical

1. None

capsaicin topical

analgesic topical

1. None

menthol topical

analgesic topical; antitussive topical

1. None

methyl salicylate topical

topical salicylate

1. antiplatelet effects
2. hyperuricemic effects

Contraindicated

• varicella vaccine, live
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

varicella vaccine, live

1 interaction

Contraindicated

methyl salicylate topical + varicella vaccine, live

contraindicated w/in 6wk of varicella vaccine: combo may incr. risk of Reye syndrome; no reports with vaccine but associated with wild-type varicella infection (mechanism unknown, systemic salicylate absorption occurs from topical use)

Avoid/Use Alternative

• enoxaparin
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

enoxaparin

1 interaction

Avoid/Use Alternative

methyl salicylate topical + enoxaparin

use alternative or monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• fondaparinux
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

fondaparinux

1 interaction

Avoid/Use Alternative

methyl salicylate topical + fondaparinux

use alternative or monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• ibuprofen
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

ibuprofen

1 interaction

Avoid/Use Alternative

methyl salicylate topical + ibuprofen

avoid combo: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• indomethacin
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

indomethacin

1 interaction

Avoid/Use Alternative

methyl salicylate topical + indomethacin

avoid combo: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• meclofenamate
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

meclofenamate

1 interaction

Avoid/Use Alternative

methyl salicylate topical + meclofenamate

avoid combo: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• piroxicam
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

piroxicam

1 interaction

Avoid/Use Alternative

methyl salicylate topical + piroxicam

avoid combo: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

Monitor/Modify Tx

• abrocitinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

abrocitinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + abrocitinib

monitor platelets, bleeding s/sx, especially during abrocitinib tx initiation or if abrocitinib 200 mg/day: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• acalabrutinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

acalabrutinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + acalabrutinib

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• ado-trastuzumab emtansine
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

ado-trastuzumab emtansine

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ado-trastuzumab emtansine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• afatinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

afatinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + afatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• alpha-tocopherol (vitamin E)
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

alpha-tocopherol (vitamin E)

1 interaction

Monitor/Modify Tx

methyl salicylate topical + alpha-tocopherol (vitamin E)

monitor bleeding signs/symptoms, especially with alpha-tocopherol doses >800 units/day: combo may increase risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• alprostadil intracavernous
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

alprostadil intracavernous

1 interaction

Monitor/Modify Tx

methyl salicylate topical + alprostadil intracavernous

monitor injection site bleeding signs/symptoms: combo may increase risk of localized bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• alprostadil intravenous
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

alprostadil intravenous

1 interaction

Monitor/Modify Tx

methyl salicylate topical + alprostadil intravenous

monitor bleeding signs/symptoms: combo may increase risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• alteplase
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

alteplase

1 interaction

Monitor/Modify Tx

methyl salicylate topical + alteplase

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• anacaulase topical
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

anacaulase topical

1 interaction

Monitor/Modify Tx

methyl salicylate topical + anacaulase topical

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• anagrelide
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

anagrelide

1 interaction

Monitor/Modify Tx

methyl salicylate topical + anagrelide

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• antithrombin
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

antithrombin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + antithrombin

monitor bleeding s/sx: combo may incr. risk of bleeding, including severe (additive effects, systemic salicylate absorption may occur from topical use)

• apixaban
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

apixaban

1 interaction

Monitor/Modify Tx

methyl salicylate topical + apixaban

monitor bleeding s/sx, especially if methyl salicylate topical applied over large surface area: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption occurs from topical use)

• asparaginase
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

asparaginase

1 interaction

Monitor/Modify Tx

methyl salicylate topical + asparaginase

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• aspirin
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

aspirin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + aspirin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding (including life-threatening), other salicylate adverse effects (additive effects, duplicate therapy, systemic salicylate absorption may occur from topical use)

• avapritinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

avapritinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + avapritinib

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• axitinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

axitinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + axitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• bevacizumab
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

bevacizumab

1 interaction

Monitor/Modify Tx

methyl salicylate topical + bevacizumab

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• binimetinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

binimetinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + binimetinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• bismuth subsalicylate
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

bismuth subsalicylate

1 interaction

Monitor/Modify Tx

methyl salicylate topical + bismuth subsalicylate

monitor bleeding signs/symptoms: combo may incr. risk of GI or other bleeding, other adverse effects (additive effects, systemic salicylate absorption occurs from topical use)

