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Adquey
difamilast topical
Peds Dosing .
- Dosage forms: OINTMENT: 1%
atopic dermatitis, mild-moderate
- [2 yo and older]
- Dose: apply bid
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- breast administration (breastfeeding patients)
- avoid: use on infected skin
Drug Interactions .
Overview
difamilast topical
PDE4 inhibitor topical
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; inadequate human data available, though risk of fetal harm low based on limited systemic absorption; no known risk of embryo-fetal toxicity based on animal data at 3x and 30x MRHD, though possible risk of skeletal variations, including supernumerary lumbar vertebra, based on conflicting animal data at 14x MRHD; risk of fetal harm, including post-implantation loss, decreased fetal weight, and visceral abnormalities, based on animal data at 263x MRHD
Lactation
Clinical Summary
avoid use on breast while breastfeeding, otherwise weigh risk/benefit on other areas; no human data available, though risk of infant harm low based on limited systemic absorption in breastfeeding patients; no human data available to assess effects on milk production
Pharmacology .
Metabolism: for difamilast: plasma extensively; CYP450: 1A2, 3A4 substrate; Info: limited systemic absorption
Excretion: for difamilast: urine; Half-life: unknown
Subclass: Atopic Dermatitis, Topical Nonsteroidal Agents ; Phosphodiesterase 4 (PDE4) Inhibitors, Dermatologic
Mechanism of Action
for difamilast: exact mechanism of action unknown; inhibits phosphodiesterase type 4 (PDE4), leading to increased intracellular cAMP levels
Formulary .
No Formulary Selected
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