• bivalirudin
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

bivalirudin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + bivalirudin

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• brentuximab vedotin
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

brentuximab vedotin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + brentuximab vedotin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• bromelain
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

bromelain

1 interaction

Monitor/Modify Tx

methyl salicylate topical + bromelain

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• bromfenac ophthalmic
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

bromfenac ophthalmic

1 interaction

Monitor/Modify Tx

methyl salicylate topical + bromfenac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• cabazitaxel
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

cabazitaxel

1 interaction

Monitor/Modify Tx

methyl salicylate topical + cabazitaxel

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• cabozantinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

cabozantinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + cabozantinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• calaspargase
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

calaspargase

1 interaction

Monitor/Modify Tx

methyl salicylate topical + calaspargase

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• cangrelor
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

cangrelor

1 interaction

Monitor/Modify Tx

methyl salicylate topical + cangrelor

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• caplacizumab
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

caplacizumab

1 interaction

Monitor/Modify Tx

methyl salicylate topical + caplacizumab

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• carfilzomib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

carfilzomib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + carfilzomib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• celecoxib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

celecoxib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + celecoxib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• cilostazol
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

cilostazol

1 interaction

Monitor/Modify Tx

methyl salicylate topical + cilostazol

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• citalopram
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

citalopram

1 interaction

Monitor/Modify Tx

methyl salicylate topical + citalopram

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, systemic salicylate absorption may occur from topical use)

• clopidogrel
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

clopidogrel

1 interaction

Monitor/Modify Tx

methyl salicylate topical + clopidogrel

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• collagenase clostridium histolyticum
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

collagenase clostridium histolyticum

1 interaction

Monitor/Modify Tx

methyl salicylate topical + collagenase clostridium histolyticum

monitor injection site bleeding s/sx: combo may incr. risk of localized bleeding, including severe (additive effects)

• cysteamine
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

cysteamine

1 interaction

Monitor/Modify Tx

methyl salicylate topical + cysteamine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• dabigatran
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

dabigatran

1 interaction

Monitor/Modify Tx

methyl salicylate topical + dabigatran

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• dalteparin
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

dalteparin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + dalteparin

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• danshen
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

danshen

1 interaction

Monitor/Modify Tx

methyl salicylate topical + danshen

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• desvenlafaxine
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

desvenlafaxine

1 interaction

Monitor/Modify Tx

methyl salicylate topical + desvenlafaxine

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, systemic salicylate absorption may occur from topical use)

• deuruxolitinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

deuruxolitinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + deuruxolitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• diclofenac
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

diclofenac

1 interaction

Monitor/Modify Tx

methyl salicylate topical + diclofenac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• diclofenac ophthalmic
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

diclofenac ophthalmic

1 interaction

Monitor/Modify Tx

methyl salicylate topical + diclofenac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• diclofenac topical
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

diclofenac topical

1 interaction

Monitor/Modify Tx

methyl salicylate topical + diclofenac topical

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• diflunisal
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

diflunisal

1 interaction

Monitor/Modify Tx

methyl salicylate topical + diflunisal

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• dimethyl fumarate
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

dimethyl fumarate

1 interaction

Monitor/Modify Tx

methyl salicylate topical + dimethyl fumarate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• diosmin
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

diosmin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + diosmin

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• dipyridamole
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

dipyridamole

1 interaction

Monitor/Modify Tx

methyl salicylate topical + dipyridamole

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• diroximel fumarate
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

diroximel fumarate

1 interaction

Monitor/Modify Tx

methyl salicylate topical + diroximel fumarate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• duloxetine
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

duloxetine

1 interaction

Monitor/Modify Tx

methyl salicylate topical + duloxetine

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• edoxaban
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

edoxaban

1 interaction

Monitor/Modify Tx

methyl salicylate topical + edoxaban

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• encorafenib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

encorafenib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + encorafenib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• epoprostenol
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

epoprostenol

1 interaction

Monitor/Modify Tx

methyl salicylate topical + epoprostenol

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• eptifibatide
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

eptifibatide

1 interaction

Monitor/Modify Tx

methyl salicylate topical + eptifibatide

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• erlotinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

erlotinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + erlotinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• escitalopram
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

escitalopram

1 interaction

Monitor/Modify Tx

methyl salicylate topical + escitalopram

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ethanol (alcoholic beverage)
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

ethanol (alcoholic beverage)

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ethanol (alcoholic beverage)

monitor bleeding signs/symptoms: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• etodolac
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

etodolac

1 interaction

Monitor/Modify Tx

methyl salicylate topical + etodolac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• evening primrose oil
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

evening primrose oil

1 interaction

Monitor/Modify Tx

methyl salicylate topical + evening primrose oil

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• fenoprofen
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

fenoprofen

1 interaction

Monitor/Modify Tx

methyl salicylate topical + fenoprofen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• fenugreek
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

fenugreek

1 interaction

Monitor/Modify Tx

methyl salicylate topical + fenugreek

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• fluoxetine
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

fluoxetine

1 interaction

Monitor/Modify Tx

methyl salicylate topical + fluoxetine

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, systemic salicylate absorption may occur from topical use)

• flurbiprofen
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

flurbiprofen

1 interaction

Monitor/Modify Tx

methyl salicylate topical + flurbiprofen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• flurbiprofen ophthalmic
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

flurbiprofen ophthalmic

1 interaction

Monitor/Modify Tx

methyl salicylate topical + flurbiprofen ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• fluvoxamine
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

fluvoxamine

1 interaction

Monitor/Modify Tx

methyl salicylate topical + fluvoxamine

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, systemic salicylate absorption may occur from topical use)

• fruquintinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

fruquintinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + fruquintinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• garlic
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

garlic

1 interaction

Monitor/Modify Tx

methyl salicylate topical + garlic

monitor bleeding s/sx, especially w/ supplemental garlic; dietary intake OK: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• gefitinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

gefitinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + gefitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• gemtuzumab ozogamicin
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

gemtuzumab ozogamicin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + gemtuzumab ozogamicin

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• ginkgo
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

ginkgo

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ginkgo

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• heparin
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

heparin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + heparin

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• hydrocortisone
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

hydrocortisone

1 interaction

Monitor/Modify Tx

methyl salicylate topical + hydrocortisone

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• ibrutinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

ibrutinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ibrutinib

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• ibuprofen lysine
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

ibuprofen lysine

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ibuprofen lysine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• icosapent ethyl
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

icosapent ethyl

1 interaction

Monitor/Modify Tx

methyl salicylate topical + icosapent ethyl

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• imatinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

imatinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + imatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• ketoprofen
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

ketoprofen

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ketoprofen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• ketorolac
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

ketorolac

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ketorolac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• ketorolac ophthalmic
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

ketorolac ophthalmic

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ketorolac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• lenvatinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

lenvatinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + lenvatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• levomilnacipran
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

levomilnacipran

1 interaction

Monitor/Modify Tx

methyl salicylate topical + levomilnacipran

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, systemic salicylate absorption may occur from topical use)

• lifileucel
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

lifileucel

1 interaction

Monitor/Modify Tx

methyl salicylate topical + lifileucel

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• magnesium salicylate
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

magnesium salicylate

1 interaction

Monitor/Modify Tx

methyl salicylate topical + magnesium salicylate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• mefenamic acid
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

mefenamic acid

1 interaction

Monitor/Modify Tx

methyl salicylate topical + mefenamic acid

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• meloxicam
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

meloxicam

1 interaction

Monitor/Modify Tx

methyl salicylate topical + meloxicam

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• methotrexate
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

methotrexate

1 interaction

Monitor/Modify Tx

methyl salicylate topical + methotrexate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• milnacipran
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

milnacipran

1 interaction

Monitor/Modify Tx

methyl salicylate topical + milnacipran

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• mitotane
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

mitotane

1 interaction

Monitor/Modify Tx

methyl salicylate topical + mitotane

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• monomethyl fumarate
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

monomethyl fumarate

1 interaction

Monitor/Modify Tx

methyl salicylate topical + monomethyl fumarate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• mycophenolate mofetil
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

mycophenolate mofetil

1 interaction

Monitor/Modify Tx

methyl salicylate topical + mycophenolate mofetil

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• mycophenolic acid
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

mycophenolic acid

1 interaction

Monitor/Modify Tx

methyl salicylate topical + mycophenolic acid

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• nabumetone
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

nabumetone

1 interaction

Monitor/Modify Tx

methyl salicylate topical + nabumetone

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• naproxen
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

naproxen

1 interaction

Monitor/Modify Tx

methyl salicylate topical + naproxen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• nattokinase
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

nattokinase

1 interaction

Monitor/Modify Tx

methyl salicylate topical + nattokinase

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• nepafenac ophthalmic
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

nepafenac ophthalmic

1 interaction

Monitor/Modify Tx

methyl salicylate topical + nepafenac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• nilotinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

nilotinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + nilotinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• nintedanib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

nintedanib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + nintedanib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• nusinersen
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

nusinersen

1 interaction

Monitor/Modify Tx

methyl salicylate topical + nusinersen

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• obinutuzumab
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

obinutuzumab

1 interaction

Monitor/Modify Tx

methyl salicylate topical + obinutuzumab

monitor platelets, bleeding s/sx; consider holding methyl salicylate topical, especially during first obinutuzumab cycle: combo may incr. risk of severe bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• omega-3-acid
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

omega-3-acid

1 interaction

Monitor/Modify Tx

methyl salicylate topical + omega-3-acid

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects)

• oxaliplatin
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

oxaliplatin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + oxaliplatin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• oxaprozin
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

oxaprozin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + oxaprozin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• pacritinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

pacritinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + pacritinib

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• paroxetine
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

paroxetine

1 interaction

Monitor/Modify Tx

methyl salicylate topical + paroxetine

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pazopanib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

pazopanib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + pazopanib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• pegaspargase
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

pegaspargase

1 interaction

Monitor/Modify Tx

methyl salicylate topical + pegaspargase

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• penicillin G
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

penicillin G

1 interaction

Monitor/Modify Tx

methyl salicylate topical + penicillin G

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• pentosan polysulfate sodium
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

pentosan polysulfate sodium

1 interaction

Monitor/Modify Tx

methyl salicylate topical + pentosan polysulfate sodium

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• piperacillin
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

piperacillin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + piperacillin

monitor bleeding s/sx, especially w/ prolonged piperacillin tx and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• pirtobrutinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

pirtobrutinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + pirtobrutinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• plasminogen, human
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

plasminogen, human

1 interaction

Monitor/Modify Tx

methyl salicylate topical + plasminogen, human

monitor bleeding s/sx, especially during and x4h after plasminogen infusion: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• ponatinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

ponatinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ponatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• porfimer
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

porfimer

1 interaction

Monitor/Modify Tx

methyl salicylate topical + porfimer

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• pralsetinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

pralsetinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + pralsetinib

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• prasugrel
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

prasugrel

1 interaction

Monitor/Modify Tx

methyl salicylate topical + prasugrel

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• probenecid
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

probenecid

1 interaction

Monitor/Modify Tx

methyl salicylate topical + probenecid

monitor uric acid levels: combo may decr. probenecid efficacy (antagonistic effects)

• ramucirumab
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

ramucirumab

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ramucirumab

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• ranibizumab
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

ranibizumab

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ranibizumab

monitor bleeding s/sx: combo may incr. risk of ocular hemorrhage (additive effects, systemic salicylate absorption may occur from topical use)

• regorafenib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

regorafenib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + regorafenib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• remibrutinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

remibrutinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + remibrutinib

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• resveratrol
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

resveratrol

1 interaction

Monitor/Modify Tx

methyl salicylate topical + resveratrol

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• reteplase
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

reteplase

1 interaction

Monitor/Modify Tx

methyl salicylate topical + reteplase

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• revakinagene taroretcel
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

revakinagene taroretcel

1 interaction

Monitor/Modify Tx

methyl salicylate topical + revakinagene taroretcel

monitor bleeding s/sx: combo may incr. risk of ocular hemorrhage (additive effects, systemic salicylate absorption may occur from topical use)

• rivaroxaban
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

rivaroxaban

1 interaction

Monitor/Modify Tx

methyl salicylate topical + rivaroxaban

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• saw palmetto
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

saw palmetto

1 interaction

Monitor/Modify Tx

methyl salicylate topical + saw palmetto

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• selpercatinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

selpercatinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + selpercatinib

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• selumetinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

selumetinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + selumetinib

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, antiplatelet and anticoagulant effects augmented by vitamin E content in selumetinib capsules; systemic salicylate absorption may occur from topical use)

• sepiapterin
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

sepiapterin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + sepiapterin

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• sertraline
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

sertraline

1 interaction

Monitor/Modify Tx

methyl salicylate topical + sertraline

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, systemic salicylate absorption may occur from topical use)

• sirolimus albumin-bound
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

sirolimus albumin-bound

1 interaction

Monitor/Modify Tx

methyl salicylate topical + sirolimus albumin-bound

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• sorafenib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

sorafenib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + sorafenib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• sotatercept
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

sotatercept

1 interaction

Monitor/Modify Tx

methyl salicylate topical + sotatercept

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding, including severe (additive effects, systemic salicylate absorption may occur from topical use)

• sulindac
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

sulindac

1 interaction

Monitor/Modify Tx

methyl salicylate topical + sulindac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• sunitinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

sunitinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + sunitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• temsirolimus
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

temsirolimus

1 interaction

Monitor/Modify Tx

methyl salicylate topical + temsirolimus

monitor bleeding signs/symptoms: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• tenecteplase
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

tenecteplase

1 interaction

Monitor/Modify Tx

methyl salicylate topical + tenecteplase

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• ticagrelor
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

ticagrelor

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ticagrelor

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• tipranavir
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

tipranavir

1 interaction

Monitor/Modify Tx

methyl salicylate topical + tipranavir

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• tirofiban
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

tirofiban

1 interaction

Monitor/Modify Tx

methyl salicylate topical + tirofiban

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• tisotumab vedotin
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

tisotumab vedotin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + tisotumab vedotin

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• tivozanib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

tivozanib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + tivozanib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• tolmetin
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

tolmetin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + tolmetin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• tovorafenib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

tovorafenib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + tovorafenib

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• trametinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

trametinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + trametinib

monitor bleeding s/sx, especially w/ concomitant dabrafenib use: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• trazodone
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

trazodone

1 interaction

Monitor/Modify Tx

methyl salicylate topical + trazodone

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, systemic salicylate absorption may occur from topical use)

• treprostinil
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

treprostinil

1 interaction

Monitor/Modify Tx

methyl salicylate topical + treprostinil

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• upadacitinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

upadacitinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + upadacitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• vadadustat
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

vadadustat

1 interaction

Monitor/Modify Tx

methyl salicylate topical + vadadustat

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• valproic acid
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

valproic acid

1 interaction

Monitor/Modify Tx

methyl salicylate topical + valproic acid

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• vandetanib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

vandetanib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + vandetanib

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• venlafaxine
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

venlafaxine

1 interaction

Monitor/Modify Tx

methyl salicylate topical + venlafaxine

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• vilazodone
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

vilazodone

1 interaction

Monitor/Modify Tx

methyl salicylate topical + vilazodone

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, systemic salicylate absorption may occur from topical use)

• vinpocetine
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

vinpocetine

1 interaction

Monitor/Modify Tx

methyl salicylate topical + vinpocetine

monitor bleeding s/sx: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• vorapaxar
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

vorapaxar

1 interaction

Monitor/Modify Tx

methyl salicylate topical + vorapaxar

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• vortioxetine
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

vortioxetine

1 interaction

Monitor/Modify Tx

methyl salicylate topical + vortioxetine

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, systemic salicylate absorption may occur from topical use)

• warfarin
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

warfarin

1 interaction

Monitor/Modify Tx

methyl salicylate topical + warfarin

monitor INR, bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (synergistic effects, systemic salicylate absorption occurs from topical use)

• willow bark
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

willow bark

1 interaction

Monitor/Modify Tx

methyl salicylate topical + willow bark

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, willow bark may contain salicylates, systemic salicylate absorption occurs from methyl salicylate topical use)

• zanubrutinib
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

zanubrutinib

1 interaction

Monitor/Modify Tx

methyl salicylate topical + zanubrutinib

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• ziv-aflibercept
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

ziv-aflibercept

1 interaction

Monitor/Modify Tx

methyl salicylate topical + ziv-aflibercept

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

Caution Advised

• salicylic acid topical
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

salicylic acid topical

1 interaction

Caution Advised

methyl salicylate topical + salicylic acid topical

caution advised: combo may incr. risk of local adverse effects if applied to overlapping area; may incr. salicylate levels, risk of systemic adverse effects (additive effects, systemic salicylate absorption occurs from topical use)

• salsalate
Advil Targeted Relief Cream (camphor/ capsaicin/ menthol/ methyl salicylate topical)

+

salsalate

1 interaction

Caution Advised

methyl salicylate topical + salsalate

caution advised: combo may incr. salicylate levels, risk of adverse effects (additive effects, systemic salicylate absorption occurs from topical use)